The activity of Wnt and Notch signalling is central to many cell fate decisions during development and to the maintenance and differentiation of stem cell populations in homeostasis. While classical views refer to these pathways as independent signal transduction devices that co‐operate in different systems, recent work has revealed intricate connections between their components. These observations suggest that rather than operating as two separate pathways, elements of Wnt and Notch signalling configure an integrated molecular device whose main function is to (...) regulate transitions between cell states in development and homeostasis. Here, we propose a general framework for the structure and function of the interactions between these signalling systems that is focused on the notion of ‘transition states’, i.e. intermediates that arise during cell fate decision processes. These intermediates act as checkpoints in cell fate decision processes and are characterised by the mixed molecular identities of the states involved in these processes.Editor's suggested further reading in BioEssays: Notch: Implications of endogenous inhibitors for therapy Abstract. (shrink)

The increasing application of artificial intelligence (AI) to healthcare raises both hope and ethical concerns. Some advanced machine learning methods provide accurate clinical predictions at the expense of a significant lack of explainability. Alex John London has defended that accuracy is a more important value than explainability in AI medicine. In this article, we locate the trade-off between accurate performance and explainable algorithms in the context of distributive justice. We acknowledge that accuracy is cardinal from outcome-oriented justice because it helps (...) to maximize patients’ benefits and optimizes limited resources. However, we claim that the opaqueness of the algorithmic black box and its absence of explainability threatens core commitments of procedural fairness such as accountability, avoidance of bias, and transparency. To illustrate this, we discuss liver transplantation as a case of critical medical resources in which the lack of explainability in AI-based allocation algorithms is procedurally unfair. Finally, we provide a number of ethical recommendations for when considering the use of unexplainable algorithms in the distribution of health-related resources. (shrink)

Automated legal reasoning and its application in smart contracts and automated decisions are increasingly attracting interest. In this context, ethical and legal concerns make it necessary for automated reasoners to justify in human-understandable terms the advice given. Logic Programming, specially Answer Set Programming, has a rich semantics and has been used to very concisely express complex knowledge. However, modelling discretionality to act and other vague concepts such as ambiguity cannot be expressed in top-down execution models based on Prolog, and in (...) bottom-up execution models based on ASP the justifications are incomplete and/or not scalable. We propose to use s(CASP), a top-down execution model for predicate ASP, to model vague concepts following a set of patterns. We have implemented a framework, called s(LAW), to model, reason, and justify the applicable legislation and validate it by translating (and benchmarking) a representative use case, the criteria for the admission of students in the “Comunidad de Madrid”. (shrink)

Volume 20, Issue 7, July 2020, Page 106-109.

Background: This research explores how public awareness and attitudes toward donation and transplantation policies may contribute to Spain's success in cadaveric organ donation. Materials and Methods: A representative sample of 813 people residing in Andalusia (Southern Spain) were surveyed by telephone or via Internet between October and December 2018. Results: Most participants trust Spain's donation and transplantation system (93%) and wish to donate their organs after death (76%). Among donors, a majority have expressed their consent (59%), and few nondonors have (...) expressed their refusal (14%). Only a minority are aware of the presumed consent system in force (28%) and feel sufficiently informed regarding the requirements needed to be an organ donor (16%). Participants mainly consider that relatives should represent the deceased's preferences and be consulted when the deceased's wishes are unknown, as is the case in Spain. Conclusion: Public trust in the transplant system may contribute to Spain's high performance in organ donation. High levels of societal support toward organ donation and transplantation do not correspond with similar levels of public awareness of donation and transplantation policies in Spain. (shrink)

Critical edition, translation and commentary of an epigram addressed by Arias Montano to Hernando Díaz, from a copy probably made by Juan Moreno Ramírez. Diaz was also gifted with knives made by Lancero in Guadalajara.

En el presente artículo se pretende poner en relación la noción de kénosis, sobre la que se configura esencialmente la concepción hermenéutica de la religión en Gianni Vattimo, con la pretensión emancipatoria que surge del nihilismo hermenéutico. Para ello rastrearemos esa concepción hermenéutica de la verdad que ya no nos violenta, a partir de la cual se estructura la religión del pensamiento débil. Además, constataremos cómo la concepción hermenéutica de la metafísica, aparte de presentarse como clave de la secularización, permitirá (...) identificar la salvación con la interpretación. Sobre estos presupuestos generales de su filosofía Vattimo anuncia la venida de Jesús como fenómeno hermenéutico. Tendremos que preguntarnos finalmente si las posibilidades de este planteamiento trágico de la kénosis se llevan hasta sus últimas consecuencias con el anuncio sociopolítico de una emancipación de corte hermenéutico. (shrink)

Emotional stimuli (e.g. words, images) are often remembered better than neutral stimuli. However, little is known about how memory is affected by an environmentally induced emotional state (without any overtly emotional occurrences) – the focus of this study. Participants were randomly assigned to discovery (n = 305) and replication (n = 306) subsamples and viewed a desktop virtual environment before rating their emotions and completing objective (i.e. item, temporal-order, duration) and subjective (e.g. vividness, sensory detail, coherence) memory measures. In both (...) samples, a Partial Least Squares Correlation analysis showed that an emotional state characterised by high negative emotion (i.e. threat, fear, anxiety) and arousal was reliably associated with better memory in both objective (i.e. item) and subjective (i.e. vividness and sensory detail) domains. No reliable associations were observed for any temporal memory measures (objective or subjective). Thus, an environmentally induced state of negative emotion corresponds with enhanced memory for indices of episodic memory pertaining to “what” happened, but not necessarily “when” it happened. (shrink)

Con el objetivo de evidenciar la forma en que la diversidad sociodemográfica ha resignificado el proceso de desarrollo territorial y origina líneas de fuga que trascienden la hegemonía de los poderes económicos-políticos-ambientales en los Llanos-Orientales, se realiza una metodología experimental que combina análisis situacionales, la genealogía, y la reconstrucción histórica de fenómenos sociales a través de 87 entrevistas a líderes sociales entre el 2019-2021. Los resultados muestran un territorio de activa conexión cultural que favorecen la lucha contra hegemónica dentro de (...) las metáforas de “el mito del Estado nación” y “la imposibilidad de generar alternativas”. El análisis expone la existencia de rebeliones de conducta a través de resistencias cotidianas creativas, políticas y culturales, que favorecen el poder de la confianza, la solidaridad, la cooperación, el afecto, así como los liderazgos colectivos. Se concluye que el poder central no tiene la capacidad de capturar estas resistencias ya que no tiene la potencia analítica para percibir la reconfiguración del espíritu humano ni las variaciones del tejido social. (shrink)

Name der Zeitschrift: Klio Jahrgang: 99 Heft: 1 Seiten: 130-148.

En la literatura sobre las emociones una de las teorías con mayor fuerza es la llamada “teoría James-Lange”. En esta obra se intenta hacer una crítica a dicha teoría a partir de algunas observaciones de Wittgenstein sobre el uso de conceptos psicológicos, sacando a la luz dos confusiones gramaticales que surgen en ella. Para ello, se construye primero la categoría de “programa de naturalización de las emociones” que recoge las teorías del Descartes, James y Prinz, siguiendo la metodología de Lakatos. (...) Luego, se identifica como problema central el de la naturalización de la intencionalidad. Para luego exponer algunas herramientas de Wittgenstein para estudiar la gramática de la pregunta por el objeto y la intencionalidad las emociones, mostrando que las respuestas del programa de naturalización no son satisfactorias y no respetan las reglas de ciertos usos del lenguaje. (shrink)

A key issue in the business ethics field is the design of effective measures for assessing the ethical culture of organizations. The Corporate Ethical Virtues Model (CEV), developed by Kaptein in 2008, is an instrument for measuring ethical culture, and has been applied, adapted and validated in different contexts. In 2013, DeBode, Armenakis, Field and Walker developed the CEV–S, a shortened version of the original scale. Both the CEV and CEV–S assess eight dimensions based on corporate ethical virtues: clarity, congruency (...) of supervisors, congruency of senior management, feasibility, supportability, transparency, discussability and sanctionability. The objective of this study is to present a Spanish version of the CEV–S and its validation process. The scale was applied to two samples of 114 and 193 Colombian employees from two companies operating in the services sector. The confirmatory factor analyses revealed a good fit for the eight-factor structure of the Spanish CEV–S and the statistical tests applied showed good levels of reliability and validity for this scale. The adequate psychometric properties shown by the Spanish CEV–S may support its use in future research to measure organizational ethical culture in Spanish-speaking settings. (shrink)

1. Cine y vanguardias : el cine como promesa estético-política desde Dziga Vertov y Jean Epstein -- 2. Deleuze y las potencias del cine : el acontecimiento de lo inorgánico -- 3. De la vida inorgánica a la vida histórica : recuperación del carácter narrativo del cine a partir de Jacques Ranciere.

Despite continuing controversies regarding the vital status of both brain-dead donors and individuals who undergo donation after circulatory death (DCD), respecting the dead donor rule (DDR) remains the standard moral framework for organ procurement. The DDR increases organ supply without jeopardizing trust in transplantation systems, reassuring society that donors will not experience harm during organ procurement. While the assumption that individuals cannot be harmed once they are dead is reasonable in the case of brain-dead protocols, we argue that the DDR (...) is not an acceptable strategy to protect donors from harm in DCD protocols. We propose a threefold alternative to justify organ procurement practices: (1) ensuring that donors are sufficiently protected from harm; (2) ensuring that they are respected through informed consent; and (3) ensuring that society is fully informed of the inherently debatable nature of any criterion to declare death. (shrink)

Bioethicists involved in end‐of‐life debates routinely distinguish between ‘killing’ and ‘letting die’. Meanwhile, previous work in cognitive science has revealed that when people characterize behaviour as either actively ‘doing’ or passively ‘allowing’, they do so not purely on descriptive grounds, but also as a function of the behaviour’s perceived morality. In the present report, we extend this line of research by examining how medical students and professionals (N = 184) and laypeople (N = 122) describe physicians’ behaviour in end‐of‐life scenarios. (...) We show that the distinction between ‘ending’ a patient’s life and ‘allowing’ it to end arises from morally motivated causal selection. That is, when a patient wishes to die, her illness is treated as the cause of death and the doctor is seen as merely allowing her life to end. In contrast, when a patient does not wish to die, the doctor’s behaviour is treated as the cause of death and, consequently, the doctor is described as ending the patient’s life. This effect emerged regardless of whether the doctor’s behaviour was omissive (as in withholding treatment) or commissive (as in applying a lethal injection). In other words, patient consent shapes causal selection in end‐of‐life situations, and in turn determines whether physicians are seen as ‘killing’ patients, or merely as ‘enabling’ their death. (shrink)

Since 1968, the irreversible loss of functioning of the whole brain, called brain death, is assimilated to individual’s death. The almost universal acceptance of this neurological criterion of death had decisive consequences for the contemporary medicine, such as the withdrawal of mechanical ventilation in these patients and organ retrieval for transplantation. The new criterion was successfully accepted in part because the assimilation of brain death state to death was presented by medicine --and acritically assumed by most of societies-- as a (...) scientific and objective fact. Nevertheless, many people do not think that the patients suffering brain death are actually dead. We show here that those people are not necessarily wrong. It can be argued that, in fact, the justification of the neurological criterion is not scientific but moral. We outline the thesis that the problem surrounding the vital status of brain dead patients is due to a confusion between factual and normative questions. Furthermore, we claim that the donation of organs and the withdrawal of life-support could be ethically acceptable even if the patients suffering brain death are considered as alive. As an alternative to the dead donor rule, we propose a justification for organ donation of brain-dead patients based on the (moral) concepts of harm and consent : what truly justifies the procurement of organs on those patients is not that they are dead, but that they wish to donate their organs and that, since they have irreversibly lost their brain, they cannot be harmed. (shrink)

Feminist reflections on the sexual division of labour have given rise to a body of knowledge on the ethics of care from different disciplines, including philosophy, in which outstanding contributions to the topic have been formulated. This approach is applicable to the analysis of any phenomenon and particularly that of disasters. As various investigations have highlighted, the consequences on the population throughout all of a disaster’s phases (prevention, emergency, and reconstruction) require an analysis of differentiated vulnerabilities based on gender and (...) other identity categories, such as social class, ethnicity, age, disability, sexual identity, etc. The interrelation between all these variables gives rise to differentiated impacts that cannot be ignored in catastrophic contexts, where survival and sustaining life are at stake, so care becomes a central issue. Research on the topic has also identified that, along with the analysis of social vulnerability, we must consider the capacity for agency, both individual and collective, where care is once again of vital importance. Considering the gender approach and its multiple intersections is thus a fundamental theoretical-practical proposal for the study of disasters from philosophy, as it implies an unavoidable epistemic, ontological, and ethical reflection in the face of risk reduction. (shrink)

Nietzsche wanted to affirm life in its totality without dispensing with either the joy of affirmation or the tragic energy of the most terrible that it implies. His thought and his life bore witness to this. However, a task of such magnitude requires the affinity of other spirits who are capable of traveling other paths than those of ascent. Bataille's immanent mysticism knows that in the sovereignty of excess the limitlessness of expenditure allows us to descend into the sacred spaces (...) of the curse. The present work wants to delve into such a physiological inner experience to see whether the Nietzschean affirmation can be consummated in this way. Como sabemos Nietzsche quiso afirmar la vida en su totalidad sin prescindir ni de la alegría misma de la afirmación, ni de la energía trágica de lo más terrible que ello implica. Sin embargo, una tarea de esa magnitud requiere la afinidad de otros espíritus que sean capaces de recorrer otras vías distintas a las del ascenso. El misticismo inmanente de Bataille sabe bien que en la soberanía del exceso la ilimitación del gasto nos permite descender a los espacios sagrados de la maldición. La afirmación nietzscheana parece querer consumarse de este modo. (shrink)

In the wake of corporate ethical scandals that have harmed millions of employees and investors, there has been an increase in the number of works written in the last decade, which aim to answer one apparently simple question: what causes unethical behavior, and what can we do, if anything, to prevent similar transgressions in the future? The extensive research around this question is the best proof of its real complexity as the challenge of disentangling the background of ethical behavior has (...) obvious academic and practical interest. This study aims to take a further step toward that goal. Much research has noted the impact of multiple aspects of organizational contexts on individuals’ ethical behavior. However, studies that analyze the impact of organizational learning capability (OLC) on employees’ ethical behavior are few and far between. This was the first aim of this study. The second centered on gaining a deeper understanding of the relationship between OLC and ethical behavior by analyzing the mediating role of employability and organizational commitment. We tested our hypotheses through a structural equation methodology applied to a sample of 641 workers from 166 Spanish consultancy firms and found a positive, direct relationship between OLC and employability, OLC and organizational commitment, employability and organizational commitment, and organizational commitment and ethical behavior. (shrink)

Resumen: Este artículo consiste en un comentario del ensayo Ser justo con Freud: La historia de la locura en la era del psicoanálisis de Derrida con el objeto de rastrear lo que no puede ser reapropiado por la presuposición del marco del debate entre Derrida y Foucault. Al analizar la pregunta “¿quién anuncia el no-recurso?”, exploraré la forma en que la escritura de Derrida es afectada por la necesidad e imposibilidad de no reprimir la sinrazón. Argumentaré que Derrida compulsivamente escribe (...) los efectos de dicha resistencia a no reprimir la sinrazón a través de la repetición de la búsqueda Foucaultiana de un más allá de la razón. Esta “compulsión de repetición’ no solamente reabre una y otra vez el debate, sino que desencadena el retorno de la sinrazón en la forma de un desarreglo de los principios de identidad y tiempo lineal, desestabilizando todo forma de autoría sobre la historia de la locura en general y cada una de sus críticas. Este artículo se aproxima a los intercambios entre Derrida y Foucault deconstruyendo la premisa de la posibilidad de un debate sobre la historia de la locura. (shrink)

Several studies have explored differences between North American and European doctor patient relationships. They have focused primarily on differences in philosophical traditions and historic and socioeconomic factors between these two regions that might lead to differences in behaviour, as well as divergent concepts in and justifications of medical practice. However, few empirical intercultural studies have been carried out to identify in practice these cultural differences. This lack of standard comparative empirical studies led us to compare differences between France and the (...) USA regarding end-of-life decision-making. We tested certain assertions put forward by bioethicists concerning the impact of culture on the acceptance of advance directives in such decisions. In particular, we compared North American and French intensive care professional's attitudes toward: (1) advance directives, and (2) the role of the family in decisions to withhold or withdraw life-support. (shrink)

La internacionalización de las economías exige de los gobiernos el fortalecimiento de las relaciones comerciales con otros países en todo el planeta. Las herramientas más utilizadas en las últimas décadas han sido los tratados de libre comercio que, además de la desgravación total o parcial y progresiva, implican cambios en las condiciones internas relativas a la normatividad aplicada, con el ánimo de facilitar las relaciones de comercio, la búsqueda de un lenguaje aduanero común, así como la estandarización de las operaciones (...) aduaneras. Es una exigencia cada vez mayor que obliga a que se hagan ajustes a los procesos y procedimientos internos; aunado a ello, están los organismos multilaterales a los que cada vez se unen más países, con el propósito de buscar mejores condiciones económicas, políticas y sociales para sus administrados, pero es necesario prestar atención a las afectaciones que tales exigencias e implementaciones presuponen no solo en el ordenamiento interno, sino en la aplicación misma de las normas. (shrink)

La revisión de las humanidades a partir de la cultura material parte de la consideración de que la conciencia y la agencia humanas no pueden disociarse de su nicho tecnológico. El presente artículo trata de indagar cómo la experiencia subjetiva de la ciudad se ha visto modificada por la universalización del smartphone como herramienta de orientación a través de los sistemas de navegación gps. Con este fin, y a través del marco teórico formulado por Henri Lefebvre, el artículo realiza un (...) análisis exploratorio acerca de la producción del espacio urbano contemporáneo. Recurriendo a la revisión crítica de la teoría cartográfica, interroga si la universalización de los mapas digitales supone una recuperación de la experiencia subjetiva o una extensión del espacio abstracto propio del capitalismo de la experiencia. (shrink)

Los estados normativos solo pueden ser percibidos a partir de su frustración. Partiendo de esta premisa, el presente artículo propone una definición filosófica de la inseguridad social, basada en la reciente revisión de la función práctica y cognitiva de dos emociones tradicionalmente entendidas como negativas: el resentimiento y la ansiedad. Se analizará el resentimiento como un potencial generador de vínculos políticos en la memoria de un pasado de protección arrebatada, y la ansiedad como un indicador epistémico en condiciones de incertidumbre (...) objetiva. Se colige una definición de la inseguridad acotada entre la retención resentida del pasado y la proyección preventiva del futuro. Normative states can only be experienced from their frustration. Based on this premise, this article proposes a philosophical definition of social insecurity, based on the recent review of the practical and cognitive function of two emotions traditionally understood as negative: resentment and anxiety. Resentment will be analyzed as a potential generator of political links in the memory of a past of rapt protection, whereas anxiety wil be understood as an epistemic indicator in conditions of objective uncertainty. A definition insecurity will be set between the resentful retention of the past and the preventive projection of the future. (shrink)