argue that natural selection does not explain the genotypic arid phenotypic properties of individuals. On this view, natural selection explains the adaptedness of individuals, not by explaining why the individuals that exist have the adaptations they do, but rather by explaining why the individuals that exist are the ones with those adaptations. This paper argues that this ‘Negative’ view of natural selection ignores the fact that natural selection is a cumulative selection process. So understood, it explains how the genetic sequences (...) that individuals inherit and that are responsible for their complex (and co-adapted) adaptations first arose in the gene-pool. (shrink)

No overarching hypotheses tie the basic mechanisms of mitochondrial reactive oxygen species (ROS) production to activity dependent synapse pruning—a fundamental biological process in health and disease. Neuronal activity divergently regulates mitochondrial ROS: activity decreases whereas inactivity increases their production, respectively. Placing mitochondrial ROS as innate synaptic activity sentinels informs the novel hypothesis that: (1) at an inactive synapse, increased mitochondrial ROS production initiates intrinsic apoptosis dependent pruning; and (2) at an active synapse, decreased mitochondrial ROS production masks intrinsic apoptosis dependent (...) pruning. Immature antioxidant defense may enable the developing brain to harness mitochondrial ROS to prune weak synapses. Beyond development, endogenous antioxidant defense constrains mitochondrial (ROS) to mask pruning. Unwanted age‐related synapse loss may arise when mitochondrial ROS aberrantly recapitulate developmental pruning. Placing mitochondrial ROS with their hands on the shears is beneficial in early but deleterious in later life. (shrink)

Athenian ostracism has long captured democratic imaginations because it seems to present clear evidence of a people (demos) routinely asserting collective power over tyrannical elites. In recent times, ostracism has been particularly alluring to militant democrats, who see the institution as an ancient precursor to modern militant democratic mechanisms such as social media bans, impeachment measures, and lustration procedures, which serve to protect democratic constitutions from anti-democratic threats. Such a way of conceptualizing ostracism ultimately stems from Aristotle’s “rule of proportion,” (...) or the removal of “outstanding” individuals in a polity who threaten to disturb the achievement of communal eudaimonia (Aris. Pol. 1284a). However, this way of interpreting the institution only presents a truncated view, one which is overly centered on the ultimate expulsion of an individual from the polity, rather than on its broader contextual telos—the transformation of the ostracized individual and of the community. To move past this simplified view, this paper considers all elements of ostracism with equal force, and argues that ostracism offered a shared opportunity and shared space for all members of the polis—citizens, non-citizens, and elite members alike—to reform the character of the subject individual and to instill and reaffirm democratic values in the community. (shrink)

Alpha-beta pruning is a technique for pruning trees in artificial intelligence game-playing. This note draws an analogy between the technique, which is, in essence, an application of many-valued logic to the cut-off of the evaluation of conditionals in computer programs (for efficiency).

Recent studies suggest that the tetracycline antibiotic minocycline, or its cousins, hold therapeutic potential for affective and psychotic disorders. This is proposed on the basis of a direct effect on microglia‐mediated frontocortical synaptic pruning (FSP) during adolescence, perhaps in genetically susceptible individuals harboring risk alleles in the complement component cascade that is involved in this normal process of CNS circuit refinement. In reviewing this field, it is argued that minocycline is actually probing and modulating a deeply evolved and intricate system (...) wherein psychosocial stimuli sculpt the circuitry of the “social brain” underlying adult behavior and personality. Furthermore, this system can generate psychiatric morbidity that is not dependent on genetic variation. This view has important ramifications for understanding “pathologies” of human social behavior and cognition as well as providing long‐sought potential mechanistic links between social experience and susceptibility to mental and physical disease. (shrink)

In this paper we present the problem of a noisy lexical taxonomy and suggest two tasks as potential remedies. The first task is to identify and eliminate incorrect hypernymy links, and the second is to repopulate the taxonomy with new relations. The first task consists of revising the entire taxonomy and returning a Boolean for each assertion of hypernymy between two nouns (e.g. brie is a kind of cheese). The second task consists of recursively producing a chain of hypernyms for (...) a given noun, until the most general node in the taxonomy is reached (e.g. brie → cheese → food → etc.). In order to achieve these goals, we implemented a hybrid hypernym-detection algorithm that incorporates various intuitions, such as syntagmatic, paradigmatic and morphological association measures as well as lexical patterns. We evaluate these algorithms individually and collectively and report findings in Spanish, English and French. (shrink)

Discussions of branching time and branching spacetime have become common in the philosophical literature. If properly understood, these conceptions can be harmless. But they are sometimes used in the service of debatable and even downright pernicious doctrines. The purpose of this chapter is to identify the pernicious branching and prune it back.

I wholeheartedly endorse Grodzinsky's program of attempting to tie the particular deficits observed in Broca's aphasics' comprehension and production to changes in their mentally represented model of grammar. At the level of detail, however, I see problems with two specific changes that Grodzinsky posits. One is a default Agent-assignment strategy in comprehension. The other is the hypothesis that production involves pruning all functional projections above Agreement Phrase.

Good Agricultural Practices are central to sustainability standards and certification programmes in the global cocoa chain. Pruning is one of the practices promoted in extension services associated with these sustainability efforts. Yet concerns exist about the low adoption rate of these GAPs by smallholder cocoa farmers in Ghana. A common approach to addressing this challenge is based on creating enabling conditions and offering appropriate incentives. We use the concepts of inscription and affordance to trace the vertically coordinated travel of recommended (...) pruning from research to extension and farming sites, and to describe how pruning is carried out differently at each site. Our analysis suggests that enactments of pruning at the extension site reduce the number of options and space for interactions, and this constrains making the practice meaningful to farmers’ repertoires. The conventions guiding and legitimising actions at this site, reinforced by sustainability standards, certification schemes and associated inspections and audits, favour standardised recommendations and consequently narrow room for context-specific diagnostics and adaptions. Therefore, we reframe the adoption problem as a matter of fit between different sites in the ‘agricultural research value chain’ embedded in the operational cocoa chain. Our contribution problematises the dominant framing of low adoption and highlights that the movement of pruning and the sequential enactment at different sites constrain the affordances available for rendering the practice meaningful to farmers’ repertoires. Consequently, addressing the low uptake of GAPs requires institutional work towards conventions that can construct a fit between sites along the agricultural research value chain. (shrink)

The English Court of Appeal is currently faced with three analytically distinct approaches to the question of when one party owes another a duty of care in respect of her economic interests, all of which bear the authority of the House of Lords. Unable to choose between them, it has recently adopted a fourth approach combining which combines them, in the apparent belief that the combination will eradicate any individual deficiencies. Against the background of a recent case, the author argues (...) that this is a holding strategy at best and methodologically deficient. He also challenges the continuing lip-service paid by courts to models of liability based upon ‘assumptions of responsibility,’ examining and criticising the causes of their persistence in the law in the face of widespread academic criticism. Instead, the author argues, the House of Lords should now clearly endorse a single reasoning strategy to economic loss cases based on the three-stage approach in Caparo Industries v Dickman. Properly understood, this approach offers the best prospect of facilitating consistent and transparent decision-making in the longer term. (shrink)

I begin with a characterization of neurolinguistic theories, trying to pinpoint some general properties that an account of brain/language relations should have. I then address specific criticisms made in the commentaries regarding the syntactic theory assumed in the target article, properties of the Trace Deletion Hypothesis (TDH) and the Tree-Pruning Hyothesis (TPH), other experimental results from aphasia, and findings from functional neuroimaging. Despite the criticism, the picture of the limited role of Broca's area remains unchanged.

Tree branches near the electric power transmission lines are of great threat to the electricity supply. Nowadays, the tasks of clearing threatening tree branches are still mostly operated by hand and simple tools. Traditional structures of the multirotor aerial robot have the problem of fixed structure and limited performance, which affects the stability and efficiency of pruning operation. In this article, in order to obtain better environmental adaptability, an active deformable trees-pruning aerial robot is presented. The deformation of the aerial (...) robot is implemented through two ways, arm telescopic and folding. In order to suppress the influence of internal and external disturbances on the system, Active Disturbance Rejection Control technology is adopted to build the flight controller. Firstly, active deformation aerial robot structure is given, followed by system dynamic model establishment under wind disturbance using the Newton–Euler method. Also, the analysis of the gusts influence on the system is considered. Then, the active deformation aerial robot system is decoupled into a combination of six SISO systems, so that a disturbance rejection controller is designed. Finally, the expanded state observer and the nonlinear state error feedback law are used to inspect and compensate the disturbance. Simulation results of attitude and position tracking as well as the antidisturbance capability show that the active deformation aerial robot with the ADRC flight controller designed in this paper has excellent attitude control capabilities during flight and trees-pruning operation. (shrink)

In a recent commentary, Kim and colleagues argued that minimal-risk research should be deregulated so that such studies do not require review by an institutional review board. They claim that regulation of minimal-risk studies provides no adequate counterbalancing good and instead leads to a costly human subjects oversight system. We argue that the counterbalancing good of regulating minimal-risk studies is that oversight exists to ensure that respect for persons and justice requirements are satisfied when they otherwise might not be.

The paper defends an Aristotelian notion of indeterminism, as rigorously formulated in the framework of branching space-times (BST) of Belnap (1992), against the model-theoretic characterization of indeterminism that Montague (1962) introduced into the philosophy of science. It delineates BST branching against the background provided by Earman's (2008) distinction between individual vs. ensemble branching. It describes a construction of physically-motivated BST models, in which histories are isomorphic to Minkowski spacetime. Finally it responds to criticism leveled against BST by addressing some semantical (...) questions, a topological issue, and the past/future asymmetry. (shrink)

Atran & Norenzayan (A&N) have not adequately supported the epistemic component of their proposal, namely, that God does not exist. A weaker, more probable hypothesis, not requiring that component – that the benefits of religious belief outweigh those of disbelief, even though we do not know whether or not God exists – is available. I counsel them to use Ockham's razor, eliminate their negative epistemic thesis, and accept the weaker hypothesis.

We show that there is a non-GL2 degree which is a minimal cover of a minimal degree. This answers a question by Lerman.

• alpha-beta pruning characterizes human play, but it ticed by early chess programmers—Turing, Shannon, Ulam, and Bernstein. We humans are not very good ing the heuristics we ourselves use. Approximations to used by Samuel, Newell and Simon, McCarthy. Proved lent to minimax by Hart and Levine, independently Knuth gives details.

The consensus among spacetime substantivalists is to respond to Leibniz's classic shift arguments, and their contemporary incarnation in the form of the hole argument, by pruning the allegedly problematic metaphysical possibilities that generate these arguments. Some substantivalists do so by directly appealing to a modal doctrine akin to anti-haecceitism. Other substantivalists do so by appealing to an underlying hyperintensional doctrine that implies some such modal doctrine. My first aim in this paper is to pose a challenge for all extant forms (...) of this consensus position. My second aim is to show what form substantivalism must take in order to uphold the consensus while addressing this challenge. The result is a novel "plenitudinous" substantivalist view, which predicts that certain modal facts about spacetime are vague or indeterminate. I then argue against this view on independent grounds, concluding that substantivalists should reject the consensus position. The paper also discusses the way forward for substantivalists in light of this conclusion. (shrink)

By what process of development he came to this opinion, though in itself an important and interesting question, is logically irrelevant to the inquiry how far the opinion itself is correct ; and among his opinions, when these have been ascertained, it becomes desirable to prune away such as seem inconsistent with his main doctrines, before those doctrines themselves are subjected to a critical scrutiny. Philosophic truth and falsehood, in short, rather than historical fact, are what primarily demand our (...) attention in this inquiry. (shrink)

The relativist's central objection to contextualism is that it fails to account for the disagreement we perceive in discourse about "subjective" matters, such as whether stewed prunes are delicious. If we are to adjudicate between contextualism and relativism, then, we must first get clear about what it is for two people to disagree. This question turns out to be surprisingly difficult to answer. A partial answer is given here; although it is incomplete, it does help shape what the relativist must (...) say if she is to do better than the contextualist in securing genuine disagreement. (shrink)

Grodzinsky's Tree-Pruning Hypothesis can be extended to explain agrammatic comprehension disorders. Although agrammatism is evidence for syntactic modularity, there is no evidence for its anatomical modularity or for its localization in the frontal lobe. Agrammatism results from diffuse left hemisphere damage – allowing the emergence of the limited right hemisphere linguistic competence – rather than from damage to an anatomic module in the left hemisphere.

The logical theory of branching space-times, which is intended to provide a framework for studying objective indeterminism, remains at a certain distance from the discussion of space-time theories in the philosophy of physics. In a welcome attempt to clarify the connection, Earman has recently found fault with the branching approach and suggested ``pruning some branches from branching space-time''. The present note identifies the different---order theoretic vs. topological---points of view of both discussion as a reason for certain misunderstandings, and tries to (...) remove them. Most importantly, we give a novel, topological criterion of modal consistency that usefully generalizes the order-theoretic criterion of directedness, and we introduce a differential-geometrical version of BST based on the theory of non-Hausdorff manifolds. (shrink)

(1) The induced colours led to perceptual grouping and pop-out, (2) a grapheme rendered invisible through ‘crowding’ or lateral masking induced synaesthetic colours — a form of blindsight — and (3) peripherally presented graphemes did not induce colours even when they were clearly visible. Taken collectively, these and other experiments prove conclusively that synaesthesia is a genuine percep- tual phenomenon, not an effect based on memory associations from childhood or on vague metaphorical speech. We identify different subtypes of number–colour synaesthesia (...) and propose that they are caused by hyperconnectivity between col- our and number areas at different stages in processing; lower synaesthetes may have cross-wiring (or cross-activation) within the fusiform gyrus, whereas higher synaesthetes may have cross-activation in the angular gyrus. This hyperconnec- tivity might be caused by a genetic mutation that causes defective pruning of con- nections between brain maps. The mutation may further be expressed selectively (due to transcription factors) in the fusiform or angular gyri, and this may explain the existence of different forms of synaesthesia. If expressed very diffusely, there may be extensive cross-wiring between brain regions that represent abstract concepts, which would explain the link between creativity, metaphor and synaesthesia (and the higher incidence of synaesthesia among artists and poets). Also, hyperconnectivity between the sensory cortex and amygdala would explain the heightened aversion synaesthetes experience when seeing numbers printed in the ‘wrong’ colour. Lastly, kindling (induced hyperconnectivity in the temporal lobes of temporal lobe epilepsy [TLE] patients) may explain the purported higher incidence of synaesthesia in these patients. We conclude with a synaesthesia-based theory. (shrink)

This article discusses explanatory theories of normative concepts and argues for a set of criteria of adequacy by which such theories may be evaluated. The criteria offered fall into four categories: ontological, theoretical, pragmatic, and moral. After defending the criteria and discussing their relative weighting, this article uses them to prune the set of available explanatory theories of oppression. Functionalist theories, including Hegelian recognition theory and Foucauldian social theory, are rejected, as are psychoanalytic theory and social dominance theory. Finally, (...) the article defends structural rational choice theory as the most promising methodology for explaining oppression. Key Words: oppression • explanation • rational choice theory. (shrink)

According to Cicero, “all emotions spring from the roots of error: they should not be pruned or clipped here and there, but yanked out” (Cicero 2002: 60). The Stoic enthusiasm for the extirpation of emotion is radical in two respects, both of which can be expressed with the claim that emotional responses are never appropriate. First, the Stoics held that emotions are incompatible with virtue , since the virtuous man will retain his equanimity whatever his fate. Grief is always vicious, (...) both bad and bad for you, even when directed at events commonly considered tragic, such as the loss of one’s child. (shrink)

This article explores how the Western theology often employed by European explorers sought to deify ‘whiteness’. Whiteness as an ideological construction found the ideal tool in Christianity and through supersessionism detached Jesus of Nazareth from his Jewish roots and clothed him in whiteness, thus making white maleness the idol that all creatures must aspire towards. In defiance, liberation theologians, in particular James Cone, coined the possibility that ‘Jesus is black’. Thus, the possibility of Jesus being anything to anyone becomes conceivable. (...) Such a usurpation of the Jesus of Nazareth on either side opens the possibility of recreating Jesus in one’s image. This is the coin of idolatry that this article will argue sits at the heart of modern theology. Assuming a dialectical hermeneutic of suspicion, this article explores the problem of modern theology and how some liberation theologies may continue to play second fiddle to the whiteness perpetuated by western theologies like pruning a bonsai tree. Notwithstanding the challenges of decolonising theology, this search conceives the possibility of a non-ideological Christianity that may be confronting the whiteness of western theology and its associated atrocities. Such a quest may lead to a framing of a transformative theology based on honest and interrogative encounter between modern theology and cultural and traditional spiritualities.Contribution: This article explores how liberation theology can become a major player in the theology arena without always playing second fiddle to Western theologies. Exploring decoloniality confronts whiteness in terms of political theology that interlinks anthropology, economics and social welfare. (shrink)

The logical theory of branching space-times, which provides a relativistic framework for studying objective indeterminism, remains mostly disconnected from discussions of space-time theories in philosophy of physics. Earman has criticized the branching approach and suggested “pruning some branches from branching space-time.” This article identifies the different—order-theoretic versus topological—perspective of both discussions as a reason for certain misunderstandings and tries to remove them. Most important, we give a novel, topological criterion of modal consistency that usefully generalizes an earlier criterion, and we (...) introduce a differential-geometrical version of branching space-times as a non-Hausdorff (generalized) manifold. (shrink)