Can epistemic luck be captured by modal conditions such as safety from error? This paper answers ‘no’. First, an old problem is cast in a new light: it is argued that the trivial satisfaction associated with necessary truths and accidentally robust propositions is a symptom of a more general disease. Namely, epistemic luck but not safety from error is hyperintensional. Second, it is argued that as a consequence the standard solution to deal with this worry, namely the invocation of content (...) variation, fails. Third, it is considered whether the condition can serve some restricted theoretical role; the hypothesis is rejected. Finally, it is tentatively suggested that epistemic luck’s hyperintensionality derives from its being an explanatory notion, and an analogy is drawn with failures of probabilstic conceptions of explanation in the philosophy of science. (shrink)

Knowledge excludes luck. According to the received view, this intuition reveals that knowing is essentially modal in character. This paper demurs. Either knowledge does not exclude luck, or the entailment reveals nothing about its conceptual character. It is argued that knowledge excludes accidentality, and that this notion is not modal but causal‐explanatory. There are three central tasks. The first is to explicate the concept of accident. The second is to argue that the concepts of luck and accident are “intensionally distinct,” (...) which is to say that no member of the intension of either holds on both. The third is to argue that an anti‐accident requirement on knowledge is preferable to an anti‐luck analogue on abductive grounds. (shrink)

Throughout the years, Sosa has taken different views on the safety condition on knowledge. In his early work, he endorsed the safety condition, but later retracted this view when first developing his much discussed virtue epistemology. Recently, Sosa has further developed his virtue theory with the notion of competence and has developed an accompanying, modified safety condition that he maintains is entailed by that theory: the SSS-safety condition. Sosa's view is that this condition holds on both knowledge and action, because (...) both knowledge and action are the manifestations of competence. The SSS-safety condition, roughly, says that if S were to make an attempt at φ-ing under certain specified shape-situation pairs, holding fixed their seat, then S would φ. The argument of this paper is that this new SSS-safety condition does not hold on either knowledge or action. We argue for this conclusion by providing a principled way to generate counter-examples to the condition for both knowledge and action. The reasoning is that there can exist a non-empty symmetric difference between the sets of shape-situation pairs under which distinct agents can manifest their epistemic and pragmatic competences, and if there can exist such a symmetric difference then the SSS-safety condition fails to hold. (shrink)

The proper function of the heart is pumping the blood. According to what we call the type etiological view, this is because previous tokens of the type HEART were selected for pumping the blood. Nanay :412–431, 2010) argues that the type etiological view is viciously circular. He claims that the only plausible accounts of trait type individuation use proper functions, such that whenever the type etiological view is supplemented with a plausible account of trait type individuation, the result is a (...) view that uses proper functions to explain proper functions. We refine this objection, and argue that Nanay at most establishes a potentially benign definitional circularity. However, we show that the type etiological view’s reliance on types nevertheless generates a vicious regress. Hence the type etiological view is false. We reject dispositional and modal alternatives to the type etiological view for the reason that they either cannot accommodate malfunction, or do so at the cost of proliferation; and then formulate a novel token etiological view that overcomes both problems because it makes no reference to trait types. (shrink)

The years between 1833 and 1945 fundamentally transformed science’s understanding of the body’s inner senses, revolutionizing fields like philosophy, the social sciences, and cognitive science. In How We Became Sensorimotor, Mark Paterson provides a systematic account of this transformative period, while also demonstrating its substantial implications for current explorations into phenomenology, embodied consciousness, the extended mind, and theories of the sensorimotor, the body, and embodiment. -/- Each chapter of How We Became Sensorimotor takes a particular sense and historicizes its (...) formation by means of recent scientific studies, case studies, or coverage in the media. Ranging among a diverse array of sensations, including balance, fatigue, pain, the “muscle sense,” and what Maurice Merleau-Ponty termed “motricity,” Paterson’s analysis moves outward from the familiar confines of the laboratory to those of the industrial world and even to wild animals and their habitats. He uncovers important stories, such as how forgotten pain measurement schemes transformed criminology, or how Penfield’s outmoded concepts of the sensory and motor homunculi of the brain still mar psychology textbooks. -/- Complete with original archival research featuring illustrations and correspondence, How We Became Sensorimotor shows how the shifting and sometimes contested historical background to our understandings of the senses are being extended even today. (shrink)

This theoretical paper argues for prioritarianism as an ethical underpinning for digital health in contexts of extreme disadvantage. In support of this claim, the paper develops three prioritarian principles for making ethical decisions for digital health programme design, grounded in the normative position that the greater the need, the stronger the moral claim. The principles are positioned as an alternative view to the prevailing utilitarian approach to digital health, which the paper argues is not sufficient to address the needs of (...) the worst off. As researchers of digital health, we must ensure that the most globally marginalised are not overlooked by overtly technocentric implementation practices. Consequently, the paper concludes by advocating for use of the three principles to support stronger critical reflection on the ethics involved in the design and implementation of digital health programmes. (shrink)

The Health (Regulation of Termination of Pregnancy) Act 2018 was commenced on 01/01/2019 in Ireland. The Act provides for legal termination of pregnancy under defined circumstances including for any reason at < 12 weeks gestation; and where two doctors agree there is ‘a condition affecting the foetus that is likely to lead to the death of the foetus either before, or within 28 days of, birth’. As such, abortion for congenital anomaly (CA) can occur at a number of time points, (...) depending on the adjudged severity. Infants born with CAs frequently require significant medical intervention and account for a high proportion of admissions to paediatric intensive care units (PICUs). The purpose of this paper was to evaluate the number of infants with CAs admitted to an Irish PICU in the period before and after the implementation of the Act. All PICU admissions < 1 month of age to a single Irish paediatric hospital between 2012 and 2021 were analysed. CAs were recorded, and the periods before and after the commencement of the Act compared. We found a difference in admissions involving CAs, particularly those related to congenital heart disease involving single ventricle anatomy. It is plausible that this difference was as a result of improved access to abortion services following the implementation of the Act. This article explores the legal conditions related to the abortion of a foetus with a CA in Ireland, and the possible impact of the Independent Review of the Operation of the Health ( Regulation of Termination of Pregnancy) Act 2018. (shrink)

The dramatic increase in the number of overseas students studying in the United Kingdom and other Western countries has required academics to reevaluate many aspects of their own, and their institutions', practices. This article considers differing cultural values among overseas students toward plagiarism and the implications this may have for postgraduate education in a Western context. Based on focus-group interviews, questionnaires, and informal discussions, we report the views of plagiarism among students in 2 postgraduate management programs, both of which had (...) a high constituency of overseas students. We show that plagiarist practices are often the outcome of many complex and culturally situated influences. We suggest that educators need to appreciate these differing cultural assumptions if they are to act in an ethical manner when responding to issues of plagiarism among international students. (shrink)

What is the Bare Particular Theory? Is it committed, like the Bundle Theory, to a constituent ontology: according to which a substance’s qualities—and according to the Bare Particular Theory, its substratum also—are proper parts of the substance? I argue that Bare Particularists need not, should not, and—if a recent objection to ‘the Bare Particular Theory’ succeeds—cannot endorse a constituent ontology. There is nothing, I show, in the motivations for Bare Particularism or the principles that distinguish Bare Particularism from rival views (...) that entails a constituent ontology. I outline a version of Bare Particularism that in rejecting a constituent ontology avoids the New Objection. I argue against Theodore Sider that this really is a distinct theory to the version of Bare Particularism that endorses a constituent ontology, and not a mere terminological variant. I show that this, the best version of the Bare Particular Theory, is also defensible against the old objections. (shrink)

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes. Whether animals can be used to predict human response to drugs and other chemicals is apparently a contentious issue. However, when one empirically (...) analyzes animal models using scientific tools they fall far short of being able to predict human responses. This is not surprising considering what we have learned from fields such evolutionary and developmental biology, gene regulation and expression, epigenetics, complexity theory, and comparative genomics. (shrink)

The dramatic increase in the number of overseas students studying in the United Kingdom and other Western countries has required academics to reevaluate many aspects of their own, and their institutions', practices. This article considers differing cultural values among overseas students toward plagiarism and the implications this may have for postgraduate education in a Western context. Based on focus-group interviews, questionnaires, and informal discussions, we report the views of plagiarism among students in 2 postgraduate management programs, both of which had (...) a high constituency of overseas students. We show that plagiarist practices are often the outcome of many complex and culturally situated influences. We suggest that educators need to appreciate these differing cultural assumptions if they are to act in an ethical manner when responding to issues of plagiarism among international students. (shrink)

The English Catholic philosopher Sir Kenelm Digby (1603–1665) has enjoyed a recent spate of scholarly attention as a prodigious traveller, political figure, and man of diverse intellectual interests. This article contributes to this scholarship by assessing the commentary on salvation at the heart of Digby’s philosophy of the soul and the historical contexts in which it was produced. It argues that Digby’s thinking on the soul was a meditation on the worldly interactions a Catholic must undertake or avoid in order (...) to achieve salvation. As such, our intellectual historical understanding of Digby is much improved when he is viewed as a scholar who constructed an identity as a thinker adept at advising others on the correct path to beatitude. This article also makes the broader argument for salvation as an important conceptual tool for early modern intellectual historians wishing to accurately map the complex relationship between theology, scholarly argument, and scholarly ambition in the seventeenth century. (shrink)

The seventeenth-century French Benedictine philosopher Dom Robert Desgabets (1610–1678) has been taken by many historians as an idiosyncratic but ultimately loyal proponent of Cartesianism in the years following Descartes’ death. As a Catholic cleric aware of the importance of squaring the new philosophical conclusions of the seventeenth-century with Church theology, Desgabets wrote extensively on the ways in which this could be achieved with regard to the most contentious and complex theological Church dogma of the time: transubstantiation. Through an examination of (...) Desgabets’ writings on transubstantiation, this article argues that he was emboldened by his particular religious context and preoccupations to undertake an in-depth theological interrogation and revision of Descartes’ eucharistic thought, which motivated him to offer a more epistemologically and theologically ambitious account of transubstantiation than Descartes himself thought possible or wise. This article therefore uses Desgabets as an example of the complex interplay between theology and “new” philosophy in the early reception of Cartesianism. It shows how this interplay allowed early, theologically minded Cartesians like Desgabets to use the intellectual resources of the Catholic Church to fortify and safeguard the legacy of Cartesianism in a way Descartes himself did not do. (shrink)

A Companion to Hermeneutics is a collection of original essays from leading international scholars that provide a definitive historical and critical compendium of philosophical hermeneutics. Offers a definitive historical, systematic, and critical compendium of hermeneutics Represents state-of-the-art thinking on the major themes, topics, concepts and figures of the hermeneutic tradition in philosophy and those who have influenced hermeneutic thought, including Kant, Hegel, Schleiermacher Dilthey, Heidegger, Gadamer, Ricoeur, Foucault, Habermas, and Rorty Explores the art and theory of interpretation as it intersects (...) with a number of philosophical and inter-disciplinary areas, including humanism, theology, literature, politics, education and law Features contributions from an international cast of leading and upcoming scholars, who offer historically informed, philosophically comprehensive, and critically astute contributions in their individual fields of expertise Written to be accessible to interested non-specialists, as well asprofessional philosophers. (shrink)

This paper argues that the inappropriate framing and implementation of plagiarism detection systems in UK universities can unwittingly construct international students as ‘plagiarists’. It argues that these systems are often implemented with inappropriate assumptions about plagiarism and the way in which new members of a community of practice develop the skills to become full members of that community. Drawing on the literature and some primary data it shows how expectations, norms and practices become translated and negotiated in such a way (...) that legitimate attempts to conform with the expectations of the community of practice often become identified as plagiarism and illegitimate attempts at cheating often become obscured from view. It argues that this inappropriate framing and implementation of plagiarism detection systems may make academic integrity more illusive rather than less. It argues that in its current framing – as systems for ‘detection and discipline’ – plagiarism detection systems may become a new micro-politics of power with devastating consequences for those excluded. (shrink)

Following the deaths of ten Irish republican hunger strikers in 1981, radical Basque nationalists and Irish republicans of the Basque izquierda abertzale and Irish republican movement respectively, began to develop ever closer ties of transnational “solidarity”. In addition to the relationship between Herri Batasuna and Sinn Féin, more ad hoc organisational links in areas such as youth, prisoner, and language advocacy, fostered a shared political culture at the intersection of both movements, which was periodically reflected through the prism of cultural (...) expression. Utilising a wide array of primary sources, this article explores and analyses, for the first time, the emergence and development of this transnational nexus, from the hunger strikes of 1981 to the signing of the Good Friday Agreement in 1998. (shrink)

This paper maintains (following Yougrau 1987; 2000 and Hinchliff 1996) that the dead and other former existents count as examples of non-existent objects. If the dead number among the things there are, a further question arises: what is it to be dead—how should the state of being dead be characterised? It is argued that this state should be characterised negatively: the dead are not persons, philosophers etc. They lack any of the (intrinsic) qualities they had while they lived. The only (...) facts involving the dead are facts about the relations they stand in—including the relations they bear to the qualities they formerly instantiated, and the intentional relations they stand in to us. Given an appropriate conception of qualities the dead can be said to be quality-less objects: bare particulars. The ‘Bare Particular Theory’ of individuals, it is argued, is coherent if and only if it concedes that the bare particulars it allows for don’t exist. The account of the dead and other former existents as bare particulars does justice to the misfortune of death, and points the way to a general theory of nonexistent objects. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:A Partial Truth (Poems 2015–19) by Christopher NorrisNiall GildeaNorris, Christopher. A Partial Truth (Poems 2015–19). The Seventh Quarry Press, 2019. 133pp.“No interval but some event takes place.”(Norris, “Freeze-Frame,” A Partial Truth)A Partial Truth, a collection of thirty-seven pieces, is the seventh volume of poetry by philosopher and literary theorist Christopher Norris. Nobody familiar with Norris’s distinguished career will be surprised to learn that his recent turn to versification (...) is not a repudiation of intellectual and rhetorical seriousness, but a re-emphasis of the same using resources not typically found in academic prose. Norris, an interdisciplinarian long before that term became a slogan, has in his work clocked up considerable epistemological mileage across diverse terrain, his critical friendship with deconstruction leading him to important interventions in analytic and Continental philosophy, institutional critique, philosophy of science and mathematics, legal studies, music, politics and, after all, creative criticism.Creative criticism is a relatively embryonic genre, until recently typified generally by a prose that owes a debt to Jacques Derrida’s Cir-confession, Glas and La carte postale. This is a style that foregrounds the philosophical unsaid – the repressed autobiographical, desirous, and otherwise messy constituents of that canon. It does so in part by jettisoning the academic politesse, and let’s say timidity, which help maintain such statutes of limitation. In a more specific way, creative criticism may be understood as a Romantic development set in train by the “Yale School” of deconstruction and its fellow travelers, straining in their own ways against the subordinate role of the reader and critic instituted by the likes of Matthew Arnold and T. S. Eliot.In the foreword to his 2017 volume The Winnowing Fan, Norris at once compliments this “strong” critical rebelliousness (xii), and critiques its ecstatic, quasi-apocalyptic hubris, provisionally aligning his own creative criticism with the “poetic diction” (xxi) of eighteenth-century figures such as Dryden and Pope. It is an analogy with caveats – not least Norris’s stated allergy to the “air of arrogance” (Tempus-Fugitives ix) of [End Page 122] their heavily end-stopped tendentiousness – but one which schematizes a poetics that both carries a definite argument and could not make this argument otherwise than in a manner reliant on verse’s formal properties.Note, however, the fact that Norris takes his distance from both strong criticism and those eighteenth-century essayists on the grounds of their shared self-assurance. A steadier presiding influence is William Empson, whose enmity towards Eliotic New Criticism, which “fixes a prescriptive gulf between poetry and other kinds of discourse,” makes him a political forebear, dissenting from modern forms of literary historical doctrinalism, specifically “that whole anti-rationalist complex of ideas that made the discontinuity between poetic and non-poetic language into a shibboleth of aesthetic, ethical, and (though rarely advertised as such) socio-political principle” (Tempus-Fugitives xix–xx). Norris is no straightforward disciple of Empson – who regarded Derrida, and the other “horrible Frenchmen” Norris used to invite him to read, as “so very disgusting, in a simple moral or social way, that I cannot stomach them” (qtd. in Haffenden 52). And yet, one constant quality of both Norris’s verse and prose criticism is a welcome sobriety of explication when it comes to the more recondite or outright flamboyant enclaves of modern European thought.A Partial Truth, and Norris’s books of verse generally, are explicit in outlining the ways in which his poetry functions as a reaction to the diaristic, mumbling slackness of much contemporary poetry; but does his turn to verse also indicate some reaction to contemporary theory? A Partial Truth’s “Foreword,” with modesty, states that “[i]f these poems have any distinctive merit then it lies in the treatment of interesting ideas in a way that deploys certain formal means to draw out complexities and further implications that would lie beyond the reach of a prose rendition” (14). We will specify some of the relations between form and discursive complexity presently, but for now, it is worth suggesting that Norris’s commitment to verse forms of historically recognizable kinds forecloses from him the mealy-mouthed, argumentatively fugitive character of... (shrink)

In 1833, Henry Alford, a Cambridge don, writes to an ‘earthly friend’ entreating help to cure his intolerance for some of his fellow Cantabrigians. He is, subsequently, visited in dreams by an unearthly friend. One hundred and sixty years later, John Holloway writes Civitatula, a poem celebrating Cambridge University's history. The year before, Holloway had been busy protesting the award of Derrida's Honorary Doctorate there. Reflecting on the turbulence of 1968, Holloway's narrator suggests a Cantabrigian encounter with extra-terrestrials as tonic (...) to this agitation. These oneiric visitations coalesce around a certain saying otherwise, which is also the saying of the other. They thus come into the orbit of Bartleby the Scrivener, he whom Derrida considers ‘the secret of literature’. This post-critical work of conspiracy theory considers, then, the force of this ‘secret’ in both space and time, whilst posing the question of how fantastic might the search for meaning become. (shrink)

This is the first study of the Cambridge Affair. Drawing upon archival and unpublished material, little-known texts pertaining to the Affair, and Derrida’s own oeuvre, this original account offers an historical and philosophical reconstruction of this crucial debate.

ABSTRACT R. P. Wolff has argued that there is an irreconcilable conflict between the distinguishing mark of every state, viz. supreme authority over all its citizens, and the primary obligation of rational beings, viz. to act autonomously by taking moral responsibility for all of their actions. Utilitarian and consent theories which seek to justify the state's claim to possess a monopoly of the rightful use of force are shown to fail and the concept of a ‘legitimate state’to be morally incoherent. (...) However, Wolff's version of individualist anarchism does not follow. Human beings are by no means equally rational or homogeneously autonomous. There are ‘states’which have a contingent and variable right to enforce obedience over an indefinitely large number of their ‘subjects’, although not over those who are autonomous because rational in high degree. (shrink)

Realists about fictional characters posit a certain theoretical role and a candidate to fill this role. I will delineate the role realists take fictional characters like Emma Woodhouse to fill, and I will argue that it is better filled by what I will call ‘characterisations’. In explaining what I mean by ‘characterisations’, I will show that the existence of these entities is comparatively uncontroversial. Realists should acknowledge their existence, but doing so, I will argue, obviates the need to acknowledge the (...) existence of Emma and other fictional individuals. (shrink)

The relationship between cognition and culture is discussed in terms of technology and representation. The computational metaphor is discussed in relation to its providing an account of cognitive and technical development: the role of representation and self-modification through environmental manipulation and the development of open learning from stigmery. A rationalisation for the transformational effects of information and representation is sought in the physical and biological theories of Autokatakinetics and Autopoiesis. The conclusion drawn is that culture, rather than being an intrinsic (...) property of our human phenotype was learned and that cultural cognition is an information transforming system that is inadequately characterised by notions of parameterised deep-structure and that it is an open and potentially unbounded informational system. (shrink)

The relationship between cognition and culture is discussed in terms of technology and representation. The computational metaphor is discussed in relation to its providing an account of cognitive and technical development: the role of representation and self-modification through environmental manipulation and the development of open learning from stigmery. A rationalisation for the transformational effects of information and representation is sought in the physical and biological theories of Autokatakinetics and Autopoiesis. The conclusion drawn is that culture, rather than being an intrinsic (...) property of our human phenotype was learned and that cultural cognition is an information transforming system that is inadequately characterised by notions of parameterised deep-structure and that it is an open and potentially unbounded informational system. (shrink)

'There is nothing outside the text.' Possibly no single statement has caused such a storm in critical theory as this famous observation by the French philosopher, Jacques Derrida. While it is often misunderstood as meaning that nothing is real and that political actions are therefore pointless, Debating Derrida demonstrates that Derrida's philosophy does not lack political conviction. Niall Lucy examines three key terms - text, writing and differance - as they are used in three famous debates: Derrida's disputes over (...) speech-acts with John R. Searle, over discourse with Michel Foucault and over apartheid. Lucy also takes up the issue of Derrida's relationship to postmodernism and questions the 'political imperative' of the need to justify philosophy and the humanities in general according to a notion of their 'usefulness'. Debating Derrida decisively shows that instead of disagreeing with Derrida, we should rather be defending him. (shrink)

Online exam supervision technologies have recently generated significant controversy and concern. Their use is now booming due to growing demand for online courses and for off-campus assessment options amid COVID-19 lockdowns. Online proctoring technologies purport to effectively oversee students sitting online exams by using artificial intelligence systems supplemented by human invigilators. Such technologies have alarmed some students who see them as a “Big Brother-like” threat to liberty and privacy, and as potentially unfair and discriminatory. However, some universities and educators defend (...) their judicious use. Critical ethical appraisal of online proctoring technologies is overdue. This essay provides one of the first sustained moral philosophical analyses of these technologies, focusing on ethical notions of academic integrity, fairness, non-maleficence, transparency, privacy, autonomy, liberty, and trust. Most of these concepts are prominent in the new field of AI ethics, and all are relevant to education. The essay discusses these ethical issues. It also offers suggestions for educational institutions and educators interested in the technologies about the kinds of inquiries they need to make and the governance and review processes they might need to adopt to justify and remain accountable for using online proctoring technologies. The rapid and contentious rise of proctoring software provides a fruitful ethical case study of how AI is infiltrating all areas of life. The social impacts and moral consequences of this digital technology warrant ongoing scrutiny and study. (shrink)

The term functional domain is often used to describe the region containing the cis acting sequences that regulate a gene locus. “Strong” domain models propose that the domain is a spatially isolated entity consisting of a region of extended accessible chromatin bordered by insulators that have evolved to act as functional boundaries. However, the observation that independently regulated loci can overlap partially or completely raises questions about functional requirements for physically isolated domain structures. An alternative model, the “weak” domain model, (...) proposes that domain structure is determined by the distribution of binding sites for positively acting factors, without a requirement for functional boundaries. The domain would effectively be the region that contains these factor-binding sites. Specificity of promoter-enhancer interactions would play a major role in maintaining the functional autonomy of adjacent genes. Sequences that interfere with these interactions (frequently characterised as insulators) would be selected against if they occurred within the domain but not at the edges, or in the interdomain regions. As a result, insulators would often be found near the borders of domains without necessarily being selected to act as boundaries. BioEssays 22:657–665, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Sir Kenelm Digby (1603–1665) was an aristocratic English Catholic philosopher who has been the subject of several recent studies, each of which has sought to demonstrate his intellectual originalit...

In this review we consider the new science of Darwinian medicine. While it has often been said that evolutionary theory is the glue that holds the disparate branches of biological inquiry together and gives them direction and purpose, the links to biomedical inquiry have only recently been articulated in a coherent manner. Our aim in this review is to make clear first of all, how evolutionary theory is relevant to medicine; and secondly, how the biomedical sciences have enriched our understanding (...) of evolutionary processes. We will conclude our review with some observations of the philosophical significance of this interplay between evolutionary theory and the biomedical sciences. (shrink)

International Journal of Philosophical Studies, Volume 20, Issue 1, Page 135-147, February 2012.

Priming of lineage‐specific genes in pluripotent embryonic stem cells facilitates rapid and coordinated activation of transcriptional programmes during differentiation. There is growing evidence that pluripotency factors play key roles in priming tissue‐specific genes and in the earliest stages of lineage commitment. As differentiation progresses, pluripotency factors are replaced at some primed genes by related lineage‐specific factors that bind to the same sequences and maintain epigenetic priming until the gene is activated. Polycomb and trithorax group proteins bind many genes in pluripotent (...) cells generating bivalent domains that contain both active and repressive histone modifications. The properties of polycomb proteins suggest that they act as gatekeepers, helping to maintain silencing in pluripotent stem cells while establishing a chromatin environment that is permissive for priming by sequence‐specific factors. The overall effect of factor‐mediated priming is to initiate the input of information required for cell differentiation before the first lineage choices have been made. (shrink)

For the relatively small number of scholars who have worked on him, the English Catholic philosopher, courtier, and pirate Sir Kenelm Digby (1603–1665) has proven a difficult figure to study compre...

BackgroundStructured, systematic methods to formulate consensus recommendations, such as the Delphi process or nominal group technique, among others, provide the opportunity to harness the knowledge of experts to support clinical decision making in areas of uncertainty. They are widely used in biomedical research, in particular where disease characteristics or resource limitations mean that high-quality evidence generation is difficult. However, poor reporting of methods used to reach a consensus – for example, not clearly explaining the definition of consensus, or not stating (...) how consensus group panellists were selected – can potentially undermine confidence in this type of research and hinder reproducibility. Our objective is therefore to systematically develop a reporting guideline to help the biomedical research and clinical practice community describe the methods or techniques used to reach consensus in a complete, transparent, and consistent manner.MethodsThe ACCORD project will take place in five stages and follow the EQUATOR Network guidance for the development of reporting guidelines. In Stage 1, a multidisciplinary Steering Committee has been established to lead and coordinate the guideline development process. In Stage 2, a systematic literature review will identify evidence on the quality of the reporting of consensus methodology, to obtain potential items for a reporting checklist. In Stage 3, Delphi methodology will be used to reach consensus regarding the checklist items, first among the Steering Committee, and then among a broader Delphi panel comprising participants with a range of expertise, including patient representatives. In Stage 4, the reporting guideline will be finalised in a consensus meeting, along with the production of an Explanation and Elaboration document. In Stage 5, we plan to publish the reporting guideline and E&E document in open-access journals, supported by presentations at appropriate events. Dissemination of the reporting guideline, including a website linked to social media channels, is crucial for the document to be implemented in practice.DiscussionThe ACCORD reporting guideline will provide a set of minimum items that should be reported about methods used to achieve consensus, including approaches ranging from simple unstructured opinion gatherings to highly structured processes. (shrink)