Covering the "long" Enlightenment, from the rise of Descartes' disciples in 1670 to the restoration of the Bourbon monarchy in 1815, the Encyclopedia of the Enlightenment contains articles ranging from discussions of mercantilism and democracy to the dissemination of ideas in salons and coffeehouses. It is also an e-reference text from Oxford's Digital Reference Shelf.

While largely studied because of their harmful effects on human health, there is growing appreciation that bacteria are important partners for invertebrates and vertebrates, including man. Epithelia in metazoans do not only select their microbiota; a coevolved consortium of microbes enables both invertebrates and vertebrates to expand the range of diet supply, to shape the complex immune system and to control pathogenic bacteria. Microbes in zebrafish and mice regulate gut epithelial homeostasis. In a squid, microbes control the development of the (...) symbiotic light organ. These discoveries point to a key role for bacteria in any metazoan existence, and imply that beneficial bacteria‐host interactions should be considered an integral part of development and evolution. (shrink)

This paper explores structuralism as a way to model theories from scientific practice. As a case study I analyzed a theory about the dynamics of the basal ganglia, a part of the brain that is involved in Parkinson's disease. After introducing the case study I explore how to structurally represent qualitative assumptions about disease, intervention and dynamical systems in general. I further explicate the structure of the basal ganglia theory in detail, how it explains Parkinson's disease and how it implies (...) treatments. I close with a consideration of how a structuralist representation could be useful in practice to explore and develop theories with the aid of a computer. (shrink)

Fiodor Dostoievski rasga el alma humana hasta dejarla herida por el sufrimiento, la culpa y el aislamiento. Y, sin embargo, la derrota no gana la batalla. La escritora sureña estadounidense Carson McCullers escribe sobre la soledad y la miseria del sur de los Estados Unidos con una mirada atenta a los paisajes desolados de la Rusia de Fiodor Dostoievski, no sólo físicos sino esencialmente metafísicos. Esta autora que ya leyó al maestro ruso a los 13 años explora las entrañas humanas (...) desde un terreno rural, desolador, inhóspito y desafortunado, con diferencias raciales, sobreexposición de alcohol y con un concepto de bien moral interno que aparece como una pulsión constante e inagotable. En esta aproximación queremos destacar cómo el misterio del mal, pero también el acto de la voluntad y la incomunicación, son aspectos que unen a ambos autores, especialmente en dos de sus obras maestras, Crimen y Castigo y El corazón es un cazador solitario, respectivamente. (shrink)

Many Western countries have introduced market principles in healthcare. The newly introduced financial instrument of “care-intensity packages” in the Dutch long-term care sector fit this development since they have some characteristics of a market device. However, policy makers and care providers positioned these instruments as explicitly not belonging to the general trend of marketisation in healthcare. Using a qualitative case study approach, we study the work that the two providers have done to fit these instruments to their organisations and how (...) that enables and legitimatises market development. Both providers have done various types of work that could be classified as market development, including creating accounting systems suitable for markets, redefining public values in the context of markets, and starting commercial initiatives. Paradoxically, denying the existence of markets for long-term care and thus avoiding ideological debates on the marketisation of healthcare has made the use of market devices all the more likely. Making the market invisible seems to be an operative element in making the market work. Our findings suggest that Dutch long-term care reform points to the need to study the ‘making’ rather than the ‘liberalising’ of markets and that the study of healthcare markets should not be confined to those practices that explicitly label themselves as such. (shrink)

Six experiments investigated variables predicted to influence subjects’ tendency to classify items by a single property instead of overall similarity, following the paradigm of Norenzayan et al., who found that European Americans tended to give more “logical” rule-based responses. However, in five experiments with Mechanical Turk subjects and undergraduates at an American university, we found a consistent preference for similarity-based responding. A sixth experiment with Korean undergraduates revealed an effect of instructions, also reported by Norenzayan et al., in which classification (...) instructions led to majority rule-based responding but similarity instructions led to overall similarity grouping. Our American subjects showed no such difference and used similarity more overall. We conclude that Americans do not have a preference for rule responding in classification and discuss the differences between tasks that reliably show strong rule or unidimensional preferences in contrast to this classification paradigm. (shrink)

Corporate citizenship challenges the foundations and working of the basic institutions market, state and civil society. These institutional changes complicate the work of the manager, because the responsibilities of management are not only increasing, they are also becoming vaguer and more elusive. In this paper, I will analyze the new, complex responsibilities of management in terms of the scope and the legitimizationof corporate citizenship. What may we expect of individual organizations? Which wishes of which stakeholders should be honored? How can (...) we legitimize the new societal and public role of business firms? The outcome of this analysis will be translated to the practice of management; how can we strengthen the social responsibility of managers? Four options will be discussed. (1) Market regulation, which binds the actions of managers. (2) Professionalization of management, which seeks for better information. (3) Moral management, which incorporates norms and values from outside the market. (4) Stakeholder management, which leaves room for the participation of stakeholders. These options can be schematized according to an internal-external axis and an objective-subjective axis. I will show that stakeholder management fits the best with the idea of corporate citizenship, but has serious risks of failing. (shrink)

The article is devoted to spelling errors of Russian learners in a French-speaking environment. Based on 1,816 spelling errors, the analysis focuses on four mechanisms (transposition, insertion, omission, and substitution), and the influence of contextual and non-contextual (cognitive, inter- and intralinguistic, extralinguistic) factors is taken into account for each mechanism in question. Despite the multidimensional nature of the factors involved, the recurrence of certain errors makes it possible to distinguish clear trends in the acquisition of linguistic facts. In addition, a (...) quantitative analysis of the obtained data allows cross-sectional studies of errors, which traces back the steps in the acquisition of various aspects of Russian spelling, from A1 to C1 level for the first time. Moreover, the qualitative analysis of errors provides valuable data for pedagogical materials. (shrink)

En la obra de Hegel la filosofía de lo bello es eminentemente filosofía del espíritu. Uno de los temas insoslayables acerca de la belleza es su presencia en la naturaleza y en el arte. En las Lecciones de Estética la belleza del arte se pondera como la más excelente. En este punto la postura hegeliana diverge llamativamente de la de Schelling; quien trató explícitamente de la relación de las artes plásticas con la naturaleza, como consta en el texto que lleva (...) este tema por título (generalmente llamado “discurso de la academia”). Su propuesta es clara: la superioridad de la naturaleza frente a las artes plásticas. Lo más interesante de esta disputa no es el desacuerdo en sí mismo, sino las argumentaciones que uno y otro autor alegan a favor de sus tesis respectivas. (cuánto se parece y cuánto divergen) A través de ellas se pueden ver los diversos matices en torno a los conceptos de belleza y de espíritu. A esta cuestión es a lo que se dedicará esta comunicación: a analizar brevemente algunos argumentos de ambos autores acerca de la belleza en la naturaleza y en el arte. A lo largo de este artículo se lleva a cabo una comparación de textos, de algunas discrepancias concretas: en todas ellas lo llamativo es cómo son a la vez tan cercanos y tan contrarios. Tanto para Schelling como para Hegel, la belleza es del espíritu: lo más bello es lo que está penetrado de espíritu y es vivificado por él. Pero más allá de estos principios comunes hay mil matices que acaban desembocando en dos posturas contrapuestas. (shrink)

Using data from 1,352 middle-school Israeli adolescents, the current study examines the interface of spirituality and character strengths and its longitudinal contribution to subjective well-being and prosociality. Participants were approached three times over a 14-months period and completed measures of character strengths, spirituality, subjective well-being (positive emotions, life satisfaction), and prosociality. Findings revealed a fourth-factor structure of character strengths that included the typical tripartite classification of intrapersonal, interpersonal, and intellectual strengths together with spirituality emerging as a statistically autonomous factor. Spirituality (...) was stable over time and contributed to higher subjective well-being and prosociality both cross-sectionally and longitudinally. Discussion focuses on spirituality as a fundamental character strength and an important aspect of positive development. (shrink)

If one of the most important aims of education on military ethics is to strengthen moral competence, we argue that it is important to base ethics education on virtue ethics, the Socratic attitude and the process of ?living learning?. This article illustrates this position by means of the example of a ?train the trainer? course on military ethics for Non-Commissioned Officers (NCOs), which is developed at the Netherlands Defence Academy, and uses a number of examples both from its structure and (...) from experiences from its actual use. (shrink)

Defining the Enlightenment as the "long eighteenth century," the Encyclopedia focuses on the entire range of philosophic and social changes engendered by the Enlightenment. It extends the conventional geographical boundaries of the Enlightenment, covering not only France, England, Scotland, the Low Countries, Italy, English-speaking North America, the German states, and Hapsburg Austria but also Iberian, Ibero-American, Jewish, Russian, and Eastern European cultures. Nor does the Encyclopedia of the Enlightenment limit itself to major centers like Paris in France and Edinburgh in (...) Scotland, but shares the rich lode of recent scholarship on "secondary" and "provincial" centers such as Berlin and Geneva; Philadelphia and Milan. The Encyclopedia of the Enlightenment brings a similar spirit of inclusion to the new theoretical and methodological approaches that have flowered in the humanities during the past two decades. Including feminist and various post-modernist reassessments alongside more traditional perspectives, the four volumes offer the broadest possible range of current knowledge. Accessibility combined with scholarly rigor make the encyclopedia the first choice for researching any aspect of the Enlightenment. Designed and organized for ease of use, its special features include more than 700 signed articles; annotated bibliographies following each article to guide further study; an extensive system of cross-references; a synoptic outline of contents; a comprehensive topical index providing easy access to networks of related articles; and high quality illustrations, including photographs, line drawings, and maps. (shrink)

John Stuart Mill is the critical transitional figure between the classical liberalism of the 19th century, with its emphasis upon the creative power of free individuals unfettered by government or social interventions, and the welfare-state liberalism of the 20th century, with its combination of individual choice in matters of belief and lifestyle and the political redistribution of wealth. In On Liberty and The Subjection of Women , Mill offered a defense of self-sovereignty and voluntary association that appeared to extend explicitly (...) to the economic spheres. Both works are celebrations of the productive and moral enhancements of individual liberty. In The Principles of Political Economy , however, Mill's categorical distinction between “production” and “distribution” assigned the latter to the “expedient” discretion of the state, inviting, in theory, a democratic redistributionist state. Mill's posthumous Essays on Socialism reveal that he was no friend of socialism or Marxism, but that he welcomed a more active and interventionist state. One of individual liberty's most notable defenders, paradoxically, provided the theoretical underpinning of its current diminution. (shrink)

Increasing complexity of projects is mentioned as one of the reasons for project failure—still. This paper presents a comparative research to investigate how project complexity was perceived by project practitioners in different industry sectors. Five sectors were included: process industry, construction industry, ICT, high-tech product development, and food processing industry. In total, more than 140 projects were included in the research, hence providing a broad view on Dutch project practice. From the complexity assessments, it is concluded that only one complexity (...) element was present in the top complexity elements of projects across the five sectors: the high project schedule drive. The variety of external stakeholders’ perspectives, a lack of resources and skills availability, and interference with existing site were found in the top lists of three sectors. It was concluded that a framework to grasp project complexity could support the management of complex projects by creating awareness for the complexities. Further research could be focused on the subjective character of complexity as well as on the application of cross-sector learning, since this research does show similarities between large technical projects in different sectors. (shrink)

Students of the Enlightenment have long assumed that the major movement towards atheism in the Ancien Régime was centered in the circle of intellectuals who met at the home of Baron d'Holbach during the last half of the eighteenth century. This major critical study shows, contrary to the accepted views, that in fact, atheism was not the common bond of a majority of the members and that, far from being alienated figures, most of the members were privileged and publicly successful (...) citizens devoted to peaceful and gradual reform. Alan Charles Kors determines the coterie's membership and discovers it to have been a diverse assemblage of philosophes, men of letters, and scientists. Analyzing the thought and behavior of those members who lived past 1789, the author argues that the hostility to the Revolution expressed by the coterie's survivors was fully consistent with their world view. Originally published in 1976. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

This article describes how methodologies of EU-funded research within the life sciences and biomedicine have recently become more gender sensitive. This transformation is the result of the Gender Impact Assessments of the EU Fifth Framework Programme, commissioned in 2000-1. The authors assessed the research programme for life sciences, which includes a large health-related component. The new guidelines for research emphasize the need for clear terminology for concepts of sex and gender and for a distinction to be made between the two, (...) for both life sciences and health research. Attention to possible sex differences, even in preclinical research, as well as to effects of gender, will lead to more adequate research data that serve the health of both men and women. The transformation to research becoming more gender-sensitive is further discussed in the context of feminist theory on the body. Being fully aware of the fact that what is happening in bodies is mediated by particular technologies, the authors make an appeal to invest in concepts that take the living and changing body into account. (shrink)

Peptides serve as important signalling molecules in development and differentiation in the simple metazoan Hydra. A systematic approach (The Hydra Peptide Project) has revealed that Hydra contains several hundreds of peptide signalling molecules, some of which are neuropeptides and others emanate from epithelial cells. These peptides control biological processes as diverse as muscle contraction, neuron differentiation, and the positional value gradient. Signal peptides cause changes in cell behaviour by controlling target genes such as matrix metalloproteases. The abundance of peptides in (...) Hydra raises the question of whether, in early metazoan evolution, cell–cell communication was based mainly on these small molecules rather than on the growth‐factor‐like cytokines that control differentiation and development in higher animals. BioEssays 23:420–427, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Although researchers studying human speech recognition (HSR) and automatic speech recognition (ASR) share a common interest in how information processing systems (human or machine) recognize spoken language, there is little communication between the two disciplines. We suggest that this lack of communication follows largely from the fact that research in these related fields has focused on the mechanics of how speech can be recognized. In Marr's (1982) terms, emphasis has been on the algorithmic and implementational levels rather than on the (...) computational level. In this article, we provide a computational-level analysis of the task of speech recognition, which reveals the close parallels between research concerned with HSR and ASR. We illustrate this relation by presenting a new computational model of human spoken-word recognition, built using techniques from the field of ASR that, in contrast to current existing models of HSR, recognizes words from real speech input. (shrink)

Here we evaluate our current understanding of the function of the nervous system in Hydra, a non‐bilaterian animal which is among the first metazoans that contain neurons. We highlight growing evidence that the nervous system, with its rich repertoire of neuropeptides, is involved in controlling resident beneficial microbes. We also review observations that indicate that microbes affect the animal's behavior by directly interfering with neuronal receptors. These findings provide new insight into the original role of the nervous system, and suggest (...) that it emerged to orchestrate multiple functions including host‐microbiome interactions. The excitement of future research in the Hydra model now relies on uncovering the common rules and principles that govern the interaction between neurons and microbes and the extent to which such laws might apply to other and more complex organisms. (shrink)

Lecture 1. Locke's theory of knowledge, guest lecture / by Alan Kors ; lecture 2. Locke's political theory, guest lecture / by Dennis Dalton ; lecture 3. montesquiey and the beginnings of political science ; lecture 4. Berkeley's idealism and the critique of materialism ; lecture 5. Hume's epistemiology ; lecture 6. Hume's theory of morality ; lecture 7. Smith's wealth of nations ; lecture 8. Rousseau's dissent, the challenge to the idea of progress, guest lecture / by Alan Kors (...) ; lecture 9. Kant's copernicus revolution, epistemiology and the critique of metaphysics ; lecture 10. Kant's moral philosophy ; lecture 11. Burke and the birth of enlightened conservatism ; lecture 12. naturalism and materialism, the boundaries of the enlightenment, guest lecture. (shrink)

This article discusses the meanings, origin, context, scope, and central intellectual claims of atheism in the Age of the European Enlightenment. It emphasizes debates about proofs of the existence of God and about the problem of categorical naturalism, that is, of whether or not the world we observe and its seeming design could be the product of unintelligent causes. It explores the philosophical origins of Enlightenment atheism both in prior heterodox and Epicurean thought, and, of even greater importance, in the (...) orthodox debates, scholarship, and mutual contestations that generated so many of the themes and often arguments of Enlightenment atheists. It pays special attention to the complexity of the relationship between philosophical skepticism and atheistic thought. Given the flowering of explicitly atheistic thought in the late French Enlightenment, the article looks closely at the work of Denis Diderot, the baron d’Holbach, and Jacques-André Naigeon. (shrink)

Cover Photograph: Transgenic Hydra provide insights of general relevance into stem cell biology. The image shows a mass culture of transgenic Hydra expressing EGFP in all of their ectodermal epithelial cells. See article by Thomas C. G. Bosch pp. 478–486.

In recent years, membrane contact sites (MCS), which mediate interactions between virtually all subcellular organelles, have been extensively characterized and shown to be essential for intracellular communication. In this review essay, we focus on an emerging topic: the regulation of MCS. Focusing on the tether proteins themselves, we discuss some of the known mechanisms which can control organelle tethering events and identify apparent common regulatory hubs, such as the VAP interface at the endoplasmic reticulum (ER). We also highlight several currently (...) hypothetical concepts, including the idea of tether oligomerization and redox regulation playing a role in MCS formation. We identify gaps in our current understanding, such as the identity of the majority of kinases/phosphatases involved in tether modification and conclude that a holistic approach—incorporating the formation of multiple MCS, regulated by interconnected regulatory modulators—may be required to fully appreciate the true complexity of these fascinating intracellular communication systems. (shrink)

There is no “after socialism.” There will not be in our or in our children's lifetimes an “after socialism.” In the wake of the Holocaust and the ruins of Nazism, anti-Semitism lay low a bit, embarrassed by its worst manifestation, its actual exercise of state dominion. In the wake of the collapse of Communism, socialism's only real and full experience of power, socialism too lays low for just a moment. Socialism's causes in the West, however, remain ever with us, the (...) product of the convergence of two extraordinary achievements: liberal free enterprise and political democracy. The former creates wealth that has transformed all human possibility, but it also gives rise to particularly deep envy. The latter allows ambition a route to power by an appeal to the democratic state to seize and redistribute wealth in the name of social equality. As Friedrich Hayek and Ludwig von Mises understood perfectly, the bounty of free enterprise leads the unproductive to believe that such wealth is a fact of nature, there for the taking. (shrink)

Atheism was the most foundational challenge to early-modern French certainties. Theologians and philosophers labelled such atheism as absurd, confident that neither the fact nor behaviour of nature was explicable without reference to God. The alternative was a categorical naturalism, whose most extreme form was Epicureanism. The dynamics of the Christian learned world, however, which this book explains, allowed the wide dissemination of the Epicurean argument. By the end of the seventeenth century, atheism achieved real voice and life. This book examines (...) the Epicurean inheritance and explains what constituted actual atheistic thinking in early-modern France, distinguishing such categorical unbelief from other challenges to orthodox beliefs. Without understanding the actual context and convergence of the inheritance, scholarship, protocols, and polemical modes of orthodox culture, the early-modern generation and dissemination of atheism are inexplicable. This book brings to life both early-modern French Christian learned culture and the atheists who emerged from its intellectual vitality. (shrink)

Atheism was the most fundamental challenge to early-modern French certainties. Leading educators, theologians and philosophers labelled such atheism as manifestly absurd, confident that neither the fact nor behaviour of nature was explicable without reference to God. The alternative was a categorical naturalism. This book demonstrates that the Christian learned world had always contained the naturalistic 'atheist' as an interlocutor and a polemical foil, and its early-modern engagement and use of the hypothetical atheist were major parts of its intellectual life. In (...) the considerations and polemics of an increasingly fractious orthodox culture, the early-modern French learned world gave real voice and eventually life to that atheistic presence. Without understanding the actual context and convergence of the inheritance, scholarship, fierce disputes, and polemical modes of orthodox culture, the early-modern generation and dissemination of absolute naturalism are inexplicable. This book brings to life that Christian learned culture, its dilemmas, and its unintended consequences. (shrink)