The evidence compiled in the target article demonstrates that the assumptions of cultural group selection theory are often met, and it is therefore a useful framework for generating plausible hypotheses. However, more can be said about how we can test the predictions of CGS hypotheses against competing explanations using historical, archaeological, and anthropological data.

Critical discussion of Michael Dummett's views on the knowledge of meaning.

An examination of Michael Dummett's views on meaning.

Because many institutions struggle to determine how best to support their institutional review board programs, we conducted an exploratory study to identify the individual, group, and institutional factors that may influence commitment to the role responsibilities of being on an IRB. We defined this commitment as consisting of time spent preparing for IRB meetings, views of the importance of serving on an IRB, time dedicated to IRB activities relative to other academic committee service, and willingness to attend IRB meetings. Our (...) study suggests that member commitment to IRB role responsibilities may be related to adequate compensation for time spent on IRB activities, serving on an IRB whose chair fosters a supportive group dynamic, IRB size, length of tenure, efficiency of protocol review, receiving training on the ethical and regulatory requirements for research with humans, and attendance of principal investigators at convened meetings. (shrink)

We conducted a retrospective review of research protocols from four IRBs at one large academic medical institution. The project examined whether having the Principal Investigator attend the initial IRB review of his or her study improves the efficiency of the review. We measured efficiency by the number of days from protocol submission to approval, volume of correspondence exchanged between investigator and IRB prior to approval, and the number of convened IRB meetings required prior to approval. We assessed two samples of (...) research records. The first cross-sectional sample was drawn concurrently from four IRBs—two that routinely invite PIs to be present when their protocols are reviewed, and two that do not. No statistical differences in review efficiency were found between these groups. The second sample was a historical comparison in which protocols from an IRB that initially did not invite PIs to attend review were compared to protocols from the same IRB after it had changed its policy to encourage PI attendance. This sample revealed that the protocols for which the PI attended were reviewed in fewer days and with fewer meetings. Further research is needed to explore whether PI attendance and other strategies may increase the efficiency of IRB review, and whether PI attendance may have other benefits besides efficiency that would make the investigator’s presence at review desirable. (shrink)

In recent years, live imaging has been adopted to study stem cells in their native environment at cellular resolution. In the skeletal muscle field, this has led to visualising the initial events of muscle repair in mouse, and the entire regenerative response in zebrafish. Here, we review recent discoveries in this field obtained from live imaging studies. Tracking of tissue resident stem cells, the satellite cells, following injury has captured the morphogenetic dynamics of stem/progenitor cells as they facilitate repair. Asymmetric (...) satellite cell division generated a clonogenic progenitor pool, providing in vivo validation for this mechanism. Furthermore, there is an emerging role of stem/progenitor cell guidance at the injury site by cellular protrusions. This review concludes that live imaging is a critical tool for discovering the distinct processes that occur during regeneration, emphasising the importance of imaging in diverse animal models to capture the entire scope of stem cell functions. (shrink)

The recently uncovered role of Fukutin‐related protein (FKRP) in fibronectin glycosylation has challenged our understanding of the basis of disease pathogenesis in the muscular dystrophies. FKRP is a Golgi‐resident glycosyltransferase implicated in a broad spectrum of muscular dystrophy (MD) pathologies that are not fully attributable to the well‐described α‐Dystroglycan hypoglycosylation. By revealing a new role for FKRP in the glycosylation of fibronectin, a modification critical for the development of the muscle basement membrane (MBM) and its associated muscle linkages, new possibilities (...) for understanding clinical phenotype arise. This modification involves an interaction between FKRP and myosin‐10, a protein involved in the Golgi organization and function. These observations suggest a FKRP nexus exists that controls two critical aspects to muscle fibre integrity, both fibre stability at the MBM and its elastic properties. This review explores the new potential disease axis in the context of our current knowledge of muscular dystrophies. (shrink)

In approaching Ch. 4 of Saving Truth from Paradox, it might be helpful first to revisit Curry’s original paper, and to revisit Lukasiewicz too, to provide more of the scenesetting that Field doesn’t himself fill in. So in §1 I’ll say something about Curry, in §2 we’ll look at what Lukasiewicz was up to in his original three-valued logic, and in §3 we’ll look at the move from a three-valued to a many-valued Lukasiewicz logic. In §4, I move on to (...) announce a theorem by H´. (shrink)

A common approach to drawing boundary between fiction and non-fiction is by appeal to the kinds of speech acts performed by authors of works of the respective categories. Searle, for example, takes fiction to be the product of illocutionary pretense of various kinds on the part of authors and non-fiction to be the product of genuine illocutionary action.1 Currie, in contrast, takes fiction to be the product of sui generis fictional illocutionary action on the part of authors and non-fiction (...) to be the product of assertion and other familiar kinds of illocutionary action.2 The central thesis of this paper is that the speech act approach to fictionality is simply a non-starter. Now it is, of course, commonplace to note that approaches of this kind run into difficulty accommodating nonliterary fictions3 and uncomposed or authorless fictions. What will be argued here, however, is that speech acts analyses are inadequate even understood narrowly as accounts of composed literary fiction. And the reason is that they fail to adequately attend to the distinction between composition and storytelling. (shrink)

Fictional truth is commonly analyzed in terms of the speech acts or propositional attitudes of a teller. In this paper, I investigate Lewis’s counterfactual analysis in terms of felicitous narrator assertion, Currie’s analysis in terms of fictional author belief, and Byrne’s analysis in terms of ideal author invitations to make-believe—and find them all lacking. I propose instead an analysis in terms of the revelations of an infelicitous narrator.

I have been dissatisfied with Walton’s make-believe model of appreciator engagement with fiction ever since my first encounter with it as a graduate student.1 What I have always objected to is not the suggestion that such engagement is broadly speaking imaginative; rather, it is the suggestion that it specifically involves de se imaginative activity on the part of appreciators. That is, while I concede that appreciators imagine (de re) of the fictional works they experience that they are thus and so, (...) I deny that they imagine (de se) experiencing an object that is thus and so.2 The main source of my dissatisfaction with the make-believe model is that it is phenomenologically unfamiliar; I have never been aware of de se imaginings of the requisite sort while appreciatively engaged with fiction.3 Of course, one could argue that it nevertheless occurs, albeit sub-consciously. But in order for this manoeuvre to be plausible, it would have to be established that there are appreciative phenomena that can only (or best) be explained by the supposition that appreciators engage in de se imagining, and which cannot be adequately explained by the supposition that they merely engage in de re imagining. Currie, for example, has argued that we need to make the former supposition in order to find a solution to the “problem of personality,” the problem of explaining why our emotional reactions to the plights of fictional characters often differ from our reactions to the similar plights of actual people.4 What I want to argue in this paper is that Currie’s defense of de se imaginative engagement is.. (shrink)

Film and the Emotions explores the complicated relationship between filmed entertainment, such as movies and television shows, and our capacity to feel emotions. This volume of The Midwest Studies in Philosophy covers topics such as the role of imagination in our capacity to respond emotionally to films, how emotions felt in response to films relate to emotions felt about real events, and the moral implications of responding emotionally to fictions, among others. This collection includes nineteen original articles from experts on (...) film and emotion, including Noel Carroll, Gregory Currie, Susan Feagin, Stacie Friend, Robert Hopkins, Peter Lamarque and Peter Goldie, Derek Matravers, Carl Plantinga, and Murray Smith. (shrink)

Currie’s (2010) argument that “i-desires” must be posited to explain our responses to fiction is critically discussed. It is argued that beliefs and desires featuring ‘in the fiction’ operators—and not sui generis imaginings (or "i-beliefs" or "i-desires")—are the crucial states involved in generating fiction-directed affect. A defense of the “Operator Claim” is mounted, according to which ‘in the fiction’ operators would be also be required within fiction-directed sui generis imaginings (or "i-beliefs" and "i-desires"), were there such. Once we appreciate (...) that even fiction-directed sui generis imaginings would need to incorporate ‘in the fiction’ operators, the main appeal of the idea that sui generis imaginings (or "i-beliefs" or "i-desires") are at work in fiction-appreciation dissipates. [This is Chapter 10 of Explaining Imagination (OUP, 2020)]. (shrink)

It seems that the Truth-teller is either true or false, but there is no accepted principle determining which it is. From this point of view, the Truth-teller is a hypodox. A hypodox is a conundrum like a paradox, but consistent. Sometimes, accepting an additional principle will convert a hypodox into a paradox. Conversely, in some cases, retracting or restricting a principle will convert a paradox to a hypodox. This last point suggests a new method of avoiding inconsistency. This article provides (...) a significant example. The Liar paradox can be defused to a hypodox by relatively minimally restricting three principles: the T-schema, substitution of identicals and universal instantiation. These restrictions are not arbitrary. For each, I identify the source of a contradiction given some presumptions. Then I propose each restriction as a reasonable way to deal with that source of contradiction. (shrink)

This paper deals with Popper's little-known work on deductive logic, published between 1947 and 1949. According to his theory of deductive inference, the meaning of logical signs is determined by certain rules derived from ?inferential definitions? of those signs. Although strong arguments have been presented against Popper's claims (e.g. by Curry, Kleene, Lejewski and McKinsey), his theory can be reconstructed when it is viewed primarily as an attempt to demarcate logical from non-logical constants rather than as a semantic foundation for (...) logic. A criterion of logicality is obtained which is based on conjunction, implication and universal quantification as fundamental logical operations. (shrink)

It is argued that causal understanding originates in experiences of acting on objects. Such experiences have consistent features that can be used as clues to causal identification and judgment. These are singular clues, meaning that they can be detected in single instances. A catalog of 14 singular clues is proposed. The clues function as heuristics for generating causal judgments under uncertainty and are a pervasive source of bias in causal judgment. More sophisticated clues such as mechanism clues and repeated interventions (...) are derived from the 14. Research on the use of empirical information and conditional probabilities to identify causes has used scenarios in which several of the clues are present, and the use of empirical association information for causal judgment depends on the presence of singular clues. It is the singular clues and their origin that are basic to causal understanding, not multiple instance clues such as empirical association, contingency, and conditional probabilities. (shrink)

Berkeley’s likeness principle is the claim that “an idea can be like nothing but an idea”. The likeness principle is intended to undermine representationalism: the view (that Berkeley attributes to thinkers like Descartes and Locke) that all human knowledge is mediated by ideas in the mind which represent material objects. Yet, Berkeley appears to leave the likeness principle unargued for. This has led to several attempts to explain why Berkeley accepts it. In contrast to ‘metaphysical’ and ‘epistemological’ interpretations available in (...) the literature, in this paper I defend a ‘conceptual’ interpretation. I argue that Berkeley accepts the likeness principle on the basis of (i) his commitment to the transparency of ideas, and (ii) his account of resemblance which he sets out in his works on vision. Thus, I provide an explanation for Berkeley’s reasons for accepting the likeness principle which, appropriately, focuses on his views concerning ideas and likeness. (shrink)

In this important new book in the IPPP series, a group of leading thinkers in psychiatry, psychology, and philosophy offer alternative perspectives that address both the scientific and clinical aspects of psychiatric validation, emphasizing throughout their philosophical and historical considerations.

For thirty years, Peter Singer's Practical Ethics has been the classic introduction to applied ethics. For this third edition, the author has revised and updated all the chapters and added a new chapter addressing climate change, one of the most important ethical challenges of our generation. Some of the questions discussed in this book concern our daily lives. Is it ethical to buy luxuries when others do not have enough to eat? Should we buy meat from intensively reared animals? (...) Am I doing something wrong if my carbon footprint is above the global average? Other questions confront us as concerned citizens: equality and discrimination on the grounds of race or sex; abortion, the use of embryos for research and euthanasia; political violence and terrorism; and the preservation of our planet's environment. This book's lucid style and provocative arguments make it an ideal text for university courses and for anyone willing to think about how she or he ought to live. (shrink)

In September 2008, the European Organization for Nuclear Research (CERN) scientists successfully switched on the historic biggest physics device, the Large ...

In my contribution to this Concise Collection on Margaret Cavendish, I focus on teaching Cavendish’s work in the context of philosophy (and, more specifically, Early Modern Philosophy). I have three aims. First, to explain why teaching women from philosophy’s history is crucially important to the discipline. Second, to outline my own reflections on teaching Cavendish’s philosophy. Third, to defend a specific claim about the benefits of teaching Cavendish to philosophy students; namely, that introducing biographical detail alongside philosophical ideas enriches the (...) learning experience. (shrink)

Margaret Macdonald was at the institutional heart of analytic philosophy in Britain in the mid-twentieth century. Yet, her views on the nature of philosophical theories diverge quite considerably from those of many of her contemporaries. In this paper, I focus on her 1953 article ‘Linguistic Philosophy and Perception’, a provocative paper in which Macdonald argues that the value of philosophical theories is more akin to that of poetry or art than science or mathematics. I do so for two reasons. First, (...) because it reveals just how far Macdonald’s meta- philosophical views diverged from those of many of her contemporaries. Second, because the discussion in LPP pre-empts recent literature on the nature of philosophical inquiry and the efficacy of philosophical arguments. Indeed, Macdonald’s paper is just as likely to provoke discussion today as it was in the 1950s. (shrink)

This paper provides a philosophical evaluation of the concept of handedness prevalent but largely unspoken in the scientific literature. This literature defines handedness as the preference or ability to use one hand rather than the other across a range of common activities. Using the philosophical discipline of phenomenology, I articulate and critique this conceptualization of handedness. Phenomenology shows defining a concept of handedness by focusing on hand use leads to a right hand biased concept. I argue further that a phenomenological (...) model based in spatial orientation rather than hand use provides a more inclusive concept of handedness. (shrink)

William Molyneux was born in Dublin, studied in Trinity College Dublin, and was a founding member of the Dublin Philosophical Society (DPS), Ireland’s counterpart to the Royal Society in London. He was a central figure in the Irish intellectual milieu during the Early Modern period and – along with George Berkeley and Edmund Burke – is one of the best-known thinkers to have come out of that context and out of Irish thought more generally. In 1688, when Molyneux wrote the (...) letter to Locke in which he posed the now famous question about a man born blind made to see, he was an active member of the DPS and was on familiar terms with several other key figures in Irish philosophy at the time. For the most part, Irish thinkers in the seventeenth and eighteenth centuries answered “no” to Molyneux’s question of whether a blind man made to see could distinguish, by sight alone, between a cube and a sphere. (shrink)

Studie over het werk van de Duitse wijsgeer Friedrich Ludwig Gottlob Frege (1848-1925).

Prospect Theory: For Risk and Ambiguity, provides a comprehensive and accessible textbook treatment of the way decisions are made both when we have the statistical probabilities associated with uncertain future events and when we lack them. The book presents models, primarily prospect theory, that are both tractable and psychologically realistic. A method of presentation is chosen that makes the empirical meaning of each theoretical model completely transparent. Prospect theory has many applications in a wide variety of disciplines. The material in (...) the book has been carefully organized to allow readers to select pathways through the book relevant to their own interests. With numerous exercises and worked examples, the book is ideally suited to the needs of students taking courses in decision theory in economics, mathematics, finance, psychology, management science, health, computer science, Bayesian statistics, and engineering. (shrink)