The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

The aim of the article is to point out the problem that started in the 2018 US Open final between Naomi Osaka and Serena Williams. During this final match, there was a conflict between the player S. Williams and the chair umpire C. Ramos, which involved a violation of rules related to coaching during the match. Subsequently, C. Ramos was banned from officiating the Williams sisters' matches at the next 2019 US Open. The authors of the article believe that the (...) tennis organizations USTA and WTA did not judge the dispute between chair umpire C. Ramos and S. Williams in accordance with their rules, as the rules allow for the sanctioning of a player who is coached during a match. While the written rules and their application during play must be taken into consideration, so must the subjective interpretation and application of the rules by a particular umpire. If our arguments are correct, C. Ramos's application of the rules during this game was in no way inconsistent with his past practice or the rules themselves. Thus, C. Ramos was a victim of the entire incident, which was also influenced by the gender narrative after the match. (shrink)

Strawson’s work seems to contain both pragmatic and semantic concepts of presupposition. The former concept has largely been studied by many philosophers and linguists, while the latter has not been properly investigated (van Fraassen being an exception). The present author explicates the semantic concept of existential presupposition in relation to deriving existential statements and distinguishing their de dicto/de re variants (in the rather generalized sense following Tichý).

Cílem této studie je představení základních tezí sociálně-politické filosofie Karla Raimunda Poppera (jak je zachycena zejména v dílech Bída historicismu a Otevřená společnost a její nepřátelé) a dále kritické zhodnocení aplikace těchto tezí při výkladu Platónovy filosofie. Je probíráno zejména Popperovo obvinění Platóna z tzv. „biologického historicismu“, dále jeho označení platónské teorie spravedlnosti jako „totalitní“ a v neposlední řadě jeho interpretace dialogu Ústava jakožto Platónova „politického programu“ určeného k přímé implementaci v praxi vyvoleným filosofem-králem. V druhé polovině této studie je (...) pak nabídnuto alternativní čtení, v němž se Platónova Ústava vyjeví ve zcela odlišném světle, než v jakém ji vidí Popper. (shrink)

The successful early acquisition of reading literacy represents a crucial learning process determining the further course of academic development (Stanovich, 2009). During this process, interactions between children and their proximal social environment are of utmost importance. Therefore, we introduce a systemic framework for the development of learning potential (e.g., Mudrak et al., 2015, 2019, 2019b; Ziegler & Stoeger, 2017) and explore the interactions between the social and motivational processes associated with reading literacy development in school-age children. We base our analysis (...) on a representative Czech sample of fourth-grade pupils involved in the Progress in International Reading Literacy study (PIRLS, Martin et al., 2016). On the basis of the systemic framework, we hypothesized hierarchical relationships among family socioeconomic status, related developmental resources (including parental support, expectations, and reading resources), children’s reading motivation (including reading engagement and reading confidence), and manifested learning outcomes (including school grades and reading competence). We implemented three structural equation models to test the hypothesized relationships. The first model tested the direct effect of developmental resources on reading competence. The second model included the motivational variables as mediators between resources and competence. The third model included school grades as mediators between resources and motivational variables. Our analyses indicated the good fit of the proposed models. The final model explained 37.8 % of the variance in children’s school grades and 46.5 % of the variance in reading literacy test scores (compared to 34.8 % in the first model). Moreover, parental socioeconomic status was strongly associated with parental expectations, which were associated with reading confidence, partially through the effect of parental expectations on children’s school grades. Reading confidence was the main predictor of reading literacy within the model, followed by the direct effects of parental resources. The results illustrate complex processes through which the family environment affects the development of learning competencies such as reading literacy by providing children with the relevant social and material resources associated with their motivation and school outcomes. We discuss some of the reasons that these relationships may take place and consider their implications for educational practice. (shrink)

This article will introduce Isaac Newton’s fundamental methodological concepts applied for a solution concerning a question of gravity in his Principia Mathematica. The method of deduction of propositions from phenomena can be described as demonstrative induction. The main aim is to show that this method proposed by Newton explicitly contains a criticism of hypothetico-deductive methodology as an inadequate approach to the study of nature. As opposed to hypothetico-deductive method, demonstrative induction is capable of producing theories with much richer empirical and (...) epistemological value. Delimitation against hypothetically deduced theories is closely connected with criticism of mechanical materialism, most notably in a form proposed by René Descartes. Consequently, it has led Newton to not only reject the universality of mechanical premise but also to certain level of immunization against all competitive hypothetically based theories. (shrink)

Model-theoretic concepts of saturation and categoricity are studied in the context of accessible categories. Accessible categories which are categorical in a strong sense are related to categories of $M$-sets ($M$ is a monoid). Typical examples of such categories are categories of $\lambda$-saturated objects.

Finitary quasivarieties are characterized categorically by the existence of colimits and of an abstractly finite, regularly projective regular generator G. Analogously, infinitary quasivarieties are characterized: one drops the assumption that G be abstractly finite. For (finitary) varieties the characterization is similar: the regular generator is assumed to be exactly projective, i.e., hom(G, –) is an exact functor. These results sharpen the classical characterization theorems of Lawvere, Isbell and other authors.

Many experimental found footage films base their meanings and effects on an interaction between the figurative content of the image and its material-technological underpinnings. Can this interaction arise accidentally without artistic appropriation? A recently digitised film by the Czech cinema pioneer Jan Kříženecký, Opening Ceremony of the Čech Bridge (1908), presents such an exercise in accidental aesthetics. At one point, the horizontal and vertical trembling of the cinematograph – obtained from the Lumière brothers – translates into a trembling of the (...) figures on the bridge so precisely that the figurative and material spheres appear to cooperate towards a common aesthetic goal. To account for such phenomena, film theory, found footage filmmaking, and archival practice need to join forces with philosophy. More specifically, Gilbert Simondon's notion of transduction, a process based on the intersection of diverse realities within a domain, allows us to conceptualise the paradoxical interaction between the figurative and material dimensions and the unintentional meanings that arise out of it. Transduction enables the distribution of elements between these heterogeneous spheres while maintaining a certain stability within a system. In the case of archival films in which transduction occurs without prior intention or expectation, transduction can be foregrounded and prolonged. The connection between transduction and the “trembling meaning” of Opening Ceremony, understood within the wider context of camera instability in experimental found footage, will uncover the aesthetic potentialities held by the autonomous creativity of film matter and its interferences with the figurative content. (shrink)

We study search problems and reducibilities between them with known or potential relevance to bounded arithmetic theories. Our primary objective is to understand the sets of low complexity consequences of theories Si2 and Ti2 for a small i, ideally in a rather strong sense of characterization; or, at least, in the standard sense of axiomatization. We also strive for maximum combinatorial simplicity of the characterizations and axiomatizations, eventually sufficient to prove conjectured separation results. To this end two techniques based on (...) the Herbrand's theorem are developed. They characterize/axiomatize Σb1-consequences of Σb2-definable search problems, while the method based on the more involved concept of characterization is easier and gives more transparent results. This method yields new proofs of Buss' witnessing theorem and of the relation between PLS and Σb1, and also an axiomatization of Σb1. (shrink)

In Fechner's psychophysics, the 'mental' and the 'physical' were conceived as two phenomenal domains, connected by functional relations, not as two ontologically different realms. We follow the path from Fechner's foundational ideas and Mach's radical programme of a unitary science to later approaches to primary, psychophysically neutral experience (phenomenology, protophysics). We propose an 'integral psychophysics' as a mathematical study of law-like, invariant structures of primary experience. This approach is illustrated by a reinterpretation of psychophysical experiments in terms of perceptual situations (...) involving a constructed apparatus and an instructed subject. The problematic notion of 'measurement of sensation' is thus eliminated: 'sensations' are merely indices for classes of perceptually equivalent configurations (states of the apparatus) specified by the instruction. The locus of the measured is in the inter-subjectively shared, communicable world—not inside the subject's mind. Finally we discuss the role of integral psychophysics as a scientia prima , logically and methodically preceding physics and psychology. (shrink)

The article presents an overview concerning Heidegger's work and life, especially with respect to the contemporary state of publishing of his texts. The article aims at showing a continuity in Heidegger's Thinking of Being on one hand, but, on the other hand, stresses also necessity of a new assessment of his thought, if we take into consideration some recently published manuscripts (especially vol. 65 and 66). The necessity of a new assessment concerns also his personal standpoints during the time of (...) his rectorate in 1933-34. The new documents are presented in volume 16 (published in 2000). The author is convinced that Heidegger is a philosopher of our future. We are still waiting for a truly philosophical assessment and exploiting of his work. (shrink)

If S, T are stationary subsets of a regular uncountable cardinal κ, we say that S reflects fully in $T, S , if for almost all α ∈ T (except a nonstationary set) S ∩ α is stationary in α. This relation is known to be a well-founded partial ordering. We say that a given poset P is realized by the reflection ordering if there is a maximal antichain $\langle X_p; p \in P\rangle$ of stationary subsets of $\operatorname{Reg}(\kappa)$ so that (...) $\forall p, q \in P \forall S \subseteq X_p, T \subseteq X_q \text{stationary}: (S We prove that if $V = L\lbrack\overset{\rightarrow\mathscr{U}}\rbrack, o^\mathscr{U} (\kappa) = \kappa^{++}$ , and P is an arbitrary well-founded poset of cardinality ≤ κ + then there is a generic extension where P is realized by the reflection ordering on κ. (shrink)

Přehledová studie sleduje a analyzuje proměny pojmu sociální inovace. Na základě silné společenské poptávky se z původně dílčí, teoreticky nediskutované a nefixované kategorie stává kategorie obecná. Pokrývá širokou oblast nemateriálních inovací a zároveň se profiluje jako aktivita normativní a intencionální, zaměřená na obecně uznávané sociální cíle. Co do ideově-hodnotových orientací současných koncepcí sociálních inovací studie identifikuje kromě mainstreamu, který zůstává u otevřených hodnotových charakteristik, ještě směr emancipačně-mobilizační a sociálně-tržně odpovědný. V epistemologické rovině se teoretici sociálních inovací hlásí především k praktickému (...) experimentování, pragmatismu, teorii komplexnosti a principům transdisciplinarity. (shrink)

The classical liberal approach to deregulation is based on the consecutive elimination of state regulatory activities and their substitution by competitive market structure. Increasing competition accompanied with decreasing arbitrary state agencies’ interventions will undoubtedly cultivate the behaviour of market agents and bring benefits to consumers.The classical liberal approach to deregulation is incompatible with the EU deregulation model, which in case of network industries is still based on the permanent existence of regulatory agencies, Third-Party-Access, public service liability, centralized control of investments (...) and the negative reciprocity. The adoption of these principals will at least delay deregulation process in transition economies but will likely preserve the cartel structure on the utility markets.Economics of regulation and implicitly economics of deregulation is a product of the Chicago School of Economics. Since current “deregulation process” leads to tighter regulation, the adequate term for it should be the reregulation.L’approche libérale classique de la réglementation repose sur l’élimination de la réglementation étatique et leur substitution par des structures marchandes concurrentielles. Une concurrence accrue et une diminution des interventions arbitraires de l’état ne pourront que modifier le comportement des agents sur le marché et engendrer des bénéfices pour les consommateurs.L’approche de la déréglementation du libéralisme classique est incompatible avec le modèle de déréglementation de l’Union Européenne : dans le cas des industries en réseau, ce dernier demeure fondé sur l’existence continue d’agences de réglementation, la responsabilité du service public, le contrôle centralisé des investissements et la réciprocité négative. L’adoption de ces principes aura pour effet au moins de retarder le processus de déréglementation dans les économies en transition et probablement aussi de préserver la structure cartellisée des marchés de services publics.L’économie de la réglementation, et par implication, l’économie de la déréglementation est une contribution émanant de l’Ecole d’Economie de Chicago. Parce que les “processus de déréglemen- tation” en vigueur induisent des réglementations plus drastiques, l’expression appropriée devrait plutôt être la re-réglementation. (shrink)

We investigate the interactions of formula complexity in weak set theories with the axioms available there. In particular, we show that swapping bounded and unbounded quantification preserves formula complexity in presence of the axiom of foundation weakened to an arbitrary set base, while it does not if the axiom of foundation is further weakened to a proper class base. More attention is being paid to the necessary axioms employed in the positive results, than to the combinatorial strength of the positive (...) results themselves. (shrink)

The aim of this article is to demonstrate the phenomenologically grounded dynamics of hearing and listening as a possible approach to our sonic experience. Its starting point is the studies of contemporary urban spaces devoted to their sonic experience. The results of these studies and their interpretation will serve as a starting point for the introduction of dynamics of hearing and listening. In the next part of this article, I will focus on the elaboration of this relationship with regard to (...) the critique of Husserl’s concept of activity and passivity in his late work Experience and Judgment and Merleau-Ponty’s concept of being-in-the-world. Based on this, in the end, certain common features will be shown, connecting the thematization of activity and passivity with the relationship of hearing and listening. (shrink)

David Lewis’ modal counterpart theory falls prey to the famous Saul Kripke’s objection, and this is mostly due to his ‘static’ ontology of possible worlds. This paper examines a genuinely realist but different, branching ontology of possible worlds and a new definition of the counterpart relation, which attempts to provide us with a better account of de remodality, and to meet satisfactorily Kripke’s claim, while being also ontologically more ‘parsimonious’.

David Lewis’ modal counterpart theory falls prey to the famous Saul Kripke’s objection, and this is mostly due to his ‘static’ ontology of possible worlds. This paper examines a genuinely realist but different, branching ontology of possible worlds and a new definition of the counterpart relation, which attempts to provide us with a better account of de remodality, and to meet satisfactorily Kripke’s claim, while being also ontologically more ‘parsimonious’.

Existentialism became one of the most fashionable philosophical currents in postwar Czechoslovakia. Whereas the orthodox Marxism of the 1950s, following Lukács’s Marxism or existentialism?, hastily condemned existentialism as an offshoot of bourgeois idealism, Marxists of the 1960s viewed existentialism as a philosophical current that deserved, at the least, serious examination. During the subsequent era of Czechoslovak “real” socialism of the 1970s and 1980s, existentialism was, as a result, interpreted as one of the sources of the 1968 “counterrevolution.” This article maps (...) and analyzes the official Marxist reception of existentialism in the course of the Stalinist, post-Stalinist and so-called real socialist periods of Czechoslovak history. However, its main focus is on the post-Stalinist period, when Czechoslovak philosophy benefited from a lively debate between Marxism and existentialism. Some participants in this debate considered existentialism to be an important rival to Marxism, one that posed the very same questions yet offered slightly different answers. At the center of the polemics lay the existentialist categories of being, existence, and freedom. (shrink)

Abstrakt/Abstract Článek pojednává o buddhistické logice a jejím vztahu k logice aristotelské, zejména k principu sporu a principu vyloučeného třetího. Dotkne se také dialetheismu a parakonzistentních logik, které se v souvislosti s interpretacemi buddhismu objevují. The article deals with the Buddhist logic and its relation to Aristotle’s logic, in particular, to the principle of non-contradiction and the principle of exluded middle. It also tackles the topic of dialetheism and paraconsistent logics, which are sometimes mentioned in connection with the interpretations of (...) Buddhism. (shrink)

In this paper we discuss the process of building a joint probability distribution from an input set of low-dimensional probability distributions. Since the solution of the problem for a consistent input set of probability distributions is known we concentrate on a setup where the input probability distributions are inconsistent. In this case the iterative proportional fitting procedure, which converges in the consistent case, tends to come to cycles. We propose a new algorithm that converges even in inconsistent case. The important (...) property of the algorithm is that it can be efficiently implemented exploiting decomposability of considered distributions. (shrink)