Pathogenesis in tauopathies involves the accumulation of tau in the brain and progressive synapse loss accompanied by cognitive decline. Pathological tau is found at synapses, and it promotes synaptic dysfunction and memory deficits. The specific role of toxic tau in disrupting the molecular networks that regulate synaptic strength has been elusive. A novel mechanistic link between tau toxicity and synaptic plasticity involves the acetylation of two lysines on tau, K274, and K281, which are associated with dementia in Alzheimer's disease (AD). (...) We propose that an increase in tau acetylated on these lysines blocks the expression of long‐term potentiation at hippocampal synapses leading to impaired memory in AD. Acetylated tau could inhibit the activity‐dependent recruitment of postsynaptic AMPA‐type glutamate receptors required for plasticity by interfering with the postsynaptic localization of KIBRA, a memory‐associated protein. Strategies that reduce the acetylation of tau may lead to effective treatments for cognitive decline in AD. (shrink)

People are ingesting various information from different sense organs all the time to complete different cognitive tasks. The brain integrates and regulates this information. The two significant sensory channels for receiving external information are sight and hearing that have received extensive attention. This paper mainly studies the effect of music and visual-auditory stimulation on electroencephalogram of happy emotion recognition based on a complex system. In the experiment, the presentation was used to prepare the experimental stimulation program, and the cognitive neuroscience (...) experimental paradigm of EEG evoked by happy emotion pictures was established. Using 93 videos as natural stimuli, fMRI data were collected. Finally, the collected EEG signals were removed with the eye artifact and baseline drift, and the t-test was used to analyze the significant differences of different lead EEG data. Experimental data shows that, by adjusting the parameters of the convolutional neural network, the highest accuracy of the two-classification algorithm can reach 98.8%, and the average accuracy can reach 83.45%. The results show that the brain source under the combined visual and auditory stimulus is not a simple superposition of the brain source of the single visual and auditory stimulation, but a new interactive source is generated. (shrink)

As one of the basic elements in acoustic events, timbre influences the brain collectively with other factors such as pitch and loudness. Research on timbre perception involve interdisciplinary fields, including physical acoustics, auditory psychology, neurocognitive science and music theory, etc. From the perspectives of psychology and physiology, this article summarizes the features and functions of timbre perception as well as their correlation, among which the multi-dimensional scaling modeling methods to define timbre are the focus; the neurocognition and perception of timbre (...) are outlined; related experiment findings on the deeper level of timbre perception in terms of neural cognition are summarized. In the meantime, potential problems in the process of experiments on timbre perception and future possibilities are also discussed. Thought sorting out the existing research contents, methods and findings of timbre perception, this article aims to provide heuristic guidance for researchers in related fields of timbre perception psychology, physiology and neural mechanism. It is believed that the study of timbre perception will be essential in various fields in the future, including neuroaesthetics, psychological intervention, artistic creation, rehabilitation, etc. (shrink)