DNA Repair: The Search for Homology

Bioessays 40 (5):1700229 (2018)
  Copy   BIBTEX

Abstract

The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51‐mediated process to match sequences at the broken end to homologous donor sequences that can be used as a template to repair the lesion. Here, in reviewing research about DSB repair, I consider the many factors that appear to play important roles in the successful search for homology by several homologous recombination mechanisms.

Categories

Keywords

Reprint years

DOI

10.1002/bies.201700229

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 92,323

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

My notes

Similar books and articles

Meiotic versus mitotic recombination: Two different routes for double‐strand break repair.Sabrina L. Andersen & Jeff Sekelsky - 2010 - Bioessays 32 (12):1058-1066.
Menage á trois: Double strand break repair, V(D)J recombination and DNA‐PK.Penny A. Jeggo, Guillermo E. Taccioli & Stephen P. Jackson - 1995 - Bioessays 17 (11):949-957.
ATP puts the brake on DNA double‐strand break repair.Karl-Peter Hopfner - 2014 - Bioessays 36 (12):1170-1178.
Mitosis, double strand break repair, and telomeres: A view from the end.Anthony J. Cesare - 2014 - Bioessays 36 (11):1054-1061.
Nijmegen breakage syndrome: consequences of defective DNA double strand break repair.Martin Digweed, André Reis & Karl Sperling - 1999 - Bioessays 21 (8):649-656.
Double-strand DNA breaks recruit the centromeric histone CENP-A.S. G. Zeitlin, N. M. Baker, B. R. Chapados, E. Soutoglou, J. Y. J. Wang, M. W. Berns & D. W. Cleveland - unknown
Bloom syndrome helicase in meiosis: Pro-crossover functions of an anti-crossover protein.Talia Hatkevich & Jeff Sekelsky - 2017 - Bioessays 39 (9):1700073.
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.Chen Bpc, Chan Dw, J. Kobayashi, S. Burma, A. Asaithamby, K. Morotomi-Yano, E. Botvinick, J. Qin & Chen Dj - unknown
Mammalian DNA single‐strand break repair: an X‐ra(y)ted affair.Keith W. Caldecott - 2001 - Bioessays 23 (5):447-455.
Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions.T. W. Lo, C. S. Pickle, S. Lin, E. J. Ralston, M. Gurling, C. M. Schartner, Q. Bian, J. A. Doudna & B. J. Meyer - unknown
Hypothesis: transcript‐templated repair of DNA double‐strand breaks.Deborah A. Trott & Andrew C. G. Porter - 2006 - Bioessays 28 (1):78-83.
A model for repair of radiation‐induced DNA double‐strand breaks in the extreme radiophile Deinococcus radiodurans.Kenneth W. Minton & Michael J. Daly - 1995 - Bioessays 17 (5):457-464.
Multi‐Invasion‐Induced Rearrangements as a Pathway for Physiological and Pathological Recombination.Aurèle Piazza & Wolf-Dietrich Heyer - 2018 - Bioessays 40 (5):1700249.
Genetic instability is prevented by Mrc1‐dependent spatio‐temporal separation of replicative and repair activities of homologous recombination.Félix Prado - 2014 - Bioessays 36 (5):451-462.
(Only) some crossover effects repaired.Christopher Potts - unknown

Analytics

Added to PP
2018-04-02

Downloads
54 (#297,460)

6 months
9 (#317,373)

Historical graph of downloads
How can I increase my downloads?

Citations of this work

Add more citations

References found in this work

No references found.

Add more references