Although germline editing has been the subject of debate ever since the 1980s, it tended to be based rather on speculative assumptions until April 2015, when CRISPR/Cas9 technology was used to modify human embryos for the first time. This article combines knowledge about the technical and scientific state of the art, economic considerations, the legal framework and aspects of clinical reality. A scenario will be elaborated as a means of identifying key ethical implications of CRISPR/Cas9 genome editing in humans and (...) possible ways of dealing with them. Unlike most other discussions of CRISPR/Cas9 germline editing, which are generally based on deontological arguments, the focus in this case will be on a consequentialistic argument against certain applications of germline and somatic editing that takes not only the potential benefits and risks but also socioeconomic issues into consideration. The practical need for an indication catalogue, guidelines for clinical trials, and for funding of basic research will be pointed out. It will be argued that this need for regulatory action and discussion does not stem primarily from the fact that CRISPR/Cas9 germline editing is revolutionary in terms of its ethical implications and potential for human therapy, although this is the prevailing view in the current discussion. Understanding the value and interest dependency of arguments put forward by different stakeholders and learning from past debates related to similar technologies might prove a fruitful method of reaching judgments and decisions that come closer to a consensus upon which society as a whole can agree - which after all should be the true goal of an ethical debate and of bioethics. (shrink)

With service robots becoming more ubiquitous in social life, interaction design needs to adapt to novice users and the associated uncertainty in the first encounter with this technology in new emerging environments. Trust in robots is an essential psychological prerequisite to achieve safe and convenient cooperation between users and robots. This research focuses on psychological processes in which user dispositions and states affect trust in robots, which in turn is expected to impact the behavior and reactions in the interaction with (...) robotic systems. In a laboratory experiment, the influence of propensity to trust in automation and negative attitudes toward robots on state anxiety, trust, and comfort distance toward a robot were explored. Participants were approached by a humanoid domestic robot two times and indicated their comfort distance and trust. The results favor the differentiation and interdependence of dispositional, initial, and dynamic learned trust layers. A mediation from the propensity to trust to initial learned trust by state anxiety provides an insight into the psychological processes through which personality traits might affect interindividual outcomes in human-robot interaction (HRI). The findings underline the meaningfulness of user characteristics as predictors for the initial approach to robots and the importance of considering users’ individual learning history regarding technology and robots in particular. (shrink)

Zusammenfassung Der Artikel argumentiert, dass die Fokussierung religionswissenschaftlicher Forschungen auf religiöse Gegenwartskulturen von einer kritischen Auseinandersetzung mit den Bedingungen von Nationalstaatlichkeit profitieren kann. Zwar setzten sich zahlreiche Studien mit den staatlichen und politischen Kontextbedingungen von Religionsgeschichte auseinander, doch fehlen dabei auffallend häufig Bezüge zu den aktuellen historischen und politikwissenschaftlichen Konzepten von Nation und Nationalstaat. In Anlehnung an die Historiker Florian Bieber, Christian Jansen und Henning Borggräfe definieren wir den Begriff der Nation als ein Narrativ, auf das sich Mitglieder einer Gemeinschaft (...) geeinigt haben und das die Grundlage für den Prozess der Nationenbildung darstellt. Anhand von zwei Fallbeispielen zur Nationalstaatsbildung in der Schweiz und Österreich zeigen wir die unterschiedlichen Einflussdynamiken von herrschaftlicher Macht, Nationalstaatsbildung, transnationalen Dimensionen und Durchsetzung des als säkular konzipierten Rechts auf die Ausformung der Religionsgeschichten. Die vergleichende Analyse generalisiert die Befunde von Nationalstaat und Religionsgeschichte und benennt drei Impulse für die weitere Forschung. (shrink)

The increasing availability of large‐scale, complex data has made research into how human genomes determine physiology in health and disease, as well as its application to drug development and medicine, an attractive field for artificial intelligence (AI) approaches. Looking at recent developments, we explore how such approaches interconnect and may conflict with needs for and notions of causal knowledge in molecular genetics and genomic medicine. We provide reasons to suggest that—while capable of generating predictive knowledge at unprecedented pace and scale—if (...) and how these approaches will be integrated with prevailing causal concepts will not only determine the future of scientific understanding and self‐conceptions in these fields. But these questions will also be key to develop differentiated policies, such as for education and regulation, in order to harness societal benefits of AI for genomic research and medicine. (shrink)

A common finding is that information order influences belief revision (e.g., Hogarth & Einhorn, 1992). We tested personal experience as a possible mitigator. In three experiments participants experienced the probabilistic relationship between pieces of information and object category through a series of trials where they assigned objects (planes) into one of two possible categories (hostile or commercial), given two sequentially presented pieces of probabilistic information (route and ID), and then they had to indicate their belief about the object category before (...) feedback. The results generally confirm the predictions from the Hogarth and Einhorn model. Participants showed a recency effect in their belief revision. Extending previous model evaluations the results indicate that the model predictions also hold for classification decisions, and for pieces of information that vary in their diagnostic values. Personal experience does not appear to prevent order effects in classification decisions based on sequentially presented pieces of information and in belief revision. (shrink)