The immense distance between God and creatures is a core statement of Gregory of Nyssa’s thought, which makes it distinctive not only in theology, but also in cosmology, anthropology, and spiritual doctrine. For him, the main distinction between beings that articulates all reality is not that of intelligible and sensible, but the one between infinite God and creatures. This paper, dealing with some selected texts regarding the creation of man, points out the main roots of Gregory’s theism: a high comprehension (...) of God’s transcendence and a proper philosophy of time and creation. From here, Gregory’s understanding of the hierarchy of beings as a non-dialectic unity of creation supported by a transcendent participation in God, and his articulation of Eternity and Time within the unique creative action of God, could be seen as a deep Christian comprehension of reality that is still intriguing for contemporary thinkers. (shrink)