Research that is initiated, designed or funded by sponsor agencies based in countries with relatively high social and economic development, and conducted in countries that are relatively less developed, gives rise to many important ethical challenges. Although clinical trials of HIV vaccines began ten years ago in the US and Europe, an increasing number of trials are now being conducted or planned in other countries, including several that are considered “developing” countries. Safeguarding the rights and welfare of individuals participating as (...) research subjects in developing countries is a priority. In September, 1997, the Joint United Nations Programme on HIV/AIDS embarked on a process of international consultation; its purpose was further to define the important ethical issues and to formulate guidance that might facilitate the ethical design and conduct of HIV vaccine trials in international contexts. This paper summarises the major outcomes of the UNAIDS consultative process. (shrink)

The paper is a critical discussion of scholarship on the "Critique of Pure Reason" published during the past ten years. The emphasis is on Anglo-American authors. I identify and discuss three main trends in the field: a shift from the general discussion of transcendental arguments to the analysis and evaluation of particular proofs in Kant; a renewed interest in the doctrine of transcendental idealism and the distinction between things in themselves and appearances; and the emergence of an entire body of (...) literature on Kant's philosophy of mind, centered around the idea of a "transcendental psychology." The main body of the text is supplemented by extensive bibliographical information provided in the notes. (shrink)

As Husserl already noticed, artworks themselves have a phenomenological character. This means, however, that to experience artworks as phenomena no “epoché” and no “phenomenological reduction” is necessary. The leading question of my essay is whether, and possibly how, this observation can be methodologically generalized for understanding phenomena. I discuss if, and possibly how, a phenomenological reflection on art allows and even demands a general conception of phenomenology that nevertheless does not confuse artworks with phenomena in general. My intention is to (...) show that and how phenomenality can be clarified with reference to its spatial character. Accordingly, works of architecture that are artworks will play a decisive role in my argument. (shrink)

Scientific exploration and thus our knowledge about the outside world is subject to the conditions of our experience.These conditions are condensed here into an interface model which,besides being physical,has an additional interface structure not reducible to physics. We suggest that this structure can dynamically be characterized by separate modes.Their selection and operation presupposes free will and a rudimentary concept of time and space. Based on some analogies with quantum networks it is argued that the 'observed' gets 'dressed'as a consequence of (...) the observing. Interface dynamics and system dynamics supplement each other without over- determination. (shrink)

Over the last two decades, the capabilities approach has become an increasingly influential theory of development. It conceptualises human wellbeing in terms of an individual's ability to achieve functionings we have reason to value. In contrast, the African ethic of ubuntu views human flourishing as the propensity to pursue relations of fellowship with others, such that relationships have fundamental value. These two theoretical perspectives seem to be in tension with each other; while the capabilities approach focuses on individuals as the (...) locus of ethical value, an ubuntu ethic concentrates on the relations between individuals. In this article, we ask: to what extent is the capabilities approach compatible with this African ethical theory? We argue that, on reflection, relations play a much stronger role in the capabilities approach than often assumed. There is good reason to believe that relationality is part of the concept of a capability itself, where such relationality has intrinsic ethical value. This understanding of the ethical centrality of relations grounds new normative perspectives on the capabilities approach, and offers a more comprehensive grasp of the relevance of relationships to empirical enquiry. (shrink)

Chemical structures are among the trademarks of our profession, as surely chemical as flasks, beakers and distillation columns. When someone sees one of us busily scribbling formulas or structures, he or she has no trouble identifying a chemist. Yet these familiar objects, which accompany our work from start to end, from the initial doodlings (Fig. I) to the final polished artwork in a publication (Fig. II), are deceptively simple. They raise interesting and difficult questions about representation. It is the intent (...) of this article to reflect upon molecular graphics. (shrink)

Fichte's System of Ethics, published in 1798, is at once the most accessible presentation of its author's comprehensive philosophical project, The Science of Knowledge or Wissenschaftslehre, and the most important work in moral philosophy written between Kant and Hegel. Fichte's ethics integrates the discussion of our moral duties into the systematic framework of a transcendental theory of the human subject. Its major philosophical themes include the practical nature of self-consciousness, the relation between reason and volition, the essential role of the (...) drives in human willing, the possibility of changing the natural world, the reality of one's own body, the reality of other human beings, and the practical necessity of social relations between human beings. This volume offers a translation of the work together with an introduction that sets it in its philosophical and historical contexts. (shrink)

Over twenty years have passed since JLME published “The Girl Who Cried Pain: A Bias Against Women in the Treatment of Pain.” This article revisits the conclusions drawn in that piece and explores what we have learned in the last two decades regarding the experience of men and women who have chronic pain and whether women continue to be treated less aggressively for their pain than men.

This contribution analyzes the general relation between nature and laboratory with respect to the alternative of a ,,presented" and a ,,self-presenting nature". It is argued that as essentially presented by technological means, ,,nature in the laboratory" has to be considered as a dimensionally reduced nature already incorporated to the objective world of man. The basic precondition of the emergence of laboratory science on the threshold of modern times was the introduction of a concept of an ,,active physics" which itself presupposed (...) the abandonment of a given ,,metaphysical" order of phenomena, especially in the sense of the Aristotelian substance-accidence-scheme. The logic of a suchlike forced ,,presentation of nature", and also the logic of the modern technology-dependent ways of progress in knowledge can precisely be analyzed within the theoretical framework of the Paul-Lorenzen-School (,,Methodological constructivism"). The concept of a ,,self-presenting nature", on the other hand, requires a genuine reflection of a philosophy of nature which is able to focus on the aspects of self-reference and differentiality of the genuine instances of nature. Finally three starting-points of a non-laboratorial way of thinking nature are discussed. German Der Beitrag analysiert das Verhältnis von Natur und Labor unter dem Gesichtspunkt der Alternative von ,,sich zeigender und ,,gezeigter Natur, wobei die im Labor auf dem Wege einer wesentlich technisch-praktischen Erwirkung konkret ,,gezeigte Natur eine der Gegenstandswelt des Menschen immer schon integrierte (und insoweit dimensional verkürzte) Natur ist. Die entscheidende Voraussetzung für die Entstehung der Laborwissenschaft an der Schwelle zur Neuzeit war die Einführung eines Konzepts ,,handelnder Physik, das seinerseits die Preisgabe einer vorgängigen ,,metaphysischen Ordnung der Phänomene (insbesondere im Sinne des Substanz-Akzidens-Gefälles) voraussetzt. Die Logik dieses ,,Zeigens der Natur ebenso wie die des modernen, technologieabhängig gewordenen Erkenntnisfortschritts ist wissenschaftstheoretisch mit den Mitteln des Methodischen Konstruktivismus präzise beschreibbar. Für den alternativen Begriff einer ,,sich zeigenden Natur als wesentlich polydimensionaler, einheitsbegrifflich nicht einholbarer Totalität bedarf es jedoch einer genuin naturphilosophischen Reflexion, die insbesondere die mit dem Natürlichen verbundenen Komponenten der Selbstbezüglichkeit und der Differentialität zu thematisieren vermag. Abschließend werden drei Ansatzpunkte eines ,,nichtlaboratorischen Naturdenkens diskutiert. (shrink)

This article compares Kant and Fichte from the double stand- point of identity and difference with regard to two thinkers who were at first united by a master-student relation but who later on drifted apart from each other due to mutual defamation. At the center of the present discussion stands the relationship between spirit of freedom and system’s form which binds Kant and Fichte beyond methodological divergences and doctrinal differ- ences. The critical comparison between Kant and Fichte will be developed (...) in four steps: it will start with the general positioning of Kant within German Idealism, and then move on to Kant’s double critical enterprise of grounding an aprioristic doctrine of principles of nature and freedom; it will later on address the conception championed by Fichte of having pre- sented the “first system of freedom”, and from there it will focus on the manifestations of freedom within Fichte’s philosophical system, with Kant’s position as contrast. (shrink)

El presente artículo compara a Kant y a Fichte en la perspectiva doble de identidad y diferencia referida a dos pensadores a quienes une una primera relación de maestro y alumno y a quienes separa una posterior difamación mutua. En el centro de la presentación se encuentra la relación entre espíritu de libertad y forma del sistema que une a Kant y a Fichte más allá de divergencias metódicas y de diferencias doctrinales. La comparación crítica entre Kant y Fichte se (...) desarrollará en cuatro etapas: partirá de la ubicación general de Kant dentro del idealismo alemán y se extenderá a la empresa doble de Kant, expresada de forma crítica, de una doctrina de los principios apriorística de naturaleza y libertad, para después ir a la concepción enfáticamente reclamada por Fichte de un “primer sistema de la libertad”,[1] y de ahí a las manifestaciones de la libertad en el sistema filosófico de Fichte, teniendo como punto de vista rector el contraste con Kant.[2] Palabras clave: [1] En la forma de citación de la Gesamtausgabe de Fichte se señalará el tomo y el volumen con números romanos y arábigos respectivamente, y después el número de página en cuestión. [2] El presente artículo es parte de un proyecto de carácter más amplio, cuyo tema es la dilucidación del aporte filosófico de Kant y de Fichte; de ahí que se haga continua referencia a publicaciones particulares de mi autoría. (shrink)

The philosophy of modality investigates necessity and possibility, and related notions--are they objective features of mind-independent reality? If so, are they irreducible, or can modal facts be explained in other terms? This volume presents new work on modality by established leaders in the field and by up-and-coming philosophers. Between them, the papers address fundamental questions concerning realism and anti-realism about modality, the nature and basis of facts about what is possible and what is necessary, the nature of modal knowledge, modal (...) logic and its relations to necessary existence and to counterfactual reasoning. The general introduction locates the individual contributions in the wider context of the contemporary discussion of the metaphysics and epistemology of modality. (shrink)