Abstract

In this work, the level of expression of the anti-apoptotic protein Bcl-2 was determined at different stages of bladder papilloma. The results showed that in the control group, this protein was expressed at a low level only in the basal layer of the epithelium lining the bladder. At the initial I stage of papilloma development during the metaplastic process in the changing epithelium, the expression of Bcl-2 protein increases to a high level in the cells of the basal layer of the epithelium with acanthosis At the II stage of papilloma, all cells of the epithelial layers are metaplastic and arranged vertically, the Bcl-2 protein is expressed at a relatively higher level in the cells of the basal and intermediate layers, and at the III stage of papilloma, the expression of this protein is even stronger.