We present an epistemological schema of natural sciences inspired by Peirce's pragmaticist view, stressing the role of the \emph{phenomenological map}, that connects reality and our ideas about it. The schema has a recognisable mathematical/logical structure which allows to explore some of its consequences. We show that seemingly independent principles as the requirement of reproducibility of experiments and the Principle of Sufficient Reason are both implied by the schema, as well as Popper's concept of falsifiability. We show that the schema has (...) some power in demarcating science by first comparing with an alternative schema advanced during the first part of the 20th century which has its roots in Hertz and has been developed by Einstein and Popper. Further, the identified differences allow us to focus in the construction of Special Relativity, showing that it uses an intuited concept of velocity that does not satisfy the requirements of reality in Peirce. While the main mathematical observation connected with this issue has been known for more than a century, it has not been investigated from an epistemological point of view. A probable reason could be that the socially dominating epistemology in physics does not encourage such line of work. We briefly discuss the relation of the abduction process presented in this work with discussions regarding ``abduction'' in the literature and its relation with ``analogy''. (shrink)

Junto con Rebeldes académicos de Iván Jaksić (SUNY 1989; UDP 2013) y Una disciplina de la distancia de Cecilia Sánchez (CESOC 1992), este libro ya forma parte del canon bibliográfico selecto y escaso que propone investigaciones de largo aliento sobre la historia de la filosofía en el Chile republicano. No se trata de una reseña de nombres y obras, ni de una historia interna del desarrollo de problemas puros o escuelas. Más bien, su foco, en afinidad con las obras mencionadas, (...) son “las distintas relaciones históricas entre las fuerzas del poder y las razones de la filosofía […] las distintas inscripciones en los también múltiples quiasmos entre saberes y poderes” (14-15), asumiendo, de modo más sustantivo, que “el bloque histórico dominante en Chile rara vez ha logrado establecer un relato coherente de la dominación, justamente porque es poco lo que le importan las razones en nombre de las cuales ejerce la fuerza” (41). (shrink)

Abstract We examine the construction of electromagnetism in its current form, and in an alternative form, from a point of view that combines a minimal realism with strict rational demands. We begin by discussing the requests of reason when constructing a theory and next, we follow the historical development as presented in the record of original publications, the underlying epistemology (often explained by the authors) and the mathematical constructions. The historical construction develops along socio-political disputes (mainly, the reunification of Germany (...) and the second industrial revolution), epistemic disputes (at least two demarcations of science in conflict) and several theories of electromagnetism. Such disputes resulted in the militant adoption of the ether by some, a position that expanded in parallel with the expansion of Prussia. This way of thinking was facilitated by the earlier adoption of a standpoint that required, as a condition for understanding, the use of physical hypothesis in the form of analogies; an attitude that is antithetic to Newton's “hypotheses non fingo”. While the material ether was finally abandoned, the epistemology survived in the form of “substantialism” and a metaphysical ether: the space. The militants of the ether attributed certainties regarding the ether to Faraday and Maxwell, when they only expressed doubts and curiosity. Thus, the official story is not the real history. This was achieved by the operation of detaching Maxwell's electromagnetism from its construction and introducing a new game of formulae and interpretations. Large and important parts of Maxwell work are today not known, as for example, the rules for the transformation of the electromagnetic potentials between moving systems. When experiments showed that all the theories based in the material ether were incorrect, a new interpretation was offered: Special Relativity (SR). At the end of the transformation period a pragmatic view of science, well adapted to the industrial society, had emerged, as well as a new protagonist: the theoretical physicist. The rival theory of delayed action at distance initiated under the influence of Gauss was forgotten in the midst of the intellectual warfare. The theory is indistinguishable in formulae from Maxwell's and its earlier versions are the departing point of Maxwell for the construction of his equations. We show in a mathematical appendix that such (relational) theory can incorporate Lorentz' contributions as well as Maxwell's transformations and C. Neumann's action, without resource to the ether. Demarcation criteria was further changed at the end of the period making room for habits and intuitions. When these intuited criteria are examined by critical reason (seeking for the fundaments) they can be sharpened with the use of the Non Arbitrariness Principle, which throws light over the arbitrariness in the construction of SR. Under a fully rational view SR is not acceptable, it requires to adopt a less demanding epistemology that detaches the concept from the conception, such as Einstein's own view in this respect, inherited from Hertz. In conclusion: we have shown in this relevant exercise how the reality we accept depends on earlier, irrational, decisions that are not offered for examination but rather are inherited from the culture. (shrink)

Este artículo examina la fenomenología que desarrolló el filósofo chileno Jorge Eduardo Rivera (1927-2017). Primeramente, se destacan algunas características generales de la filosofía de Rivera. Luego, se enjuicia la propuesta heideggeriana de un giro hermenéutico de la fenomenología husserliana que formula Rivera, fijándose especialmente en la interpretación ofrecida de Husserl y en otras posibilidades que ofrece la misma fenomenología. En tercer término, se muestra la concepción universitaria de la filosofía de Rivera, y su identificación de los peligros que acechan a (...) las universidades, sugiriéndose luego otras formas de amenazas universitarias actuales y otras alternativas fenomenológicas para concebir a la universidad contemporáneamente. (shrink)

We integrate dualistic conceptions of the real with Peirce's perspectives about reality and abduction, emphasizing the concept of reason underlying Peirce's thoughts. Peirce's abduction is related to the notions of retrogression and grounding in Hegel, later re-encountered in Hansonian-abduction. Abduction in turn is considered in relation to abstraction acquiring its fullest sense as a stage in the process of producing a theory. The process is iterative and self improving, it incorporates ``turbid thinking'' making it increasingly ``clear'' at successive iterations that (...) incorporate the lessons taught by failed predictions, i.e., refutations. The cycle of thoughts promoted by doubts comes to rest when belief is reached. We discuss how this coming to rest depends on a criterion for cessation of doubts. The observation is illustrated with two different criteria, one proposed by Mach that only demands analogy and the criteria of dualists such as Goethe and Whewell that inspire the present work. Hence, it is possible to produce, and socially accept, imperfect theories unless we demand the highest level of rationality, avoiding any leftover of the turbid thoughts that have been used in the early developments. This work rests upon the existence of some objective form of reason. Influenced by a constructivist, Piagetian, perspective of science, we propose and discuss a small number of conditions that we identify as characteristics of rational abduction: rules for the rational construction of theories. We show how a classical example of belief that satisfies today's most common definition of abduction does not match the standards of rational retroduction. We further show how the same rules indicate the partial detachment of Special Relativity from the observable world, a fact actually known to Einstein. We close arguing that there is an urgent need to develop a critical epistemology incorporating dualistic perspectives. (shrink)

We present a fully relational definition of inertial systems based in the No Arbitrariness Principle, that eliminates the need for absolute inertial frames of reference or distinguished reference systems as the ``fixed stars'' in order to formulate Newtonian mechanics. The historical roots of this approach to mechanics are discussed as well. The work is based in part in the constructivist perspective of space advanced by Piaget. We argue that inertial systems admit approximations and that what is of practical use are (...) precisely such approximations. We finally discuss a slightly larger class of systems that we call ``relatively inertial'' which are the fundamental systems in a relational view of mechanics. (shrink)

In the present essay we attempt to reconstruct Newtonian mechanics under the guidance of logical principles and of a constructive approach related to the genetic epistemology of Piaget and García. Instead of addressing Newton’s equations as a set of axioms, ultimately given by the revelation of a prodigious mind, we search for the fundamental knowledge, beliefs and provisional assumptions that can produce classical mechanics. We start by developing our main tool: the no arbitrariness principle, that we present in a form (...) that is apt for a mathematical theory as classical mechanics. Subsequently, we introduce the presence of the observer, analysing then the relation objective–subjective and seeking objectivity going across subjectivity. We take special care of establishing the precedence among all contributions to mechanics, something that can be better appreciated by considering the consequences of removing them: the consequence of renouncing logic and the laws of understanding is not being able to understand the world, renouncing the early elaborations of primary concepts such as time and space leads to a dissociation between everyday life and physics, the latter becoming entirely pragmatic and justified a-posteriori, changing our temporary beliefs has no real cost other than effort. Finally, we exemplify the present approach by reconsidering the constancy of the velocity of light. It is shown that it is a result of Newtonian mechanics, rather than being in contradiction with it. We also indicate the hidden assumption that leads to the contradiction. (shrink)

Se propone una lectura de los textos del filósofo chileno Carlos Ruiz Schneider que presta atención a las citas que contiene y asume que éstas exceden su uso ilustrativo y autorizador, para funcionar como modo de expresión estético-político de un pensar filosófico comprometido con una democracia radical. Para ello se proyectan y reformulan categorías de análisis de crítica cultural y artística extraídas del trabajo de Nelly Richards (complementadas con aportes de la filosofía contemporáneas: Heidegger, Derrida, Foucault y Butler), pertinentes para (...) configurar lo que podría denominarse un ‘estilo epocal’ en el pensamiento crítico chileno de fines del siglo XX. A partir de esta lectura, se abre una reflexión más general sobre la posibilidad de la democracia en la indecible y, por tanto, secreta complicidad pensante desencadenada por las enunciaciones. _Palabras claves:_ Filosofía – Democracia – Cita – Obscenidad – Estética. (shrink)

While mechanics was developed under the idea of reciprocal action (interactions), electromagnetism, as we know it today, takes a form more akin to unilateral action. Interactions call for spatial relations, unilateral action calls for space, just one reference centre. In contrast, interactions are matters of relations that require at least two centres. The development of the relational electromagnetism encouraged by Gauss appears to stop around 1870 for reasons that are not completely clear but are certainly not solely scientific. By the (...) same time, Maxwell recognised the equivalence in formulae of his electromagnetism and the one advocated by Gauss and called for an explanation of why such theories so differently conceived have such a large part in common. In this work we reconstruct and update the relational electromagnetism up to the contributions of Lorentz guided by the non-arbitrariness principle (NAP) that requests arbitrary choices to be accompanied by groups of symmetries. We show that a-priori there must be two more symmetries in electromagnetism, one related to the breaking (in the description) of the relation source/detector and one relating all the perceptions of the same source by detectors moving with different (constant) relative velocities. We show that the idea of electromagnetic waves put forward in concept by Lorenz (1861-1863) before Maxwell (1865) and in formulae (1867) just after Maxwell, together with the ``least action principle'' proposed by Lorentz are enough to derive Maxwell's equations, the continuity equation and the Lorentz' force, and that there is a dual formulation in terms of fields of the receiver (as opposed to fields of the source). While Galilean transformations are associated with removing the arbitrariness implied in the election of a reference space, they will not explicitly appear in a formulation based upon a relational space although we occasionally mention their usefulness. In contrast, Lorentz' transformations will emerge in this formulation involving the relations between the perceived fields of different receivers. Moreover, the role of the full Poincaré-Lorentz group as a group of transformations of the perceived actions is elucidated. In summary, we answer Maxwell's philosophical question showing how the same theory in formulae can be abduced using different inferred entities. Each form of abduction implies as well an interpretation and a facilitation of the theoretical construction. This work relies heavily on logical concepts as abduction put forward by C. Peirce, needed for the construction of theories. (shrink)

In the present essay we attempt to reconstruct Newtonian mechanics under the guidance of logical principles and of a constructive approach related to the genetic epistemology of Piaget and García (Psychogenesis and the history of science, Columbia University Press, New York, 1989). Instead of addressing Newton’s equations as a set of axioms, ultimately given by the revelation of a prodigious mind, we search for the fundamental knowledge, beliefs and provisional assumptions that can produce classical mechanics. We start by developing our (...) main tool: the no arbitrariness principle, that we present in a form that is apt for a mathematical theory as classical mechanics. Subsequently, we introduce the presence of the observer, analysing then the relation objective–subjective and seeking objectivity going across subjectivity. We take special care of establishing the precedence among all contributions to mechanics, something that can be better appreciated by considering the consequences of removing them: (a) the consequence of renouncing logic and the laws of understanding is not being able to understand the world, (b) renouncing the early elaborations of primary concepts such as time and space leads to a dissociation between everyday life and physics, the latter becoming entirely pragmatic and justified a-posteriori (because it is convenient), (c) changing our temporary beliefs has no real cost other than effort. Finally, we exemplify the present approach by reconsidering the constancy of the velocity of light. It is shown that it is a result of Newtonian mechanics, rather than being in contradiction with it. We also indicate the hidden assumption that leads to the (apparent) contradiction. (shrink)

A simple model for the description of atomic and ionic species with spectra exhibiting a quantum defect is solved using the Lie algebra su(1, 1). The quantum defect of bound states is related to the phase shift of scattering states. The resonances are discussed in terms of the nonunitary representations of this algebra.

Russian-speaking homecare workers deploy two divergent discursive practices—professionalism and sainthood—in understanding carework. These two meaning-making systems have consequences for how this work is performed and experienced by workers. Surprisingly, the division is not based on gender. Instead, immigration laws filter Jewish and Orthodox Christian immigrants from the former Soviet Union into two separate sets of resettlement institutions. The characteristics of these separate institutional settings shape the discursive tools available to these two groups, leading Jewish refugees to deploy professionalism while Orthodox (...) Christian immigrants deploy sainthood. These discursive practices affect gendered identities, allowing workers in some cases to renegotiate hegemonic notions of masculinity and create new models of “feminine” caregiving. (shrink)

Resumen:Junto con Rebeldes académicos de Iván Jaksić (SUNY 1989; UDP 2013) y Una disciplina de la distancia de Cecilia Sánchez (CESOC 1992), este libro ya forma parte del canon bibliográfico selecto y escaso que propone investigaciones de largo aliento sobre la historia de la filosofía en el Chile republicano. No se trata de una reseña de nombres y obras, ni de una historia interna del desarrollo de problemas puros o escuelas. Más bien, su foco, en afinidad con las obras mencionadas, (...) son “las distintas relaciones históricas entre las fuerzas del poder y las razones de la filosofía […] las distintas inscripciones en los también múltiples quiasmos entre saberes y poderes” (14-15), asumiendo, de modo más sustantivo, que “el bloque histórico dominante en Chile rara vez ha logrado establecer un relato coherente de la dominación, justamente porque es poco lo que le importan las razones en nombre de las cuales ejerce la fuerza” (41). (shrink)

La teoría hegeliana de la propiedad según emerge en el derecho abstracto de la persona tal como es diseñado en la _Filosofía del Derecho_ afirma que la propiedad es la objetivación externa de la voluntad libre mediante la apropiación de cosas exteriores, que la propiedad no solamente mienta un mundo dado ya de antemano y al cual está referido el agente de praxis, sino también la diferencia absoluta entre personas y cosas y el problema protoeconómico del acceso de aquellas a (...) estas mediante actos, que la propiedad racionalmente necesaria para la libre personalidad supone el reconocimiento entre las autoconciencias, y que la propiedad, sin rechazar el formalismo típico del derecho privado, también exige la concreta universalidad del derecho público, un acceso a la misma por parte de todos y cada cual, y su organización y distri-bución universal a través de mecanismos institucionales y estatales. (shrink)

This article reconstructs Kant’s and Hegel’s moral, political, and legal treatment of tolerance in the larger context of their philosophies of religion and freedom. Kant and Hegel have similar initial remarks on tolerance, religion, and fanaticism, then seem to separate when they resort respectively to respect and recognition—they agree in the end when the former defines intersubjective respect as recognition and the latter defines legal and political recognition as including respect. All of this allows us to better understand, first, the (...) extent of their repulse of practical-religious dogmatism, and secondly, that tolerance, in contrast to violent and superstitious fanaticism, is nothing more than a peculiar facet of respect and recognition. (shrink)

El artículo presenta el razonamiento de Zubiri acerca de la plausible existencia de Dios que se deriva de la estructura del cosmos. Dicho razonamiento, que muestra una faceta poco conocida de la fi losofía de la religión de este autor, aborda una de las cuestiones más espinosas de la historia de la filosofía, recurriendo expresamente al modelo estándar del universo que se ha forjado la astrofísica y aplicando varias de las categorías características de la metafísica elaborada por el propio Zubiri. (...) We expound Zubiri's argument for the plausible existence of God, based on the structure of the universe. This argument, which displays a not very well known aspect of Zubiri's philosophy of religion, tackles one of the thorniest subjects in the history of philosophy. It resorts specifi cally to the standard model of the universe developed in 20th century astrophysics, while applying many of the categories which are characteristic of Zubiri's metaphysics. (shrink)

Antonio González has developed a philosophical and theological approach about the notions of acts and things, specially in regard to his moral, social and political dimensions. His phenomenological philosophy is elaborated through intellectual combat with phaenomena, problems and aporias, not that much by means of interpretation of other works. Thence he extracts an idea of religion and a theology whose core is the liberation of the retribution, of the condemnation of poor and sinners, of the ecclesiastical Constantinianism, of the state (...) violence. In these pages I try to identify and even to criticize the phenomenology of the author so much respect to the acts and what in them emerge, as regarding the possibilities that it opens to the philosophical conceptualization of religions and to the political-theological character of Christianity. (shrink)

W. H. Hudson tuvo un contacto muy temprano con El origen de las especies; probablemente haya leído el libro el mismo año de su aparición . Esta lectura lo acercó a una filosofía naturalista que, a la vez, lo alejó de la formación materna en cuestión religiosa, y lo condujo a asumir una posición evolucionista crítica. De hecho, contradijo observaciones de Darwin que éste revisó, además de mencionarlo en la segunda edición de El origen de las especies . Asimismo, son (...) numerosas las citas que Hudson hace de Darwin en sus textos. Aunque pueden marcarse diferencias, ciertos tópicos generales del evolucionismo, son fácilmente reconocibles a lo largo de su producción. El trabajo pretende avanzar sobre estos aspectos para identificar cuán profundamente caló en su concepción del mundo la perspectiva evolucionista.W. H. Hudson had an early contact with The Origin of Species. He may have read it in the same year of its publication . This reading brought him close to a naturalist philosophy that, in turn, took him away from an education in religious practice, fostered by his mother, and made him adopt a critical evolutionist position. In fact, he contradicted Darwin's observations, which he latter reviewed, in addition to mentioning him in the second edition of The Origin of Species . Also, there are numerous quotations of Darwin in Hudson's works. Even though differences can be noted, certain general topics on evolutionism may be easily recognized throughout his production. This paper attempts to move forward in these aspects in order to identify how deeply the evolutionist perspective influenced Hudson's conception of the world. (shrink)

Este trabajo muestra cómo es que Zubiri discutió a lo largo de su extensa obra —incorporando textos y cursos suyos recientemente editados— que exista una presunción intelectual en favor del ateísmo y en cambio sugirió que este está en idéntica posición intelectiva que el teísmo y el agnosticismo, para lo cual se reconstruyen en la filosofía madura de Zubiri sus análisis tanto del logos ateo como de la razón del ateísmo y se añaden finalmente algunas perspectivas especialmente práctico-políticas de prolongar (...) esta filosofía del ateísmo. (shrink)

The “impossibility” in our title is similar to what Emmanuel Falque designates by the notion of “outside phenomenon”, namely a region as excepting itself from the dialectic of logos and chaos. “Out of phenomenon” in the sense here of a principial impossibility of “saying oneself”, affecting in turn the “self” (saying oneself) and its expression (saying oneself). Phenomenology has taught us that there is no ego as below the cogito. No self‑foundation guarantees the reference that is marked in the (lexical) (...) expression: “self”. From this correlation between egoism and narrativity, we will retain in this article only the essential affirmation, namely that the self is above all a saying: an act of speech, not about itself, nor from itself, but as adhering to itself in such a way that no gap remains between the word (self) and the referent (self). The self becomes from then on like a performance (of language). Almost a reduction. But what happens when the self is affected by a radical aphasia? (shrink)

This paper addresses two subject matters. The first one is a parallel between the conceptions of democracy and university developed by Jaime Guzmán and Jorge Millas in the historical context surrounding 1973’s military strike. It serves as a documentary point of reference an exchange between Guzmán and Millas at the editorial pages of El Mercurio paper during the summer of 1976. The other subject matter is the configuration of the post-military strike philosophical field, as system of rules and strategies of (...) enunciation. The Guzmán-Millas transaction enables to see how the rules of the philosophical field are tied with models of university and democracy imposed by the post-strike State. (shrink)

RESUMEN Algunos textos de Abelardo, Tomás de Aquino, Llull y el Cusano, no solo muestran una forma específicamente medieval de encarar la diversidad interreligiosa, sino aun algo más, a saber, que las apreciables diferencias políticas y epistémicas que separan al medioevo de la modernidad no implican que la tolerancia sea una noción propiamente moderna, ni que su versión medieval resulte ajena a cierta admisión de la libertad religiosa y de la pluralidad en la verdad. ABSTRACT The examination of texts by (...) Abelard, Thomas Aquinas, Llull, and Nicholas of Cusa shows that they do not merely reflect a specifically medieval way of addressing interreligious diversity. Rather, it shows that the significant political and epistemic differences separating the Middle Ages from Modernity do not imply that tolerance is a specifically modern concept, and that the medieval version of tolerance allows for a certain degree of religious freedom and pluralism regarding truth. RESUMO Alguns textos de Abelardo, Tomás de Aquino, Llull e Nicolau de Cusa não somente mostram uma forma especificamente medieval de encarar a diversidade inter-religiosa, mas também algo mais: as apreciáveis diferenças políticas e epistêmicas que separam a Idade Média da Modernidade não implicam que a tolerância seja uma noção propriamente moderna, nem que sua versão medieval acabe sendo alheia a certa admissão da liberdade religiosa e da pluralidade na verdade. (shrink)

El artículo, que supone una determinada interpretación de la filosofía de la religión de Zubiri, intenta reconstruir el hipotético diálogo de ella con la filosofía analítica de la religión. así, primeramente, expone las varias coincidencias de ambas en torno a la cuestión del significado del lenguaje religioso. Enseguida, muestra tanto sus acuerdos como sus divergencias en lo que toca a la racionalidad de las creencias religiosas. Y dentro de esto último, por fin, sugiere que para las dos la teología filosófica (...) y la teodicea constituyen un terreno imprescindible para cualquier filosofía de la religión que pretenda ser rigurosa y actual. (shrink)

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

A growing body of research has suggested that high levels of family functioning—often measured as positive parent–child communication and low levels of parental stress—are associated with stronger cognitive development, higher levels of school engagement, and more successful peer relations as youth age. The COVID-19 pandemic has brought tremendous disruption to various aspects of daily life, especially for parents of young children, ages 3–5, who face isolation, disconnection, and unprecedented changes to how they engage and socialize. Fortunately, both youth and parent (...) brains are plastic and receptive to change. Resilience research shows that factors such as engaging in acts of kindness, developing trusting relationships, and responding compassionately to the feelings of others can help lay new neural pathways and improve quality of life. Yet, little research has investigated the effects of brain healthy parental practices of kindness with pre-school aged children. The current study examines whether an interactive, parent–child kindness curriculum can serve as a potentiator for brain health as measured by resilience and child empathy levels. During a peak of the pandemic, mother participants between the ages of 26–46 completed questionnaires on parental resilience levels and parent-reported child empathic pro-social behaviors before and after engaging in a 4 weeks online, self-paced, kindness curriculum. Half of the group received additional brain health education explaining the principles of neuroplasticity, empathy, perspective taking, and resiliency. Mothers in both groups showed increased resilience and reported higher levels of empathic behavior in their child after completing the curriculum. There was no significant difference between groups. Comparison of mean resilience levels during COVID-19 to pre-pandemic general means indicated that mothers are reporting significantly lower levels of resilience as well as decreased empathetic behaviors in their children. These results support the notion that kindness is a powerful brain health booster that can increase resilience and empathy. This research study was timely and relevant for parents in light of the myriad of stresses brought about by the ongoing COVID-19 pandemic. There are broader public health implications for equipping individuals with tools to take a proactive and preventative approach to their brain health. (shrink)

The demonstration that pluripotent stem cells could be generated by somatic cell reprogramming led to wonder if these so-called induced pluripotent stem (iPS) cells would extend our investigation capabilities in the cancer research field. The first iPS cells derived from cancer cells have now revealed the benefits and potential pitfalls of this new model. iPS cells appear to be an innovative approach to decipher the steps of cell transformation as well as to screen the activity and toxicity of anticancer drugs. (...) A better understanding of the impact of reprogramming on cancer cell-specific features as well as improvements in culture conditions to integrate the role of the microenvironment in their behavior may strengthen the epistemic interest of iPS cells as model systems in oncology. (shrink)

Whole eye transplantation (WET) remains experimental. Long presumed impossible, recent scientific advances regarding WET suggest that it may become a clinical reality. However, the ethical implications of WET as an experimental therapeutic strategy remain largely unexplored. This article evaluates the ethical considerations surrounding WET as an emerging experimental treatment for vision loss. A thorough review of published literature pertaining to WET was performed; ethical issues were identified during review of the articles.