Drawing on ethical and legal frameworks in the Netherlands, the United States and France, we examine whether physicians are expected to inform patients about potentially relevant opportunities for expanded access to investigational drugs. While we found no definitive legal obligation, we argue that physicians have a moral obligation to discuss opportunities for expanded access with patients who have run out of treatment options to prevent inequality, to promote autonomy, and to achieve beneficence.

What constitutes numerically one and the same tradition diachronically, at different times? This question is the focus of often violent dispute in societies. Is it capable of a rational resolution? Many accounts attempt that resolution with a diagnosis of ambiguity of the disputed concept-Islam, Marxism, or democracy for example. The diagnosis offered is in terms of vagueness, namely the vague criteria for sameness or similarity of central beliefs and practices.

an examination of both the causal theory of action and the agent causalist theory, and a proposal for a third alternative.

A discussion of three central ideas in action theory; trying to act, doing or acting, one's action causing further consequences.

This annotated bibliography comprehensively covers the entire range of international English-language philosophy serials. Over 300 citations represent serials that are especially instrumental in philosophical research and development. The entries are arranged alphabetically by title for rapid use and are fully annotated. Each entry includes detailed information about publishers, prices, circulation, manuscript selection, indexes and abstracts, target audiences, and acceptance rates. In addition, the annotations evaluate critically the strengths and weaknesses of the serial as it substantially impacts philosophy and its related (...) disciplines. The Guide also includes an extensive subject index and a geographical index. (shrink)

Whether some condition is equivalent to a conjunction of some conditions has been a major issue in analytic philosophy. Examples include: knowledge, acting freely, causation, and justice. Philosophers have striven to offer analyses of these, and other concepts, by showing them equivalent to such a conjunction. Timothy Williamson offers a number of arguments for the idea that knowledge is ‘prime’, hence not equivalent to or composed by some such conjunction. I focus on one of his arguments: the requirement that such (...) conjuncts must be freely recombinable. Although there has been a great deal of discussion of Williamson's arguments, the flaw I describe has gone unnoticed. Williamson's argument is expressed in terms of conditions, and cases of the condition. Does the condition include specific information, or is the specific information only part of the case? His argument equivocates between more and less general specifications of the conditions. Once this distinction is clarified, his argument can be seen to be vitiated by this conflation. Neither option yields a sound argument for Williamson's desired conclusion. (shrink)

When seriously ill patients reach the end of the standard treatment trajectory for their condition, they may qualify for the use of unapproved, investigational drugs regulated via expanded access programs. In medical-ethical discourse, it is often argued that expanded access to investigational drugs raises ‘false hope’ among patients and is therefore undesirable. We set out to investigate what is meant by the false hope argument in this discourse. In this paper, we identify and analyze five versions of the false hope (...) argument which we call: (1) the limited chance at benefit argument, (2) the side effects outweighing benefits argument, (3) the opportunity costs argument, (4) the impossibility of making informed decisions argument, and (5) the difficulty of gaining access argument. We argue that the majority of these five versions do not provide normative ground for disqualifying patients’ hopes as false. Only when hope is rooted in a mistaken belief, for example, about the likelihood of benefits or chances on medical risks, or when hope is directed at something that cannot possibly be obtained, should it be considered false. If patients are adequately informed about their odds of obtaining medical benefit, however small, and about the risks associated with an investigational treatment, it is unjustified to consider patients’ hopes to be false, and hence, to deny them access to investigational drug based on that argument. (shrink)

A comparison of disjunctive theories of action and perception. The development of a theory of action that warrants the name, a disjunctive theory. On this theory, there is an exclusive disjunction: either an action or an event (in one sense). It follows that in that sense basic actions do not have events intrinsic to them.

There appear to be multifunctional artefacts of a type such that none of their functions can be attributed only to some proper part of the artefact. I use two examples of allegedly multifunctional artefacts of this kind in what follows, one due to Lynne Rudder Baker (aspirin) and another of my own (a spork). The two examples are meant to make the same point. I discuss her aspirin example, since its discussion has entered the literature, but without its being dealt (...) with satisfactorily. My example is, I believe, more intuitive than that of aspirin, which Baker introduced in her response to a challenge to her views, and so I will mostly rely on my example of a spork, especially at the end of the paper, to make my case. -/- I argue that in at least those two cases, if the standard arguments for distinguishing between an object and what constitutes it are sound, an argument showing that what we might have taken to be a single multifunctional object is in fact a case of multiple single-function artefacts which collocate. Or almost. There is one further assumption needed for these cases, beyond what the constitution cases require, and I produce reasons for accepting that assumption. (shrink)

This paper presents new results from a detailed study of the structure of autocatalytic sets. We show how autocatalytic sets can be decomposed into smaller autocatalytic subsets, and how these subsets can be identified and classified. We then argue how this has important consequences for the evolvability, enablement, and emergence of autocatalytic sets. We end with some speculation on how all this might lead to a generalized theory of autocatalytic sets, which could possibly be applied to entire ecologies or even (...) economies. (shrink)

Book synopsis: What is the relationship between philosophy, social theory and empirical research? In what ways can we claim to 'know' the social world? What properties does the social world possess and what are their implications? This ground-breaking and multi-disciplinary book brings together a distinguished team of leading thinkers to discuss issues surrounding and informing questions such as: what is the 'social', in what ways can we 'know' it, and how can our findings be validated? These issues are discussed in (...) an accessible way, including the relationship of philosophical and research issues to each other, the nature of social reality, properties that may be ascribed to the social, research accounts and rhetorical 'persuasion', and the relations between 'gender and knowing'. The overall concern of the book is to clarify how and in what ways we can claim to know the social world and what implications and consequences this may have for social scientific practice. For too long philosophers, social theorists and methodologists have talked past each other, often unaware of the mutually beneficial insights that each offers the other. This book is intended to contribute to a more constructive encounter and dialogue in order to advance understanding of the problems and possibilities surrounding the quest to know the social world. With this overall aim in mind, it will be essential reading for advanced undergraduates and postgraduate students in the social sciences, as well as philosophers, social theorists, methodologists and social researchers in general. (shrink)

O presente artigo discute o conceito de cidadania e sua relação com as questões educacionais, sobretudo, as relacionadas ao campo da Educação de Jovens e Adultos. Constitui-se como resultado de pesquisa intitulada “Cidadania e EJA: concepções e desafios que marcam a escola pública brasileira” no âmbito do Núcleo de Estudos sobre Trabalho e Educação da Faculdade de Educação da Universidade Federal de Juiz de Fora. O texto destaca como o conceito de cidadania se desenvolveu historicamente, buscando seus fundamentos ideológicos e (...) políticos no liberalismo, correlacionando-o com a perspectiva de Estado e de educação defendida por essa corrente. Demonstra que a concepção burguesa de cidadania se desdobra sobre o campo educacional, expondo sua relação com a acumulação flexível de cunho capitalista. A concepção marxista de educação rompe com essa unilateralidade, apresentando a universalização do trabalho e da educação como expressão do humano, da pluralidade cultural e das concepções de mundo que marcam as experiências coletivas e individuais. Nesse modelo, as exigências educacionais para jovens e adultos são direcionadas a tornar esses sujeitos capazes de enfrentar, mesmo que minimamente, o mercado globalizado e assumir projetos de vida pautados no mérito das ações econômicas – por meio de uma educação ao longo da vida, com o objetivo de se manterem na condição de empregáveis. Portanto, o texto que se segue visa contribuir com as reflexões de educadores que almejam a construção de uma educação socialista e democrática. Esse processo, que se estabelece nos âmbitos coletivo e social – possível apenas com o rompimento e a superação do modelo social de capital e com a instauração de uma sociedade com novas formas de sentir, pensar e agir no mundo. Palavras-chave: Cidadania. Liberalismo. Educação. Jovens. Adultos. (shrink)

The authors of this volume discuss the relevance and influence of various Old and New Testament documents, and early Christian and Jewish texts in terms of their impact in shaping the moral character, identity, and behaviour of the specific communities in which they were produced as well as their ethical application throughout the centuries. Against a narrow understanding of ethics, the term "application" is not used to analyse the texts of the Bible as step-by-step manuals for moral conduct. Rather, the (...) contributors engage with biblical texts within the framework of a complex hermeneutical process of application of the relevance of these texts in contemporary ethical discourse. Contributors: Paul N. Anderson, Robert L. Brawley, Cilliers Breytenbach, Ulrich Busse, R. Alan Culpepper, Jan Willem van Henten, Rainer Hirsch-Luipold, Stephan Joubert, Craig R. Koester, Bart J. Koet, Michael Labahn, Tobias Nicklas, Bert Jan Lietaert Peerbolte, Udo Schnelle, Michael Theobald, D. Francois Tolmie, Joseph Verheyden, Ben Witherington, III, Ellen van Wolde, Michael Wolter, Mirjam Zimmermann, Ruben Zimmermann. (shrink)

Argument that Marx has a realist ontology and a correspondence theory of truth. His views are compared to both Hegel's and Kant's. This interpretation departs from more Hegelian, 'idealist' interpretations that often rely on misunderstanding some of the work of the early Marx. There is also a discussion and partial defence of Lenin's Materialism and Empirio-Criticism.

Book synopsis: The Routledge Encyclopedia of Philosophy is the most ambitious international philosophy project in many years. Edited by Edward Craig and assisted by thirty specialist subject editors, the REP consists of ten volumes of the world's most eminent philosophers writing for the needs of students and teachers of philosophy internationally. The REP is a project on an unparalleled scale.

Book synopsis: This is the first volume of a two-volume introduction to and guide through philosophy. It is intended to orientate, assist, and stimulate the reader at every stage in the study of the subject. Eleven extended essays have been specially commissioned from leading philosophers; each surveys a major area of the subject and offers an accessible but sophisticated account of the main debates. An extended introduction maps out the philosophical terrain and explains how the different subjects relate to each (...) other. The first part of the book deals with the foundations of philosophical enquiry: epistemology; philosophical logic; methodology; metaphysics; and the philosophy of mind. The second part offers four historical chapters, two on ancient and two on modern philosophy, introducing great thinkers from the past, explaining and discussing their ideas, and showing the value of studying them today. The third part comprises two chapters devoted to questions of value, in ethics and aesthetics. Full annotated bibliographies are provided at the ends of chapters to serve as guides to further reading. This is real philosophy, not simplified philosophy; it will be accessible for the beginner but equally valuable for the third-year student. Deep and challenging questions are not shirked; the reader will be given a sense of involvement in the practice of philosophy today. (shrink)

This year we celebrated Stuart Kauffman’s 80th birthday. Kauffman has contributed many original ideas to science. One of them is that of autocatalytic sets in the context of the origin of life. An autocatalytic set is a self-sustaining chemical reaction network in which all the molecules mutually catalyze each other’s formation from a basic food source. This notion is often seen as a “counterargument” against the dominant genetics-first view of the origin of life, focusing more on metabolism instead. The original (...) notion was introduced back in 1971, but it has taken several decades for this idea to really catch on. Thanks to theoretical as well as experimental progress in more recent research on autocatalytic sets, especially over the past 15 years, the idea now seems to be gaining significant interest and support. In this tribute to Kauffman’s work and ideas, a brief history of research on autocatalytic sets is presented. (shrink)

This paper argues that Spinoza held substances other than God to be inconceivable. It uses this claim to develop a novel response to the Problem of Other Substances, the problem of explaining why some of Spinoza’s proofs for God’s existence cannot be used to prove the existence of a non-divine substance instead.

The link between leadership and mental health at the workplace is well established by prior research. However, most of the studies have addressed this relationship from a single-source perspective. The aim of this study was to examine how supervisor and employee ratings of health-oriented leadership correspond to each other and which sources are predictive for employee mental health. We assessed data within 99 teams containing 713 employees in 11 different companies in Southern Germany. Supervisors and their staff completed questionnaires on (...) the supervisors’ health-oriented staff-care dimensions awareness, value of health and health behavior and current mental distress. Hierarchical linear models revealed that supervisors’ self-ratings were significantly related to their employees’ ratings only on the health behavior dimension, but not on the health awareness and value of health dimensions. Also, supervisors rated themselves significantly higher on HoL compared to their employees. Employee ratings of HoL significantly predicted their own level of mental distress, whereas supervisor ratings of HoL did not predict employees’ mental distress at the team level. Supervisors’ self-ratings of HoL did not influence the relationship between employee ratings of HoL and their mental distress on an individual level. These results highlight the complex relationship between multisource assessments of HoL and employee mental health, emphasizing the importance of subjective perception for mental health. Future studies should investigate under which conditions supervisor and employee ratings correspond to each other and are predictive for mental health at the workplace. (shrink)

Researchers have studied the athletes' dual careers with the aim of helping them to combine the sport and the academic–vocational sphere. Most of this research has addressed the study–sport combination, but there is a lack of studies on the work–sport combination. The main objective of this research was to explore the subjective perceptions of Spanish elite athletes when attempting to combine their careers as professional athletes with a second profession or trade. Further, this study aims to identify the access to (...) facilitating resources and the perception of obstacles and barriers to the development of a dual career. A qualitative approach was chosen to address these research questions. Interpretative phenomenological analysis was carried out on a sample of 18 elite athletes, and the data were collected using semi-structured interviews based on a set of superordinate and subordinate categories. The results showed that the athletes interviewed possessed valuable resources such as the transference of sports values to the work sphere. However, important barriers were highlighted such as the perception of sport institutions as absent entities in the work–sport combination. Thus, the study of this type of dual career seems to be one of the challenges facing the interested scientific community for the coming years. (shrink)

El presente artículo explora el carácter farmacológico de la tecnología a partir del caso del software libre de navegación anónima por internet y su potencial político. Se defiende la tesis de que el software, que es la base del sistema de vigilancia y control psicopolítico neoliberal descrito por Byung-Chul Han, puede ser al mismo tiempo, cuando se implementa en programas de código abierto que camuflan nuestra huella digital, una herramienta para la resistencia y emancipación. Esto se debe a que dicha (...) implementación ataca los principios fundamentales de la lógica de dominación dataísta: la transparencia y la predictibilidad. (shrink)

Chantal Maillard ha sido una de las pensadoras más relevantes de los últimos años. Su método creativo yatrevido ha indagado en una de las tensiones más importantes de la cultura actual: aquella que resulta de los encuentros y conflictos entre filosofía y poesía. Partiendo de la perspectiva maillardiana, este artículo aborda el lugar de lo poético en el mundo actual. Para ello, se postula que la distinción entre poesía y poema es una de las hipótesis centrales de la propuesta de (...) Maillard y es la que permite comprender que lo poético hace parte del flujo existencial por el que un fenómeno concreto de mundo puede acabar y dar lugar a otro, respondiendo a las insatisfacciones que alimentan el deseo por algo distinto a lo que ya-está. (shrink)

Se explora el desarrollo del campo de la Alfabetización Mediática y Digital en México, entre 2000 y 2021, mediante el análisis bibliométrico de publicaciones en Scopus y Web of Science, a partir del uso de frases sinónimas. Se observa una incipiente y dispersa producción científica en dicha área del conocimiento para el periodo de estudio.

How can we picture the days of December 19th and 20th 2001 ? Where can we trace its origins and driving force? Which has been the leading subject? Are there any clues which enable us to recognize the movement as well as the obstacles it will have to overcome? The labour of the movement in Argentina does not only show the peculiarities of our history, but it also refutes the series of arguments on universal circulation asserting that the passage front (...) fordism to post fordism implies the inevitable destruction-disappearance of all social achievements that can be credited to the movements action in the past. The ungovernability that began in 1955 is today more serious than ever, because it is not the result nor of the incompetence of the succeeding governments nor of the imposition of the international financial centres, but, on the contrary, it is the result of the movement’s action through the years. (shrink)

Este trabajo analiza los discursos de científicos españoles residentes en Bochum (Alemania), y de parte de ellos que, tras pasar una larga etapa en dicha ciudad, habían retornado. El mismo muestra cómo experimentan una dificultosa adaptación caracterizada por un sentimiento de infravaloración laboral, una falta de estabilidad y la añoranza de ciertos aspectos propios de la cultura española como la calidad del ocio y la mayor sociabilidad de su población. Por otro lado, se observa un retorno singularizado por la desincronización (...) con sus lugares de origen, debido a que sienten que el tiempo ha pasado muy rápido en los mismos, mientras que para ellos sus vidas se ha ralentizado. (shrink)

El texto trata de abordar la noción de «significante» lacaniano desde una hermenéutica filosófica. Para ello se recorrerán algunos momentos clave de la elaboración de Lacan sin dar por supuesto ningún uso o definición que se promueve del término en cuestión, todo ello con la intención de subrayar aspectos como el del sentido y la vedad que desde un análisis hermenéutico-filosófico pueden ser captados en toda su profundidad.

This paper presents an analysis and critique of Roger Penrose’s epistemological, methodological, and ontological positions. The analysis is relevant not only because Penrose is an influential scientist, but also because of the particular traits of his thought. These traits are directly connected with his background and approach to science: ontological and epistemological realism, mathematical Platonism, emphasis on the continuities of science, epistemological inclusiveness and essential openness of science, the role of common sense, emphasis on the connection between science, ethics, and (...) philosophy. The paper articulates Penrose’s position and criticizes some of its possible shortcomings. It contributes to the perception of science as an open activity, as illustrated in Penrose’s particular approach, and provides an interesting case-study that can contribute to understanding how epistemological and ontological positions are connected with particular scientific practices. (shrink)