Using Sneed''s metatheory an attempt is made to reconstruct Hodgkin and Huxley''s theory of excitation of cell membranes. The structure of this theory is uncovered by defining set-theoretical predicates for the partial potential models, potential models, and models of the theory. The function of permeability is said to be the only theoretical function with respect to this theory. The main underlying assumptions of the theory are briefly outlined.

Using Sneed's metatheory an attempt is made to reconstruct Hodgkin and Huxley's theory of excitation of cell membranes. The structure of this theory is uncovered by defining set-theoretical predicates for the partial potential models, potential models, and models of the theory. The function of permeability is said to be the only theoretical function with respect to this theory. The main underlying assumptions of the theory are briefly outlined.

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The ability to take others’ perspectives on the self has important psychological implications. Yet the logically and developmentally prior question is how children develop the capacity to take others’ perspectives. We discuss the development of joint attention in infancy as a rudimentary form of perspective taking and critique examples of biological and individualistic approaches to the development of joint attention. As an alternative, we present an activity-based relational perspective according to which infants develop the capacity to coordinate attention with others (...) by differentiating the perspectives of self and other from shared activity. Joint attention is then closely related to language development, which makes further social development possible. We argue that the ability to take the perspective of others on the self gives rise to the possibility of language, rationality and culture. (shrink)

The ability to take others’ perspectives on the self has important psychological implications. Yet the logically and developmentally prior question is how children develop the capacity to take others’ perspectives. We discuss the development of joint attention in infancy as a rudimentary form of perspective taking and critique examples of biological and individualistic approaches to the development of joint attention. As an alternative, we present an activity-based relational perspective according to which infants develop the capacity to coordinate attention with others (...) by differentiating the perspectives of self and other from shared activity. Joint attention is then closely related to language development, which makes further social development possible. We argue that the ability to take the perspective of others on the self gives rise to the possibility of language, rationality and culture. (shrink)

We agree that social interaction is crucial for understanding the development of theory of mind, but suggest that further elaboration of certain issues is needed. Detailed description of the knowledge structure of a developing theory of mind is necessary, and the notion of criteria for the use of mental state terms requires consideration of the sentence structures in which such terms appear.

In the following post I want to explain my concept of practical philosophy, which is developed in critical discussion of Immanuel Kant’s ethics. I will try to outline a conception of the good, and at least differentiate it for the areas of law and morality. On the one hand, I will show that the human rights form the normative center of the concept of freedom and are grounded in the moral idea of humanity in all of us. On the other (...) hand, this human rights-centered concept of freedom can only be used consistently, if considered together with a policy-driven concept of peace, whose core is in principle, but not categorically, nonviolence. Finally, I will discuss advantages and problems resulting from the reflection and application of my new social imperative which combines the basic principles of peace and freedom. (shrink)

In a subject-philosophical perspective, a musical work embodies the creativity of a subject that has become a construction. As a temporal movement itself, it first expands internally sound-temporally as well as sound-spatially: in the form of an invented succession of tones and, derived from this by negation, also of a simultaneity of sounds (level 1). The content of this imagined temporal-spatial formation can be individual associations, feelings, sensations, moods and atmospheres, which can be conceptually interpreted as musical units (level 2). (...) If the subjectively imagined musical units are then also successfully objectified in the musical material of the external world, the subject realizes and changes itself in it as a tonally individual expression of itself (level 3). (shrink)

Notwithstanding many similarities between Thelen et al.'s and Piaget's accounts of the A-not-B error, we argue that, in contrast to Piaget, they do not explicitly address the issue of objectivity. We suggest that this omission is partly due to the fact that Thelen et al. and Piaget's accounts are pitched at different levels of explanation.

Este texto trata da questão da percepçãodo "outro" no pensamento de Hegel,Husserl, Heidegger e Levinfü!, evidenciando osparadoxos que surgem quando a razão imanentepretende 11propriar -se da questão e realçando astei;isões presentes na própria questão, sugerindodimensões alternativas da racionalidade para aabordagem do problema.

Philosophy and Structure. On why it is necessary for hermeneutic philosophy to make use of structural theory. In this essay I give reasons for the thesis that hermeneutic philosophy has to adopt considerations on structural theory in order to avoid the paradox of historism. Concepts of structure like 'criticism', 'centralism', 'creativity' etc. possess both a metaphilosophical and an empirical status which enables us to compare and to combine differend and opposed philosophies by means of common structures. Such an hermeneutic reflection (...) on philosophical structures requires the methodical work of fiction and selection. Otherwise relativism concerning the evaluation of philosophical traditions would be the result. (shrink)