Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face transplantation must meet all the ethical requirements (...) usually applied to health care research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and transplantation. Finally, we maintain that the time has come to move facial transplantation research into the clinical phase. (shrink)

Main Response Topics ? Introduction ? Open display and public evaluation ? Publicity versus patient privacy ? Facial tissue donation ? Validity of Louisville Instrument for Risk Acceptance ? Patients' understanding of risk ? Face versus hand transplantation ? Rejection rates/risks ? Patient compliance ? Exit strategy ? Functional recovery ? Societietal implications ? Psychological implications ? Conclusion: Uncertainty likely to persist.

Este artículo propone considerar a la alimentación en general y a los ultraprocesados y bebidas azucaradas en lo particular, como un tema que atañe a la bioética global. La primera sección explica la relación entre el consumo de los alimentos ultraprocesados y la salud, la segunda, relaciona a las llamadas enfermedades no transmisibles y la salud mental con la alimentación y la tercera sección, argumenta el papel que debe jugar la bioética, en especial la global, en materia de alimentación.

This book provides an up-to-date revision of materialism’s central tenets, its main varieties, and the place of materialistic philosophy vis a vis scientific knowledge. Materialism has been the subject of extensive and rich controversies since Robert Boyle introduced the term for the first time in the 17th century. But what is materialism and what can it offer today? The term is usually defined as the worldview according to which everything real is material. Nevertheless, there is no philosophical consensus about whether (...) the meaning of matter can be enlarged beyond the physical. As a consequence, materialism is often defined in stark exclusive and reductionist terms: whatever exists is either physical or ontologically reducible to it. This conception, if consistent, mutilates reality, excluding the ontological significance of political, economic, sociocultural, anthropological and psychological realities. Starting from a new history of materialism, the present book focuses on the central ontological and epistemological debates aroused by today’s leading materialist approaches, including some little known to an anglophone readership. The key concepts of matter, system, emergence, space and time, life, mind, and software are checked over and updated. Controversial issues such as the nature of mathematics and the place of reductionism are also discussed from different materialist approaches. As a result, materialism emerges as a powerful, indispensable scientifically-supported worldview with a surprising wealth of nuances and possibilities. (shrink)

Macroscopic irreversible processes emerge from fundamental physical laws of reversible character. The source of the local irreversibility seems to be not in the laws themselves but in the initial and boundary conditions of the equations that represent the laws. In this work we propose that the screening of currents by black hole event horizons determines, locally, a preferred direction for the flux of electromagnetic energy. We study the growth of black hole event horizons due to the cosmological expansion and accretion (...) of cosmic microwave background radiation, for different cosmological models. We propose generalized McVittie co-moving metrics and integrate the rate of accretion of cosmic microwave background radiation onto a supermassive black hole over cosmic time. We find that for flat, open, and closed Friedmann cosmological models, the ratio of the total area of the black hole event horizons with respect to the area of a radial co-moving space-like hypersurface always increases. Since accretion of cosmic radiation sets an absolute lower limit to the total matter accreted by black holes, this implies that the causal past and future are not mirror symmetric for any spacetime event. The asymmetry causes a net Poynting flux in the global future direction; the latter is in turn related to the ever increasing thermodynamic entropy. Thus, we expose a connection between four different “time arrows”: cosmological, electromagnetic, gravitational, and thermodynamic. (shrink)

The main thesis of this paper is that for Socrates political virtue is accomplished exclusively in the sphere of pure language or gesture. The argument consists of three parts. First, following on from the lectures entitled What is Called Thinking?, I examine Heidegger’s interpretation of the figure of Socrates in relation to the themes of language and gesture. Following on from this analysis, I remark that Heidegger overlooks important aspects of Socrates’ understanding of the relation between political virtue and speech. (...) Subsequently, based on the analysis of a central passage from Plato's Apology, I argue that virtue requires the public communicability of speech, and that it imposes itself over language and gestures as a principle of action that precedes and exceeds conceptual knowledge. Finally, I conclude by stating that political power is restricted to the medium of language, to what language itself does or says. (shrink)

It is a remarkable fact that all processes occurring in the observable universe are irre- versible, whereas the equations through which the fundamental laws of physics are formu- lated are invariant under time reversal. The emergence of irreversibility from the funda- mental laws has been a topic of consideration by physicists, astronomers and philosophers since Boltzmann's formulation of his famous \H" theorem. In this paper we shall discuss some aspects of this problem and its connection with the dynamics of space-time, (...) within the framework of modern cosmology. We conclude that the existence of cosmological horizons allows a coupling of the global state of the universe with the local events deter- mined through electromagnetic processes. (shrink)

Macroscopic irreversible processes emerge from fundamental physical laws of reversible character. The source of the local irreversibility seems to be not in the laws themselves but in the initial and boundary conditions of the equations that represent the laws. In this work we propose that the screening of currents by black hole event horizons determines, locally, a preferred direction for the flux of electromagnetic energy. We study the growth of black hole event horizons due to the cosmological expansion and accretion (...) of cosmic microwave background radiation, for different cosmological models. We propose generalized McVittie co-moving metrics and integrate the rate of accretion of cosmic microwave background radiation onto a supermassive black hole over cosmic time. We find that for flat, open, and closed Friedmann cosmological models, the ratio of the total area of the black hole event horizons with respect to the area of a radial co-moving space-like hypersurface always increases. Since accretion of cosmic radiation sets an absolute lower limit to the total matter accreted by black holes, this implies that the causal past and future are not mirror symmetric for any spacetime event. The asymmetry causes a net Poynting flux in the global future direction; the latter is in turn related to the ever increasing thermodynamic entropy. Thus, we expose a connection between four different “time arrows”: cosmological, electromagnetic, gravitational, and thermodynamic. (shrink)

Presentism is, roughly, the metaphysical doctrine that maintains that whatever exists, exists in the present. The compatibility of presentism with the theories of special and general relativity was much debated in recent years. It has been argued that at least some versions of presentism are consistent with time-orientable models of general relativity. In this paper we confront the thesis of presentism with relativistic physics, in the strong gravitational limit where black holes are formed. We conclude that the presentist position is (...) at odds with the existence of black holes and other compact objects in the universe. A revision of the thesis is necessary, if it is intended to be consistent with the current scientific view of the universe. (shrink)

The thesis of this paper is that truth in politics is intersubjectively constituted within a set of relationships irreducible to the oppositions of truth and falsehood or veracity and lying. First, I examine the link between factual truth and politics, and argue that this sort of truth pervades our experience and tends to become background knowledge. Second, I propose a reading of Plato’s Apology according to which the truth in politics is grounded on an intersubjective normative and epistemological horizon, which (...) is vicariously communicated as gesture. Third, in relation to Plato’s Republic and Gorgias, I inquire about the semantic connections between fiction and lie and assert that the expression of the truth in politics requires a poetic endeavor, which blurs the lines separating veracity and lying. Finally, based on Agamben’s interpretation of Plato’s Hippias Minor, I conclude that the institution of the truth in politics requires diverse expressive and interpretive capacities. (shrink)

We present a formal analysis of the Cosmological Argument in its two main forms: that due to Aquinas, and the revised version of the Kalam Cosmological Argument more recently advocated by William Lane Craig. We formulate these two arguments in such a way that each conclusion follows in first-order logic from the corresponding assumptions. Our analysis shows that the conclusion which follows for Aquinas is considerably weaker than what his aims demand. With formalizations that are logically valid in hand, we (...) reinterpret the natural language versions of the premises and conclusions in terms of concepts of causality consistent with (and used in) recent work in cosmology done by physicists. In brief: the Kalam argument commits the fallacy of equivocation in a way that seems beyond repair; two of the premises adopted by Aquinas seem dubious when the terms ‘cause’ and ‘causality’ are interpreted in the context of contemporary empirical science. Thus, while there are no problems with whether the conclusions follow logically from their assumptions, the Kalam argument is not viable, and the Aquinas argument does not imply a caused origination of the universe. The assumptions of the latter are at best less than obvious relative to recent work in the sciences. We conclude with mention of a new argument that makes some positive modifications to an alternative variation on Aquinas by Le Poidevin, which nonetheless seems rather weak. (shrink)

Materialism has been the subject of extensive and rich controversies since Robert Boyle introduced the term for the first time in the 17th century. But what is materialism and what can it offer today? The term is usually defined as the worldview according to which everything real is material. Nevertheless, there is no philosophical consensus about whether the meaning of matter can be enlarged beyond the physical. As a consequence, materialism is often defined in stark exclusive and reductionist terms: whatever (...) exists is either physical or ontologically reducible to it. This conception, if consistent, mutilates reality, excluding the ontological significance of political, economic, sociocultural, anthropological and psychological realities. Starting from a new history of materialism, the present book focuses on the central ontological and epistemological debates aroused by today’s leading materialist approaches, including some little known to an anglophone readership. The key concepts of matter, system, emergence, space and time, life, mind, and software are checked over and updated. Controversial issues such as the nature of mathematics and the place of reductionism are also discussed from different materialist approaches. As a result, materialism emerges as a powerful, indispensable scientifically-supported worldview with a surprising wealth of nuances and possibilities. (shrink)

A realistic axiomatic formulation of nonrelativistic quantum mechanics for a single microsystem with spin is presented, from which the most important theorems of the theory can be deduced. In comparison with previous formulations, the formal aspect has been improved by the use of certain mathematical theories, such as the theory of equipped spaces, and group theory. The standard formalism is naturally obtained from the latter, starting from a central primitive concept: the Galilei group.

We present a deductive theory of space-time which is realistic, objective, and relational. It is realistic because it assumes the existence of physical things endowed with concrete properties. It is objective because it can be formulated without any reference to cognoscent subjects or sensorial fields. Finally, it is relational because it assumes that space-time is not a thing but a complex of relations among things. In this way, the original program of Leibniz is consummated, in the sense that space is (...) ultimately an order of coexistents, and time is an order of succesives. In this context, we show that the metric and topological properties of Minkowskian space-time are reduced to relational properties of concrete things. We also sketch how our theory can be extended to encompass a Riemannian space-time. (shrink)

We present an axiomatization of non-relativistic Quantum Mechanics for a system with an arbitrary number of components. The interpretation of our system of axioms is realistic and objective. The EPR paradox and its relation with realism is discussed in this framework. It is shown that there is no contradiction between realism and recent experimental results.

This paper explores the theme of torture in the Colombian Truth Commission’s Final Report, focusing on its characterization of torture as a way of annulling a person’s identity. Drawing on Jean Améry’s approach, I argue that torture destroys the victim’s world and explore the further implications of this assertion. I begin by highlighting how the history of torture distorts legal and medical practices, masquerading as a quest for truth while exercising a farce of power, disintegrating the victim’s lived body. By (...) delving into Merleau-Ponty’s notion of “flesh,” I also explain how torture erodes the carnal trust that connects us to the world and enables proper communication. Consequently, torture results in an utter negation of the self and the world. In conclusion, I suggest that torture as understood as the destitution of a person’s world, can serve as a paradigm for comprehending the experiences of violence faced by victims in Colombia. (shrink)

Despite the central presence of materialism in the history of philosophy, there is no universal consensus on the meaning of the word “matter” nor of the doctrine of philosophical materialism. Dictionaries of philosophy often identify this philosophy with its most reductionist and even eliminative versions, in line with Robert Boyle’s seventeenth century coinage of the term. But when we take the concept back in time to Greek philosophers and forward onto our own times, we recognize more inclusive forms of materialism (...) as well as complex interplays with non-materialist thought about the place of matter in reality, including Christian philosophy and German idealism. We define philosophical materialism in its most general way both positively (the identification of reality with matter understood as changeability and plurality) and negatively (the negation of disembodied living beings and hypostatized ideas). This inclusive approach to philosophical materialism offers a new light to illuminate a critical history of the concept of matter and materialism from Ancient Greece to the present that is also attentive to scientific developments. By following the most important connections and discontinuities among theoretical frameworks on the idea of matter, we present a general thread that offers a rich and plural, but highly cohesive, field of investigation. Finally, we propose building on rich non-reductionist materialist philosophies, such as Mario Bunge’s systemic materialism and Gustavo Bueno’s discontinuous materialism, to elaborate powerful theoretical alternatives to both physicalism and spiritualism. (shrink)

This chapter contains sections titled: Introduction Argentina Mexico The Southern Cone The Northern Part of South America and Central America Conclusion References Further Reading.

Schönberg ha sido uno de los compositores más decisivos del pasado siglo. Su propuesta musical, su intento de buscar nuevos lenguajes para expresarla, su diagnóstico de la muerte de la música tonal, puede ser equiparado con la constatación nietzscheana de la ¿muerte de Dios¿, con la pérdida de todos los axiomas últimos e inamovibles que suministran valor al mundo y sentido a la existencia. Ambos desarrollaron una visión trágico-musical del mundo, que no pesimista; ambos se acercaron a la realidad desde (...) la afirmación y la inocencia propias del artista, experimentando sus aspectos más disonantes con desconocida alegría y serenidad. (shrink)

This work tries to demonstrate, in first place, that the “gnoseological” approach to the question for the science defended by Gustavo Bueno in fact only fits in the gnoseological materialism, the theory proposed by Bueno, while adequationism, theoreticism and descriptionsm would be theories of the science that genuinely would adopt the “epistemological” approach. In second place, we sustain that the epistemological and gnoseological approaches are generated in the soul/body alternative outlined by Cartesian dualism, because while the first one conceives (...) the subject that makes the sciences as a mere mind that operates with propositions or concepts “about the things”, the second one understands it as a (soulless) mechanical body that builds the sciences operating “with the things themselves”. Since in Descartes the soul is the instance that knows, the option for the body of the gnoseological materialism explains its (self) positioning regardless of the question of knowledge. Lastly, we examine some problems that this Cartesian notion of subject implicates for the gnoseological materialism’s conception of “human and ethological sciences”. (shrink)

Se explora las posibles divergencias y convergencias entre los filósofos Gustavo Bueno y Marc Richir a través de la obra de Ricardo Sánchez Ortiz de Urbina.

Hasta el día de hoy, y ya agotada la primera edición del libro que comentamos, ninguno de sus lectores, ni críticos, ya sea públicamente o en privado, que sepamos, ha destacado como se merece, la dedicatoria del mismo a Gustavo Bueno. Y sin embargo, el texto que comentamos se define no sólo como «teoría de los niveles fenomenológicos», la cual se «inscribe, más bien, en las coordenadas de una fenomenología renovada, no estándar» (prólogo, pag.14), sino también como «materialismo fenomenológico», (...) pero un materialismo que se enraíza en el «materialismo filosófico», el sistema filosófico construido por Gustavo Bueno y sus discípulos, el primero de los cuales fue Ricardo Sánchez Ortiz de Urbina, y que ateniéndonos a la dedicatoria que destacamos al iniciar este comentario, parece seguir siéndolo. (shrink)

El presente trabajo trata de demostrar, en primer lugar, que el enfoque “gnoseológico” de la pregunta por la ciencia defendido por Gustavo Bueno corresponde en rigor únicamente al materialismo gnoseológico, la teoría propuesta por Bueno, mientras que el adecuacionismo, el teoreticismo y el descripcionismo serían teorías de la ciencia que genuinamente adoptarían el enfoque “epistemológico”. En segundo lugar, se sostiene que los enfoques epistemológico y gnoseológico se generan en la alternativa planteada por el dualismo cartesiano alma/cuerpo, pues mientras el (...) primero concibe al sujeto que hace las ciencias como una mera mente que opera con proposiciones o conceptos “sobre las cosas”, el segundo lo entiende como un cuerpomecánico que construye las ciencias operando “con las cosas mismas”. Puesto que en Descartes es el alma la instancia que conoce, la opción por el cuerpo del materialismo gnoseológico explica su posición al margen de la cuestión del conocimiento. Por último, se examinan algunos problemas que esta noción cartesiana del sujeto conlleva para la concepción de las “ciencias humanas y etológicas” del materialismo gnoseológico.This work tries to demonstrate, in first place, that the “gnoseological” approachto the question for the science defended by Gustavo Bueno in fact only fits in thegnoseological materialism, the theory proposed by Bueno, while adequationism, theoreticism and descriptionsm would be theories of the science that genuinely would adopt the “epistemological” approach. In second place, we sustain that the epistemological and gnoseological approaches are generated in the soul/body alternative outlined by Cartesian dualism, because while the first one conceives the subject that makes the sciences as a mere mind that operates with propositions or concepts “about the things”, the second one understands it as a mechanical body that builds the sciences operating “with the things themselves”. Since in Descartes the soul is the instance that knows, the option for the body of the gnoseologicalmaterialism explains its positioning regardless of the question ofknowledge. Lastly, we examine some problems that this Cartesian notion of subject implicates for the gnoseological materialism’s conception of “human and ethological sciences”. (shrink)

El autor pasa revista a la concepción de la historia como disciplina que exhibe el filósofo Fernando Miguel Pérez Herranz. El motivo de este concienzudo análisis es la publicación en marcha del magno proyecto Más allá de imperios y naciones (4 vols.) iniciado en 2023 y que ya cuenta con dos tomos en el mercado: Rutas, fronteras y complejidad y Singularidad imperial: del Mediterráneo al Atlántico. Esta concepción del estatuto gnoseológico de la historia tiene en Lindos y tornadizos (2016) y (...) en Ambiguus proetus (2019) dos momentos esenciales que dibujan el paso Herranz a su perspectiva (la morfología filosófica) en el debate entre Gustavo Bueno y Ricardo Sánchez Ortiz de Urbina a cuenta del sujeto trascendental. En tal contexto cobran relevancia las hipercategorías formuladas por Pérez Herranz y cuyo estatuto resulta problemático. (shrink)

Previously, the author tried to show that some arguments in one of the two versions of Nicholas of Autrecourt’s Quaestio de intensione visionis are taken almost verbatim from the anonymous Tractatus de sex inconvenientibus. This paper concentrates on the arguments themselves in order to consider two main issues: the ‘translatability’ of limit decision problems, manifest in Autrecourt’s juxtaposition of questions de maximo et minimo, de primo et ultimo instanti, and the intension and remission of forms; the importance of Parisian discussions (...) of limit decision problems prior to the adoption of the new analytical languages developed at Oxford. Thus, the paper is divided in two sections, the first concerning some arguments of Autrecourt’s question, the second focusing on the link between one of Autrecourt’s arguments and the medieval tradition of commentaries on Aristotle’s De caelo, in which it is possible to find some antecedents of the analytical approach that later Parisian scholars would apply to these problems. (shrink)

Este artículo pretende rastrear en dos de los últimos escritos de Judith Butler, Dispossession y Los sentidos del sujeto, su preocupación por la posibilidad de agencia crítica de los sujetos. Para ello, será necesario comprender que su concepción del sujeto no es la humanista; en cambio, propone un sujeto vulnerable y en relación de interdependencia con los demás. Las condiciones socioculturales que permiten emerger al sujeto butleriano no han de ser entendidas, por otra parte, como un constructivismo sino que, a (...) través de la senda de la deconstrucción, nos proponen pensar la libertad de los sujetos sin perder de vista la desposesión constitutiva y diferencialmente producida. (shrink)

Nos deteremos aqui sobre a crítica de Matthew Kramer em relação à interpretação de Quentin Skinner sobre o conceito de “liberdade” em Hobbes contida em seu artigo “On the Unavoidability of Actions: Quentin Skinner, Thomas Hobbes, and the Modern Doctrine of Negative Liberty” (2001). Nele, Kramer trata do então crescente interesse do projeto intelectual de Skinner pelo pensamento hobbesiano, algo já evidenciado desde a publicação de seu livro Liberdade Antes do Liberalismo (1998). Kramer toma como referência central de sua resposta (...) o artigo de Skinner intitulado “Thomas Hobbes on the Proper Signification of Liberty”, criticando a sua posição e contrastando com algumas de suas próprias ideias sobre “liberdade” e “não-liberdade”. Através dessas considerações, Kramer reavalia a noção da liberdade em Hobbes, tomando-a como o protótipo liberal da liberdade negativa por excelência, demonstrando assim os supostos equívocos contidos na interpretação de Skinner sobre ela. Buscamos defender aqui, contudo, que a proposta interpretativa de Kramer carece da devida fundamentação metodológica que correlaciona o neorrepublicanismo de Skinner no campo da filosofia política com certos princípios oriundos de sua historiografia que não são devidamente considerados pelo primeiro. A sua crítica estaria, assim, comprometida por uma abordagem desconectada do pensamento e das intenções de Hobbes enquanto um agente político inserido em um determinado contexto linguístico e social, quadro que seria posteriormente resgatado de maneira primorosa por Skinner em seu estudo Hobbes and Republican Liberty (2008). (shrink)

Conceptual engineering is commonly characterized as the method for assessing and improving our representational devices. Little has been said, however, on how best to construe these representational devices—in other words, on what conceptual engineering should be all about. This paper tackles this problem with a basic strategy: First, by presenting a taxonomy of the different possible subject matters for conceptual engineering; then, by comparatively assessing them and selecting the most conducive one with a view to making conceptual engineering an actionable (...) method, that is, a method that can be applied effectively and consistently to specific case studies. The outcome is that conceptual engineering should be all about concepts on pain of pragmatic inconsistencies otherwise. (shrink)

Considering the case of Juan de Vilanova y Piera, often celebrated as the first scientist to accept the prehistoric antiquity of palaeolithic paintings, we explore some of the problems related to the concept of ‘precursor’ in the field of the history of science. In the first section, we propose a brief history of this notion focusing on those authors who have reflected critically on the meaning of predecessors. In the second section, the example of Vilanova illustrates the ways in which (...) historians of science have created precursors. From the vantage of modern science, precursors have traditionally been defined as those who first indicated or announced ideas or theories later accepted by the scientific community. As a result, they have been represented as ‘heroes’ struggling hard to defeat the ignorance of their time. As the case of Juan de Vilanova illustrates, this traditional view is unsatisfactory in many ways. For this reason we consider in the third section a number of methodological strategies to promote a more adequate approach to pioneers. In particular, we suggest that the best way to surmount hagiographical approaches to past scientists is to put them in their own intellectual and historical contexts. (shrink)

This chapter focuses on the golden era and proposes an exercise of creativity whereby we imagine Diana, the Amazon, becoming Wonder Woman in order to overthrow Man's World. Through Wonder Woman's story, we can build a feminist epic that depicts women who fight patriarchy. In the novel Lesbian Peoples: Material for a Dictionary, Wittig and Zeig describe the Amazons as the warriors thanks to whom we have been able to enter the Golden Age, an age without patriarchy or sex differences. (...) Diana, by becoming Wonder Woman and by fighting against heteropatriarchal injustice, leads the war toward the destruction of this dualistic division. The connection between Amazons and Guerrilleres, between two generations of fighters against patriarchy, aims to inspire our sorority and union in this fight against heteronormative, oppressive structures that affect us all, especially women and other subjects with alternative sexual and gender identities. (shrink)