v. 1. Editorial introduction -- v. 2. The English and Latin texts (i) -- v. 3. The English and Latin texts (ii).

Dynamin is a GTPase that regulates late events in clathrin‐coated vesicle formation. Our current working model suggests that dynamin is targeted to coated pits in its unoccupied or GDP‐bound form, where it is initially distributed uniformly throughout the clathrin lattice. GTP/GDP exchange triggers its release from these sites and its assembly into short helices that encircle the necks of invaginated coated pits like a collar. GTP hydrolysis, which is required for vesicle detachment, presumably induces a concerted conformation change, tightening the (...) collar. Unlike most of its GTPase cousins that serve as molecular switches, dynamin has a low affinity for GTP, a very high intrinsic rate of GTP hydrolysis and functions as a homo‐oligomer. A concerted conformational change resulting from coordinated GTP hydrolysis by the dynamin oligomer might be sufficient to generate force. In this case, dynamin would be the first GTPase identified that acts as a structural protein with mechano‐chemical function. (shrink)

When we consider some controversies among scholars about whether brainstem death is death, we should clearly identify what the controversy is about. Is it about whether the brainstem dead can be ca...

Dale Dorsey considers one of the most fundamental questions in philosophical ethics: to what extent do the demands of morality have normative authority over us and our lives? Must we conform to moral requirements? Most who have addressed this question have treated the normative significance of morality as simply a fact to be explained. But Dorsey argues that this traditional assumption is misguided. According to Dorsey, not only are we not required to conform to moral demands, conforming to morality's (...) demands will not always even be normatively permissible---moral behavior can be wrong. This view is significant not only for understanding the content and force of the moral point of view, but also for understanding the basic elements of how one ought to live. (shrink)

How do communities establish shared communication systems? The Common Knowledge view assumes that symbolic conventions develop through the accumulation of common knowledge regarding communication practices among the members of a community. In contrast with this view, it is proposed that coordinated communication emerges a by‐product of local interactions among dyads. A set of multi‐agent computer simulations show that a population of “egocentric” agents can establish and maintain symbolic conventions without common knowledge. In the simulations, convergence to a single conventional system (...) was most likely and most efficient when agents updated their behavior on the basis of local rather than global, system‐level information. The massive feedback and parallelism present in the simulations gave rise to phenomena that are often assumed to result from complex strategic processing on the part of individual agents. The implications of these findings for the development of theories of language use are discussed. (shrink)

Much of knowing what to do is knowing what to do for ourselves, but knowing how to act in our best interest is complex---we must know what benefits us, what burdens us, and how these facts present and constitute considerations in favor of action. Additionally, we must know how we should weigh our interests at different times---past, present, and future. Dale Dorsey argues that a theory of prudence is needed: a theory of how we ought to act when we (...) are acting for ourselves. A Theory of Prudence provides a comprehensive account of prudence, including the metaethics of prudential value, the nature of the personal good, the reasons of prudence, and the structure of prudential normativity over time. (shrink)

Table of Contents Perspectives on Animal Cognition Chapter 1 The Myth of Anthropomorphism John Andrew Fisher Chapter 2 Gendered Knowledge? Examining Influences on Scientific and Ethological Inquiries Lori Gruen Chapter 3 Interpretive Cognitive Ethology Hugh Wilder Chapter 4 Concept Attribution in Nonhuman Animals: Theoretical and Methodological Problems in Ascribing Complex Mental Processes Colin Allen and Marc Hauser Cognitive and Evolutionary Explanations Chapter 5 On Aims and Methods of Cognitive Ethology Dale Jamieson and Marc Bekoff Chapter 6 Aspects of the (...) Cognitive Ethology of an Injury-Feigning Bird, The Piping Plover Carolyn Ristau Chapter 7 Tradition in Animals: Field Observations and Laboratory Analysis Bennett G. Galef Chapter 8 The Study of Adaptation Randy Thornhill Chapter 9 The Units of Behavior in Evolutionary Explanations Sandra D. Mitchell Chapter 10 Levels of Analysis and the Functional Significance of Helping Behavior Walter D. Koenig and Ron Mumme Recognition, Choice, Vigilance, and Play Chapter 11 The Ubiquitous Concept of Recognition with Special Reference to Kin Andrew R. Blaustein and Richard H. Porter Chapter 12 Do Animals Choose Habitats? Michael Rosenzweig Chapter 13 The Influence of Models on the Interpretation of Vigilance Steven L. Lima Chapter 14 Is There an Evolutionary Biology of Play? Alex Rosenberg Chapter 15 Intentionality, Social Play, and Definition Colin Allen and Marc Bekoff Communication and Language Chapter 16 Communication and Expectations: A Social Process and the Cognitive Operation It Depends upon and Influences W. John Smith Chapter 17 Animal Communication and Social Evolution Michael Philips and Steven Austad Chapter 18 Animal Language: Methodological and Interpretive Issues Sue Savage-Rumbaugh and Karen E. Brakke Chapter 19 Knowledge Acquisition and Asymmetry between Language Comprehension and Production: Dolphins and Apes as General Models for Animals Louis M. Herman and Palmer Morrel-Samuels Animal Minds Chapter 20 Evolution and Psychological Unity Roger Crisp Chapter 21 The Mental Lives of Nonhuman Animals John Dupré Chapter 22 Inside the Mind of a Monkey Robert M. Seyfarth and Dorothy L. Cheney Chapter 23 Science and Our Inner Lives: Birds of Prey, Bats, and the Common Bi-ped Kathleen Akins Chapter 24 Afterword: Ethics and the Study of Animal Cognition. (shrink)

In 1963 Niko Tinbergen published a paper, "On Aims and Methods of Ethology," dedicated to his friend Konrad Lorenz. Here Tinbergen defines ethology as "the biological study of behavior," and seeks to demonstrate "the close affinity between Ethology and the rest of Biology." Tinbergen identifies four major areas of ethology: causation, survival value, evolution, and ontogeny. Our goal is to attempt for cognitive ethology what Tinbergen succeeded in doing for ethology: to clarify its aims and methods, to distinguish some of (...) its varieties, and to defend the fruitfulness of the research strategies that it has spawned. (shrink)

The shape of a life hypothesis holds, very roughly, that lives are better when they have an upward, rather than downward, slope in terms of momentary well-being. This hypothesis is plausible and has been thought to cause problems for traditional principles of prudential value/rationality. In this article, I conduct an inquiry into the shape of a life hypothesis that addresses two crucial questions. The first question is: what is the most plausible underlying explanation of the significance of a life’s shape? (...) The second question is: given its most plausible explanation, what does the shape of a life hypothesis teach us about the nature of prudential value? (shrink)

Subjectivism about well-being holds that ϕ is intrinsically good for x if and only if, and to the extent that, ϕ is valued, under the proper conditions, by x. Given this statement of the view, there is room for intramural dissent among subjectivists. One important source of dispute is the phrase “under the proper conditions”: Should the proper conditions of valuing be actual or idealized? What sort of idealization is appropriate? And so forth. Though these concerns are of the first (...) importance, this essay focuses on a second source of dispute. As stated, subjectivists must account for what it means for an individual x to value ϕ under any conditions. Though there has been some disagreement, most subjectivists hold that x values ϕ if and only if x desires ϕ. This essay argues that subjectivists have erred in accepting a desiderative theory of valuing. Instead, it argues that subjectivists should hold that x values ϕ to the extent that x judges or believes that ϕ is good for x. The resulting “judgment subjectivism” is intuitively superior to, and maintains important structural advantages over, its desiderative rival. (shrink)

Many find it plausible to posit a category of supererogatory actions. But the supererogatory resists easy analysis. Traditionally, supererogatory actions are characterized as actions that are morally good, but not morally required; actions that go the call of our moral obligations. As I shall argue in this article, however, the traditional analysis can be accepted only by a view with troubling consequences concerning the structure of the moral point of view. I propose a different analysis that is extensionally correct, avoids (...) the problems of the traditional view, and, incidentally, also defuses any objection to act-consequentialism, or any other first-order moral theory, on grounds that it cannot accommodate the supererogatory. (shrink)

The emergence of controlled, Maastricht Category III, non-heart-beating organ donation programs has the potential to greatly increase the supply of donor solid organs by increasing the number of potential donors. Category III donation involves unconscious and dying intensive care patients whose organs become available for transplant after life-sustaining treatments are withdrawn, usually on grounds of futility. The shortfall in organs from heart-beating organ donation following brain death has prompted a surge of interest in NHBD. In a recent editorial, the British (...) Medical Journal described NHBD as representing “a challenge which the medical profession has to take up.”. (shrink)

Welfare is at least occasionally a temporal phenomenon: welfare benefits befall me at certain times. But this fact seems to present a problem for a desire-satisfaction view. Assume that I desire, at 10am, January 12th, 2010, to climb Mount Everest sometime during 2012. Also assume, however, that during 2011, my desires undergo a shift: I no longer desire to climb Mount Everest during 2012. In fact, I develop an aversion to so doing. Imagine, however, that despite my aversion, I am (...) forced to climb Mount Everest. Does climbing Mount Everest benefit me? If so, when? A natural answer seems to be that if in fact it does benefit me, it benefits me at no particular time, and hence the desire-satisfaction view cannot accommodate the phenomenon of temporal welfare. In this paper, I argue, first, that a desire-satisfaction view can accommodate the phenomenon of temporal welfare only by accepting what I call the “time-of-desire” view: that p benefits x at t only if x desires p at t . Second, I argue that this view can be defended from important objections. (shrink)

A feminist study of language and its rules argues that men have shaped it in order to instill their own prejudices and viewpoints on society, and shows how male-slanted language affects all women's lives.

One important proposal about the nature of well-being, prudential value or the personal good is that intrinsic values for a person ought to ‘resonate’ with the person for whom they are good. Indeed, virtually everyone agrees that there is something very plausible about this necessary condition on the building blocks of a good life. Given the importance of this constraint, however, it may come as something of a surprise how little reason we actually have to believe it. In this paper, (...) I'd like to do two things: first, to illustrate just how philosophically tenuous this thesis is, despite its apparent attraction, and to correct, or at least begin to correct, this state of affairs. My argument—which I call the ‘relationship to value’ argument—focuses in part on what it means to be a valuer—specifically, the peculiar relationship valuing agents bear to objects of value. (shrink)

Perfectionism, or the claim that human well-being consists in the development and exercise of one’s natural or essential capacities, is in growth mode. With its long and distinguished historical pedigree, perfectionism has emerged as a powerful antedote to what are perceived as significant problems in desiderative and hedonist accounts of well-being. However, perfectionism is one among many views that deny the influence of our desires, or that cut the link between well-being and a raw appeal to sensory pleasure. Other views (...) include, for instance, the “objective list” view,1 the so-called “restricted achievement” view,2 and various hybrid views that combine an appeal to desire or pleasure with an objective standard of evaluation of those desires or pleasures. (shrink)

An important platitude about prudential rationality is that I should not refuse to sacrifice a smaller amount of present welfare for the sake of larger future benefits. I ought, in other words, to treat my present and future as of equal prudential significance. The demands of prudence are less clear, however, when it comes to one’s past selves. In this paper, I argue that past benefits are possible in two ways, and that this fact cannot be easily accommodated by traditional (...) approaches to prudential rationality. Against univocal accounts of prudential rationality, I hold that the possibility of past benefits suggests that a bias toward the present and future is defensible when it comes to some welfare goods, but that prudential reasons are temporally neutral between when it comes to the success or failure of one’s long-term projects. (shrink)

University of Alberta Forthcoming in Utilias Consider Lives for Headaches: there is some number of headaches such that the relief of those headaches is sufficient to outweigh the good life of an innocent person. Lives for Headaches is unintuitive, but difficult to deny. The argument leading to Lives for Headaches is valid, and appears to be constructed out of firmly entrenched premises. In this paper, I advocate one way to reject Lives for Headaches; I defend a form of lexical superiority (...) between values. Based on an inquiry into the notion of human well-being, I argue that no amount of headaches is sufficient to outweigh the disvalue of the loss of a good life. Though this view has been thought subject to devastating objections, these objections are not dispositive against the form of value superiority I advance here. (shrink)

This book is the first to engage Zen Buddhism philosophically on crucial issues from a perspective that is informed by the traditions of western philosophy and religion. It focuses on one renowned Zen master, Huang Po, whose recorded sayings exemplify the spirit of the 'golden age' of Zen in medieval China, and on the transmission of these writings to the West. The author makes a bold attempt to articulate a post-romantic understanding of Zen applicable to contemporary world culture. While deeply (...) sympathetic to the Zen tradition, he raises serious questions about the kinds of claims that can be made on its behalf. (shrink)

Rule consequentialism holds that an action's moral standing depends on its relation to the moral code whose general adoption would have the best consequences. Heretofore rule consequentialists have understood the notion of a code's being generally adopted in terms of its being generally obeyed or, more commonly, its being generally accepted. I argue that these ways of understanding general adoption lead to unacceptable formulations of the theory. For instance, Brad Hooker, Michael Ridge, and Holly Smith have recently offered different answers (...) to the question of what ‘acceptance rate’ we should build into our formulation of rule consequentialism, and all are unsatisfactory. I argue instead for a novel approach to formulating rule consequentialism, ‘uniform-moral-education’ rule consequentialism, on which what it means for a moral code to be generally adopted is not for it to be generally followed or generally accepted, but instead for it to be generally taught. (shrink)

An important constraint on the nature of intrinsic value---the “Supervenience Principle” (SP)---holds that some object, event, or state of affairs ϕ is intrinsically valuable only if the value of ϕ supervenes entirely on ϕ 's intrinsic properties. In this paper, I argue that SP should be rejected. SP is inordinately restrictive. In particular, I argue that no SP-respecting conception of intrinsic value can accept the importance of psychological resonance, or the positive endorsement of persons, in explaining value.

Argument-giving reasons for a view-is our model of rational dispute resolution. Fogelin suggests that certain "deep" disagreements cannot be resolved in this way because features of their context "undercut the conditions essential to arguing" . In this paper we add some detail to Fogelin's treatment of intractable disagreements. In doing so we distinguish between his relatively modest claim that some disputes cannot be resolved through argument and his more radical claim that such disputes are beyond rational resolution. This distinction, along (...) with some ofthe detail we add to Fogelin's treatment, sheds some useful light on the project of informal logic. (shrink)

Miller, D., G. Nadathur, F. Pfenning and A. Scedrov, Uniform proofs as a foundation for logic programming, Annals of Pure and Applied Logic 51 125–157. A proof-theoretic characterization of logical languages that form suitable bases for Prolog-like programming languages is provided. This characterization is based on the principle that the declarative meaning of a logic program, provided by provability in a logical system, should coincide with its operational meaning, provided by interpreting logical connectives as simple and fixed search instructions. The (...) operational semantics is formalized by the identification of a class of cut-free sequent proofs called uniform proofs. A uniform proof is one that can be found by a goal-directed search that respects the interpretation of the logical connectives as search instructions. The concept of a uniform proof is used to define the notion of an abstract logic programming language, and it is shown that first-order and higher-order Horn clauses with classical provability are examples of such a language. Horn clauses are then generalized to hereditary Harrop formulas and it is shown that first-order and higher-order versions of this new class of formulas are also abstract logic programming languages if the inference rules are those of either intuitionistic or minimal logic. The programming language significance of the various generalizations to first-order Horn clauses is briefly discussed. (shrink)

A rarely studied motive for engaging in face-to-face arguing is to display one’s identity. One way people can manage their impressions is to give reasons for their commitments. This appears to be the first study to focus on this reason for arguing. 461 undergraduates recalled an episode in which they had argued to display own identity. They filled out trait measures as well as instruments describing the episode. Identity display arguments do not require controversy, are not very emotional episodes, can (...) partly serve many communication goals, and are polite. People who have high predilection to argue for identity display are both self- and other-oriented, although the correlations with self-oriented measures are stronger. This study not only describes episodes containing arguments for identity display, but also indicates the balance between self- and other-orientations that are involved. (shrink)

This comprehensive, general introduction to Schelling's philosophy shows that it was Schelling who set the agenda for German idealism and defined the term of its characteristic problems.

In recent years, many resourceful thinkers have brought a new clarity to the issues surrounding the doctrine of the Trinity. Two incompatible families of Trinitarian doctrine have been clearly distinguished: Social Trinitarianism and Latin Trinitarianism. I argue here that no theory in either camp has yet evaded the triune pitfalls of inconsistency, unintelligibility, and poor fit with the Bible. These two main approaches appear to be hopeless, and I argue that appeals to ‘mystery’ are no way to avoid the difficulties (...) at hand. Thus, the Trinitarian project is as yet unfinished. (shrink)

In this paper, I argue that hedonism about well-being faces a powerful dilemma. However, as I shall try to show here, this choice creates a dilemma for hedonism. On a subjective interpretation, hedonism is open to the familiar objection that pleasure is not the only thing desired or the only thing for which we possess a pro-attitude. On an objective interpretation, hedonism lacks an independent rationale. In this paper, I do not claim that hedonism fails once and for all. However, (...) this dilemma illustrates a serious problem for hedonism, the solution to which is not immediately obvious, and which must be addressed if hedonism is to be considered a serious competitor for the true theory of well-being. (shrink)

A common presupposition in metaethical theory is that moral assessment comes in two flavors, one of which is sensitive to our epistemic circumstances, the second of which is not so sensitive. Though this thought is popular, a number of questions arise. In this paper, I limit my discussion to what I dub the "explanatory question": how one might understand the construction of subjective moral assessment given an explanatorily prior objective assessment. I argue that a proper answer to this question is (...) important not simply for its own sake, but because it also sheds new light on important challenges to the existence of both objective and subjective moral obligations. (shrink)

Current understanding of the development of quantity representations is based primarily on performance in the number‐line task. We posit that the data from number‐line tasks reflect the observer's underlying representation of quantity, together with the cognitive strategies and skills required to equate line length and quantity. Here, we specify a unified theory linking the underlying psychological representation of quantity and the associated strategies in four variations of the number‐line task: the production and estimation variations of the bounded and unbounded number‐line (...) tasks. Comparison of performance in the bounded and unbounded number‐line tasks provides a unique and direct way to assess the role of strategy in number‐line completion. Each task produces a distinct pattern of data, yet each pattern is hypothesized to arise, at least in part, from the same underlying psychological representation of quantity. Our model predicts that the estimated biases from each task should be equivalent if the different completion strategies are modeled appropriately and no other influences are at play. We test this equivalence hypothesis in two experiments. The data reveal all variations of the number‐line task produce equivalent biases except for one: the estimation variation of the bounded number‐line task. We discuss the important implications of these findings. (shrink)

The demandingness of act consequentialism is well-known and has received much sophisticated treatment.1 Few have been content to defend AC’s demands. Much of the response has been to jettison AC in favor of a similar, though significantly less demanding view.2 The popularity of this response is easy to understand. Excessive demandingness appears to be a strong mark against any moral theory. And if excessive demandingness is a worry of this kind, AC’s goose appears cooked: attempts to show that AC is (...) not particularly demanding are implausible at best. Given that AC requires agents to promote goodness, and given that “goodness” here is most often construed as impartial and aggregative between persons, were I in a position to save others from death by sacrificing myself, I am morally required, on. (shrink)

ABSTRACT:Current literature in moral and political philosophy is rife with discussion of adaptive preferences. This is no accident: while preferences are generally thought to play an important role in a number of normative domains, adaptive preferences seem exceptions to this general rule—they seem problematic in a way that preference-respecting theories of these domains cannot adequately capture. Thus, adaptive preferences are often taken to be theoretically explanatory: a reason for adjusting our theories of the relevant normative domains. However, as I shall (...) argue here, the relentless focus on the phenomenon of preference adaptation is a mistake. While I do not take a stand on whether typical examples of adaptive preferences are or are not problematic, I argue here that if they are problematic, it cannot be because they are adaptive. (shrink)

Open theists agree that God lacks what is normally called “comprehensive” foreknowledge, but why believe this? Open theists answer in three ways, which I call the narrow road, the wide road, and the shortcut to open theism. Here I argue that (1) the narrow road faces a difficulty concerning the doctrine of divine omniscience which doesn’t arise for the wide road, (2) the wide road is well-motivated and appealing, given certain philosophical commitments, (3) the shortcut is too simple to work, (...) and (4) William Lane Craig’s objections to the wide road fail. I conclude with some observations about the state of the dispute between open theists and their critics. (shrink)

In this article, I articulate and explore a novel constructivist approach to metanormativity that is inspired by David Hume’s metaesthetics. This view, which I call perfectionist Humean constructivism, rejects the claim that practical reasons are constructed by each individual’s valuing attitudes, holding instead that they are constructed by humanity’s shared evaluative nature. I hold that this approach can plausibly respond to a persistent worry for extant versions of Humean constructivism without embracing the commitments of either a Kantian constructivism or a (...) metaphysically robust form of metanormative realism. (shrink)