This article explores the overlap between systems biology and predictive neuroscience, placing them in their larger context, the contemporary trend of bioinformatic convergence across the sciences. These two domains overlap with respect to their interest in data accumulation and data integration; their reliance on computational statistical correlation; and their translational goals, that is, producing practical fruits and applications from the interscientific cross-pollination that contemporary data-integrative approaches make possible. The interventions that such translational conversations generate are medical and social in nature, (...) and are aimed at both prevention and treatment. It will be argued that such approaches, socially and medically applied, contain potential for conveying both agency-enhancing and agency-diminishing social messages. The article concludes with a call to balance the overwhelmingly quantitative focus characteristic of predictive neuroscience with more qualitative empirical methodologies. This would represent a double helical approach. (shrink)

ABSTRACT Rosalind Franklin is best known for her informative X-ray diffraction patterns of DNA that provided vital clues for James Watson and Francis Crick's double-stranded helical model. Her scientific career did not end when she left the DNA work at King's College, however. In 1953 Franklin moved to J. D. Bernal's crystallography laboratory at Birkbeck College, where she shifted her focus to the three-dimensional structure of viruses, obtaining diffraction patterns of Tobacco mosaic virus (TMV) of unprecedented detail and clarity. (...) During the next five years, while making significant headway on the structural determination of TMV, Franklin maintained an active correspondence with both Watson and Crick, who were also studying aspects of virus structure. Developments in TMV research during the 1950s illustrate the connections in the emerging field of molecular biology between structural studies of nucleic acids and of proteins and viruses. They also reveal how the protagonists of the “race for the double helix” continued to interact personally and professionally during the years when Watson and Crick's model for the double-helical structure of DNA was debated and confirmed. (shrink)

ABSTRACT Rosalind Franklin is best known for her informative X-ray diffraction patterns of DNA that provided vital clues for James Watson and Francis Crick's double-stranded helical model. Her scientific career did not end when she left the DNA work at King's College, however. In 1953 Franklin moved to J. D. Bernal's crystallography laboratory at Birkbeck College, where she shifted her focus to the three-dimensional structure of viruses, obtaining diffraction patterns of Tobacco mosaic virus (TMV) of unprecedented detail and clarity. (...) During the next five years, while making significant headway on the structural determination of TMV, Franklin maintained an active correspondence with both Watson and Crick, who were also studying aspects of virus structure. Developments in TMV research during the 1950s illustrate the connections in the emerging field of molecular biology between structural studies of nucleic acids and of proteins and viruses. They also reveal how the protagonists of the “race for the double helix” continued to interact personally and professionally during the years when Watson and Crick's model for the double-helical structure of DNA was debated and confirmed. (shrink)

We consider iterations of general elementary embeddings and, using this notion, point out helices of consistency-wise implications between large large cardinals.Up to now, large cardinal properties have been considered as properties which cannot be accessed by any weaker properties and it has been known that, with respect to this relation, they form a proper hierarchy. The helices we point out significantly change this situation: the same sequence of large cardinal properties occurs repeatedly, changing only the parameters.As results of our investigation (...) of this helical structure, we have new characterizations of extendible cardinals and of Vopěnkan cardinals in terms of elementary embeddings from the universe V, a new large large cardinal property which looks like Shelahness properly between Vopěnkaness and almost hugeness, and a more direct relation between Vopěnkaness and Woodinness than already known.We also consider limits of the helices and relations with the axioms I1–I3. (shrink)

The development of X-ray diffraction photography was central to the discovery of the helical structure of DNA in 1953. Unfortunately the story of how this technique was developed receded into the background as subsequent attention focused on the moment of discovery by Watson and Crick. As a result the importance of photography as ‘data’ and the role it plays in scientific discovery is underplayed. We seek to rectify this situation by presenting this story and by drawing conclusions about the importance (...) of this form of photography in scientific investigation as well as for the insights it gives us regarding the process of discovery. (shrink)

The traditional disputants in the free will discussion--the libertarian, soft determinist, and hard determinist--agree that free will is a coherent concept, while disagreeing on how the concept might be satisfied and whether it can, in fact, be satisfied. In this innovative analysis, Richard Double offers a bold new argument, rejecting all of the traditional theories and proposing that the concept of free will cannot be satisfied, no matter what the nature of reality. Arguing that there is unavoidable conflict within (...) our understanding of moral responsibility and free choice, Double seeks to prove that when we ascribe responsibility, blame, or freedom, we merely express attitudes, rather than state anything capable of truth or falsity. Free will, he concludes, is essentially an incoherent notion. (shrink)

The following is a criticism designed to apply to most libertarian free will theorists. I argue that most libertarians hold three beliefs that jointly show them to be unsympathetic or hard-hearted to persons whom they hold morally responsible: that persons are morally responsible only because they make libertarian choices, that we should hold persons responsible, and that we lack epistemic justification for thinking persons make such choices. Softhearted persons who held these three beliefs would espouse hard determinism, which exonerates all (...) persons of moral responsibility, or, at least, would not espouse libertarianism. I do not address the view held by some libertarians that we do have epistemic justification for thinking that persons make libertarian choices, a minority position that I believe cannot be sustained. (shrink)

Philosophers’ intuitions about what constitutes autonomy are largely driven by the exemplars or paradigms that we recognize. There are indefinitely many exemplars, inasmuch as there are relatively private personae that serve as autonomy exemplars such as our parents, third grade teacher, or, for the megalomaniac, oneself. But among Western philosophers there are doubtless some exemplars that are widely shared and broadly influential. Philosophical exemplars include Socrates, Aristotle’s magnanimous man, Kant’s noumenal self that is perfectly attuned to the moral law, Mill’s (...) anti-authoritarian non-conformist, Marx’s manin-society, Nietzsche’s Zarathustra, and Sartre’s authentic youth who must decide whether to join the French resistance or stay at home for the sake of his mother. Exemplars from outside of philosophy include Antigone, Christ, Faust, Ibsen’s Enemy of the People, Winston Churchill, and even figures from popular culture such as the baseball player Ted Williams, the free spirited flower children of the 1960s, and practically any character that John Wayne ever played. (shrink)

The objection to R-S accounts that was raised by the possibility of external agents requires the acceptance of two premises, viz., that all R-S accounts allow for puppeteers and that puppeteers necessarily make us unfree. The Metaphilosophical reply shows that to the extent that puppeteers are more problematic than determinism per se, pup-peteers may be explicitly excluded since they violate our paradigm of free will. The Metaphilosophical reply also suggests that we should not expect our mature R-S account to supply (...) logically necessary and sufficient conditions for free will, but rather give us answers that agree with our intuitions regarding paradigms of free and unfree decisions. The Irrelevancy reply completed our reply to incompatibilists who continue to object that determinism per se destroys the R-S program. It may be debated whether my autonomy variable account is a satisfactory way to spell out the Irrelevancy reply, but I think that this type of approach suggests the way to vindicating the R-S view from an important type of objection. (shrink)

In “The Moral Hardness of Libertarianism”, I accuse libertarians of being morally unsympathetic if they hold three widely shared beliefs: that persons are morally responsible only if they make libertarian choices; that we should hold persons morally responsible; and that we lack epistemic justification for thinking persons make libertarian choices. In “Hard-Heartedness and Libertarianism”, John Lemos, relying on the Kantian principle of ends, suggests a way for libertarians to accept these three beliefs while avoiding the charge of hard-heartedness. In this (...) paper, I criticize Lemos’s rebuttal. (shrink)

Psychiatry is increasingly dominated by the reductionist claim that mental illness is caused by neurobiological abnormalities such as chemical imbalances in the brain. Critical psychiatry does not believe that this is the whole story and proposes a more ethical foundation for practice. This book describes an original framework for renewing mental health services in alliance with people with mental health problems. It is an advance over the polarization created by the "anti-psychiatry" of the past.

Why is debate over the free will problem so intractable? In this broad and stimulating look at the philosophical enterprise, Richard Double uses the free will controversy to build on the subjectivist conclusion he developed in The Non-Reality of Free Will (OUP 1991). Double argues that various views about free will--e.g., compatibilism, incompatibilism, and even subjectivism--are compelling if, and only if, we adopt supporting metaphilosophical views. Because metaphilosophical considerations are not provable, we cannot show any free will theory (...) to be most reasonable. Metaphilosophy and Free Will deconstructs the free will problem and, by example, challenges philosophers in other areas to show how their philosophical argumentation can succeed. (shrink)

The belief that only free will supports assignments of moral responsibility -- deserved praise and blame, punishment and reward, and the expression of reactive attitudes and moral censure -- has fueled most of the historical concern over the existence of free will. Free will's connection to moral responsibility also drives contemporary thinkers as diverse in their substantive positions as Peter Strawson, Thomas Nagel, Peter van Inwagen, Galen Strawson, and Robert Kane. A simple, but powerful, reason for thinking that philosophers are (...) correct in making moral responsibility the prize of the free will problem is this: If we disassociate free will from deserved praise, blame, punishment and reward, reactive attitudes and moral censure, then why care about free will? If free will is not pinned down as that degree of freedom in our choices that we need for moral responsibility, it is difficult to see why anyone would or should care about free will. In this article I argue that some of the most prominent recent writing on free will becomes sidetracked from this key issue. For this reason, a good deal of the literature is so much spilled ink as philosophers misdirect their energies. In section 1 I elaborate just what I believe the key issue in the free will problem is. In section 2 I illustrate what an answer to the key issue requires. In section 3 I suggest motivations for misdirection. In sections 4, 5, and 6 I provide detailed examples of misdirection from compatibilists and libertarians. In sections 7 and 8 I describe some non-misdirected answers to the key question. (shrink)

In "The Illusion of Conscious Will," Daniel Wegner (2002) argues that our commonsense belief that our conscious choices cause our voluntary actions is mistaken. Wegner cites experimental results that suggest that brain processes initiate our actions before we become consciously aware of our choices, showing that we are systematically wrong in thinking that we consciously cause our actions. Wegner's view leads him to conclude, among other things, that moral responsibility does not exist. In this article I propose some ways that (...) traditional philosophical defenders of moral responsibility, both compatibilists and libertarians, might accept Wegner's empirical premise regarding the will but amend their theories so that they may reject his conclusion regarding moral responsibility. (shrink)

John searle has recently claimed to have dissolved what daniel dennett calls 'hume's problem'--The question whether the explanation of behavior by appeal to mental representations can be done without circularity or infinite regress. Searle argues that a careful analysis of the concept of an intentional state shows that mental representations do not require intentional "homunculi" to explain how intentional states have their contents, And, Hence dennett's worry is groundless. I argue that searle's conceptual analysis of intentional states, Even if correct, (...) Provides no clue of an answer to the worry underlying hume's problem. (shrink)

Adopting meta‐level Free Will Subjectivism is one among several ways to maintain that persons never experience moral freedom in their choices. The other ways of arguing against moral freedom I consider are presented by Saul Smilansky, Ted Honderich, Bruce Waller, Galen Strawson, and Derk Pereboom. In this paper, without arguing for the acceptance of free will subjectivism, I argue that subjectivism has some moral and theoretical advantages over its kindred theories.

Confidence ratings have often been integrated into reasoning and intelligence tasks as a means for assessing meta-reasoning processes. Although it is often assumed that eliciting these judgements throughout reasoning tasks has no effect on the underlying performance outcomes, this is yet to be established empirically. The current study examines whether eliciting CR from participants during a fluid-reasoning task influences their performance and how this effect is moderated by their initial self-confidence in their own reasoning abilities. In a first experiment, we (...) found that participants performing CR during Raven's Progressive Matrices significantly outperformed a control group who did not provide ratings. Additionally, a second experiment demonstrated that CR only facilitated performance in participants who have a high level of initial self-confidence in their reasoning ability, whereas they were detrimental to participants low in self-confidence. (shrink)

Beginning Philosophy offers students and general readers a uniquely straightforward yet challenging introduction to fundamental philosophical problems. Readily accessible to novices yet rich enough for more experienced readers, it combines serious investigation across a wide range of subjects in analytic philosophy with a clear, user-friendly writing style. Topics include logic and reasoning, the theory of knowledge, the nature of the external world, the mind/body problem, normative ethics, metaethics, free will, the existence of God, and the problem of evil. A concluding (...) chapter outlines the worldview developed in the text and connects that view to questions about the meaning of life. The interconnection of philosophical problems and the relationship of philosophy and science are emphasized throughout. The book includes both extensive quotes from historical figures such as Aquinas, Descartes, and Hume and references to philosophically minded nonphilosophers like Dostoevski, Stephen Jay Gould, and Carl Sagan. Beginning Philosophy is designed for use in introductory philosophy courses at a wide range of institutions. It contains numerous pedagogical materials at the end of each chapter: sections called "misconceptions" list errors that introductory readers should avoid; guide questions prompt students to explain in their own words what the text is saying; review questions help students prepare for examinations; open-ended discussion questions call for independent judgment; and annotated bibliographies provide suggestions for further reading. The volume is further enhanced by a list of famous quotations from philosophers, a glossary of philosophical terms, a glossary of names of the most famous philosophers and scientists discussed in the text, and an extensive bibliography listing every work cited. (shrink)

A distinction between the use of computational models in cognitive science and a philosophically inspired reductivist thesis is developed. PF is found questionable for phenomenal states, and, by analogy, dubious for the nonphenomenal introspectible mental states of common sense. PF is also shown to be threatened for the sub-cognitive theoretical states of cognitive science by the work of the so-called New Connectionists. CMM is shown to be less vulnerable to these criticisms.