Slavery, which is thought to have existed since the appearance of mankind in stage of history, has developed in parallel with the civilization progress of mankind. The altering conditions, particularly the developments in production relations that are based on economic activities, have also shaped slavery. In the Early Ages, slaves were used only in agricultural production, but later on, they were begun to be used in various areas. The developments experienced throughout the history in slavery have followed different courses in (...) every society and every civilization. Slavery, which has possessed differences in geographical context, was shaped by social values and belief systems. Scientific and intellectual developments since 18th century, which is also known as the Age of Enlightenment, have influenced many institutions of societies and caused a change in the institution of slavery as well. The modern and libertarian ideological movements, which developed in the West, spread to the Ottoman State in the 19th century and led to significant shifts in the life of the state and society. Ottoman State followed modern developments in the slavery system and took some measures to ban slavery in its territory, particularly since the Tanzimat era. One of the regions where these measures were taken is the Middle East. Archival documents were used for this study which includes the initiatives of the Ottoman State that tried to terminate the slave trade in the region with various instructions and firmans. According to documents there was an intense effort to block this trade in the Middle East where was an important slave trade area with regard to Ottoman geography. However, despite these hard efforts, it is seen that a complete success regarding blocking slave trade in the Middle East could not be achieved. (shrink)