RESUMO Neste artigo pretendo expor sinteticamente os problemas levantados contra uma das formas de realismo científico conhecida como realismo experimental, além de propor uma formulação mais aceitável do mesmo, resistente a tais críticas. Os problemas alegados pelos oponentes do realismo experimental variam desde a acusação de inadequação em relação à prática da comunidade científica, até a inconsistência ao admitir entidades e propriedades postuladas teoricamente recusando, entretanto, as teorias em que tais entidades e propriedades aparecem. Some-se a essas críticas a de (...) que o próprio critério do realismo de entidades seria implausível, seja porque falha na produção de crenças verdadeiras ou porque não fornece garantias melhores do que outras formas de realismo científico. Argumentarei que, adotando o realismo experimental exclusivamente como um critério epistêmico e aplicando tal critério às propriedades é possível contornar as críticas, reabilitando uma proposta realista que muitos consideravam já descartada. ABSTRACT In this paper, I will expose briefly the problems raised against one kind of scientific realism known by experimental realism and also will propose an acceptable formulation of that realism, resistant to those criticisms. The problems claimed by the experimental realism’s opponents range from the accusation of inadequacy with the scientific community’s practice to the claim that the admission of entities and proprieties without accepting the theories in which those proprieties and entities are supposed is incoherent. Besides, there is another criticism which states that the entities realism’s criterion is implausible, either because it fails to produce true beliefs or because there is no better warranty in adopting it than other kinds of scientific realism. I will argue that adopting experimental realism exclusively as an epistemic criterion and applying that criterion to proprieties it is possible to escape the criticisms, rehabilitating a realist propose that many people though already discarded. (shrink)

O problema envolvendo o estatuto ontológico das entidades inobserváveis postuladas pelas teorias científicas é um dos mais centrais em filosofia da ciência. O objetivo deste pequeno artigo é o de oferecer um mapa dos posicionamentos mais recentes, sem a ambição de aprofundá-los. O enfoque será nos principais argumentos a favor e contra a capacidade de a ciência descrever corretamente a realidade natural inobservável. Mais especificamente, exporei o argumento do sucesso para o realismo e uma variação do mesmo, bem como as (...) críticas ao referido argumento, tais como a metaindução pessimista, a subdeterminação das teorias pela evidência e uma abordagem darwinista, que evita a ideia de sucesso. Concluirei apresentando como tais argumentos exigiram uma seletividade na abordagem realista, hoje concentrada em três ramos cujos nomes estão de acordo com os elementos sobre os quais cada filosofia recomenda ser realista: realismo explanacionista, realismo de entidades e realismo estrutural. Por uma questão de enfoque, darei apenas uma descrição resumida de cada ramo de realismo citado. (shrink)

No presente trabalho procurarei expor dois desafios antirrealistas ancorados na história da ciência, que Stanford apelidou respectivamente de ‘antiga’ e ‘nova indução pessimista’. Argumentarei que existe uma solução realista já disponível a ambos os desafios pessimistas: o realismo experimental, inicialmente proposto por Hacking e Cartwritght, segundo o qual é possível comprometer-se com entidades teóricas com as quais desenvolvemos interações causais e com as quais produzimos fenômenos controlados, sem que tal compromisso se estenda às teorias mesmas. Tomarei como parâmetro não propriamente (...) os argumentos de Hacking e Cartwright que sofrem inúmeras críticas, mas uma formulação sofisticada do realismo experimental proposta por Egg. (shrink)

The present paper aims to give an account of pessimistic meta-induction and reply to some representative realist authors who want to consider PMI a fallacy. Most of that accounts are misinterpretations of Laudant’s ideas and fails the target. This work intend that PMI is neither a induction nor a reductio, but a skeptic challenge. If this is right then PMI could not be a fallacy and the realism cannot escape from the task of explain why the success is a good (...) indication for the truthlikeness of the current theories. (shrink)

A paramount, yet unresolved issue in personalised medicine is that of automated reasoning with clinical guidelines in multimorbidity settings. This entails enabling machines to use computerised generic clinical guideline recommendations and patient-specific information to yield patient-tailored recommendations where interactions arising due to multimorbidities are resolved. This problem is further complicated by patient management desiderata, in particular the need to account for patient-centric goals as well as preferences of various parties involved. We propose to solve this problem of automated reasoning with (...) interacting guideline recommendations in the context of a given patient by means of computational argumentation. In particular, we advance a structured argumentation formalism ABA+G (short for Assumption-Based Argumentation with Preferences (ABA+) and Goals) for integrating and reasoning with information about recommendations, interactions, patient’s state, preferences and prioritised goals. ABA+G combines assumption-based reasoning with preferences and goal-driven selection among reasoning outcomes. Specifically, we assume defeasible applicability of guideline recommendations with the general goal of patient well-being, resolve interactions (conflicts and otherwise undesirable situations) among recommendations based on the state and preferences of the patient, and employ patient-centered goals to suggest interaction-resolving, goal-importance maximising and preference-adhering recommendations. We use a well-established Transition-based Medical Recommendation model for representing guideline recommendations and identifying interactions thereof, and map the components in question, together with the given patient’s state, prioritised goals, and preferences over actions, to ABA+G for automated reasoning. In this, we follow principles of patient management and establish corresponding theoretical properties as well as illustrate our approach in realistic personalised clinical reasoning scenaria. (shrink)

Multimorbidity, the presence of multiple health conditions that must be addressed, is a particularly difficult situation in patient management raising issues such as the use of multiple drugs and drug-disease interactions. Clinical Guidelines are evidence-based statements which provide recommendations for specific health conditions but are unfit for the management of multiple co-occurring health situations. To leverage these evidence-based documents, it becomes necessary to combine them. In this paper, using a case example, we explore the use of argumentation schemes to reason (...) and combine evidence-based recommendations from clinical guidelines, expected effects, conflicts stemming from said recommendations, and preferences regarding treatment goals. We compare the results of reasoning using the schemes for practical reasoning and argument from negative consequences in the Carneades Argumentation System with those of ASPIC-G, an extension of the artificial intelligence system ASPIC+. (shrink)

The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane properties and trafficking of proteins. As such, lipids are important regulators of brain function and have been implicated in neurodegenerative and mood disorders. Importantly, environmental chronic stress has been associated with anxiety and depression and its exposure in rodents has been extensively used as a model to study these diseases. With (...) the accessibility to modern mass‐spectrometry lipidomic platforms, it is now possible to snapshot the extensively interconnected lipid network. Here, we review the fundamentals of lipid biology and outline a framework for the interpretation of lipidomic studies as a new approach to study brain pathophysiology. Thus, lipid profiling provides an exciting avenue for the identification of disease signatures with important implications for diagnosis and treatment of mood disorders. (shrink)