BackgroundSocial cognitive impairments adversely affect social functioning in patients with schizophrenia. Although pharmacological interventions have been suggested to provide some benefits on social cognition, little information is available on the comparative efficacy of pharmacotherapy. Thus, the aim of this planned systematic review and network meta-analysis is to perform a quantitative comparison of the effects of various psychotropic drugs, including supplements, on social cognition disturbances of schizophrenia.MethodsThe literature search will be carried out using the PubMed, Embase, Cochrane Central Register of Controlled (...) Trials, PsycINFO, ClinicalTrials.gov, and International Clinical Trials Registry Platform databases from inception onward. Randomized controlled trials that examined the efficacy of drugs in social cognitive disturbances will be included, based on the most recent studies and the broader literature than previously searched. This protocol defines a priori the methods that will be used for study selection, data collection, quality assessment, and statistical syntheses.DiscussionThe findings this work are expected to help promote the development of better therapeutics of social cognitive impairments in schizophrenia and related psychiatric conditions.Systematic Review Registration[www.crd.york.ac.uk/prospero], identifier [CRD42021293224]. (shrink)

Though there has been an array of methods to evaluate the extent of sarcoidosis, it is generally difficult to detect central nervous system involvement. Recently it has become accepted that 18F-FDG PET is more sensitive than gallium scintigraphy in finding sarcoid lesions, however its usefulness and limitations for detecting sarcoidosis in the central nervous system, especially in the spinal cord, has rarely been investigated. Two patients with pathologically confirmed sarcoidosis manifested spinal symptoms. We conducted 18F-FDG PET along with conventional imagings (...) before and after treatment. Abnormal FDG uptakes which could not be detected by gallium scintigraphy were shown in the spinal cords in both patients. These abnormal uptakes were diminished in accordance with clinical improvement after treatment. Our findings suggest that 18F-FDG PET is effective in detecting and tracking the activity of spinal sarcoidosis. (shrink)

Samuel Lytler Metcalfe was an American chemist and physician who wrote a voluminous work, Caloric Its Mechanical Chemical and Vital Agencies in the Phenomena of Nature ; attempting to account for all natural phenomena in terms of caloric. The book came out at the time when the concept of caloric was being gradually discarded and the law of conservation of energy was about to appear. Metcalfe was convinced that caloric would be the key to unlock the secrets of nature; in (...) order to develop the practical implications of his views he made research trips twice to England , and there he completed Caloric. (shrink)

History of Buddhist philosophy, with special reference to canonical and early philosophical literature, presenting Sarvāstivāda and Theravāda school.

ABSTRACTAnother individual’s gaze automatically shifts an observer’s attention to a location. This reflexive response occurs even when the gaze is presented subliminally over a short period. Another’s gaze also increases the preference level for items in the gaze direction; however, it was previously unclear if this effect occurs when the gaze is presented subliminally. This study showed that the preference levels for nonsense figures looked at by a subliminal gaze were significantly greater than those for items that were subliminally looked (...) away from. Targets that were looked at by a subliminal gaze were detected faster ; however, the participants were unable to detect the gaze direction. These results indicate that another individual’s gaze automatically increases the preference levels for items in the gaze direction without conscious awareness. (shrink)

Modal realism -- Time, space, world -- Existence -- Actuality -- Modal realism and modal tense -- Transworld individuals and their identity -- Existensionalism -- Impossibility -- Proposition and relief -- Fictional worlds -- Epistemology.

This article considers the implications of the early development of London Zoo. It gives insight into the differences between the ideal image of the zoo, the real situation under which the zoo was managed, and popular perceptions of the zoo. The discussion explores three areas: the heterogeneous audience of the zoo, the aestheticization of the zoo and its animal displays, and the pedagogy of observing nonhuman animals in the zoo. The zoo's ideals confronted various difficulties, while the pedagogy of zoo (...) visits, which developed within a frame of natural theology, was subject to various applications. The article argues that these differences were not evidence of the zoo's failure to consolidate its ideological backbone in Victorian society. It concludes that such divergence characterized the zoo's unique capacity both to evoke and to receive competing ideals, anxieties and criticism. (shrink)

Molecular and biochemical analysis of the biogenesis of peroxisomes has made rapid progress in recent years. Research on the mechanism of targeting of peroxisomal proteins has revealed that many, but not all, peroxisomal proteins have a conserved tripeptide motif in their carboxy‐terminal portions which is required for entry into peroxisomes; the topogenic signal mechanism thus differs in these instances from those employed in mitochondria and endoplasmic reticulum. Other factors involved in peroxisome biogenesis are also coming to light.

Reading “The Tale of Genji”: Sources from the First Millennium. Edited by Thomas Harper and Haruo Shirane. New York: Columbia University Press, 2015. Pp. xx + 610. $65.

The paper attempts to construct a global model of a social contract using well-known metaphors of two great philosophers: Jean-Jacques Rousseau and John Locke. By modelling a global social contract, I mean the formulation of a social contract using two sets of data: one is global citizens' preferences about values and norms while the other is sovereign states' participation in multilateral treaties. Both Rousseau and Locke formulate their versions of social contract theories in the national context of eighteenth-century Europe. This (...) paper tries my hands on extending their theories to the global context. This paper attempts to link empirically the relationship between global citizens' preferences as gauged by the World Values Survey and sovereign states' participation in 120 multilateral treaties deposited to the United Nations. To see the link between citizens and treaties (quasi-legislative outcomes, sort of), dimensional similarities of the cosmos of citizens' preference and the cosmos of sovereign states' willingness to join multilateral treaties are examined. Once done, all the sovereign states are located in each of the two cosmoses, citizens and states, and the correlation coefficients between them are measured. Based on these empirical results, the nature of the global quasi-legislative process is clarified. Conclusions and implications are drawn. (shrink)

「意識のクオリア」も五感も、すべては錯覚だった。「心は脳が作り上げた幻想である」ことを述べた著者が、自己意識や五感が錯覚であることに的を絞って説明。.

Call a sentential context semantically transparent if and only if all synonymous expressions are substitutable for one another in it salva veritate. Nathan Salmon has boldly advanced a refreshingly crisp semantic theory according to which belief contexts are semantically transparent. If he is right, belief contexts are much better behaved than widely suspected. Impressive as it is, this author does not believe that Salmon’s theory is completely satisfactory. This article tries to show that Salmon’s theory, in conjunction with a number (...) of auxiliary but important claims he makes to buttress the theory, seems to lead to failure of semantic transparency of belief contexts. (shrink)

闇斎門下の個性豊かな諸家の事跡を通して、垂加神道の史的展開を検討すると共に、『日本書紀』神代巻の解釈に見える思想の根幹を明らかにする。.