Glycerol is a small and simple molecule produced in the breakdown of glucose, proteins, pyruvate, triacylglycerols and other glycerolipid, as well as release from dietary fats. An increasing number of observations show that glycerol is probably involved in a surprising variety of physiopathologic mechanisms. Glycerol has long been known to play fundamental roles in several vital physiological processes, in prokaryotes and eukaryotes, and is an important intermediate of energy metabolism. Despite some differences in the details of their operation, many of (...) these mechanisms have been preserved throughout evolution, demonstrating their fundamental importance. In particular, glycerol can control osmotic activity and crystal formation and then act as a cryoprotective agent. Furthermore, its properties make it useful in numerous industrial, therapeutic and diagnostic applications. Few studies have focussed directly on glycerol, however, and while its metabolism is increasingly well documented, much of the details remain unknown. Considering the importance of glycerol in multiple vital physiological processes, its study could help unlock important physiopathological mechanisms. BioEssays 23:534–542, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

“X-Firsters” hold that there is some normative feature that is fundamental to all others (and, often, that there’s some normative feature that is the “mark of the normative”: all other normative properties have it, and are normative in virtue of having it). This view is taken as a starting point in the debate about which X is “on first.” Little has been said about whether or why we should be X-Firsters, or what we should think about normativity if we aren’t (...) X-Firsters. Hence the chapter’s two main goals. First, to provide a simple argument that one shouldn’t be an X-Firster about the normative domain, which starts with the observation that analogous views have dubious merits in analogous domains. Second, to offer an alternative view—taking normativity to be a determinable explained in terms of its determinates—that offers an interesting way to think about the structure and unity of normativity. (shrink)

Supporters of open borders sometimes argue that the state has no pro tanto right to restrict immigration, because such a right would also entail a right to exclude existing citizens for whatever reasons justify excluding immigrants. These arguments can be defeated by suggesting that people have a right to stay put. I present a new form of the exclusion argument against closed borders which escapes this “right to stay put” reply. I do this by describing a kind of exclusion that (...) has not been discussed in depth, which I call “territorial exclusion.” Territorial exclusion is the process according to which the group that wishes to exclude current citizens secedes from the territory in which those citizens reside. I argue that the wrongness of territorial exclusion explains why there is no pro tanto right for a state to exclude immigrants, because otherwise there would be a pro tanto right for the state to kick people out by seceding from the territory they inhabit. Because kicking people out like this is typically wrong, borders cannot be closed. (shrink)

The potential to collect brain data more directly, with higher resolution, and in greater amounts has heightened worries about mental and brain privacy. In order to manage the risks to individuals posed by these privacy challenges, some have suggested codifying new privacy rights, including a right to “mental privacy.” In this paper, we consider these arguments and conclude that while neurotechnologies do raise significant privacy concerns, such concerns are—at least for now—no different from those raised by other well-understood data collection (...) technologies, such as gene sequencing tools and online surveillance. To better understand the privacy stakes of brain data, we suggest the use of a conceptual framework from information ethics, Helen Nissenbaum’s “contextual integrity” theory. To illustrate the importance of context, we examine neurotechnologies and the information flows they produce in three familiar contexts—healthcare and medical research, criminal justice, and consumer marketing. We argue that by emphasizing what is distinct about brain privacy issues, rather than what they share with other data privacy concerns, risks weakening broader efforts to enact more robust privacy law and policy. (shrink)

Motion—and, in particular, local motion or change in location—plays a central role in Kenelm Digby’s natural philosophy and in his arguments for the immateriality of the soul. Despite this, Digby’s account of what motion consists in has yet to receive much scholarly attention. In this paper, I advance a novel interpretation of Digby on motion. According to it, Digby holds that for a body to move is for it to divide from and unify with other bodies. This is a view (...) of motion—as change in relations of parthood—that Alison Peterman attributes to Digby’s contemporary and acquaintance, Margaret Cavendish. Having shown that Digby’s presentation of the view predates Cavendish’s by more than a decade, I make a case that Digby’s work influenced Cavendish’s on this topic. In developing and defending my reading, I consider to what extent the Digbean account of motion and the arguments for it accord with the ideals of the mechanical philosophy emerging in the early modern period. (shrink)

I ask you to X. You now have a reason to X. My request gave you a reason. How? One unpopular theory is the epistemic account, according to which requests do not create any new reasons but instead simply reveal information. For instance, my request that you X reveals that I desire that you X, and my desire gives you a reason to X. Peter Schaber has recently attacked both the epistemic account and other theories of the reason-giving force of (...) requests. Schaber defends a new theory of the reason-giving force of requests according to which request give reasons because it is valuable for requesters and requestees that requests have this power. In this paper I argue that Schaber's attack on the epistemic account fails, and that his own theory ought to be rejected because it faces compelling objections. (shrink)

Plato's dialogues frequently criticize traditional Greek myth, yet Plato also integrates myth with his writing. Daniel S. Werner confronts this paradox through an in-depth analysis of the Phaedrus, Plato's most mythical dialogue. Werner argues that the myths of the Phaedrus serve several complex functions: they bring nonphilosophers into the philosophical life; they offer a starting point for philosophical inquiry; they unify the dialogue as a literary and dramatic whole; they draw attention to the limits of language and the limits (...) of knowledge; and they allow Plato to co-opt cultural authority as a way of defining and legitimating the practice of philosophy. Platonic myth, as a species of traditional tale, is thus both distinct from philosophical dialectic and similar to it. Ultimately, the most powerful effect of Platonic myth is the way in which it leads readers to participate in Plato's dialogues and to engage in a process of self-examination. (shrink)

This book is a study of the role of intellect in human action as described by Thomas Aquinas. One of its primary aims is to compare the interpretation of Aristotle by Aquinas with the lines of interpretation offered in contemporary Aristotelian scholarship. The book seeks to clarify the problems involved in the appropriation of Aristotle's theory by a Christian theologian, including such topics as the practical syllogism and the problems of akrasia. Westberg argues that Aquinas was much closer to Aristotle (...) than is often recognized, and he puts forward important new interpretations of the relation of intellect and will in the stages of intention, deliberation, decision, and execution. In the concluding section of the book, he shows how this new interpretation yields fruitful insights on a range of theological topics, including sin, law, love, and the moral virtues. (shrink)

Abstract This paper offers an appraisal of Phillip Pettit's approach to the problem how a merely finite set of examples can serve to represent a determinate rule, given that indefinitely many rules can be extrapolated from any such set. I argue that Pettit's so-called ethnocentric theory of rule-following fails to deliver the solution to this problem he sets out to provide. More constructively, I consider what further provisions are needed in order to advance Pettit's general approach to the problem. I (...) conclude that what is needed is an account that, whilst it affirms the view that agents' responses are constitutively involved in the exemplification of rules, does not allow such responses the pride of place they have in Pettit's theory. (shrink)

Can a liberal state exclude illiberal immigrants in order to preserve its liberal status? Hrishikesh Joshi has argued that liberalism cannot require a commitment to open borders because this would entail that liberalism is committed to its own demise in circumstances in which many illiberal immigrants aim to immigrate into a liberal society. I argue that liberalism is committed to its own demise in certain circumstances, but that this is not as bad as it may appear. Liberalism’s commitment to its (...) own demise is merely a reflection of the fact that it must take into account the rights of outsiders, not just the rights of existing citizens, and of the fact that circumstances of injustice can sometimes leave liberal societies with no correct choice. (shrink)

This paper aims to understand Hegel’s claim in the introduction to his Philosophy of Mind that mind is an actualization of the Idea and argues that this claim provides us with a novel and defensible way of understanding Hegel’s naturalism. I suggest that Hegel’s approach to naturalism should be understood as ‘formal’, and argue that Hegel’s Logic, particularly the section on the ‘Idea’, provides us with a method for this approach. In the first part of the paper, I present an (...) interpretation of Hegel’s method in which life plays a central role. In the second part of the paper, I develop Hegel’s method by providing a reading of Hegel’s Subjective Spirit, focusing on the sections ‘Anthropology’ and ‘Phenomenology’ in particular, arguing that they display the dialectic between life and cognition outlined by Hegel’s Idea. (shrink)

This paper aims to understand Hegel’s claim in the introduction to his Philosophy of Mind that mind is an actualization of the Idea and argues that this claim provides us with a novel and defensible way of understanding Hegel’s naturalism. I suggest that Hegel’s approach to naturalism should be understood as ‘formal’, and argue that Hegel’s Logic, particularly the section on the ‘Idea’, provides us with a method for this approach. In the first part of the paper, I present an (...) interpretation of Hegel’s method in which life plays a central role. In the second part of the paper, I develop Hegel’s method by providing a reading of Hegel’s Subjective Spirit, focusing on the sections ‘Anthropology’ and ‘Phenomenology’ in particular, arguing that they display the dialectic between life and cognition outlined by Hegel’s Idea. (shrink)

This essay considers the critical response to Hegel's view of Socrates we find in Kierkegaard's dissertation, The Concept of Irony. I argue that this dispute turns on the question whether or not the examination of particular thinkers enters into Socrates’ most basic aims and interests. I go on to show how Kierkegaard's account, which relies on an affirmative answer to this question, enables him to provide a cogent defence of Socrates' philosophical practice against Hegel's criticisms.

According to ethical objectivism, what a person should do depends on the facts, as opposed to their perspective on the facts. A long-standing challenge to this view is that it fails to accommodate the role that norms play in guiding a person’s action. Roughly, if the facts that determine what a person should do lie beyond their ken, they cannot inform a person’s deliberations. This paper explores two recent developments of this line of thought. Both focus on the epistemic counterpart (...) to ethical objectivism, according to which what a person should believe depends on the facts, as opposed to their perspective on the facts. The suggestion in each case is that epistemic objectivism faces a distinctive problem in accommodating guidance. Insofar as objectivism concerning the epistemic domain stands or falls with objectivism concerning the ethical domain, this is a problem for objectivism more generally. In this paper, I show that those arguments are not successful. The upshot is that the objectivist – whether ethical or epistemic – need not reject the idea that norms serve a guiding function. (shrink)

Chapter I: The Geometry of Visibles 1 . The N on- Euclidean Geometry of Visibles In the chapter "The Geometry of Visibles" in Inquiry into the Human Mind, ...

Lovejoy (1873-1962) was America's foremost historian of ideas, a major participant in the philosophical debates of the twentieth century, and a prominent advocate of academic freedom. The product of an emotionally unsettled childhood and an evangelical father, Lovejoy reacted against his father by postulating the certainty of self-sufficient reason. He believed that only the principles of reason could order the world and so make our universe intelligible. Originally published in 1980. A UNC Press Enduring Edition -- UNC Press Enduring Editions (...) use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value. (shrink)

The _Physics_ is a foundational work of western philosophy, and the crucial one for understanding Aristotle's views on matter, form, essence, causation, movement, space, and time. This richly annotated, scrupulously accurate, and consistent translation makes it available to a contemporary English reader as no other does—in part because it fits together seamlessly with other closely associated works in the New Hackett Aristotle series, such as the _Metaphysics_, _De Anima_, and forthcoming _De Caelo_ and _On Coming to Be and Passing Away_. (...) Eventually the series will include all of Aristotle's works. Sequentially numbered endnotes provide the information most needed at each juncture, while a detailed Index of Terms indicates places where focused discussion of key notions occurs. An illuminating general Introduction describes the book that lies ahead, explaining what sort of work it is and what sorts of evidence it relies on. (shrink)

The almost 300 articles contain not only historical accounts but also some indication of the state of present day study in classical philosophy.

Despite myriad controversies about reasons, two theses are frequently taken for granted: (i) reasons are sources of normative support for actions, attitudes, etc; and (ii) reasons, at least in simple, paradigmatic cases, consist in atomic facts. Call this conjunction “the atomic view.” Against this, we advocate what we call “the cluster view,” on which even in the simplest cases, the normative support for an action or attitude is typically provided by a whole cluster of facts. Moreover, many of these facts (...) are on an explanatory par—they each play the same kind of role in explaining why there is normative support for the action or attitude in question. We show that presupposition of the atomic view generates unnecessary (psuedo-)puzzles⁠—about topics such as rationality, moral worth, and doxastic justification⁠—that can be largely (dis)solved with the cluster view in place. The cluster view’s ability to do this constitutes an argument in its favor, beyond intuitive considerations that we also adduce. (shrink)

The university has long been oriented toward a meritocratic ideal that emphasizes individual labor and individual measures of success. However, recent studies showing the professorate to be depressed, lonely, and extremely anxious about their future careers raise questions about the merits of such meritocracy. Drawing upon classical sociological theories of solidarity as well as recent scholarship on meritocracy in American culture this essay argues that the meritocratic ideals of contemporary academia have stripped it of the ability to produce the genuine (...) solidarity that sustains communities. (shrink)

Quine’s notion of fact of the matter has received very little attention, although a good grasp of it is crucial to an understanding of some of Quine’s famous formulations of the indeterminacy of translation thesis. The notion is used and cited by many but has to my knowledge never been thoroughly analysed. In the present article, I attempt to analyse and clarify it. In the first section, my exposition focuses on the relations Quine has developed between his notion of fact (...) of the matter and his views on physicalism and ontology. The main conclusion of this section is that Quine’s notion of fact of the matter is ontological. That is to say, for Quine, the notion concerns extralinguistic reality, which is ultimately described by physics. In the second section, I try to show what relations Quine sees between facts of the matter and truth. The main conclusion of this section is that, for Quine, facts of the matter determine truth. This determination is to be understood in the context of Quine’s genetic approach to evidence, which reveals that it is through the mechanism of conditioned response that facts of the matter determine truth. It is hoped that the present analyses will shed new light on Quine’s controversial indeterminacy of translation thesis as well as on the asymmetry that Quine sees between that thesis and underdetermination of theory. (shrink)

In 1992, the Canadian Psychiatric Association launched Canada’s first national campaign against mental illness, Mental Illness Awareness Week. I stress that pharmaceutical sponsorship of the first five years of MIAW was integral to shaping the trajectory of the campaign and marks a shift in the way stigma is conceived and resisted in Canada: what was an interpersonal process based on social norms becomes refigured as “self-stigma,” or an individualized process in which lack of information, education, and self-assessment contribute to an (...) inability to consider oneself as at-risk for a disease, condition, or disorder. (shrink)

RÉSUMÉ: Je propose iei une interprétation de la position quinienne sur l’asymetrie entre l’indétermination de la traduction et la sous-détermination. Je discute les articIes de Chomsky, Rorty et Friedman, qui prétendent montrer que l’asymétrie défendue par Quine est inacceptable. J’examine en outre les points de vue de Føllesdal et Gibson, deux auteurs en accord avec Quine au sujet de l’asymétrie. Je défends l’idée selon laquelle il faut admettre le réalisme de Quine, mais pas son physicalisme, pour être en mesure de (...) reeonnaître l’asymétrie entre le cas des théories scientifiques et celui des manuels de traduction.ABSTRACT: I propose an interpretation of Quine’s position on the asymmetry between indeterminacy of translation and underdetermination of theory. The positions of Chomsky, Rorty, and Friedman, who reject the asymmetry, are presented and criticized. The same is done with Føllesdal’s and Gibson’s views, which are favourable to Quine’s. I argue that we must admit Quine’s realism but not his physicalism in order to accept the asymmetry. (shrink)

Dans la première section du présent article, mon but est d’extraire le contenu de la thèse de l’indétermination de la traduction, à partir d’une revue de plusieurs formulations de Quine. Je tente d’identifier ce qui est constant et ce qui varie dans celles-ci. Je retiens ce qui est constant comme le coeur de la thèse et je considère ce qui varie comme secondaire. J’arrive ainsi à lire une seule thèse à travers les diverses formulations. Je dois admettre, par ailleurs, que (...) les variations sont suffisamment importantes pour semer la confusion. Dans la deuxième section, je retrace les arguments offerts par Quine en guise de justification de l’indétermination de la traduction. Je rappelle l’évolution de cette argumentation et je montre qu’il y a des variations là aussi : au début, Quine fait surtout appel à son physicalisme et, à la fin, il invoque seulement son behaviorisme. Même si je conclus qu’il ne s’agit pas là d’un changement radical, force est d’admettre que le changement est suffisamment important pour déconcerter plus d’un lecteur. Finalement, dans la troisième section, je montre comment mon interprétation de la thèse de l’indétermination de Quine, si elle est correcte, contribue au débat sur l’asymétrie avec la sous-détermination. Les deux premières sections de l’article permettant de distinguer clairement les arguments épistémologiques du contenu ontologique de la thèse de l’indétermination de la traduction, il devient facile d’admettre l’asymétrie défendue par Quine : l’indétermination de la traduction est une thèse ontologique ; elle ne peut donc pas être confondue avec la sous-détermination, une thèse épistémologique.In the first section of this article, my aim is to grasp the content of Quine’s indeterminacy of translation thesis. I propose a review of Quine’s formulations, and I try to identify what is constant and what varies in them. Guided by charity, I keep what is constant as the core of Quine’s thesis, and I consider what varies as secondary. I thus achieve to read a single thesis throughout all the formulations. I must admit, however, that the variations are important enough to be confusing. In the second section, I identify Quine’s arguments for indeterminacy of translation. I retrace the evolution of his argumentation, and I notice that there are variations there too. At first, Quine appeals mainly to physicalism, and, at the end, he appeals only to behaviorism. Although I think that this is not a radical change of mind, I conclude that the change is, once again, important enough to have confused some readers. Finally, in the third section, I show how my interpretation of Quine’s indeterminacy of translation contributes to the debate over the asymmetry between this latter thesis and underdetermination of theory : my analysis of Quine’s treatment of indeterminacy of translation leads me to conclude that, whereas the arguments are epistemological, the content of the thesis is ontological. Once this ontological content is well seen, it is easy to acknowledge, with Quine, the asymmetry with underdetermination, which is an epistemological claim. (shrink)

Quine’s notion of fact of the matter has received very little attention, although a good grasp of it is crucial to an understanding of some of Quine’s famous formulations of the indeterminacy of translation thesis. The notion is used and cited by many but has to my knowledge never been thoroughly analysed. In the present article, I attempt to analyse and clarify it. In the first section, my exposition focuses on the relations Quine has developed between his notion of fact (...) of the matter and his views on physicalism and ontology. The main conclusion of this section is that Quine’s notion of fact of the matter is ontological. That is to say, for Quine, the notion concerns extralinguistic reality, which is ultimately described by physics. In the second section, I try to show what relations Quine sees between facts of the matter and truth. The main conclusion of this section is that, for Quine, facts of the matter determine truth. This determination is to be understood in the context of Quine’s genetic approach to evidence, which reveals that it is through the mechanism of conditioned response that facts of the matter determine truth. It is hoped that the present analyses will shed new light on Quine’s controversial indeterminacy of translation thesis as well as on the asymmetry that Quine sees between that thesis and underdetermination of theory. (shrink)

A la vérité, la pensée de Kant, et c'est là son originalité, propose une sagesse authentique qui se fonde dans le concept de devoir au sens de la loi morale. Contrairement à ce que certains auteurs (V. Brochard, P. Aubenque, M. Foucault) ont pu soutenir, il n'y a pas lieu d'opposer les sagesses de la philosophie grecque et la philosophie pratique de Kant, qui ne serait pas une sagesse, mais une morale du devoir. Le présent ouvrage montre que cette sagesse (...) doit se comprendre comme l'individuation de l'exigence de la vertu, soit comme une tension entre l'impératif moral et l'accomplissement d'une ascétique éthique soucieuse de réaliser l'humanité dans sa destination complète. (shrink)

What does it mean to consider the world of AI through a Christian lens? Rapid developments in AI continue to reshape society, raising new ethical questions and challenging our understanding of the human person. Encountering Artificial Intelligence draws on Pope Francis’ discussion of a culture of encounter and broader themes in Catholic social thought in order to examine how current AI applications affect human relationships in various social spheres and offers concrete recommendations for better implementation. The document also explores questions (...) regarding personhood, consciousness, and the kinds of relationships humans might have with even the most advanced AI. Through these discussions, this book investigates the theoretical and practical challenges to interpersonal encounter raised by the age of AI. (AI Research Group for the Centre for Digital Culture of the Dicastery of Culture and Education of the Holy See). (shrink)

On interprète généralement la philosophie morale de Kant à partir d'un certain nombre de thèses devenues classiques et qui demeurent souvent ininterrogées. Il est ainsi entendu que la morale chez Kant ne se fonde pas sur la religion et qu'elle ne présuppose pas l'existence de Dieu, que la liberté constitue la clé de voûte du système et que l'autonomie du sujet moral en est le coeur. Mais ces thèses, qui sont exactes, ne peuvent être pleinement comprises qu'en rapport avec la (...) question de Dieu. La liberté de l'homme et l'absolu même de la loi morale renvoient au mystère insondable de l'existence de Dieu et de la présence du divin en l'homme. Dieu, et non sa seule idée, est même reconnu dans les derniers écrits comme le principe suprême de la philosophie. Il est alors possible d'interpréter la pensée kantienne tout entière comme un chemin vers Dieu et même, à un certain point de vue, comme une phénoménologie du divin. (shrink)

L'existence de l'homme n'est pas précédée par une essence qui la déterminerait. Mais elle n'est pas davantage une création de soi-même qui s'expérimenterait hors de toute référence à une exigence morale et à l'idée d'une destination de l'être humain. L'existence n'est proprement humaine que quand elle surgit et se développe librement, c'est-à-dire quand elle se fonde dans l'articulation du pouvoir de l'esprit et de la loi morale. L'entreprise critique se caractérise par son exploration et sa fondation de l'humain et par (...) son exigence de légitimation d'une telle fondation. A cette fin, elle présuppose un contrat d'humanité qui doit être reconnu comme le principe de la pensée kantienne. Il s'agit donc de s'interroger sur la légitimité d'un tel contrat, si l'on veut mettre à l'épreuve la fondation de la philosophie critique. (shrink)

La philosophie critique de Kant serait marquée, selon Michel Foucault, par son enfermement dans le transcendantal, pensé comme immuable. Il faudrait prendre conscience de l'historicité de l'esprit, pour tenter cette épreuve de liberté qu'est la création de soi. Or, le présent ouvrage montre que c'est précisément dans la philosophie transcendantale, interprétée ici dans un tout autre sens que celui proposé par Michel Foucault, que se manifeste, chez Kant, le pouvoir d'une liberté proprement humaine, soit la vie transcendantale d'un esprit capable, (...) à chaque instant, de se transformer dans la conscience de son devoir. (shrink)

C'est en mettant en oeuvre l'Idée de la philosophie comme métaphysique scientifique que Kant met au jour l'"être" de l'homme, c'est-à-dire l'a priori transcendantal qui fonde l'existence proprement humaine. Il y aurait donc cooriginarité de l'existence de l'homme et de l'essence de la "philosophie". De ce point de vue, l'existence, à proprement parler, est"philosophique". Ainsi, 1'"éthique" existentielle peut être pensée comme l'Idée même de la "vérité", "vérité" de l'homme, "être" - "devoir-être" qui fonde la représentation de toute "vérité" théorique, esthétique (...) et pratique. Mais comment penser l'origine même de cette Idée d'une "vérité" de l'existence humaine, c'est-à-dire d'un "propre" de l'homme? Donc l'origine de l'Idée même de "philosophie"? Ce qui est le plus originaire, ne serait-ce pas la résolution d'exister (et de concevoir l'existence) d'une manière spécifique, que nous qualifions de "philosophique"? Mais si l'Idée de l'existence humaine se conçoit en termes de décisionnisme "philosophique", quel est le "sens" de ce décisionnisme? Autrement dit, puisque la question "qu'est-ce que l'homme" est, comme le soutient Kant, la question de la "philosophie", qu'est-ce donc que la "philosophie"? (shrink)

La philosophie critique de Kant, en posant la question de la possibilité, mise en oeuvre architectoniquement, du pouvoir de penser, s'institue comme "ontologie" existentielle. L'architectonique des pouvoirs de l'esprit, en sa destination "morale", constitue, en effet, l'"Etre" même de l'homme, soit la fondation (transcendantale) de toute manière d'exister proprement "humaine", les troubles existentiels se révélant être, par hypothèse, autant de déconstitutions de cette architectonique. Le problème du surgissement de l'Idée architectonique et de sa mise en oeuvre temporelle peut donc être (...) interprété comme problème d'une anthropologie transcendantale. Il s'agit de penser par là le "temps" même de l'existence. Si le "temps" n'est rien en dehors de l'esprit, son surgissement ne peut être que celui d'une "liberté". Ainsi, le problème de l'architectonique permet de concevoir le "temps" comme création continuée, oeuvre de la "liberté". Le problème du "temps" ne se limite donc pas chez Kant à l'"exposition" d'une Esthétique transcendantale ni, comme le montre l'architectonique des temporalités, au seul "schématisme" de l'entendement pur. Mais si le "temps" surgit comme "liberté", son essence est nécessairement "pratique". L'existence de l'homme, saisie à ce niveau d'une cooriginarité transcendantale de la "liberté" et du "temps", peut alors être comprise en sa dimension "morale" : l'homme s'assignerait de lui-même la tâche transcendantale de produire le "temps", ce "devoir" étant reconnu ici au fondement de l'effectivité de tout pouvoir de l'esprit. (shrink)

La philosophie kantienne du droit, qui se fonde dans l'Idée morale des droits de l'homme, a pour condition la politique (le droit public) et s'inscrit dans la perspective de l'Idée de république. La république, en son opposition au despotisme, est la manière de gouverner conformément à l'idéal de la paix perpétuelle, qui requiert, à l'intérieur des Etats et entre eux, l'exigence morale du droit public, c'est-à-dire de l'institution d'un peuple comme volonté souveraine éclairée. Mais le droit des hommes n'est sacré (...) que pour autant qu'il se fonde dans la loi morale, elle-même pensée comme sainte. l'administration de ce droit, qui n'est autre que la politique, se fonde donc dans l'Idée de Dieu. Ce livre montre comment la pensée juridico-politique procède d'une application de l'Idée pratique de liberté, comment cette pensée se constitue architectoniquement, et quels sont le sens et la valeur de la théologie morale (ou rationnelle) dans la constitution de la pensée et de l'action politiques. (shrink)

La philosophie pense la vérité non comme un universel déterminé, mais dans une tension vers un universel toujours à trouver : ainsi se définit la "réflexion" au sens kantien, l'universel vers lequel tend la philosophie et qui oriente sa recherche incessante étant l'Idée d'humanité. La vérité est l'oeuvre d'une "décision", non arbitraire, de la pensée : elle est, en effet, à la fois produite "librement" et reconnue comme nécessaire. Ce livre propose une analyse du décisionnisme philosophique tel que le conçoit (...) Kant. (shrink)

TRAGICALLY, ETHNIC CONFLICTS HAVE BECOME ONE OF THE HALLMARKS of the post-Cold War era. In response to this, two distinct traditions appear to be emerging.The first continues the classical just war tradition while the second represents a new "reconciliation tradition," built largely around questions of restorative justice in areas of social division. Our goal in this essay is to begin a rapprochement of these divergent traditions by asking the question, what does a restorative justice perspective offer to the just war (...) tradition? We proceed in three stages: first, we survey the current state of the just war tradition; second, we introduce the reconciliation tradition, drawing on both reconciliation thinkers and the practical experience of experiments in social reconciliation in South Africa and Rwanda; and third, we draw these two traditions together with a series of constructive proposals for how the reconciliation tradition can enrich the just war tradition. (shrink)

This dissertation intends to contribute to the discussion about the asymmetry W. V. Quine sees between indeterminacy of translation and underdetermination of theory. Quine often formulates the asymmetry by saying that there is a fact of the matter to physics but none to translation. The first chapters of the dissertation constitute an attempt of clarification of that notion of fact of the matter. They contain an analysis of the relations between Quine's notion of fact of the matter, his physicalism, and (...) his conception of truth. The main conclusion of those chapters is that the notion of fact of the matter is physicalistic, which means that it is what, according to Quine, embodied the nature of extralinguistic reality that determines truth. The next chapters contain an analysis of Quine's indeterminacy of translation thesis and underdetermination of theory. The main conclusions of those chapters are the following: indeterminacy of translation is an ontological thesis, and its content has not changed through Quine's writings, although the formulations of the thesis have varied; Quine's definitive arguments for indeterminacy of translation are not to be found in his physicalism, but in his behaviorism; underdetermination of theory is a methodological doctrine, for it concerns the evidential link between observation and theory; there is an asymmetry between indeterminacy of translation and underdetermination of theory. The remaining chapters of the dissertation constitute a review of the main texts by other authors addressing Quine's claim that there is an asymmetry between indeterminacy of translation and underdetermination of theory. The positions of Noam Chomsky, Richard Rorty, and Micheal Friedman are analyzed and criticized. The positions of Dagfinn Follesdal and Roger Gibson have appeared to our lights as the ones that should be taken most seriously. Follesdal is the one who seems to have accomplished the last progresses in the discussion over the asymmetry between underdetermination of theory and indeterminacy of translation by distinguishing clearly Quine's epistemological arguments for indeterminacy of translation thesis from the ontological content of that thesis. (shrink)

In-course marks and final grades each have their own nature and purpose and conflating the two does a disservice to both. Final grades represent a fixed and final statement about how a student did in the course in the end. They are a communication between the professor and anyone who will pick up that student’s transcript someday. In-course marks, by contrast, are a communication between the professor and student alone, and ought to be representative of an ongoing conversation about how (...) the student is currently doing in the course. They are subject to change with each lecture, assessment, and conversation, and should embody that dynamism and potential for progress. Building upon the pedagogical concepts of differentiated learning, growth mindset, and backward course design, this paper will examine the advantages of differentiating between the two types of grades and present three grading models that incorporate the distinction. (shrink)

There has recently been a focus on the question of statue removalism. This concerns what to do with public history statues that honour or otherwise celebrate ethically bad historical figures. The specific wrongs of these statues have been understood in terms of derogatory speech, inapt honours, or supporting bad ideologies. In this paper I understand these bad public history statues as history, and identify a distinctive class of public history-specific wrongs. Specifically, public history plays an important identity-shaping role, and bad (...) public history can commit specifically ontic injustice. Understanding bad public history in terms of ontic injustice helps understand not just to address bad public history statues, but also understand the value of public history more broadly. (shrink)

A new high‐resolution structure of a pain‐sensing ion channel, TRPA1, provides a molecular scaffold to understand channel function. Unexpected structural features include a TRP‐domain helix similar to TRPV1, a novel ligand‐binding site, and an unusual C‐terminal coiled coil stabilized by inositol hexakisphosphate (IP6). TRP‐domain helices, which structurally act as a nexus for communication between the channel gates and its other domains, may thus be a feature conserved across the entire TRP family and, possibly, other allosterically‐gated channels. Similarly, the TRPA1 antagonist‐binding (...) site could also represent a druggable location in other ion channels. Combined with known TRPA1 functional properties, the structural role for IP6 leads us to propose that polyphosphate unbinding could act as a molecular kill switch for TRPA1 inactivation. Finally, although packing of the TRPA1 membrane‐proximal region hints at a mechanism for electrophile sensing, the details of how TRPA1 responds to noxious reactive electrophiles and temperature await future studies.Also watch the Video Abstract. (shrink)