The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create (...) new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease. (shrink)

Este artigo retoma os conceitos de poder disciplinar e biopoder em Michel Foucault para, então, fazer um diagnóstico do contexto pandêmico causado pela Covid-19. Ao se considerar que mais da metade da população mundial foi orientada ao isolamento social, bem como à alteração de hábitos cotidianos a fim de diminuir a propagação do vírus SARS-CoV-2, é possível perceber em Foucault as medidas da técnica disciplinar e da tecnologia biopolítica, ambas direcionadas à preservação da vida da população. Considera-se que o poder (...) disciplinar e o biopoder funcionam na atual pandemia num contexto inédito, marcado pelo avanço tecnológico. (shrink)

With the end of the Cold War, political and ideological competition has decreased as a stated reason for space exploration. The possibility of establishing a settlement on Mars is being seriously evaluated by state and commercial space agencies, which includes objectives to expand human civilization and ensure the continuity of the human species. The technological challenges associated with space settlement continue to receive significant attention, but the success of space settlement will also depend on other human factors. This study presents (...) a high-level overview of some potential issues that could arise with the development of a permanent populationand a space economyon Mars. This study highlights some of the anticipated problems of overnance, trade, production, and proliferation that will need pragmatic solutions to ensure the sustainability of a martian settlement. This paper is intended to instigate further discussion and research regarding human and economic factors that could enable or constrain future settlements on Mars. (shrink)

Two sextants constructed for Tycho Brahe are preserved in the National Technical Museum in Prague. One was constructed by Erasmus Habermel, the other by Jost Bürgi. Both were made in the year 1600. To overcome the observational errors, several improvements were made in the construction of these instruments, especially in the case of Bürgi's sextant. It would appear both from these instruments and from his tables of sines that Tycho wanted to reduce the errors to one minute of arc. A (...) replica of Bürgi's sextant, which is currently under construction, will allow the accuracy of the instrument to be tested. (shrink)

ABOUT THE BOOK:Sri Aurobindo has developed an original system of the Vedanta called Integral Advaitism. This book gives a systematic, thorough and authentic exposition of his thought. The fundamental and living issues, namely, the concept of the Absol.

Hannah Arendt plačiai žinoma kaip filosofė, kuri mėgino reabilituoti senovės graikų politikos sampratą. Remiantis Žmogaus būklės skaitymu, Arendt paprastai laikoma „graikofile“, jai prikišama „Atėnų nostalgija“. Sunku paneigti Arendt simpatijas graikams – ji iš tiesų atsigręžė į atėniečių politikos supratimą, bandydama jame iškristalizuoti kertinius autentiškos politikos elementus. Vis dėlto ši interpretacija yra pernelyg vienpusiška. Didžiausius nuopelnus politikos suvokimo srityje Arendt priskiria ne graikams, o romėnams. Pastarieji žymiai geriau sprendė politikos stabilumo, tęstinumo ir tvarumo problemą. Visą dėmesį sutelkiant į veiksmą, spontaniškumą ir (...) nepaprastus žygdarbius, kyla grėsmė destabilizuoti ir „išcentruoti“ politinės bend­rijos gyvenimą. Romėnai, įvesdami tokias sąvokas kaip tradicija, autoritetas, steigties (įkūrimo) šventumas, teisė (lex), taip pat pabrėždami politinę atleidimo ir pažado reikšmę, atveria graikams svetimą politinės sedimentacijos plotmę. Ši plotmė suteikia būtinus saugiklius, be kurių tvari politinė egzistencija yra neįmanoma. (shrink)

Background and AimsEnd-of-life discussions can be difficult for seriously ill adolescents and young adults. Researchers aimed to determine whether completing Voicing My CHOiCES —a research-informed advance care planning guide—increased communication with family, friends, or health care providers, and to evaluate the experience of those with whom VMC was shared.MethodsFamily, friends, or HCPs who the AYAs had shared their completed VMC with were administered structured interviews to assess their perception of the ACP discussion, changes in their relationship, conversation quality, and whether (...) the discussion prompted changes in care. Open-ended responses underwent thematic analysis.ResultsOne-month post-completion, 65.1% of AYA had shared VMC completion with a family member, 22.6% with a friend, and 8.9% with an HCP. Among a sample of respondents, family and friends reported a positive change in their relationship with the AYA. Participant descriptions of the experience fell into five themes: positive experience, difficult experience, appreciated a guide to facilitate discussion, provided relief, and created worry/anxiety. Only 1 HCP noted a treatment change. Family, friends, and HCP did not think the AYA would have discussed EoL preferences without completing VMC.ConclusionsVMC has potential to enhance communication about ACP between AYA and their family and friends, though less frequently with HCPs. Participants reported a positive change in their relationship with the AYA after discussing VMC, and described experiencing the conversation as favorable, even when also emotionally difficult. (shrink)

This paper examines Hannah Arendt’s account of the relationship between politics and morality. Many critics have argued that Arendt’s conception of political action lacks any moral foundations, while others have tried to focus on her understanding of thinking as a normative source of her ethics. In contrast to these views, I present an alternative explanation and argue that the sources of Arendt’s political ethics are located neither in the faculty of thinking nor in extrapolitical moral norms or rules, but in (...) the ontological conditions of action, specifically worldliness, natality and plurality. This interpretation allows us to make sense of Arendt’s fragmented, unsystematic accounts of the various virtues and moral dispositions required for authentic politics: courage, responsibility, care, respect, moderation, solidarity and gratitude. In particular, an inquiry into the ontological sources of political ethics provides a solid normative grounding for the two moral dispositions—promise and forgiveness—that form an explicit “moral code” of political action for Arendt. (shrink)

The paper is aimed at rationalizing relationships between the structure of inorganic compounds in condensed phases and their melting and boiling points. It is documented that the main factor governing both points is their molecular or polymeric nature. In case of polymeric ionic compounds, the higher actual charge bearing by the ions involved, the higher their melting/boiling points. In case of covalent polymers, the value of both points increases with polymer dimensionality and with the number and energy of the respective (...) covalent bonds. In case of molecular compounds, both points depend on the weight and shape of molecules, the presence of hydrogen bonds, and electric quadrupole moment. (shrink)

In this article, which is based on twenty four months of combined online and off-line ethnographic research, I show the way that some Iranian diasporic bloggers use their weblogs as entrepreneurship resources during the ‘war on terror’. Through a discourse analysis of a documentary film about Weblogistan and interviews with diasporic Iranian bloggers in Toronto, I argue that Weblogistan is implicated in discourses of militarism and neoliberalism that interpellate the representable Iranian blogger as a gendered neoliberal homo oeconomicus. The production (...) of knowledge about Iran in transnational encounters between the media, think tanks, policy institutions and the Iranian diasporic self-entrepreneurs, relies on gendered civilizational discourses that are inherently tied to the ‘war on terror’. Following feminist scholars who have theorized militarism and gender, I argue that dominant representations of Weblogistan produce different gendered subject positions for Iranian bloggers. Although the masculine blogger soldier takes freedom to Iran through his active participation in proper politics (enabled by his freedom of speech in North America and Europe), the woman blogger finds freedom of expression in writing about sex and telling the truth of her sex in a confessional mode. It is in this war of representation that women bloggers negotiate their subjectivity while shuttling in and out of local and global politics, as subjects of politics (markers of freedom and oppression) and political abjects (not worthy of political participation). (shrink)

ABSTRACT The purpose of this paper is to reveal how the responses of the others compose and expand the narratives of an early years teacher and also how these responses appear in narratives in the context of non-face-to-face and asynchronous support, due to the covid-19 pandemic. The narrative methodology of research in education, in dialogue with the contributions of the Bakhtinian philosophy, was used to interpret the responses materialized in the narratives and the way the teacher reorganizes her work based (...) on them. It was shown that whereas the narratives were related to face-to-face work, the babies’ responses came up from the unfinishedness utterances that the teacher produced from her experience with them; as regarding the narratives about non-face-to-face work, the responses came from the utterances produced by the families, based on what they experienced in their relationship with the babies. In both situations, the teacher tried to reorganize her work in relation to the responses of her others. (shrink)

本书包括:在北京广播学院的讲演;在北京青年政治学院报告;沈昌案答辩词;李之焕案答辩词等内容。.

The two waves of COVID-19 in India have had severe consequences for the lives of people. The Indian State-imposed various regulatory mechanisms like lockdowns, encouraged remote work, online teaching in academic institutions, and enforced adherence to the COVID protocols. The use of various technologies especially digital/online technologies not only helped to adapt to the “new normal” and cope with the disruptions in pursuing everyday activities but also to manage one’s well-being. However, the availability and accessibility of digital technologies to various (...) sections of the population were not uniform. This paper reports a series of three studies examining the nature of pandemic stress, the impact of technology use on people’s emotional well-being during turbulent times, and the effects of technology use on psychological resources like resilience, self-efficacy, motivation to work, and emotional well-being. The differences in the residential background and SES in the extent of the use of technology and strength of psychological resources were assessed. The findings indicated that the most common causes of concern included worrying about family, friends, partners, fears of getting and giving the viral infection to someone; frustration and or boredom; and changes in normal sleep patterns. It was noted that technology was a double-edged sword and created barriers as well as opportunities for the people. Also, self-efficacy mediated the relationship between the use of technology and emotional wellbeing. The results have policy implications for building resilient communities in the post COVID period. (shrink)

Over the past decade, Convergence Research has increasingly gained prominence as a research, development, and innovation (RDI) strategy to address grand societal challenges. However, a dearth of research-based evidence is available to aid researchers, research teams, and institutions with navigating the complexities attendant to the specifics of Convergence Research. This paper presents a multilevel research agenda that accounts for an integral understanding of Convergence Research as a complex adaptive system. Furthermore, by developing a framework that accounts for ancillary, yet essential, (...) systems associated with Convergence Research, we enrich the agenda with a literature-steeped discussion that considers how systems-based practices of collaboration, inquiry, and context interact with the processes and products of Convergence Research. Finally, we synthesize and apply insights from the reviewed literature by providing paths for empirical exploration emphasizing systems-based practices. In so doing, we delineate an extended boundary for a research stream that both clarifies and enlarges our understanding of Convergence Research as a ‘system-of-systems’. (shrink)

Immanuel Kant, with his “brilliantly dry style” (Schopenhauer), expounds the notable theory that “objects are approaching to the mind” via the spectacle metaphor by addressing transcendental idealism in support of the mind as an active knower (mind-making nature), not passive in a realistic sense, while objects of knowledge conform to the mind begotten in categories of understanding. On Kant’s view, James Conant writes, “Kant’s term for this unity, considered at this level of abstraction, is the original synthetic unity of the (...) understanding. This admits of forms of further determination, one sensible and one intellectual. This form of unity – categorial unity – characterizes both the manner in which objects are given to us in intuition and the manner in which concepts are combined in judgments” (Conant 2016: 114). -/- Insofar the same pioneering stance is reflected in the Groundwork of Metaphysics of Morals (Kant 1972) and the Critique of Practical Reason (Kant 1996), where Kant underscores the accessible account of reason and freedom as the content of fundamental moral principle toward a kind of universalizable moral duty attuned with the formulation of categorical imperative. The justification and groundwork of these moral laws cannot be liaison in sensory experience but on pure reason, which Kant calls “a priori,” a conviction stems from the understanding of rational necessitation of moral obligation and free autonomous agency. This interpretation absorbs the practical principle that underlies the subjective maxim to justify the necessary and sufficient conditions for a universal moral law. Kant starts out saying that an act is morally right if it is performed for the sake of broadening the vista of maxim infused by goodwill consisting of the categorical imperative that sounds an exceptionless command, abstract law, and universally applicable normative principle as well. For Kant, the categorical imperative has many-sided structures: a. Ethical requirements are rational requirements of the moral agent. b. The rational requirement goes toward universal laws. c. These moral requirements must be followed by equality, freedom, and goodwill. (shrink)

Anthropogenic climate change poses some difficult ethical quandaries for non-anthropocentrists. While it is hard to deny that climate change is a substantial moral ill, many types of non-human organisms stand to benefit from climate change. Modelling studies provide evidence that net primary productivity (NPP) could be substantially boosted, both regionally and globally, as a result of warming from increased concentrations of greenhouse gases. The same holds for deployment of certain types of climate engineering, or large-scale, technological modifications of the global (...) environment in order to prevent or slow anthropogenic climate change. For example, solar radiation management with stratospheric aerosol injections could benefit plant life by promoting enhanced photosynthesis, increasing diffuse radiation, and reducing heat stress. This has a surprising implication: from some non-anthropocentric perspectives, certain scenarios of climate change and climate engineering might bring about morally better states of affairs when compared to emission-mitigation baselines. (shrink)

There is a growing need to identify what really can converge classroom learning to the real-life practising of ethical principles. We examine if the effectiveness of ethics education can be improved through meditation-based mindfulness intervention. Our baseline experiment is a procedurally modified version of the anagram exercise (Ruedy and Schweitzer 2010) for measuring unethical behaviour. We introduce a brief meditation intervention to induce instant mindfulness. Our findings indicate substantive evidence confirming the positive effect of the state of mindfulness on ethical (...) behaviour. Subjects in the meditation group engage in more low-level cheating compared to the control group who cheated more severely. Gender and academic grade do not influence ethical behaviour. Mindfulness fosters composure, mental poise, and a conducive environment for upholding ethical values, as indicated by a lower incidence of cheating in our study. We propose to promote a learning environment with mindfulness intervention in educational programmes. (shrink)

Presents the life and social ethics of the great Chinese sage.

We investigate whether the display of portfolio performance as coming from one large portfolio or two smaller subportfolios matters to individuals and whether prospect theory can explain this preference. To this end, we run a large survey experiment of 3267 individuals in 5 European countries presenting an identical overall return as coming from one portfolio or two smaller subportfolios to individuals. We also elicited the coefficients of the prospect theory value function through price list lotteries. In losses, following prospect theory (...) and mental accounting predictions, we observe emprically a preference for the display of returns as coming from 2 subportfolios, one displaying a small gain and the other a large loss, over a unique portfolio displaying the aggregated resulting loss. As expected, for an overall gain, individuals favor one portfolio over two subportfolios, one displaying a small loss and the other a larger gain. The shape of the value function does not explain individuals’ preferences. The reference point seems to be the main factor involved in explaining individuals’ choice of two subportfolio presentations of the outcome. (shrink)

The paper is aimed at defining reduction, oxidation, and redox reactions based both on the oxidation number and charge changes in reacting species. It is rationalized that the processes of oxidation and reduction, usually occurring simultaneously, can occur also as independent processes. It is explained that in balancing chemical equations of redox reactions the “gain” or “loss” of electrons should be understood as changes in oxidation number. A formal expressions “+n e−” and “−n e−” represent in reality a decrease and (...) increase in oxidation number by n units, respectively. (shrink)