Abstract

The aim of this work is to study the effect of coupling on a metabolic pathway. Specifically we assume that metabolites can exchange matter with outside pools via passive diffusion. The existence of periodic solutions in such a system is considered and resolved using the dual input describing function method. In one particular case of coupling for all permissible parameter sets the minimum dimension is given so that it is possible to detect a periodic solution. The results obtained are compared with previously derived results for systems without coupling. It is concluded that coupling with exterior pools of metabolites can give rise to steady state instead of periodic solution.