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Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
Journal of Medical Ethics 46 (12):808-812 (2020)
Abstract
To counter the pandemic caused by severe acute respiratory syndrome coronavirus 2, some have proposed accelerating SARS-CoV-2 vaccine development through controlled human infection trials. These trials would involve the deliberate exposure of relatively few young, healthy volunteers to SARS-CoV-2. We defend this proposal against the charge that there is still too much uncertainty surrounding the risks of COVID-19 to responsibly run such a trial.Author Profiles
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Citations of this work
Pandemic Ethics and Status Quo Risk.Richard Yetter Chappell - 2022 - Public Health Ethics 15 (1):64-73.
COVID-19 controlled human infection studies: worries about local community impact and demands for local engagement.Kyungdo Lee & Nir Eyal - 2021 - Journal of Medical Ethics 47 (8):539-542.
Do coronavirus vaccine challenge trials have a distinctive generalisability problem?Nir Eyal & Tobias Gerhard - 2022 - Journal of Medical Ethics 48 (9):586-589.
Uncertainty, error and informed consent to challenge trials of COVID-19 vaccines: response to Steel et al.Arnon Keren & Ori Lev - 2020 - Journal of Medical Ethics 46 (12):813-814.
Exploring the ethics of tuberculosis human challenge models.Abie Rohrig, Josh Morrison, Gavriel Kleinwaks, Jonathan Pugh, Helen McShane & Julian Savulescu - forthcoming - Journal of Medical Ethics.
References found in this work
A core precautionary principle.Stephen M. Gardiner - 2006 - Journal of Political Philosophy 14 (1):33–60.
Why high-risk, non-expected-utility-maximising gambles can be rational and beneficial: the case of HIV cure studies.Lara Buchak - 2016 - Journal of Medical Ethics (2):1-6.
A framework for risk-benefit evaluations in biomedical research.Annette Rid & David Wendler - 2011 - Kennedy Institute of Ethics Journal 21 (2):141-179.
Ethical Criteria for Human Challenge Studies in Infectious Diseases: Table 1.Ben Bambery, Michael Selgelid, Charles Weijer, Julian Savulescu & Andrew J. Pollard - 2016 - Public Health Ethics 9 (1):92-103.
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