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  1. Tăng cường khả năng sáng tạo văn hóa thông qua hoạt động bảo tồn đa dạng sinh học và chống biến đổi khí hậu.Nguyễn Minh Hoàng - 2024 - Kinh Tế Và Dự Báo.
    Khi các sản phẩm văn hóa chú trọng vào kết nối con người với thiên nhiên, nâng cao nhận thức về giá trị của thiên nhiên và trách nhiệm của con người với thiên nhiên, thì chúng ta mới có thể tiếp tục bảo tồn và nâng cao khả năng sáng tạo văn hóa của xã hội.
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  2. Bảo vệ đa dạng sinh học và chống biến đổi khí hậu là bảo vệ khả năng sáng tạo văn hóa của xã hội.Nguyễn Minh Hoàng - manuscript
    Các nhà khoa học trong lĩnh vực nhân học, địa lý và các lĩnh vực khác trong khoa học xã hội và nhân văn từ lâu đã cho rằng môi trường sống của con người ảnh hưởng sâu sắc đến hệ thống giá trị và thực tiễn văn hóa của họ. Shota Shibasaki, Ryosuke Nakadai và Yo Nakawake đã phát triển dựa trên ý tưởng này, chứng minh rằng các đặc điểm sinh thái địa phương định hình sự xuất hiện (...)
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  3. Conserving biodiversity and combating climate change can help maintain cultural creativity.Minh-Hoang Nguyen & Quan-Hoang Vuong - manuscript
    Scientists in anthropology, geography, and other fields within social sciences and humanities have long suggested that the environments in which people live deeply influence their cultural value systems and practices. Shota Shibasaki, Ryosuke Nakadai, and Yo Nakawake have built on this idea, demonstrating that local ecological characteristics shape the appearance of trickster animals in folklore. Based on their finding and the SM3D (Serendipity-Mindsponge-3D) knowledge management framework, we discuss how the individuals’ or groups’ ability to create cultural products depends on the (...)
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  4. An indirect perspective to link genetic mosaicism and tumorigenesis.Leone Albinati & Renée Beekman - forthcoming - Bioessays:2400102.
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  5. How are Trypanosoma brucei receptors protected from host antibody‐mediated attack?Sourav Banerjee, Nicola Minshall, Helena Webb & Mark Carrington - forthcoming - Bioessays:2400053.
    Trypanosoma brucei is the causal agent of African Trypanosomiasis in humans and other animals. It maintains a long‐term infection through an antigenic variation based population survival strategy. To proliferate in a mammal, T. brucei acquires iron and haem through the receptor mediated uptake of host transferrin and haptoglobin‐hemoglobin respectively. The receptors are exposed to host antibodies but this does not lead to clearance of the infection. Here we discuss how the trypanosome avoids this fate in the context of recent findings (...)
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  6. Flavin‐containing monooxygenase (FMO): Beyond xenobiotics.Ajay Bhat, Faith R. Carranza, Angela M. Tuckowski & Scott F. Leiser - forthcoming - Bioessays:2400029.
    Flavin‐containing monooxygenases (FMOs), traditionally known for detoxifying xenobiotics, are now recognized for their involvement in endogenous metabolism. We recently discovered that an isoform of FMO, fmo‐2 in Caenorhabditis elegans, alters endogenous metabolism to impact longevity and stress tolerance. Increased expression of fmo‐2 in C. elegans modifies the flux through the key pathway known as One Carbon Metabolism (OCM). This modified flux results in a decrease in the ratio of S‐adenosyl‐methionine (SAM) to S‐adenosyl‐homocysteine (SAH), consequently diminishing methylation capacity. Here we discuss (...)
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  7. Sustainability in a broad sense: An essential aspect of scientific conferences.Malene Brohus, Martin D. Bootman & Geert Bultynck - forthcoming - Bioessays:2400017.
    This article reflects on sustainability in the context of scientific conferences with emphasis on environmental, diversity, inclusivity, and intellectual aspects. We argue that it is imperative to embrace sustainability as a broad concept during conference organization. In‐person conferences have an obvious environmental impact but mitigating strategies can be implemented, such as incentivizing low‐emission travel, offering fellowships to support sustainable traveling, and promoting use of public transport or car‐pooling. Utilizing eco‐conscious venues, catering, and accommodations, along with minimizing resource wastage, further reduces (...)
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  8. Recent insights from human induced pluripotent stem cell models into the role of microglia in amyotrophic lateral sclerosis.Lara M. Nikel, Kevin Talbot & Björn F. Vahsen - forthcoming - Bioessays:2400054.
    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, primarily leading to the degeneration of motor neurons. The traditional focus on motor neuron‐centric mechanisms has recently shifted towards understanding the contribution of non‐neuronal cells, such as microglia, in ALS pathophysiology. Advances in induced pluripotent stem cell (iPSC) technology have enabled the generation of iPSC‐derived microglia monocultures and co‐cultures to investigate their role in ALS pathogenesis. Here, we briefly review the insights gained from these studies into the role of microglia in ALS. (...)
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  9. Động vật hoang dã sử dụng cây thuốc để chữa lành vết thương: Đó có thể là do serendipity không?Nguyễn Thị Hồng Nguyễn & Nguyễn Minh Hoàng - 2024 - Kinh Tế Và Dự Báo.
    Trong một nghiên cứu gần đây được công bố trên Tạp chí Scientific Reports, các nhà nghiên cứu đã lần đầu tiên ghi lại việc động vật hoang dã sử dụng một loại cây có dược tính để chữa lành vết thương.
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  10. Serendipity.Minh-Hoang Nguyen & Tam-Tri Le - 2022 - Scholarly Community Encyclopedia.
    Serendipity is defined as an ability to notice, evaluate, and take advantage of unexpected information for survival purposes (both natural and social). The concept has been discussed for centuries. Still, it has only caught the attention of academia quite recently due to its strategic advantage in all aspects of life, such as daily life activities, science and technology, business and entrepreneurship, politics and economics, education administration, career choice and development, etc.
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  11. Матеріали круглого столу «Зелені рішення як пріоритет корпоративної соціальної відповідальності», 16.05.2023 р., м. Дніпро. Укладачі: І.Ю.Приварникова, О.А.Зінченко. Дніпро: ДНУ, 2023. 232 с. DOI: 10.15421/conf.2023.01.І. Ю Приварникова & О.А Зінченко (eds.) - 2023 - Oles Honchar Dnipro National University.
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  12. Nature’s Role in Sustainable Waste Management and Conservation.Minh-Phuong Thi Duong - 2024 - Sm3D Portal.
    Despite the numerous benefits of natural solutions, potential challenges and limitations impede their widespread adoption. A recent paper suggests these obstacles may include financial issues through the stock market and eco-deficit of environmental companies and investors. Specifically, natural solutions, such as biological waste management methods utilizing organisms like black soldier flies, face challenges due to financial considerations and the prevailing eco-deficit culture within the business and investment sectors.
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  13. Pollinator Diversity: Essential for Ecosystem Health, Agriculture, and Cultural Heritage.Minh-Phuong Thi Duong - 2024 - Sm3D Portal.
    The importance of focusing on long-term sustainability in pollinator conservation and sustainable ecosystem management cannot be underestimated. Cultivating an eco-surplus culture plays a key role in maintaining ecosystem health, particularly by protecting pollinator species essential for ecosystem functioning and agricultural productivity. This cultural approach emphasizes environmental stewardship and conserving and generating surplus resources beyond immediate human needs, which is vital for future nature-based innovations. Additionally, ecological surplus culture highlights the resilience necessary to address significant environmental challenges such as habitat loss (...)
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  14. Nutrition from insects: An age-old Vietnamese view versus the modern world’s perspective.Minh-Hoang Nguyen & Vuong Quan Hoang - manuscript
    Due to the rising pressure from population growth and environmental crises induced by anthropogenic food production activities, the production and consumption of insects have been promoted internationally. The current paper discusses the nutritional and environmental benefits of insect consumption and the socio-cultural and psychological factors that constrain such a habit on an international scale. Then, some historical and cultural information regarding insect consumption in Vietnam is provided to highlight the potential of insect consumption standardization. Unlike those in Western societies, where (...)
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  15. Plasticity mechanisms of genetically distinct Purkinje cells.Stijn Voerman, Robin Broersen, Sigrid M. A. Swagemakers, Chris I. De Zeeuw & Peter J. van der Spek - forthcoming - Bioessays:2400008.
    Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...)
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  16. Tuning synaptic strength by regulation of AMPA glutamate receptor localization.Imogen Stockwell, Jake F. Watson & Ingo H. Greger - forthcoming - Bioessays:2400006.
    Long‐term potentiation (LTP) of excitatory synapses is a leading model to explain the concept of information storage in the brain. Multiple mechanisms contribute to LTP, but central amongst them is an increased sensitivity of the postsynaptic membrane to neurotransmitter release. This sensitivity is predominantly determined by the abundance and localization of AMPA‐type glutamate receptors (AMPARs). A combination of AMPAR structural data, super‐resolution imaging of excitatory synapses, and an abundance of electrophysiological studies are providing an ever‐clearer picture of how AMPARs are (...)
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  17. Wild animals using medicinal plants for healing: Can that be serendipity?Minh-Hoang Nguyen - 2024 - Sm3D Portal.
    In a recent study published in Scientific Reports, the researchers documented the first wild animal seen using a plant with known medicinal properties to heal a wound.
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  18. Nghi thức ăn “cá một nắng” kiểu hoàng gia bị tiết lộ.Nguyễn Thị Quỳnh Yến - 2022 - Ngụ Ngôn Bói Cá.
    Tháng 9-2017, trang thông tin The Scottish Wildlife Trust đăng một bài tin ảnh vừa thú vị, vừa kích thích trí tò mò về chim bói cá ở Montrose Basin, Scotland. Bài viết kể về việc nhiếp ảnh gia Ron Mitchell tình cờ nhiều lần bắt gặp cả anh cả chị bói cá “ghim” con mồi lên cành cây! Con mồi ở đây là loài cá gai (tên tiếng Anh: stickleback).
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  19. Heterochromatin repeat organization at an individual level: Rex1BD and the 14‐3‐3 protein coordinate to shape the epigenetic landscape within heterochromatin repeats. [REVIEW]Jinxin Gao & Fei Li - forthcoming - Bioessays:2400030.
    In eukaryotic cells, heterochromatin is typically composed of tandem DNA repeats and plays crucial roles in gene expression and genome stability. It has been reported that silencing at individual units within tandem heterochromatin repeats exhibits a position‐dependent variation. However, how the heterochromatin is organized at an individual repeat level remains poorly understood. Using a novel genetic approach, our recent study identified a conserved protein Rex1BD required for position‐dependent silencing within heterochromatin repeats. We further revealed that Rex1BD interacts with the 14‐3‐3 (...)
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  20. Looking across the gap: Understanding the evolution of eyes and vision among insects.Maike Kittelmann & Alistair P. McGregor - 2024 - Bioessays 46 (5):2300240.
    The compound eyes of insects exhibit stunning variation in size, structure, and function, which has allowed these animals to use their vision to adapt to a huge range of different environments and lifestyles, and evolve complex behaviors. Much of our knowledge of eye development has been learned from Drosophila, while visual adaptations and behaviors are often more striking and better understood from studies of other insects. However, recent studies in Drosophila and other insects, including bees, beetles, and butterflies, have begun (...)
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  21. Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.Matthew J. Dalby, Vanja Pekovic-Vaughan, Daryl P. Shanley, Joe Swift, Lisa J. White & Elizabeth G. Canty-Laird - 2024 - Bioessays 46 (5):2300223.
    Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three‐dimensional network of macromolecules that provides our tissues with structure and biomechanical resilience. Imbalance between damage and repair/regeneration causes the ECM to undergo structural deterioration with age, contributing to age‐associated pathology. The ECM ‘Ageing Across the Life Course’ interdisciplinary research network (ECMage) was established to bring together researchers in the United Kingdom, and internationally, working on the emerging field (...)
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  22. New approaches for low phototoxicity imaging of living cells and tissues.Wiktoria Kasprzycka, Wiktoria Szumigraj, Przemysław Wachulak & Elżbieta Anna Trafny - 2024 - Bioessays 46 (5):2300122.
    Fluorescence microscopy is a powerful tool used in scientific and medical research, but it is inextricably linked to phototoxicity. Neglecting phototoxicity can lead to erroneous or inconclusive results. Recently, several reports have addressed this issue, but it is still underestimated by many researchers, even though it can lead to cell death. Phototoxicity can be reduced by appropriate microscopic techniques and carefully designed experiments. This review focuses on recent strategies to reduce phototoxicity in microscopic imaging of living cells and tissues. We (...)
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  23. The complexities of ligand/receptor interactions: Exploring the role of molecular vibrations and quantum tunnelling.Oné R. Pagán - 2024 - Bioessays 46 (5):2300195.
    Molecular vibrations and quantum tunneling may link ligand binding to the function of pharmacological receptors. The well‐established lock‐and‐key model explains a ligand's binding and recognition by a receptor; however, a general mechanism by which receptors translate binding into activation, inactivation, or modulation remains elusive. The Vibration Theory of Olfaction was proposed in the 1930s to explain this subset of receptor‐mediated phenomena by correlating odorant molecular vibrations to smell, but a mechanism was lacking. In the 1990s, inelastic electron tunneling was proposed (...)
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  24. Activating the abscission checkpoint: Top2α senses chromatin bridges in cytokinesis.Eleni Petsalaki & George Zachos - 2024 - Bioessays 46 (5):2400011.
    How chromatin bridges are detected by the abscission checkpoint during mammalian cell division is unknown. Here, we discuss recent findings from our lab showing that the DNA topoisomerase IIα (Top2α) enzyme binds to catenated (“knotted”) DNA next to the midbody and forms abortive Top2‐DNA cleavage complexes (Top2ccs) on chromatin bridges. Top2ccs are then processed by the proteasome to promote localization of the DNA damage sensor protein Rad17 to Top2‐generated double‐strand DNA ends on DNA knots. In turn, Rad17 promotes local recruitment (...)
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  25. TAXA DE CONCEPÇÃO AO PRIMEIRO SERVIÇO DE VACAS LEITEIRAS EM ANESTRO PRÉ-SINCRONIZADAS.Rayssa Milena Hilgenberg - 2022 - Dissertation, Centro Universitário Campo Real
    RESUMO O presente trabalho mostra as atividades realizadas do período de 01 de julho a 01 de novembro na JRM Agropecuária. As atividades foram desenvolvidas na área de bovinocultura de leite, este trabalho foi desenvolvido sob orientação do professor mestre Rodrigo Dorneles Tortorella e supervisão do médico veterinário André Ricardo, em conjunto com o médico veterinário Breno. Durante o período de estágio foi acompanhado as atividades realizadas no setor de manejo, reprodução, bezerreiro e recria da fazenda, além de acompanhar as (...)
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  26. EFEITO DA APLICAÇÃO DO GNRH NO INÍCIO DOS PROTOCOLOS DE IATF, À BASE DE ESTRÓGENO E PROGESTERONA, SOBRE A PRENHEZ POR IATF DE VACAS LEITEIRAS MESTIÇAS.Lorrany Evelyn Tavares - 2023 - Dissertation, Universidade Federal de Uberlândia - Ufu
    RESUMO A inseminação artificial em tempo fixo (IATF) é uma das biotecnologias de reprodução mais estudadas dos últimos anos, e a busca pelo equilíbrio entre a fisiologia animal e o controle hormonal fomenta uma série de estudos. Sendo assim, o objetivo com este trabalho foi avaliar a eficiência da aplicação do hormônio liberador de gonadotrofinas (GnRH) no dia zero (D0) do protocolo de IATF, a base de estrógeno e progesterona sobre a taxa de penhez por IATF. O experimento foi desenvolvido (...)
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  27. Bài KH&PT nỗ lực truyền thông bảo tồn cheo cheo lưng bạc.Bài Scicomm - 2024 - Bảo Tồn Cheo Cheo.
    Cheo cheo lưng bạc là loài đặc hữu của Việt Nam, và cho tới nay cũng chưa nơi nào khác từng phát hiện.
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  28. Kêu gọi sử dụng tên gọi bản địa cheo cheo lưng bạc trong khoa học và truyền thông quốc tế.Dương Thị Minh Phượng - 2024 - Khoa Học Và Phát Triển (16/4/2024).
    Việc sử dụng chính thức tên gọi bản địa "cheo cheo" trong công tác khoa học và truyền thông của cộng đồng quốc tế sẽ giúp bảo tồn loài móng guốc chỉ được biết đến ở Việt Nam này hiệu quả hơn, theo hai tác giả của lời kêu gọi.
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  29. Timelines: Short Essays and Verse in the Philosophy of Time.Edward A. Francisco - 2024 - Morrisville, North Carolina: Lulu Press.
    Timelines is an inquiry into the nature of time, both as an apparent feature of the external physical world and as a fundamental feature of our experience of ourselves in the world. The principal argument of Timelines is that our coventional ideas about time are largely mistaken and that what we think of as independent physical time is actually our calibration of a certain relation between events. Namely, the relation between time-keeping events and the causal sequential differences of physical processes (...)
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  30. METODOLOGIA E MANEJO REPRODUTIVO APLICADO EM BOVINOS LEITEIROS.Bruna Cardoso Lemes, Gabriel Destefani de Souza, Jaqueline Aparecida Sousa Pereira, Jéssica Elizei Dande, Marcelo de Figueiredo Filiardi Filho, Vinícius de Moura Ribeiro Monticeli & Elizângela Guedes - 2022 - Revista Agroveterinária Do Sul de Minas 4 (1):153-172.
    Resumo: Sabe-se que a pecuária é uma parcela do agronegócio que move a economia do país, e incluso está a produção leiteira, que tem, a cada ano seu desenvolvimento elevado, de forma em que é priorizado a eficiência no aumento de sua produção, com o objetivo de suprir a demanda, e a maior rentabilidade do produtor. Diante disso, medidas de manejo reprodutivo e alimentar são adotadas, sendo estas capazes de elevar a produtividade com o menor custo possível. O trabalho objetivou (...)
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  31. Efeitos da raça e do manejo nutricional sobre as características de qualidade da carcaça e da carne em ovinos (2nd edition).Emanuel Isaque Cordeiro da Silva - 2024 - Revista Universitária Brasileira 2 (1):61-81.
    R E S U M O Diante do grande consumo de carne a nível mundial, bem como a ascensão do vegetarianismo e veganismo, os consumidores de carne, especialmente de carne de grandes animais, estão cada vez mais exigentes quantos aos aspectos sensoriais e características organolépticas e de bem-estar animal cabendo, com isso, ao mercado abastecer o mercado cárneo com produtos de alta qualidade. Deve-se assegurar a qualidade para satisfazer o consumidor. A qualidade da carcaça, assim como a da carne podem (...)
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  32. The role of lipoylation in mitochondrial adaptation to methionine restriction.Jingyuan Xue & Cunqi Ye - forthcoming - Bioessays:2300218.
    Dietary methionine restriction (MR) is associated with a spectrum of health‐promoting benefits. Being conducive to prevention of chronic diseases and extension of life span, MR can activate integrated responses at metabolic, transcriptional, and physiological levels. However, how the mitochondria of MR influence metabolic phenotypes remains elusive. Here, we provide a summary of cellular functions of methionine metabolism and an overview of the current understanding of effector mechanisms of MR, with a focus on the aspect of mitochondria‐mediated responses. We propose that (...)
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  33. How astrocytic chloride modulates brain states.Verena Untiet & Alexei Verkhratsky - forthcoming - Bioessays:2400004.
    The way the central nervous system (CNS) responds to diverse stimuli is contingent upon the specific brain state of the individual, including sleep and wakefulness. Despite the wealth of readout parameters and data delineating the brain states, the primary mechanisms are yet to be identified. Here we highlight the role of astrocytes, with a specific emphasis on chloride (Cl−) homeostasis as a modulator of brain states. Neuronal activity is regulated by the concentration of ions that determine excitability. Astrocytes, as the (...)
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  34. Suplementação e formulação de sal mineral e mistura múltipla para bovinos (2nd edition). [REVIEW]Emanuel Isaque Cordeiro da Silva - 2024 - Revista Universitária Brasileira 2 (1):27-52.
    In Brazilian conditions of bovines creation in semi-extensive and essentially extensive systems, the animals present irregular performance depending on the time of year. During the waters station, that is, the rainy season, the animals perform better; notwithstanding, during dry rain-scarce periods, meat and milk production declines sharply, animals lose weight and the growth rhythm of steers and heifers is reduced. This occurs at the expense of the surplus or lack of forage in the pasture that the animals have access to. (...)
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  35. Centromere diversity: How different repeat‐based holocentromeres may have evolved.Yi-Tzu Kuo, Veit Schubert, André Marques, Ingo Schubert & Andreas Houben - forthcoming - Bioessays:2400013.
    In addition to monocentric eukaryotes, which have a single localized centromere on each chromosome, there are holocentric species, with extended repeat‐based or repeat‐less centromeres distributed over the entire chromosome length. At least two types of repeat‐based holocentromeres exist, one composed of many small repeat‐based centromere units (small unit‐type), and another one characterized by a few large centromere units (large unit‐type). We hypothesize that the transposable element‐mediated dispersal of hundreds of short satellite arrays formed the small centromere unit‐type holocentromere in Rhynchospora (...)
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  36. Is violence escalation the consequence of art vandalism, road blockades, and assaults for the cause of climate change mitigation?Quan-Hoang Vuong, Viet-Phuong La & Minh-Hoang Nguyen - manuscript
    Environmental activism is expected to improve society’s well-being and environmental sustainability. Nevertheless, some inappropriate ways of activism, like road blockage, art vandalism, assaults, etc., have been recently conducted and risked causing adverse repercussions, including violence escalation. The current study aims to explore which types of environmental activism are more likely to escalate violence between activists, affected citizens, and police. Bayesian Mindsponge Framework (BMF) analytics was employed to analyze a dataset of 89 blockage, vandalism, and harassment cases in 13 countries in (...)
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  37. Chuyện kể về cheo cheo lưng bạc và Sách đỏ IUCN.Vương Quân Hoàng - 2024 - Rừng Việt Nam.
    Trong công việc nghiên cứu, chỉ có một số nhỏ để lại những cảm xúc dài lâu và ngẫm ngợi sâu xa. Tháng tư này, đối với chúng tôi là bài về con cheo cheo lưng bạc, đặc hữu của thiên nhiên Việt Nam.
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  38. Line Theory: Effect, Node, and Line in Space.Tom M. D. - manuscript
    This paper introduces a conceptual framework, denoted as ‘Line Theory,’ which is predicated on the procedural anatomy inherent in ordinary plans. A plan, recognized as a set of instructions for execution, undergoes in-depth scrutiny to analyze its constituent elements. The concise examination delves into the formation of line and effect within real space stemming from procedures. Line theory serves the purpose of elucidating the absolute optimization of plans. It is formulated to inaugurate an exploration into the veracity of procedures and (...)
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  39. Considerações legais e forenses do aborto infeccioso bovino na “Saúde Única”: Revisão (18th edition).Jackson Barros Do Amaral, Vinícius José Moreira Nogueira & Wendell da Luz Silva (eds.) - 2024 - Londrina: Pubvet.
    In Brazil, the social demand for veterinary expertise is growing. However, there is still a shortage of professionals trained in this area to apply specific knowledge to each case. Studies and research into forensic veterinary medicine are necessary for veterinary experts to assist in investigations and legal proceedings. Veterinary medicine has subjects on its curriculum that cover the knowledge needed to apply in the fields of animal health, public health and the environment. The interaction between human and veterinary medicine, as (...)
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  40. Review | Im Haus der Weisheit. Die arabischen Wissenschaften als Fundament unserer Kultur. [REVIEW]Cristina Chitu - 2020 - Polylog. Zeitschrift Für Interkulturelles Philosophieren 43.
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  41. Towards an integrated understanding of inflammatory pathway influence on hematopoietic stem and progenitor cell differentiation.Michael Allara & Juliet R. Girard - 2024 - Bioessays 46 (4):2300142.
    Recent research highlights that inflammatory signaling pathways such as pattern recognition receptor (PRR) signaling and inflammatory cytokine signaling play an important role in both on‐demand hematopoiesis as well as steady‐state hematopoiesis. Knockout studies have demonstrated the necessity of several distinct pathways in these processes, but often lack information about the contribution of specific cell types to the phenotypes in question. Transplantation studies have increased the resolution to the level of specific cell types by testing the necessity of inflammatory pathways specifically (...)
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  42. MYRF: A unique transmembrane transcription factor‐ from proteolytic self‐processing to its multifaceted roles in animal development.Yingchuan B. Qi, Zhimin Xu, Shiqian Shen, Zhao Wang & Zhizhi Wang - 2024 - Bioessays 46 (4):2300209.
    The Myelin Regulator Factor (MYRF) is a master regulator governing myelin formation and maintenance in the central nervous system. The conservation of MYRF across metazoans and its broad tissue expression suggest it has functions extending beyond the well‐established role in myelination. Loss of MYRF results in developmental lethality in both invertebrates and vertebrates, and MYRF haploinsufficiency in humans causes MYRF‐related Cardiac Urogenital Syndrome, underscoring its importance in animal development; however, these mechanisms are largely unexplored. MYRF, an unconventional transcription factor, begins (...)
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  43. NLRC5/MHC class I transactivator: A key target for immune escape by SARS‐CoV‐2.Baohui Zhu, Ryota Ouda, Yusuke Kasuga, Paul de Figueiredo & Koichi S. Kobayashi - 2024 - Bioessays 46 (4):2300109.
    Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS‐CoV‐2 infection studies and analysis of COVID‐19 patient samples, we found that SARS‐CoV‐2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC class I genes. (...)
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  44. Clathrin controls bidirectional communication between T cells and antigen presenting cells.Audun Kvalvaag & Michael L. Dustin - 2024 - Bioessays 46 (4):2300230.
    In circulation, T cells are spherical with selectin enriched dynamic microvilli protruding from the surface. Following extravasation, these microvilli serve another role, continuously surveying their environment for antigen in the form of peptide‐MHC (pMHC) expressed on the surface of antigen presenting cells (APCs). Upon recognition of their cognate pMHC, the microvilli are initially stabilized and then flatten into F‐actin dependent microclusters as the T cell spreads over the APC. Within 1–5 min, clathrin is recruited by the ESCRT‐0 component Hrs to (...)
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  45. Symbiont effector‐guided mapping of proteins in plant networks to improve crop climate stress resilience.Laura Rehneke & Patrick Schäfer - 2024 - Bioessays 46 (4):2300172.
    There is an urgent need for novel protection strategies to sustainably secure crop production under changing climates. Studying microbial effectors, defined as microbe‐derived proteins that alter signalling inside plant cells, has advanced our understanding of plant immunity and microbial plant colonisation strategies. Our understanding of effectors in the establishment and beneficial outcome of plant symbioses is less well known. Combining functional and comparative interaction assays uncovered specific symbiont effector targets in highly interconnected plant signalling networks and revealed the potential of (...)
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  46. Are fetal microchimerism and circulating fetal extracellular vesicles important links between spontaneous preterm delivery and maternal cardiovascular disease risk?Elizabeth A. Bonney, Ryan C. V. Lintao, Carolyn M. Zelop, Ananth Kumar Kammala & Ramkumar Menon - 2024 - Bioessays 46 (4):2300170.
    Trafficking and persistence of fetal microchimeric cells (fMCs) and circulating extracellular vesicles (EVs) have been observed in animals and humans, but their consequences in the maternal body and their mechanistic contributions to maternal physiology and pathophysiology are not yet fully defined. Fetal cells and EVs may help remodel maternal organs after pregnancy‐associated changes, but the cell types and EV cargos reaching the mother in preterm pregnancies after exposure to various risk factors can be distinct from term pregnancies. As preterm delivery‐associated (...)
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  47. Are non‐protein coding RNAs junk or treasure?Nils G. Walter - 2024 - Bioessays 46 (4):2300201.
    The human genome project's lasting legacies are the emerging insights into human physiology and disease, and the ascendance of biology as the dominant science of the 21st century. Sequencing revealed that >90% of the human genome is not coding for proteins, as originally thought, but rather is overwhelmingly transcribed into non‐protein coding, or non‐coding, RNAs (ncRNAs). This discovery initially led to the hypothesis that most genomic DNA is “junk”, a term still championed by some geneticists and evolutionary biologists. In contrast, (...)
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  48. Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus.Koshiro Mitsui & Aki Takahashi - 2024 - Bioessays 46 (4):2300213.
    Aggressive behavior is instinctively driven behavior that helps animals to survive and reproduce and is closely related to multiple behavioral and physiological processes. The dorsal raphe nucleus (DRN) is an evolutionarily conserved midbrain structure that regulates aggressive behavior by integrating diverse brain inputs. The DRN consists predominantly of serotonergic (5‐HT:5‐hydroxytryptamine) neurons and decreased 5‐HT activity was classically thought to increase aggression. However, recent studies challenge this 5‐HT deficiency model, revealing a more complex role for the DRN 5‐HT system in aggression. (...)
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  49. The T‐locus – inspiration and distraction?Robert P. Erickson - forthcoming - Bioessays:2400021.
    The T/t locus was a major focus of study by mouse geneticists during the 20th century. In the 70s, as the study of cell surface antigens controlling transplantation antigens was taking off, several laboratories hypothesized that alleles of this locus would control cell surface antigens important for embryonic development. One such antigen, the embryonal carcinoma F9 antigen was said to be an example. Other antigens were described on sperm and embryos that were said to be controlled by alleles at the (...)
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  50. Cái tôi thấp là chìa khóa để có trí khôn tương tác với thế giới tự nhiên.Dương Thị Minh Phượng & Nguyễn Minh Hoàng - 2024 - Kinh Tế Và Dự Báo.
    Thuật ngữ "sự thông thái" hay "trí tuệ" thường được sử dụng và truyền đạt qua các thế hệ như một hình thức thể hiện cơ sở hiểu biết chung về cách thức sống, được tích lũy và kế thừa từ một nền văn hóa sang nền văn hóa khác. Có trí tuệ hay trở nên thông thái là khao khát của nhiều người bởi lẽ nó không chỉ biểu hiện của sự thông minh, mà còn liên quan đến khả (...)
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