Statistics play a critical role in biological and clinical research. To promote logically consistent representation and classification of statistical entities, we have developed the Ontology of Biological and Clinical Statistics (OBCS). OBCS extends the Ontology of Biomedical Investigations (OBI), an OBO Foundry ontology supported by some 20 communities. Currently, OBCS contains 686 terms, including 381 classes imported from OBI and 147 classes specific to OBCS. The goal of this paper is to present OBCS for community critique and to describe a (...) number of use cases designed to illustrate its potential applications. The OBCS project and source code are available at http://obcs.googlecode.com. (shrink)

Statistics play a critical role in biological and clinical research. However, most reports of scientific results in the published literature make it difficult for the reader to reproduce the statistical analyses performed in achieving those results because they provide inadequate documentation of the statistical tests and algorithms applied. The Ontology of Biological and Clinical Statistics (OBCS) is put forward here as a step towards solving this problem. Terms in OBCS, including ‘data collection’, ‘data transformation in statistics’, ‘data visualization’, ‘statistical data (...) analysis’, and ‘drawing a conclusion based on data’, cover the major types of statistical processes used in basic biological research and clinical outcome studies. OBCS is aligned with the Basic Formal Ontology (BFO) and extends the Ontology of Biomedical Investigations (OBI), an OBO (Open Biological and Biomedical Ontologies) Foundry ontology supported by over 20 research communities. We discuss two examples illustrating how the ontology is being applied. In the first (biological) use case, we describe how OBCS was applied to represent the high throughput microarray data analysis of immunological transcriptional profiles in human subjects vaccinated with an influenza vaccine. In the second (clinical outcomes) use case, we applied OBCS to represent the processing of electronic health care data to determine the associations between hospital staffing levels and patient mortality. Our case studies were designed to show how OBCS can be used for the consistent representation of statistical analysis pipelines under two different research paradigms. By representing statistics-related terms and their relations in a rigorous fashion, OBCS facilitates standard data analysis and integration, and supports reproducible biological and clinical research. (shrink)

According to a popular line of thought, moral exemplars have a key role to play in moral development and moral education and by paying attention to moral exemplars we can learn about what morality requires of us. However, when we pay attention to what many moral exemplars say about their actions, it seems that our moral obligations are much more demanding than we typically think they are. Some philosophers have argued that this exemplar testimony gives us reason to accept a (...) radically demanding view of morality. We argue against this view by appealing to similar testimony from aesthetic exemplars. If we accept that the testimony of moral exemplars gives us reason to accept a radically demanding view of morality, then we should accept that the testimony of aesthetic exemplars supports a radically demanding view of aesthetic normativity. We argue that we should reject both arguments for radically demanding views, and instead see the testimony of exemplars as having something important to tell us about the nature of ideals. What we learn about morality and aesthetics from attending to the lives of moral exemplars is that those who embody an ideal are subject to obligations that others are not. (shrink)

Many people who perform paradigmatic examples of acts of supererogation claim that they could not have done otherwise. In this paper I will argue that these self-reports from moral exemplars present a challenge to the traditional view of supererogation as involving agential sacrifice. I will argue that the claims made by moral exemplars are plausibly understood as what Bernard Williams calls a ‘practical necessity’. I will then argue that this makes it implausible to view these acts as involving agential sacrifice.

In this entry I will introduce two such puzzles that relate to the heroic actions and testimony. I will first introduce the basic idea of supererogation and why some heroic actions give us reason to accept the existence of supererogatory actions. I will then introduce the problem that supererogation raises for moral theory and explain the main responses that have been offered to this problem. I will then explain two related problems that arise from the way that heroes describe their (...) actions and explore how moral philosophers might respond to these problems. (shrink)

Some contemporary theologians dismiss the classical discussions of the existence and nature of God as out of step with and unworthy of serious consideration by so-called "modern man." Others contend that even though the historical giants of philosophical theology generally had an intimate acquaintance with Sacred Scripture, their philosophical biases beguiled them unwittingly into forming conceptions of God that are wholly foreign to as well as incompatible with the biblical conception of God. These two distinct lines of criticism sometimes converge (...) in the suggestion that today's philosophical theologians should forsake their old heroes for duly modern ones like Whitehead, Heidegger, and Wittgenstein, whose writings allegedly provide philosophical outlooks more in tune with biblical categories of thought. Just as often, however, we find an attitude of distrust toward any sort of metaphysical reflection on the ostensible theological claims of the Judaeo-Christian tradition--both on the part of those who believe that the Judaeo-Christian myths have at most only ethical and perhaps political significance and on the part of those who believe that metaphysical inquiry invariably distorts theological truths by displacing Sacred Scripture as the foundation of the life of faith. Despite their disagreements, however, all sides concur in assigning little if any systematic importance to traditional philosophical theology. (shrink)

Philosophers are by now familiar with “the” paradox of supererogation. This paradox arises out of the idea that it can never be permissible to do something morally inferior to another available option, yet acts of supererogation seem to presuppose this. This paradox is not our topic in this paper. We mention it only to set it to one side and explain our subtitle. In this paper we introduce and explore another paradox of supererogation, one which also deserves serious philosophical attention. (...) People who perform paradigmatic acts of supererogation very often claim and believe that their acts were obligatory. Plausibly, this is simply a mistake insofar as the actions really are “above and beyond the call of duty,” as common sense would have it. The fact that moral heroes tend to view their actions in this apparently mistaken way is puzzling in itself, and we might learn something interesting about the moral psychology of such individuals if we could explain this tendency. However, this puzzling aspect of the moral psychology of moral heroes is also the chief ingredient in a deeper puzzle, one perhaps more worthy of the title “paradox.” In this paper we present and try to resolve this paradox. The paradox arises when we combine our initial observation about the moral psychology of moral heroes with three plausible claims about how these cases compare with one in which the agent realizes her act is “above and beyond.” The first of these three additional claims is that the agent who mistakenly claims that the act is obligatory is no less virtuous than someone who performs such an act whilst correctly judging it to be obligatory. The second is that the agent who makes such a mistake would display more moral wisdom if she judged the act to be supererogatory. The third is that there is no other relevant difference between the two agents. These three claims, together with a plausible principle about the way in which the virtues work, give rise to a paradox. We consider several ways in which this paradox might be resolved. We argue that the most plausible resolution is to reject the claim that there is no other relevant difference between the two agents. More specifically, we argue that a relevant difference is that the agent who makes this mistake does so because of the depth of their commitment to certain moral values, and that this is itself an important moral virtue: moral depth. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Sick with PassionAlfred LouchOpera: Desire, Disease, Death, by Linda and Michael Hutcheon; xvi & 294 pp. Lincoln: University of Nebraska Press, 1996, $40.00.IDriving east from the Auvergne you may chance upon La Chaise-Dieu, a charming village where a very acceptable cafe confronts the fortress-like Abbatiale de St Robert across the village square. The church itself is an imposing monument to the ephemeral glory of the Avignon Pope Clement VI, (...) but its most extraordinary feature is a fresco in the aisle to the left of the choir. Called the Danse Macabre, it depicts death as a sequence of skeletons, each of which beckons, pleads with, consoles, or compels its many victims—young and old, rich and poor, exalted or mean—toward their inevitable end. At times the skeleton’s posture is sinister and threatening, at others, as with children, it seems to turn away, as if to shield them from its fearful aspect. The skeletons seem to catch the movement of a single dancer as they select one partner after another, taking the life of each in a graceful though ghastly movement.The fresco depicts the Black Death—art inspired by disease and contagion. But even if you were as innocent of history as the typical American tourists you would confront in the fresco the undeniable image of death, and the caprice of its visitation, a thought contrasting strangely with the enduring granite of the church. Your experience may be enriched by history and lead you to moralize on the contrast [End Page 155] between the pomp and grandeur of the papal builder and the fresco’s depiction of the vanity of human wishes. But it would be a jarring note if some know-it-all in the company of viewers were to lecture for all to hear on the transmission and symptoms of pasteurella pestis. That is another story, and an interesting one, but not here and now.And so it is, if not so abrasively, with a recent book by Linda and Michael Hutcheon on desire, disease, and death in opera. They hope to shed new light, by combining literary analysis and the medical theory of disease and contagion, on the themes and purposes of opera, or certain operas anyway. Somehow the passages on mycobacterium tuberculosis, treponema pallidum, and vibrio cholerae, together with graphic descriptions of the symptoms caused by these micro-organisms, and an accompanying photograph of syphilitic gummæ seem intrusive, just as talk about the etiology and the pathology of the plague strikes a discordant note as we look upon the Danse Macabre in wonder and fear. The Hutcheons, a husband and wife team who practice, respectively, medicine and literary criticism, tell the reader they are opera lovers. I hope their affection is not prompted only by infection.But why shouldn’t medicine and its history be relevant to literary, artistic, or musical creation? Think here of a question Wittgenstein asks in Zettel (paragraph 610): “Why should there not be a psychological regularity to which no physiological regularity corresponds? If this upsets our concept of causality then it is high time it was upset.” He did not mean to say that it would not be surprising if someone talked and acted and looked like a person but turned out to have an empty skull. But he did mean surely that talk about human projects and emotions is complete as it stands; what is going on in the neurons and what busy microbes are doing are other stories. Literature is about human projects, the skill or clumsiness with which they are pursued, the responses to success and failure, achievement and frustration. Opera, which, ever since someone had the idea of putting story to song, raided literary invention for its subject matter, is the same. Heroes and villains may of course be expected to be vulnerable to the various vicissitudes of life. Diseases may lay them low, as well as passing trains. But disease enters their stories to delay or frustrate or put period to their projects, not as new characters on the stage. If you read about the death of Ivan Illych and come away dissatisfied because Tolstoy failed to identify the... (shrink)

Alfred North Whitehead's SCIENCE AND THE MODERN WORLD, originally published in 1925, redefines the concept of modern science.

Philospher, mathematician, and general man of science, Alfred North Whitehead was a polymath whose interests and generous sympathies encompassed entire worlds.

Alfred North Whitehead was a prominent English mathematician and philosopher who co-authored the highly influential Principia Mathematica with Bertrand Russell. Originally published in 1919, and first republished in 1925 as this Second Edition, An Enquiry Concerning the Principles of Natural Knowledge ranks among Whitehead's most important works; forming a perspective on scientific observation that incorporated a complex view of experience, rather than prioritising the position of 'pure' sense data. Alongside companion volumes The Concept of Nature and The Principle of (...) Relativity, it created a framework for Whitehead's later metaphysical speculations. This is an important book that will be of value to anyone with an interest in the relationship between science and philosophy. (shrink)

This classic text in American Philosophy by one of the foremost figures in American philosophy offers a concise analysis of the various factors in human nature which go toward forming a religion, to exhibit the inevitable transformation of religion with the transformation of knowledge and to direct attention to the foundation of religion on our apprehension of those permanent elements by reason of which there is a stable order in the world, permanent elements apart from which there could be no (...) changing world. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Autonomous Agents addresses the related topics of self-control and individual autonomy. "Self-control" is defined as the opposite of akrasia-weakness of will. The study of self-control seeks to understand the concept of its own terms, followed by an examination of its bearing on one's actions, beliefs, emotions, and personal values. It goes on to consider how a proper understanding of self-control and its manifestations can shed light on personal autonomy and autonomous behaviour. Perspicuous, objective, and incisive throughout, Alfred Mele makes (...) a convincing case for the value of individual autonomy. (shrink)

Le present volume rassemble plusieurs etudes qu' Alfred Schutz avait consacrees a diverses questions qui gravitent autour d'un probleme philosophique majeur: celui de la socialite. La plupart de ces etudes ont Me publiees ailleurs, mais elles etaient dispersees et d'un acces parfois difficile. Tel quel, l'ouvrage que nous presentons n' est que la premiere partie d'un ensemble dans lequell'auteur se proposait de faire reunir par son disciple et ami Maurice Natanson les nombreux essais qu'il avait ecrits depuis son arrivee (...) aux Etats-Unis au debut de la demiere guerre. La mort l'empecha de voir realiser ce projet. 11 nous a semble que la pUblication successive de cet ensemble, dans la fidelite aux indications laissees par l'auteur, etait Ie plus bel hommage que nous pussions rendre a ce penseur qui fut notre ami et meritait sans nul doute de tenir dans Ie courant phenomenologique une place de premier plan que faillirent lui refuser les circonstances dramatiques de sa vie, jointes a sa trop grande modestie per­ sonnelle. II me faudrait ici parler de l'homme, evoquer sa finesse d'esprit, son ironie penetrante, sa serenite et son courage dans l' exil, l' event ail tres vaste de ses preoccupations, Ie don de jeu­ nesse et de sympathie grftce auquel il entreprit a quarante ans d'assimiler avec bonheur une culture nouvelle, pour y exceller bientOt. (shrink)

Originally published in 1928 this book was an attempt to acquaint the general public with the fundamentals of Individual Psychology. At the same time it is a demonstration of the practical application of these principles to the conduct of everyday relationships, and the organization of our personal life. Based upon a years’ lectures to audiences at the People’s Institute in Vienna, the purpose of the book was to point out how the mistaken behaviour of the individual affects harmony of our (...) social and communal life; to teach the individual to recognize their own mistakes; and finally, to show them how they may effect a harmonious adjustment to the communal life. Adler felt that mistakes in business or in science were costly and deplorable, but mistakes in the conduct of life are usually dangerous to life itself. This book is dedicated by the author in his preface ‘to the task of illuminating man’s progress toward a better understanding of human nature.’. (shrink)

Le present volume rassemble plusieurs etudes qu' Alfred Schutz avait consacrees a diverses questions qui gravitent autour d'un probleme philosophique majeur: celui de la socialite. La plupart de ces etudes ont Me publiees ailleurs, mais elles etaient dispersees et d'un acces parfois difficile. Tel quel, l'ouvrage que nous presentons n' est que la premiere partie d'un ensemble dans lequell'auteur se proposait de faire reunir par son disciple et ami Maurice Natanson les nombreux essais qu'il avait ecrits depuis son arrivee (...) aux Etats-Unis au debut de la demiere guerre. La mort l'empecha de voir realiser ce projet. 11 nous a semble que la pUblication successive de cet ensemble, dans la fidelite aux indications laissees par l'auteur, etait Ie plus bel hommage que nous pussions rendre a ce penseur qui fut notre ami et meritait sans nul doute de tenir dans Ie courant phenomenologique une place de premier plan que faillirent lui refuser les circonstances dramatiques de sa vie, jointes a sa trop grande modestie per­ sonnelle. II me faudrait ici parler de l'homme, evoquer sa finesse d'esprit, son ironie penetrante, sa serenite et son courage dans l' exil, l' event ail tres vaste de ses preoccupations, Ie don de jeu­ nesse et de sympathie grftce auquel il entreprit a quarante ans d'assimiler avec bonheur une culture nouvelle, pour y exceller bientOt. (shrink)

I ON THE PRIMITIVE TERM OF LOGISTICf IN this article I propose to establish a theorem belonging to logistic concerning some connexions, not widely known, ...

Originally published in 1928 this book was an attempt to acquaint the general public with the fundamentals of Individual Psychology. At the same time it is a demonstration of the practical application of these principles to the conduct of everyday relationships, and the organization of our personal life. Based upon a years’ lectures to audiences at the People’s Institute in Vienna, the purpose of the book was to point out how the mistaken behaviour of the individual affects harmony of our (...) social and communal life; to teach the individual to recognize their own mistakes; and finally, to show them how they may effect a harmonious adjustment to the communal life. Adler felt that mistakes in business or in science were costly and deplorable, but mistakes in the conduct of life are usually dangerous to life itself. This book is dedicated by the author in his preface ‘to the task of illuminating man’s progress toward a better understanding of human nature.’. (shrink)

A dissertation in the tradition of logical positivism includes a discussion of the functions and methods of philosophy and a critique of ethics and theology.

How might people be wronged in relation to their feelings, moods, and emotions? Recently philosophers have begun to investigate the idea that these kinds of wrongs may constitute a distinctive form of injustice: affective injustice (Archer & Mills 2019; Mills 2019; Srinivasan 2018; Whitney 2018). In previous work, we have outlined a particular form of affective injustice that we called emotional imperialism (Archer & Matheson 2022). This paper has two main aims. First, we aim to provide an expanded account of (...) the forms that emotional imperialism can take. We will do so by drawing inspiration from William Reddy’s concept of an emotional regime and investigating ways in which colonial powers of the 18th to 20th Centuries sought to impose their emotional regimes on their colonial subjects. Second, we will offer more expansive accounts of both emotional imperialism and affective injustice that can accommodate these additional forms of emotional imperialism. (shrink)

The contents of this book were originally delivered at Trinity College in the autumn of 1919 as the inaugural course of Tarner lectures.

Phenomenological foundations - The cognitive setting of the life-world - Acting in the life-world - The world of social relationships - Realms of experience - The province of sociology.

Is it appropriate to honour and admire people who have created great works of art, made important intellectual contributions, performed great sporting feats or shaped the history of a nation if those people have also acted immorally? This book provides a philosophical investigation of this important and timely question. -/- The authors draw on the latest research from ethics, value theory, philosophy of emotion, social philosophy and social psychology to develop and substantiate arguments that have been made in the public (...) debates about this issue. They offer a detailed analysis of the nature and ethics of honour and admiration, and present reasons both in favor and against honouring and admiring the immoral. They also take on the important matter of whether we can separate the achievements of public figures from their immoral behavior. Ultimately, the authors reject a "one-size-fits-all" approach and argue that we must weigh up the reasons for and against honouring and admiring in each particular case. -/- Honouring and Admiring the Immoral is written in an accessible style that shows how philosophy can engage with public debates about important ethical issues. It will be of interest to scholars and students working in moral philosophy, philosophy of emotion, and social philosophy. (shrink)

Modes of Thought was written 20 years ago from lectures delivered by Whitehead at Wellesley, the University of Chicago, and Harvard. In it Whitehead developed the brilliant new concepts of clarity and precision of statement which have since become fundamental principles of construction underlying all of the fields of modern intellectual analysis.

Importance.--Expression.--Understanding.--Perspective.--Forms of process.--Civilized universe.--Nature lifeless.--Nature alive.--The aim of philosophy.

Is it appropriate to honor artists who have created great works but who have also acted immorally? In this article, after arguing that honoring involves identifying a person as someone we ought to admire, we present three moral reasons against honoring immoral artists. First, we argue that honoring can serve to condone their behavior, through the mediums of emotional prioritization and exemplar identification. Second, we argue that honoring immoral artists can generate undue epistemic credibility for the artists, which can lead (...) to an indirect form of testimonial injustice for the artists’ victims. Third, we argue, building on the first two reasons, that honoring immoral artists can also serve to silence their victims. We end by considering how we might respond to these reasons. (shrink)

When The Concept of Nature by Alfred North Whitehead was first published in 1920 it was declared to be one of the most important works on the relation between philosophy and science for many years, and several generations later it continues to deserve careful attention. Whitehead explores the fundamental problems of substance, space and time, and offers a criticism of Einstein's method of interpreting results while developing his own well-known theory of the four-dimensional 'space-time manifold'. With a specially commissioned (...) new preface written by Michael Hampe, this book is presented in a fresh series livery for the twenty-first century for a new generation of readers. (shrink)

A classic in the area, originally published in 1901, this book is a survey of the past work in the field of philosophy of religion, a conspectus of literature and comparison of methods and theologies from the Reformation to the start of the twentieth century. The Introduction part of the volume offers a classification system to explain the order of the detailed section of the book. Lesser-known theologians are covered as well as great thinkers, a deliberate choice on the part (...) of the author. Within each chapter, types of theism are then broken down into sections on individual thinkers, or group of thinkers with a reference to their main works. (shrink)

Der Autor versucht die Literaturtheorie der Enzyklopädisten im Kontext jener liberalen Ideologie der Aufklärung zu situieren, die vom Handelsbürgertum ausgeht und auf eine Überwindung des Feudalabsolutismus hinzielt. Im Verhältnis von Schriftsteller und Gesellschaft konkretisiert sich ein neues Selbstverständnis der Intelligenz, die im Rahmen der politischen Emanzipation des Bürgertums einen gesellschaftlich relevanten Standpunkt für ihre eigene Arbeit zu definieren versucht.

First published in Great Britain in 1948, this book examines the definition of goodness as being distinct from the question of _What things are good?_ Although less immediately and obviously practical, Dr. Ewing argues that the former question is more fundamental since it raises the issue of whether ethics is explicable wholly in terms of something else, for example, human psychology. Ewing states in his preface that the definition of goodness needs to be confirmed before one decides on the place (...) value is to occupy in our conception of reality or on the ultimate characteristics which make one action right and another wrong. This book discusses these issues. (shrink)

My topic lies on conceptual terrain that is quite familiar to philosophers. For others, a bit of background may be in order. In light of what has filtered down from quantum mechanics, few philosophers today believe that the universe is causally deterministic. That is, to use Peter van Inwagen's succinct definition of “determinism,” few philosophers believe that “there is at any instant exactly one physically possible future.” Even so, partly for obvious historical reasons, philosophers continue to argue about whether free (...) will and moral responsibility are compatible with determinism. Compatibilists argue for compatibility, and incompatibilists argue against it. Some incompatibilists maintain that free will and moral responsibility are illusions. But most are libertarians, libertarianism being the conjunction of incompatibilism and the thesis that at least some human beings are possessed of free will and moral responsibility. (shrink)

One of the major philosophical texts of the 20th century, Process and Reality is based on Alfred North Whitehead’s influential lectures that he delivered at the University of Edinburgh in the 1920s on process philosophy. Whitehead’s master work in philsophy, Process and Reality propounds a system of speculative philosophy, known as process philosophy, in which the various elements of reality into a consistent relation to each other. It is also an exploration of some of the preeminent thinkers of the (...) seventeenth and eighteenth centuries, such as Descartes, Newton, Locke, and Kant. The ultimate edition of Whitehead’s magnum opus, Process and Reality is a standard reference for scholars of all backgrounds. (shrink)

This classic undergraduate treatment examines the deductive method in its first part and explores applications of logic and methodology in constructing mathematical theories in its second part. Exercises appear throughout.

One of the major philosophical texts of the 20th century, Process and Reality is based on Alfred North Whitehead’s influential lectures that he delivered at the University of Edinburgh in the 1920s on process philosophy. Whitehead’s master work in philsophy, Process and Reality propounds a system of speculative philosophy, known as process philosophy, in which the various elements of reality into a consistent relation to each other. It is also an exploration of some of the preeminent thinkers of the (...) seventeenth and eighteenth centuries, such as Descartes, Newton, Locke, and Kant. The ultimate edition of Whitehead’s magnum opus, Process and Reality is a standard reference for scholars of all backgrounds. (shrink)