On the representation of the Nakba in regional literature and film.

As Medicine shifts from a paternalistic practice to a patient-centered approach, the concept of medical informed consent (IC) has evolved to safeguard patient autonomy. However, its current implementation still presents many challenges in clinical practice. We assessed the knowledge and attitudes of the general Lebanese population regarding the IC process as well as their sociodemographic and medical correlates. An anonymous online survey was distributed to the Lebanese population using social media channels. A sample of 500 adults with an average age (...) of 36.2 ± 13.5 years, including 319 females and 181 males, was recruited. Most of the respondents had a university degree (85.8%), reported previous hospital admissions (75.9%) and had signed an IC for surgical procedures (40.7%). Few participants were knowledgeable about IC Lebanese law. Variability in knowledge level was significantly related to gender and a previous hospitalization history. Positive attitudes toward patient autonomy (53.1%) and shared decision-making (57.5%) correlated with older age, female gender, graduate education, and a previous history of signing an IC document. Males were more likely to believe that IC has positive effects on health than females. This is the first study that provides novel findings regarding Lebanese peoples’ awareness of the ethico-legal components of medical IC. (shrink)

This engaging book explores Senator Bernie Sanders’s 2020 presidential campaign, a radical movement that represented a diverse voter base. As such, it had to navigate the complexities of class, identity, and their interrelation. The thesis author Marc Léger seeks to defend is that the campaign ultimately failed in this endeavor. Rather than reassert the centrality of class in socialist politics, he argues, the campaign indulged a dubious politics of division.

Author Marc James Léger responds to Elias Khoury’s review of his book _Bernie Bros Gone Woke: Class, Identity, Neoliberalism_, which was published in volume 17 of the _International Journal of __Žižek Studies_. While Léger accepts the one mistake in the book that Khoury correctly identifies, he takes issue with nearly everything else in Khoury’s review, which involves fallacies, misquotations, reductive arguments, misdirection and failure to mention anything that would contradict Khoury’s generally false claims. Léger describes (...) the possibility of academic foul play in the context of a public secret directed against him and that he has been struggling against since the late 1990s. (shrink)

Supervenience is one of the 'hot discoveries' of analytic philosophy, and this collection of essays on the topic represents an examination of it and its application to major areas of philosophy. The interest in supervenience has much to do with the flexibility of the concept. To say that x supervenes on y indicates a degree of dependence without committing one to the view that x can be reduced to y. Thus supervenience is a relationship that has the potential of replacing (...) the traditional notion of dependence, while performing at least part of the function reductive relationships were supposed to fulfil. Moreover, since it is a topic-neutral concept, supervenience has a wide range of applicability. (shrink)

Ever since the early days of quantum mechanics it has been suggested that consciousness could be linked to the collapse of the wave function. However, no detailed account of such an interplay is usually provided. In this paper we present an objective collapse model where the collapse operator depends on integrated information, which has been argued to measure consciousness. By doing so, we construct an empirically adequate scheme in which superpositions of conscious states are dynamically suppressed. Unlike other proposals in (...) which “consciousness causes the collapse of the wave function,” our model is fully consistent with a materialistic view of the world and does not require the postulation of entities suspicious of laying outside of the quantum realm. (shrink)

Knowledge is inextricably bound to power in the context of settler colonialism where apprehension of the Other is a tool of domination. Tracing the development of the “settler colonial” paradigm, this article deconstructs Zionist and Israeli dispossession of Palestinian land and sovereignty, applying the sociology of knowledge production to the study of the Israeli-Palestinian case. The settler colonial paradigm, linked to Israeli critical sociology, post-Zionism, and postcolonialism, reemerged following changes in the political landscape from the mid-1990s that reframed the history (...) of the Nakba as enduring, challenged the Jewish definition of the state, and legitimated Palestinians as agents of history. Palestinian scholars in Israel lead the paradigm’s reformulation. This article offers a phenomenology of Palestinian positionality, a critical potential for decolonizing the settler colonial structure and exclusive Jewish sovereignty, to consolidate a field of study that shapes not only research into the Israeli-Palestinian case but approaches to decolonization and liberation. (shrink)

Topics covered in Discrete Mathematics have become essential tools in many areas of studies in recent years. This is primarily due to the revolution in technology, communications, and cyber security. The book treats major themes in a typical introductory modern Discrete Mathematics course: Propositional and predicate logic, proof techniques, set theory (including Boolean algebra, functions and relations), introduction to number theory, combinatorics and graph theory. An accessible, precise, and comprehensive approach is adopted in the treatment of each topic. The ability (...) of abstract thinking and the art of writing valid arguments are emphasized through detailed proof of (almost) every result. Developing the ability to think abstractly and roguishly is key in any areas of science, information technology and engineering. Every result presented in the book is followed by examples and applications to consolidate its comprehension. The hope is that the reader ends up developing both the abstract reasoning as well as acquiring practical skills. All efforts are made to write the book at a level accessible to first-year students and to present each topic in a way that facilitates self-directed learning. Each chapter starts with basic concepts of the subject at hand and progresses gradually to cover more ground on the subject. Chapters are divided into sections and subsections to facilitate readings. Each section ends with its own carefully chosen set of practice exercises to reenforce comprehension and to challenge and stimulate readers. As an introduction to Discrete Mathematics, the book is written with the smallest set of prerequisites possible. Familiarity with basic mathematical concepts (usually acquired in high school) is sufficient for most chapters. However, some mathematical maturity comes in handy to grasp some harder concepts presented in the book. (shrink)

Originally published in 1985, this is a short meditation by a great old man on people relating to other people who are dying, and the need for all of us to open ...

At Aur. Vict. Caes. 10.5, the reading lautus should be retained; -que is a dittography and should be deleted. At 13.3, satis should be emended into sagatis. This article also provides a brief analysis of Victor's references to clothing and attempts to explain why he comments on the Dacian costume at 13.3, the only ethnographic reference to clothing in the entire work.

This article articulates a sociological conception of settler colonial remembering as a tool of legitimation. Theories of memory in the context of settler colonialism generally center counter-memories by the subaltern or colonized, or official hegemonizing representations at the level of state institutions. Underexamined is the dialectical nature of memory and discursive representations that help reproduce settler colonial processes of accumulation and displacement at the micro-level. The article draws on archival data from avowedly socialist-leftist Zionist colonies to explicate patterned representations of (...) Palestinian villages that Zionist forces gradually displaced prior to and during the 1948 War/Nakba. I demonstrate how the colonial settlers attributed political meaning through five representational modes: contrasting the indigenous as backward and primitive and settlers as progressive and developed; denying an indigenous connection to the land; emphasizing amiable relations through the promotion of cultural progress and settler superiority; asymmetrically assessing settler and indigenous belongings to national collectives; and legitimizing land purchases that dispossessed indigenous cultivators, despite the settlers’ socialist ideology, while reducing conflict to the issue of economic compensation. I theorize a form of settler colonial memory based not merely on erasure, but on recognition and disavowal. Finally, I argue that local memory is a significant site of production in which the conceptual tools to both trace the historical processes of supremacy and subvert asymmetrical sociality lie. (shrink)

This article extends critical trends of citizenship studies and the theory of accumulation by dispossession to articulate how settler colonial citizenship is instantiated through the active accrual of land and resources and how the emerging settler colonial citizenship entrenches both structural subjugation and resistance. The article then examines the reformation of the boundaries of citizenship through indigenous agency. I do so through examining the Palestinian citizens in Israel, specifically centering the Internally Displaced Persons—Palestinians who received Israeli citizenship even as they (...) were displaced from their places of origin. I conclude by asserting citizenship’s double paradox in settler colonial contexts: It regulates certain rights and mobilities but simultaneously entraps the indigenous in a structure in which recursive accumulation is constitutive, thus entrenching dispossession and the further loss of collective rights and other claims. (shrink)

Is genre film comparable to a thought experiment?Revising concepts of determinism and agency in three film noirs The philosophical approach of film genres, first popularized by authors like Stanley Cavell, allows to consider genre films as narrative variations as pertinent to philosophical discourse as can be a traditional thought experiment, since every question on the essence of a genre and every discussion related to its inner functions, its mechanisms and its themes, generate naturally a philosophical discourse on the way a (...) director uses filmic and narrative tools to transform his intentions into a specific system of meaning. This study adopts formalist and philosophical approaches to connect the narratives of the movies to the discourses it is prone to generate. The corpus draws on the ‘primitive scene' in three films noirs, Out of the Past, The Lady from Shanghai et Criss Cross : the tragic meeting of an anti-hero with the woman who will be responsible of his fall. Indeed, the sequence showing this first meeting becomes an exercise in style where forerunning signs of the two protagonists' fall organize the writing and the mise-en-scene, and explicitly shows how questions of agency and determinism are intimately articulated to the narrative and formal frame of the movies. (shrink)

This essay deals with Nina Bouraoui’s mixed-race identity as presented in her autobiographical novels Garçon manqué and Mes mauvaises pensées. The métis question takes the shape of a representation of an ethnicized, dual and fractured identity. My argument explores a contradiction at work in Bouraoui’s texts: while reclaiming the existence of a Franco-Algerian métis identity, Bouraoui represents the métis as the incarnated perpetuation of the historical tensions that divided France and Algeria. The narratives simultaneously construct and deconstruct Bouraoui’s Franco-Algerian métis (...) identity. I examine how Bouraoui represents her Algerian legacy and appropriates a familial history to construct herself as Algerian. I analyze how traumatic memories of asphyxiation are a metaphor for Bouraoui’s difficult relationship with her French self, symbolized by the motif of white skin. And I consider how the ends of the two novels provide a problematic acceptance and fulfillment of Bouraoui’s métis identity. (shrink)

A look at the nature of the universe, God, and our place within it explores the transformational role of consciousness in all human enterprise, offering inspirational insights into questions about religion, human existence, and good and evil.

Cause and effect relationships play a central role in how we perceive and make sense of the world around us, how we act upon it, and ultimately, how we understand ourselves. Almost two decades ago, computer scientist Judea Pearl made a breakthrough in understanding causality by discovering and systematically studying the “Ladder of Causation” [Pearl and Mackenzie 2018], a framework that highlights the distinct roles of seeing, doing, and imagining. In honor of this landmark discovery, we name this the Pearl (...) Causal Hierarchy (PCH). In this chapter, we develop a novel and comprehensive treatment of the PCH through two complementary lenses, one logical-probabilistic and another inferential-graphical. Following Pearl’s own presentation of the hierarchy, we begin by showing how the PCH organically emerges from a well-specified collection of causal mechanisms (a structural causal model, or SCM). We then turn to the logical lens. Our first result, the Causal Hierarchy Theorem (CHT), demonstrates that the three layers of the hierarchy almost always separate in a measure theoretic sense. Roughly speaking, the CHT says that data at one layer virtually always underdetermines information at higher layers. Since in most practical settings the scientist does not have access to the precise form of the underlying causal mechanisms – only to data generated by them with respect to some of PCH’s layers – this motivates us to study inferences within the PCH through the graphical lens. Specifically, we explore a set of methods known as causal inference that enable inferences bridging PCH’s layers given a partial specification of the SCM. For instance, one may want to infer what would happen had an intervention been performed in the environment (second-layer statement) when only passive observations (first-layer data) are available. We introduce a family of graphical models that allows the scientist to represent such a partial specification of the SCM in a cognitively meaningful and parsimonious way. Finally, we investigate an inferential system known as docalculus, showing how it can be sufficient, and in many cases necessary, to allow inferences across PCH’s layers. We believe that connecting with the essential dimensions of human experience as delineated by the PCH is a critical step towards creating the next generation of AI systems that will be safe, robust, human-compatible, and aligned with the social good. (shrink)

Confidentiality is a central bioethical principle governing the provider–patient relationship. Dating back to Hippocrates, new laws have interpreted it for the age of precision medicine and electronic medical records. This is where the discussion of privacy and technology often ends in the scientific health literature when Internet-related technologies have made privacy a much more complex challenge with broad psychological and clinical implications. Beyond the recognised moral duty to protect patients’ health information, clinicians should now advocate a basic right to privacy (...) as a means to safeguard psychological health. The article reviews empirical research into the functions of privacy, the implications for psychological development and the resigned sentiment taking hold regarding the ability to control personal data. The article concludes with a call for legislative, educational and research steps to readjust the equilibrium between the individual and ‘Big Data’. (shrink)

It typically taken for granted that agents can be morally responsible for such things as, for example, the death of the victim and the capture of the murderer in the sense that one may be blameworthy or praiseworthy for such things. The primary task of a theory of moral responsibility, it is thought, is to specify the appropriate relationship one must stand to such things in order to be morally responsible for them. I argue that this common approach is problematic (...) because it attempts to explain the way in which an agent can be morally responsible for something that is external to her, the agent. Since, I argue, everything that matters for moral responsibility is internal to the agent, the accounts that emerge from this approach are committed to a particular form of moral luck. Instead, we should reject this form of moral luck, and with it, the possibility of moral responsibility for objects external to the agent. We are, I argue, morally responsible only for our inner willings. Thus, a form of internalism about moral responsibility is defended. (shrink)

Many of those working on moral responsibility assume that "once blameworthy, always blameworthy." They believe that blameworthiness is like diamonds: it is forever. We argue that blameworthiness is not forever; rather, it can diminish through time. We begin by showing that the view that blameworthiness is forever is best understood as the claim that personal identity is sufficient for diachronic blameworthiness. We argue that this view should be rejected because it entails that blameworthiness for past action is completely divorced from (...) the distinctive psychological features of the person at the later time. This is because on none of the leading accounts of personal identity does identity require the preservation of any distinctive psychological features, but merely requires some form of continuity. The claim that blameworthiness is forever should therefore be rejected. We then sketch an account of blameworthiness over time, and consider two objections. (shrink)

This article contributes to the literature on national varieties of socially responsible investment (SRI) by demonstrating how Scandinavian SRI developed from the 60s and onwards. Combining findings on Scandinavian SRI with insights from previous research and institutional theory, the article accounts for the role of changes in societal values and norms, the mechanisms by which SRI practices spread, and how investors adopt and transform practices to suit their surrounding institutional contexts. Especially, the article draws attention to how different categories of (...) investors act as institutional entrepreneurs during specific historical periods, and how these roles come to shift as institutional rule systems of varying societal levels change. Thus, the insights gained are useful in the future research agenda concerned with advancing knowledge on idiosyncrasies and commonalities of national SRI manifestations, and to understand the reasons underlying such characteristics. (shrink)

I argue that curiosity about the world deserves attention as a moral virtue, even apart from the role it may play in (the more generally praised) love of wisdom. First, close relationships and caring are reasonably considered part of a well-lived life, and curiosity is important for caring both about people and about things in the world. Second, curiosity helps us to define an appropriate way for persons to be affected by certain situations. Perhaps most important, curiosity can help one (...) to live well because it addresses the most fundamental existential task humans face, the need to see their lives as meaningful. I argue that curiosity is a distinctive virtue but suggest that related virtues (e.g., receptivity, reverence) may contribute to different kinds of worthy engagement with the world. (shrink)

The object of this paper is to show how one is able to construct a paraconsistent theory of models that reflects much of the classical one. In other words the aim is to demonstrate that there is a very smooth and natural transition from the model theory of classical logic to that of certain categories of paraconsistent logic. To this end we take an extension of da Costa''sC 1 = (obtained by adding the axiom A A) and prove for it (...) results which correspond to many major classical model theories, taken from Shoenfield [5]. In particular we prove counterparts of the theorems of o-Tarski and Chang-o-Suszko, Craig-Robinson and the Beth definability theorem. (shrink)

This article examines humanist works written in the immediate aftermath of Stefano Porcari's failed conspiracy against Pope Nicholas V. While they were designed to flatter the pope and support papal claims to temporal power, these works use images and adopt rhetorical startegies that are republican and not, as one would expect, imperial in origin. The humanists were so devoted not only to classical form, but also to Roman republican ideals that they sometimes present Porcari positively, have heroes of the Roman (...) republic comment on the modern papacy, and construct a strained theory of papal liberty. (shrink)

T echnocrati c fundamentalis m (neocons ) an d theocrati c fundamentalis m (teocons) ar e t w o manifestation s o f politica l though t v e r y restrict i v e o f democra c y . Th e f irst on e ha s a highe r incidenc e i n th e f iel d o f econo m y an d th e secon d on e i n tha t o f the (...) religion , bu t bot h imp l y a stron g challeng e fo r th e democrati c State . Thi s a r ticl e deals wit h th e mor e o r les s fo r ma l conjunctio n bet w ee n bot h kind s o f fundamentalism , that appear s an d acts , e v e n a t a globa l l e v el , a s a v e r y conse r v at i v e reactio n agains t the mai n demand s o f c i vi c laicis m an d o f pr o g ress i v e policies . Th e autho r maintain s that th e an s w e r t o thes e n e w fundamentalisms , li k e t o th e ol d d o gmatisms , i s no t a t all th e relat i vism , bu t th e critica l an d aut o critica l thought . Th e poin t i s t o ad v ance , with thi s critica l attitude , i n th e const r uctio n o f n e w democrati c fo r mulations , pr o vided wit h a mor e stron g fundamen t i n te r m s o f ethica l l e gitima c y an d socia l l e gitimation. (shrink)

Desde la tradición de los estudios de gubernamentalidad y sus resonancias en las sociologías políticas y de la educación, en este artículo se recuperan los debates vigentes en torno a las nociones de gubernamentalidad, gobierno y biopolítica desarrolladas en la vasta obra de Michel Foucault y sus continuadoras/es para enlazarlas con las discusiones sobre el objeto de estudio y el campo teórico de la política educativa, enfatizando el potencial analítico que ofrece su grilla de inteligibilidad para los fenómenos educativos propios (...) de las sociedades posdisciplinares. En esa dirección, este trabajo esboza una serie de propuestas epistemológicas, teóricas y metodológicas producidas a partir de una investigación empírica recientemente finalizada (Aguirre, 2022), de corte descriptivo y de carácter cualitativo. En vistas a estos propósitos, se producen diálogos interdisciplinares a la vez que se tensionan y discuten algunos supuestos clásicos y tradicionales de la política educativa, para incitar una renovación analítica que posibilite el estudio de las relaciones sociales de autogobierno y gobierno de las/os otras/os en tanto articulaciones históricas entre el saber, el poder y la subjetividad. Finalmente, se exponen algunos indicios y propuestas para el abordaje sociológico de los fenómenos educativos contemporáneos, que convocan y promueven la necesidad de producir ciertos desplazamientos epistemológicos en el campo teórico de la política educativa, así como invitan a la reconfiguración de sus objetos de estudio en el marco de la adscripción a un enfoque posestructuralista. (shrink)

A marxist view on the priority of the function of the stimulation of creativity as compared to the other functions of art 59 2.3.1. ...

We prove the following instance of a conjecture stated in [P. E. Eleftheriou and Y. Peterzil, Definable quotients of locally definable groups, Selecta Math. 18 885–903]. Let [Formula: see text] be an abelian semialgebraic group over a real closed field [Formula: see text] and let [Formula: see text] be a semialgebraic subset of [Formula: see text]. Then the group generated by [Formula: see text] contains a generic set and, if connected, it is divisible. More generally, the same result holds when (...) [Formula: see text] is definable in any o-minimal expansion of [Formula: see text] which is elementarily equivalent to [Formula: see text]. We observe that the above statement is equivalent to saying: there exists an [Formula: see text] such that [Formula: see text] is an approximate subgroup of [Formula: see text]. (shrink)

The concept of truth arguably plays a central role in many areas of philosophical theorizing. Yet, what seems to be one of the most fundamental principles governing that concept, i.e. the equivalence between P and , is inconsistent in full classical logic, as shown by the semantic paradoxes. I propose a new solution to those paradoxes, based on a principled revision of classical logic. Technically, the key idea consists in the rejection of the unrestricted validity of the structural principle of (...) contraction. I first motivate philosophically this idea with the metaphysical picture of the states-of-affairs expressed by paradoxical sentences as being distinctively . I then proceed to demonstrate that the theory of truth resulting from this metaphysical picture is, in many philosophically interesting respects, surprisingly stronger than most other theories of truth endorsing the equivalence between P and (for example, the theory vindicates the validity of the traditional laws of excluded middle and of non-contradiction, and also vindicates the traditional constraint of truth preservation on logical consequence). I conclude by proving a cutelimination theorem that shows the consistency of the theory. (shrink)

Some accounts of moral responsibility hold that an agent's responsibility is completely determined by some aspect of the agent's mental life at the time of action. For example, some hold that an agent is responsible if and only if there is an appropriate mesh among the agent's particular psychological elements. It is often objected that the particular features of the agent's mental life to which these theorists appeal (such as a particular structure or mesh) are not necessary for responsibility. This (...) is because there appear to be cases in which an agent acts at an earlier time which causes her to lack the appropriate psychological features at some later time and yet, intuitively, she is responsible at that later .. (shrink)

This paper distinguishes between synchronic responsibility (SR) and diachronic responsibility (DR). SR concerns an agent’s responsibility for an act at the time of the action, while DR concerns an agent’s responsibility for an act at some later time. While most theorists implicitly assume that DR is a straightforward matter of personal identity, I argue instead that it is grounded in psychological connectedness. I discuss the implications this distinction has for the concepts of apology, forgiveness, and punishment as well as the (...) way in which this distinction can be used to defend quality of will accounts of responsibility against objections involving psychological manipulation. I argue that the intuition that a manipulated agent is not responsible can be explained by appeal to the conditions of DR and, as such, does not unproblematically shed light on the conditions of SR. (shrink)

This article discusses the issue of abortion in the context of the dispute between progressive and neoconservative political forces in Brazil. The article analyses ADPF 442, a legal instrument known as a Motion of Noncompliance with a Fundamental Precept, which was lodged with the Supreme Court as part of a feminist litigation strategy in the country. The motion calls for the Supreme Court to decide on the constitutionality of the decriminalisation of abortion within the first 12 weeks of gestation. Methodologically, (...) the analysis combines a literature review with participant observation and corpus linguistics analysis. ADPF 442 is considered a key event in the use of judicialisation to voice demands for women’s rights in current-day Brazil, and this work examines the testimonies as representative of the discourse and strategies at play in the broader field of abortion and its major actors, both for and against its decriminalisation. (shrink)

Many theorists have found the notion of forgiveness to be paradoxical, for it is thought that only the blameworthy can be appropriately forgiven but that the blameworthy are appropriately blamed not forgiven. Some have appealed to the notion of repentance to resolve this tension. But others have objected that such a response is explanatorily inadequate in the sense that it merely stipulates and names a solution leaving the transformative power of repentance unexplained. Worse still, others have objected that such a (...) response cannot succeed because no amount of repentance can render the blameworthy not blameworthy. I argue that this latter objection is based on a mistaken assumption, the acknowledgement of which has the power to resolve the paradox in a way that meets the explanatory adequacy challenge, and, more generally, has significant implications with which any full theory of forgiveness must engage. (shrink)

The aim of the present study was to examine the mediation effects of resilience and stress, two perceived opposite constructs, in the relationship between mindfulness and happiness. Mindful Attention Awareness Scale, Connor–Davidson Resilience Scale, Subjective Happiness Scale, Depression Anxiety Stress Scales short version-21 were administered to 523 undergraduate university students in India. Structural Equation Modeling with bootstrapping was applied to test the mediating effects of resilience and stress. Results showed that resilience and stress partially mediated the mindfulness-happiness relationship. In addition, (...) resilience partially mediated the relationship of mindfulness to stress. Findings suggest that mindfulness may play an influential role in enhancing happiness through the mediating effects of resilience and stress. (shrink)

In this interdisciplinary article, we investigate the relationship between creativity and the immune system; the creative features of the immune system and how the immune system and its role in regulating homeostasis might be related to creative cognition. We argue that within a multivariate approach of creativity, the immune system is a contributing factor. New directions for research are also discussed. When astronauts and cosmonauts venture into the new and extreme environment of outer space, their immune system needs to instantly (...) adapt and find new answers to survive biologically and psychologically. Many astronauts report interest in creative activities and therefore represent an interesting group to investigate creativity in relation with the immune system. Little is known regarding how the immune system interacts with and supports creative cognition and behavior, if an individual’s immune system, interacting with cognition, adapts more originally to a new environment compared to another’s; in other words, if there is creativity in the domain of the immune system, and the creative properties and functions of the immune system itself. (shrink)

The dissemination and reception of Bernard Bolzano's ideas were not only mediated by his personal circumstances and context but also by the vicissitudes of his work. This paper traces the fate of his works from his death in 1848 to the publication of the first volume of his Gesamtausgabe in 1969, and it does so with the help of one of the last published volumes of this edition, namely the Bolzano‐Gesamtbibliographie 1804–1999. As the paper shows, this book is more than (...) a mere list of publications and constitutes a highly valuable resource for anyone interested in Bolzano studies, the use of which is explained in detail. (shrink)

Enhancer elements are short stretches of nucleotides operationally defined by their cis‐acting ability to increase the transcription of nearby genes. They function relatively independently of position, orientation, and distance. Some show narrow tissue specificity while others permit constitutive expression in many different cell types. Although the first enhancer was described for simian virus 40 (SV40) more than five years ago, its mechanism of action has remained unclear. This review describes some of the models proposed to explain the physical role of (...) enhancers in eukaryotic transcription. (shrink)

This article examines problems that may arise when addressing liability resulting from the genetic modification of microbes, animals, and plants. More specifically, it evaluates how uncertainties relating to the outcomes of these biotechnological innovations affect—or may affect—the courts' application of the reasonable foreseeability requirement and, hence, liability under the tort of negligence. The article also examines how concern expressed by society about injuries feared to result from these genetically modified products could have an impact on the way the courts assess (...) reasonable foreseeability in this area. (shrink)

Dense pairs of geometric topological fields have tame open core, that is, every definable open subset in the pair is already definable in the reduct. We fix a minor gap in the published version of van den Dries's seminal work on dense pairs of o-minimal groups, and show that every definable unary function in a dense pair of geometric topological fields agrees with a definable function in the reduct, off a small definable subset, that is, a definable set internal to (...) the predicate. For certain dense pairs of geometric topological fields without the independence property, whenever the underlying set of a definable group is contained in the dense-codense predicate, the group law is locally definable in the reduct as a geometric topological field. If the reduct has elimination of imaginaries, we extend this result, up to interdefinability, to all groups internal to the predicate. (shrink)

In [E. Baro, M. Otero, On o-minimal homotopy, Quart. J. Math. 15pp, in press ] o-minimal homotopy was developed for the definable category, proving o-minimal versions of the Hurewicz theorems and the Whitehead theorem. Here, we extend these results to the category of locally definable spaces, for which we introduce homology and homotopy functors. We also study the concept of connectedness in -definable groups — which are examples of locally definable spaces. We show that the various concepts of connectedness associated (...) to these groups, which have appeared in the literature, are non-equivalent. (shrink)

In Crull it is argued that, in order to confront outstanding problems in cosmology and quantum gravity, interpretational aspects of quantum theory can by bypassed because decoherence is able to resolve them. As a result, Crull concludes that our focus on conceptual and interpretational issues, while dealing with such matters in Okon and Sudarsky, is avoidable and even pernicious. Here we will defend our position by showing in detail why decoherence does not help in the resolution of foundational questions in (...) quantum mechanics, such as the measurement problem or the emergence of classicality. (shrink)

In 1817, in the preface to his Rein analytischer Beweis, Bernard Bolzano revealed that he had decided to postpone the publication of any subsequent instalment of his Beyträge zu einer begründeteren Darstellung der Mathematik because of the few and ‘superficial’ reviews of its first instalment, published in 1810. Bolzano’s transcriptions of the only two known reviews of this book are conserved at the Literární archiv Památníku národního písemnictví / Muzea literatury, in Prague, together with another manuscript on his Beyträge, the (...) provenance of which was unknown to Bolzano’s scholars until recently. In this paper it is shown that this latter manuscript is a draft of an announcement that was published at the time and that was indeed written at least to some extent by Bolzano himself. This hitherto unknown announcement of Bolzano’s Beyträge not only solves the mystery surrounding that manuscript, but also helps to date the publication of this book more precisely and provides an unusual insight into what we must take Bolzano himself to have considered most noteworthy about his work, namely his study on logic. The paper includes a transcription of the manuscript and an English translation of the announcement. (shrink)

The Consistent Histories (CH) formalism aims at a quantum mechanical framework which could be applied even to the universe as a whole. CH stresses the importance of histories for quantum mechanics, as opposed to measurements, and maintains that a satisfactory formulation of quantum mechanics allows one to assign probabilities to alternative histories of a quantum system. It further proposes that each realm, that is, each set of histories to which probabilities can be assigned, provides a valid quantum-mechanical account, but that (...) different realms can be mutually incompatible. Finally, some of its proponents offer an “evolutionary” explanation of our existence in the universe and of our preference for quasiclassical descriptions of nature. The present work questions the validity of claims offered by CH proponents asserting that it solves many interpretational problems in quantum mechanics. In particular, we point out that the interpretation of the framework leaves vague two crucial points, namely, whether realms are fixed or chosen and the link between measurements and histories. Our claim is that by doing so, CH overlooks the main interpretational problems of quantum mechanics. Furthermore, we challenge the evolutionary explanation offered and we critically examine the proposed notion of a realm-dependent reality. (shrink)