ObjectivePrevious studies have demonstrated altered brain activity in strabismic amblyopia. In this study, low-frequency repetitive transcranial magnetic stimulation was applied in children with strabismic amblyopia after they had undergone strabismus surgery. The effect of rTMS was investigated by measuring the changes of brain features using the amplitude of low-frequency fluctuation.Materials and MethodsIn this study, 21 SA patients were recruited based on their age, weight, and sex. They all had SA in their left eyes and they received rTMS treatment one month (...) after strabismus surgery. Their vision before and after surgery were categorized as pre-rTMS and post-rTMS. All participants received rTMS treatment, underwent magnetic resonance imaging, and their data were analyzed using the repeated measures t-test. The team used correlation analysis to explore the relationship between logMAR visual acuity and ALFF.ResultsPre- versus post-rTMS values of ALFF were significantly different within individuals. In the POT group, ALFF values were significantly decreased in the Angular_R, Parietal_Inf_L, and Cingulum_Mid_R while ALFF values were significantly increased in the Fusiform_R and Frontal_Inf_Orb_L compared to the PRT stage.ConclusionOur data showed that ALFF recorded from some brain regions was changed significantly after rTMS in strabismic amblyopes. The results may infer the pathological basis of SA and demonstrate that visual function may be improved using rTMS in strabismic amblyopic patients. (shrink)

More and more studies showed that strabismus is not simply an ocular disease, but a neuro-ophthalmology disease. To analyze potential changes in brain activity and their relationship to behavioral performance in comitant strabismus patients and healthy controls. Our study recruited 28 patients with comitant strabismus and 28 people with matched weight, age range, and sex ratio as healthy controls. Using resting-state functional magnetic resonance imaging, we evaluated fALFF to compare spontaneous brain activity between comitant strabismus and healthy controls. We did (...) hospital anxiety and depression scale questionnaires for these patients. We found significantly lower fALFF value in comitant strabismus patients compared with controls in the left frontal superior medial gyrus and the right middle cingulum. In the latter region, fALFF was significantly negatively correlated with the hospital anxiety and depression scale, as well as the duration of disease. Receiver operating characteristic curve analysis indicated that the fALFF method has clear potential for the diagnosis of comitant strabismus patients. These results revealed abnormal spontaneous activity in two brain regions of comitant strabismus patients, which may indicate underlying pathologic mechanisms and may help to advance clinical treatment. (shrink)

The autophagy initiation complex is brought about via a highly ordered and stepwise assembly process. Two crucial signaling molecules, mTORC1 and AMPK, orchestrate this assembly by phosphorylating/dephosphorylating autophagy‐related proteins. Activation of Atg1 followed by recruitment of both Atg9 vesicles and the PI3K complex I to the PAS (phagophore assembly site) are particularly crucial steps in its formation. Ypt1, a small Rab GTPase in yeast cells, also plays an essential role in the formation of the autophagy initiation complex through multiple regulatory (...) pathways. In this review, our primary focus is to discuss how signaling molecules initiate the assembly of the autophagy initiation complex, and highlight the significant roles of Ypt1 in this process. We end by addressing issues that need future clarification. (shrink)

Game experiments designed to test the effectiveness of reward and/or punishment incentives in promoting cooperative behavior among their participants are quite common. Results from two such recent experiments conducted in Beijing, based on the Prisoner’s Dilemma (PD) game and Public Goods Game respectively, are summarized here. The unexpected empirical outcomes for the repeated PD game, that cooperation actually decreased when the participants had the option of using a costly punishment strategy and that participants who used costly punishment in some round (...) of the repeated game often did so in the first round, are discussed in terms of differences in attitudes toward reputation in Chinese culture compared to other locations (mostly in Western society) where similar experiments have been conducted. The second experiment models an institution providing incentives to increase contribution levels (i.e., cooperation) to the public good. The results show that combined institutional reward and punishment is the most effective means to increase cooperation, followed by a scheme using only punishment. It is shown how these empirical results are related to the theoretical predictions that assume players play rationally by optimizing their personal payoff given their opponents’ actions in these multi-player games. (shrink)

国家社会科学基金项目获“高等学校优秀青年教师教学科研奖励计划资助”(TRAPOYT).

Ongoing electroencephalography signals are recorded as a mixture of stimulus-elicited EEG, spontaneous EEG and noises, which poses a huge challenge to current data analyzing techniques, especially when different groups of participants are expected to have common or highly correlated brain activities and some individual dynamics. In this study, we proposed a data-driven shared and unshared feature extraction framework based on nonnegative and coupled tensor factorization, which aims to conduct group-level analysis for the EEG signals from major depression disorder patients and (...) healthy controls when freely listening to music. Constrained tensor factorization not only preserves the multilinear structure of the data, but also considers the common and individual components between the data. The proposed framework, combined with music information retrieval, correlation analysis, and hierarchical clustering, facilitated the simultaneous extraction of shared and unshared spatio-temporal-spectral feature patterns between/in MDD and HC groups. Finally, we obtained two shared feature patterns between MDD and HC groups, and obtained totally three individual feature patterns from HC and MDD groups. The results showed that the MDD and HC groups triggered similar brain dynamics when listening to music, but at the same time, MDD patients also brought some changes in brain oscillatory network characteristics along with music perception. These changes may provide some basis for the clinical diagnosis and the treatment of MDD patients. (shrink)

本书从经验的角度研究介绍感觉、知觉、思维、情感等精神官能的活动机理,又从实践的角度剖析主观内在走向外在和由外在走向内在的活动原则。.

Ben shu yi "zhou xin shi dai" Zhongguo wen hua ren wen xing te zheng xing cheng ji qi dui Zhongguo zhe xue te zhi de su zao wei qie ru dian, zai xi tong shu li ru xue xin xing lun de ji ben zhu ti he li shi fa zhan, jie shi qi te zheng de ji chu shang, cong dao de yu sheng ming, dao de shi jian deng fang mian dui tang jun yi dao de (...) xing shang xue jin xing le shen ru de yan jiu. (shrink)

This paper tries to clarify the theory of difference in terms of ji or soku ("即") that is developed by Nishida Kitarō and Mou Zongsan, comparing it with contemporary occidental Metaphysics of difference. It is known that Nishida's argument for basho or place shows a kind of hesitation between identity and difference; several Kyoto philosophers, along with recent researchers, interpret Nishida's philosophy of "absolutely contradictory identity" in terms of soku as an ontology of not identity but of difference. A similar (...) hesitation is seen in Mou Zongsan's metaphysical argument for the difference between the act- and being- strata, which leads him to affirm the "identical" completeness of yuanjiao in terms of ji. I argue that these arguments become fully intelligible only as the result of their ontology of difference that strikingly resembles Deleuze's post-Heideggerian metaphysical attempt. This interpretation also shows how far their ontological speculation in terms of ji/ soku owes to the heritage of East Asian Buddhism because the contradiction between identity and difference is most seriously explored in the Tiantai tradition. (shrink)

本书评介了自柏拉图到罗兰·巴特的重要文艺思潮发展阶段以及这些阶段中的重要思想家,内容包括经典时代的文艺理论;中世纪文论;新古典主义的兴衰等.

本書可謂宋教授打從心性潛修後而有的領悟之作。讀者若能內修本心、外練世事，來此讀書，將別有一番新譯在心頭。.

本书为读者系统讲述先秦百家思想的精髓,各派思想的斗争融会,以及儒家思想的演变过程。.

本书以自由的两种类型为基点, 在着力分析了自由和自由主义的内涵、自由主义的演进思路的基础上, 运用历史尤其是思想史的研究方法, 对英国革命时期、启蒙时代至19世纪中叶西欧自由主义思潮演变的轨迹做了细致的梳理和分析.

“国家教育部人文社会科学重点研究基地山西大学科学技术哲学研究中心”基金资助出版.

本书是从经济学的角度研究“关系论”的专著,在系统阐述了经济学的关系论转向后,进一步对计量经济学进行了研究,并给出了在关系论框架下使用计量分析工具建构经济学知识的方法框架。主要包括了“修补完全理性:行为 经济学的心理现实化”、“放弃完全理性:行为经济学对正统经济学微观理论基础的解构”、“经济学何以可能”、“主体关系导向的计量经济学:通向关系论经济学的途径”、“知识何以可能”等方面的内容。.

本书内容包括:欧文·白璧德及其“人文主义”思想;“人文主义”译入中国:《学衡》徐震堮译文研究;“人文主义”的本土化(中国化):《学衡》胡先骕译文研究等。.

儀式是理解人類文化的一把鑰匙。作為人類基本經驗形態的展演，儀式涉及人類文化的諸多方面，是闡釋特定文化經驗、觀察文化意蘊、理解不同文化體系的表達模式的切入點。本書秉承審美人類學的理念，把儀式作為人類的基 本文化形式和審美文化機制，在全面理解儀式理論觀念和相關概念的基礎上，闡釋了儀式與審美制度、審美認同和審美交流的關系，為讀者理解審美人類學提供了重要參考。 張良叢，哈爾濱師范大學文學院副教授，馬列文論研究會理事，主要從事審美人類學和西方文學理論研究。.

本书采取“心身互渗”的立场,从仁与乐两个角度阐发万物一体观,在追溯王阳明一体之仁的思想谱系基础上,揭示出一体之仁的六个基本面向,并对王阳明的万物一体论的言说方式进行了反思。.