This review addresses the 100-year-old Hill equation (published in January 22, 1910), the first formula relating the result of a reversible association (e.g., concentration of a complex, magnitude of an effect) to the variable concentration of one of the associating substances (the other being present in a constant and relatively low concentration). In addition, the Hill equation was the first (and is the simplest) quantitative receptor model in pharmacology. Although the Hill equation is an empirical receptor model (its parameters have (...) only physico-chemical meaning for a simple ligand binding reaction), it requires only minor a priori knowledge about the mechanism of action for the investigated agonist to reliably fit concentration-response curve data and to yield useful results (in contrast to most of the advanced receptor models). Thus, the Hill equation has remained an important tool for physiological and pharmacological investigations including drug discovery, moreover it serves as a theoretical basis for the development of new pharmacological models. (shrink)

Recensendo nel 1923 il film Phantom di Murnau (1922), Balazs lo descrive come «un buon film tedesco»: tedesco non a causa del luogo in cui è stato prodotto ma del suo «stile» particolare, caratterizzato dal tentativo di «spiritualizzare la tecnica cinematografica». Questa possibilità di conciliare spirito e tecnica si fonda, secondo Balazs, sulla capacità del film di captare fotograficamente la Stimmung - termine intraducibile, che renderemo a volte con ‘tonalità affettiva’, ‘situazione’ o ‘a...

ABSTRACTThe general assumption that people fail to notice discrepancy between their answer and the normative answer in the conjunction fallacy task has been challenged by the theory of Logical Intuition. This theory suggests that people can detect the conflict between the heuristic and normative answers even if they do not always manage to inhibit their intuitive choice. This theory gained support from the finding that people report lower levels of confidence in their choice after they commit the conjunction fallacy compared (...) to when their answer is not in conflict with logic. In four experiments we asked the participants to give probability estimations to the options of the conflict and no-conflict versions of the tasks in the original set-up of the experiment or in a three-option design. We found that participants perceive probabilities for the options of the conflict version less similar than for the no-conflict version. As people are less confident when choosing between more similar options, this simil.. (shrink)

Physicalism is often characterized as an empirical hypothesis. But according to an alternative conceptualization, it is instead a stance or an attitude. I analyze Roy Wood Sellars’s materialist philosophy in order to show that it is a counterexample to a specific physicalist empirical hypothesis: the minimal completeness of the physical. However, it is arguably not reducible to a stance: it is a meaningful metaphysical thesis with substantive cognitive content.

The notion of common cause closedness of a classical, Kolmogorovian probability space with respect to a causal independence relation between the random events is defined, and propositions are presented that characterize common cause closedness for specific probability spaces. It is proved in particular that no probability space with a finite number of random events can contain common causes of all the correlations it predicts; however, it is demonstrated that probability spaces even with a finite number of random events can be (...) common cause closed with respect to a causal independence relation that is stronger than logical independence. Furthermore it is shown that infinite, atomless probability spaces are always common cause closed in the strongest possible sense. Open problems concerning common cause closedness are formulated and the results are interpreted from the perspective of Reichenbach's Common Cause Principle. (shrink)

Words can mean different things to different people. This can be problematic, mainly for those working together in a bureaucratic institution, such as the secret service. Shared, certified, explicit and codified definitions offer a counter to subjective, solitary and/or culturally dominant definitions. It’s true that codified secrecy terms for secret services can be seen to involve a number of political, cultural, subcultural “languages”, but if words come from unclassified or declassified files, memorandums and/or records, one needs a deep understanding of (...) the secret services. A remarkable feature of this bureaucratic language is the evolving nature of, certain “keywords” as important signifiers of historical transformation. Thus, the changes in the language of the secret services depends at least as much on the internal changes of the secret services as on the transformation in the external political-social environment. In spite of the confusion of Hungarian secret services in the revolutions of 1918–1919 and the disintegration of the Austrian-Hungarian Monarchy, in the early 1920’s became a stable system. Between the two World Wars, the Hungarian State Police directed by the Ministry of Internal Affairs, the Military Intelligence and Counter-Espionage directed by the Ministry of Defence, and the Hungarian Royal Gendarmerie directed by both of the Ministries had their own operational service. This structure existed unchanged until 1945. Simultaneously with the forward advance of the soviet troops, government began to re-establish the former system of the secret services in the eastern part of the country. After WWII, in 1946, the “State-protection Department” as political police became independent from the police. However, from the beginning, they remained under the control of the Communist Party. After 1950, the State Security Authority provided special services for the MIA and the Military Political Directorate of the MoD. After quashing the revolution in 1956, in the spring of 1957, the MIA Political Investigation Department was established which—with slight modifications—kept the structure created during the “state protection era”. The MIA III. The State-Protection General Directorate was established in 1962. The reorganization was finalized in the middle of the 1960’s, which resulted in the new system, which—with the structure of Directorates—became the ultimate structure of the state secret police until the abolishment of the MIA General Directorate III in January 1990. These organizational transformations were largely the result of exogenous historical-political changes. Moreover, each new period had a major impact on the organizational communication, language use and vocabulary of the secret services. This study seeks to interpret these historical transformations. (shrink)

Hawthorne, Landes, Wallmann and Williamson argue that the Principal Principle implies a version of the Principle of Indifference. We show that what the Authors take to be the Principle of Indifference can be obtained without invoking anything which would seem to be related to the Principal Principle. In the Appendix we also discuss several Conditions proposed in the same paper.

Name der Zeitschrift: Zeitschrift für kritische Sozialtheorie und Philosophie Jahrgang: 5 Heft: 1 Seiten: 86-102.

In this article I offer an interpretation of the fundamental problem of phenomenology in terms of a philosophy of revelation proposing in this way the renewal of the last important development of Western philosophy both in terms of its metaphysical aspiration and scientific relevance. After the general introduction, I outline the philosophical problem of revelation. I show how this philosophy influenced early phenomenology. I explain the underlying subject matter in the history of phenomenology, i.e. the notion of disclosure. I also (...) outline what I term “apocalyptic phenomenology” in order to focus on the understanding of revelation. In this part I offer details of the notion of newness and the appropriate method applied here. Finally, I summarize the scientific relevance of my approach in the context of logic, methodology, disciplinarity with a special emphasis on the study of religion. (shrink)

In this study, we investigated whether control of the conflict between incongruent heuristic and analytical answer options in a reasoning task is modulated by the presence of conflict on previous trials. In two experiments, we found that the incongruency of the previous trial has a significant effect on the control exhibited on the current trial. Our data also showed that this adaptation effect is modulated by the incongruency of the previous series of trials. These results demonstrate the same control adaptation (...) effects for a reasoning task as observed for standard response interference tasks. Coinciding control effects in the two research areas suggest that cognitive control might be an important mechanism underlying performance on reasoning tasks. Based on these results we argue that the study of cognitive control in reasoning could potentially facilitate the refinement of empirical predictions and provide a new tool to explore the exertion of top-down control in human thinking. (shrink)

We investigate Maxwell's attempt to justify the mathematical assumptions behind his 1860 Proposition IV according to which the velocity components of colliding particles follow the normal distribution. Contrary to the commonly held view we find that his molecular collision model plays a crucial role in reaching this conclusion, and that his model assumptions also permit inference to equalization of mean kinetic energies, which is what he intended to prove in his discredited and widely ignored Proposition VI. If we take a (...) charitable reading of his own proof of Proposition VI then it was Maxwell, and not Boltzmann, who gave the first proof of a tendency towards equilibrium, a sort of H-theorem. We also call attention to a potential conflation of notions of probabilistic and value independence in relevant prior works of his contemporaries and of his own, and argue that this conflation might have impacted his adoption of the suspect independence assumption of Proposition IV. (shrink)

We call attention to different formulations of how physical laws relate to what is physically possible in the philosophical literature, and argue that it may be the case that determinism fails under one formulation but reigns under the other. Whether this is so depends on our view on the nature of laws, and may also depend on the inter-theoretical relationships among our best physical theories, or so shall we argue.

Jeffrey conditioning is said to provide a more general method of assimilating uncertain evidence than Bayesian conditioning. We show that Jeffrey learning is merely a particular type of Bayesian learning if we accept either of the following two observations: – Learning comprises both probability kinematics and proposition kinematics. – What can be updated is not the same as what can do the updating; the set of the latter is richer than the set of the former. We address the problem of (...) commutativity and isolate commutativity from invariance upon conditioning on conjunctions. We also present a disjunctive model of Bayesian learning which suggests that Jeffrey conditioning is better understood as providing a method for incorporating unspecified but certain evidence rather than providing a method for incorporating specific but uncertain evidence. The results also generalize over many other subjective probability update rules, such as those proposed by Field and Gallow. (shrink)

We argue that the truth of determinism is not an interpretation-free fact and we systematically overview relevant interpretational choices that are less known in the philosophical literature. After bypassing the well known interpretational problem that arises in quantum mechanics we identify three further questions about the representational role of the mathematical structures employed by physical theories. Finally we point out that even if we settle all representational issues the received view of physical possibility may also allow the truth of determinism (...) to depend on prior philosophical convictions, notably on one's philosophical account of the nature of laws. (shrink)

This paper argues, first, that one can render Protagoras’s view on the teach ability of political virtue coherent by distinguishing between the affect required for achieving it and the capacity for developing these affect into fully fledged virtues. Second, the paper argues that by focusing on Books II - III of the Republic one might see an affinity between between Protagoras’s suggestion that virtuous citizens might give advice, without ruling it, in the affairs of the city and Plato’s conservative practical (...) political theory. (shrink)

Biró, B. and I. Sain, Peano arithmetic as axiomatization of the time frame in logics of programs and in dynamic logics, Annals of Pure and Applied Logic 63 201-225. We show that one can prove the partial correctness of more programs using Peano's axioms for the time frames of three-sorted time models than using only Presburger's axioms, that is it is useful to allow multiplication of time points at program verification and in dynamic and temporal logics. We organized the paper (...) as follows: 1. Preliminaries, 2. The main result, 3. Peano arithmetic with bounded multiplication, 4. Connections with temporal logics and dynamic logics, Acknowledgements, References. (shrink)

The volume offers the first-ever synthetic overview of the history of modern political thought in East Central Europe. Covering twenty national cultures and languages wedged between Russia, Turkey, Austria and Germany, it goes beyond the conventional nation-centered narrative and offers a novel vision of transnational intellectual history. The authors focus on the ways political thinkers outside of Western Europe sought to bridge the gap between an idealized Western modernity and their own societies. Mapping these discourses and debates from the Enlightenment (...) to the First World War, the volume helps rethinking some of our basic assumptions about the history of modern European culture and politics. (shrink)

The volume, stemming from the long-term cooperation of scholars working on East Central European intellectual history, discusses the patterns of patriotic and national identification in the light of the multiplicity of levels of ethnic, cultural and political allegiances characterizing this region in the early modern period.

The article traces the development of Hungarian intellectual history of the early modern period from the emergence of the national romantic constructions of literary history to the recent turn towards contextualist and conceptual history. One of its main findings is the ideological importance of this period for the formation of the national canon, as it became a central point of reference for the emerging local methodological tradition of intellectual history, even if it was often compartamentalized under other categories. From this (...) perspective, the article puts particular emphasis on ideological constructions seeking to define the nation and depict the emergence of modern national identity. This finding also offers a vantage point for analyzing the interplay between literary history and the socio-culturally focused approaches, which can be considered the main framework for the developments of the last two decades, when these local historiographical traditions entered into an interesting dialogue with the Western European and American schools of intellectual history. Along these lines, while pointing out the discursive continuities with the previous paradigms, which are shaping even the contemporary historiographical production, the article also ponders the ways in which the inherited (post-)romantic constructions can be successfully challenged. (shrink)

The ingenious thought of Anton Günther (1783–1863) is rarely mentioned in the annals of nineteenth-century philosophy. However, in the eyes of his contemporaries, Günther belonged to the key thinkers of his age on par with Kant, Fichte, Hegel, and Schelling. Günther was an original writer yet he left many of his insights undeveloped or ambiguously formulated. As a flamboyant and popular debater, he attacked the most influential philosophers of his time. His attacks were aimed especially at what he termed the (...) unavoidable pantheism of these thinkers, a pantheism Günther often identified with monism. Monism, semi-monism, pantheism, and semi-pantheism are recurring charges of Günther against many influential thinkers, including even Descartes, whose thought Günther considered otherwise epoch-making. Based on a reformed Cartesianism, Günther elaborated his antidote he termed dualism. Yet Güntherian dualism turns out to be a synthesis properly termed organicism. On such a basis, Günther carried out a heroic attempt to transcend the horizon of traditional views and open the vista of an I-centered philosophy built on the universal notion of revelation. By re-reading this Bohemia-born thinker, one can have a better understanding of the scope and influence of what we term Austrian Philosophy. (shrink)

‘Das Lebendige ist schön’: Remarks on Hegel’s Conception of Art The true importance of the role of the interpretation of art in Hegel’s later thinking is understandable only now, after the publication of the almost original version of the lectures on aesthetics. This article aims to highlight a usually neglected reading of Hegelian aesthetics, namely its Vergangenheitscharakter. The starting point for this is a thesis of Hegel’s: ‘What is alive is beautiful, in so far as the soul becomes apparent in (...) it.’It is ‘not yet sufficient’, yet it is true that in its endless approximation to a spiritually real ‘doubling of the Idea’it aims at something indefinite, or, rather, we are, with a work of art, in an unreal place or in a place where things are continuously changeable. The work of art entered into a time of art and history, which requires interpretation, whereby the ever- ‘changeable appearance of the Beautiful’ is manifested in the work of art itself. Its being alive accepts being threatened only by its conceptual/illusory appearance. (shrink)

Im Allgemeinen widmet sich das vorliegende Buch dem gemeinsamen Problembereich der zeitgenössischen Theologie und Philosophie, aber den konkreten Anlass der hiesigen Beiträgen geben jedoch die Parallelität in der Erscheinung der Enzyklika Fides et Ratio vom Papst Hl. Johannes Paulus II., und die Heiligsprechung Edith Steins (Mitpatronin Europas) von demselben heiligen Papst. Die Autoren des Bandes reflektieren sich auf die Gemeinsamkeit des Denkens dieser zwei Heiligen des 20. Jahrhunderts, auf ihre philosophischen Engagements in der christlichen Philosophie, sowie auf die heutigen Möglichkeiten (...) des gemeinsamen Denkens von Philosophie und Theologie. (shrink)

There are three major themes in the dialogue thought to be Plato’s Statesman: the nature of statesmanship, the difference between perfect and less than perfect regimes and the method of division. In this paper I focus on the first two themes. I argue, first, that the dialogue makes a plausible case for what it takes to be a wise statesman. In doing so, I play down the importance of the second theme: the difference between regimes. In fact, I consider this (...) discussion to be deeply flawed and even irrelevant to the argument of the first. My main purpose is to provide a critical analysis of the political theory articulated in the dialogue. My analysis is made plausible by abandoning the traditional view that the Statesman was written Plato in its entirety as a unified whole. In my view, a close reading of the text supports the hypothesis that it is, at best, semi-authentic; namely, that it is most likely a collage of fragments written at different times by Plato and other members of the Academy. (shrink)

This paper has two aims: to show the affinities between Schopenhauer’s and Spinoza’s ethics and ontology, and to show that Spinoza’s position, where it is in conflict with it, is superior to Schopenhauer’s. The main focus is on Schopenhauer’s attacks on the affirmation of the will-to-live. It is argued that these attacks are not even convincing in terms of what he says about “better knowledge”, namely, that they are valid only against vulgar forms of affirmations of the Will. Also, it (...) is argued that Schopenhauer’s attacks on Spinoza do not carry much weight. For, they are either the result of misunderstandings or, when they are not, they are based on assumptions rejected by Spinoza himself. In conclusion, it is claimed that Schopenhauer’s synthesis of Plato’s, Kant’s and Hindu philosophy into a “single thought” is neither as original nor as convincing as he took it to be. (shrink)