BackgroundBreast cancer patients are at elevated risk of depression during treatment, thus provoking the chance of poor clinical outcomes. This retrospective cohort study aimed to investigate whether integrating Chinese herbal medicines citation into conventional cancer therapy could decrease the risk of depression in the long-term breast cancer survivors.MethodsA cohort of patients aged 20–70 years and with newly diagnosed breast cancer during 2000–2008 was identified from a nationwide claims database. In this study, we focused solely on survivors of breast cancer at (...) least1 year after diagnosis. After one-to-one matching for age, sex, and baseline comorbidities, breast cancer patients who received and did not receive CHM treatment were enrolled. The incidence rate and hazard ratio citation for depression between the two groups was estimated at the end of 2012. A Cox proportional hazard model was constructed to examine the impact of the CHM use on the risk of depression.ResultsDuring the study period, the incidence rate of depression was significantly lower in the treated cohort than in the untreated cohort [8.57 compared with 11.01 per 1,000 person-years citation], and the adjusted HR remained significant at 0.74 in a Cox proportional hazards regression model. The corresponding risk further decreasing to 43% among those using CHM for more than 1 year.ConclusionFinding from this investigation indicated that the lower risk of depression observed in breast cancer patients treated with CHM, suggesting that CHM treatment should be considered for disease management toward breast cancer. Yet, the optimal administered dose should be determined in further clinical trials. (shrink)

Explaining how stereotypes and norms influence role-identities during reflected appraisal processes, we develop a theory about diverse groups of minority men—the “minority masculinity stress theory”—and apply it to Asian American men. We conceptually integrate hegemonic masculinity, stereotypes, and mental health to examine how Asian American men experience masculinity and how their experiences are uniquely stressful. We analyze elicited text from an open-ended questionnaire to explain two experiences of masculinity-related stress: trying to live up to the masculine ideal and enacting work-related (...) role-identities. Regarding the former, we discuss four illustrations—toughness, body image, restrictive emotionality, and heterosexuality—and two involving the latter—achiever and provider. We found that Asian American men receive stereotypical reflected appraisals that contradict potentially positive self-concepts and emphasize achievement beyond typical standards of hegemonic masculinity. Moreover, Asian American men’s role-identities contradict hegemonic masculinity, resulting in reflected appraisals that predispose them toward stress. (shrink)

The mechanistic significance of a kinetic isotope effect on a cytochrome P‐450catalyzed reaction depends, fundamentally, on the nature of the interaction of the substrate with the active site of the enzyme as well as on the nature of the chemistry of the reaction catalyzed. Consequently, kinetic isotope effects can be used to extract information on the topology of the enzyme and the mechanism of substrate oxidation. Kinetic isotope effect studies are sometimes accompanied by ‘metabolic switching’ or a change in metabolic (...) pathway, catalyzed either by the same enzyme or by a different enzyme. For the specific case where ‘metabolic switching’ gives rise to a change in regional specificity for the cytochrome P‐450 catalyzed metabolism of a compound, this change can be explained in terms of the topological constraints on substrate binding imposed by the active site of the enzyme. (shrink)

Nanotechnology shows great promise in a variety of applications with attractive economic and societal benefits. However, societal issues associated with nanotechnology are still a concern to the general public. While numerous technological advancements in nanotechnology have been achieved over the past decade, research into the broader societal issues of nanotechnology is still in its early phases. Based on the data from the Web of Science database, we applied the main path analysis, cluster analysis and text mining tools to explore the (...) main research fronts and hierarchical structure of these societal issues. We found that the research studies fell into four categories: "General Toxicity and EHS (Environment, Health and Safety)," "Medicine and Cytotoxicity," "Assessment and Regulation," and "Environment and Ecotoxicity." These research studies have disclosed much information about the potential effect of nanotechnology on public health and the environment. Relatively speaking, the studies on the assessment, regulation, preventive solutions, and environmental protection are just emerging. This finding indicates that an abundance of effort should be conducted on these emerging themes to maximize the benefits of nanotechnology while minimizing its potential harm. The implications for various parties in this domain are also presented. (shrink)

Over the past decades, anti-cancer treatments have evolved rapidly from cytotoxic chemotherapies to targeted therapies including oral targeted medications and injectable immunooncology and cell therapies. New anti-cancer medications come to markets at increasingly high prices, and health insurance coverage is crucial for patient access to these therapies. State laws are intended to facilitate insurance coverage of anti-cancer therapies.Using Massachusetts as a case study, we identified five current cancer coverage state laws and interviewed experts on their perceptions of the relevance of (...) the laws and how well they meet the current needs of cancer care given rapid changes in therapies. Interviewees emphasized that cancer therapies, as compared to many other therapeutic areas, are unique because insurance legislation targets their coverage. They identified the oral chemotherapy parity law as contributing to increasing treatment costs in commercial insurance. For commercial insurers, coverage mandates combined with the realities of new cancer medications — including high prices and often limited evidence of efficacy at approval — compound a difficult situation. Respondents recommended policy approaches to address this challenging coverage environment, including the implementation of closed formularies, the use of cost-effectiveness studies to guide coverage decisions, and the application of value-based pricing concepts. Given the evolution of cancer therapeutics, it may be time to evaluate the benefits and challenges of cancer coverage mandates. (shrink)

En este texto abordo una de las propuestas ontológicas, epistémicas y metodológicas que sintetiza mejor el trabajo de las epistemologías feministas sobre cómo conceptualizar las nociones de género y sexo, así como su relación en el ámbito biológico. Describo los alcances y limitaciones de esta propuesta y muestro que la propia noción de sexo implica un sesgo androcéntrico desde el que se legitima la dicotomía endógeno/exógeno, un reduccionismo funcional, la idea de coherencia interna y la reducción de nuestra complejidad biológica (...) a los rasgos vinculados con la reproducción respecto a las diferencias biológicas en general y, como mostraré, en el ámbito biomédico en particular al caracterizar las prevalencias y el desarrollo de enfermedades. En contraste, propongo la idea de epigenealogía para una reconceptualización histórica de nuestra materialidad biológica capaz de profundizar en cómo nuestra plasticidad a través de los procesos epigenéticos danza sincrónicamente con nuestra experiencia social, contingente y situada. (shrink)

“Hay un amplio cielo azul. Debajo estoy yo, parada en una esquina del jardín. Mucha gente conoce a mis padres, y la mayoría me conoce a mí; algunos conocen el jardín y hay quienes inclusive caminaron hasta este rincón. Pero yo, entre todas las personas que hay bajo el cielo, soy la única que conoce a este pequeño retoño de manzana. Por eso puedo decir sin insolencia que en realidad me pertenece, porque cuando estoy lejos no le queda más remedio (...) que existir en mis pensamientos. Pienso: ¿Qué es lo qué pienso?”. (shrink)

Lu Ciccia realizó investigaciones en el Departamento de Fisiología del Sistema Nervioso de la Universidad de Buenos Aires, para luego doctorarse en Estudios de Género por la misma universidad. Actualmente, por las derivas de la vida, es académica del Centro de Investigaciones y Estudios de Género de la UNAM. Refiero a la trayectoria de la autora para mostrar hasta qué punto su libro más reciente, La invención de los sexos, es una exposición integral y provocadora de los años de investigación (...) aquí descritos. Este volumen es original en nuestra lengua porque desarrolla una forma de trabajo en la cual los estudios feministas incorporan críticamente en sus registros las formas de investigación de las ciencias experimentales. (shrink)

A través de un largo excurso por la historia de España, el autor se propone descubrir la particularidad de la Ilustración en el país ibérico para desmontar la tesis según la cual, aquende los Pirineos, no hubo propiamente un Siglo de las Luces, y por lo tanto, tampoco una auténtica filosofía moderna. Presenta en un segundo momento la figura intelectual del padre Benito Feijoo como ejemplo paradigmático de lo que fue la Ilustración española y su diferencia con el Enlightement inglés, (...) las Lumières francesas y la Aufklärung alemana. Se desarrolla la idea según la cual el siglo XVIII sentó las bases de una revolución cultural de carácter supranacional que se materializó en la Constitución de Cádiz de 1812, luego abortada por la Restauración absolutista de Fernando VII. (shrink)

本书分为“我与《周易》”、“《周易》之义理”、“历代易学研究”、“韩国二李易学研究”、“《周易》与史学”五编,基本概括了吕绍纲先生易学研究的各个方面,浓缩了吕绍纲先生易学研究的精华。.

本书记录了我国南宋时期的思想家、文学家、改革家陈亮的生平事迹。他一生不忘恢复主张变革国策;他是南宋词史上不可忽视的名家。.

This paper is an original attempt to understand the foundations of economic reasoning. It endeavors to rigorously define the relationship between subjective interpretations and objective valuations of such interpretations in the context of theoretical economics. This analysis is substantially expanded through a dynamic approach, where the truth of a valuation results in an updated interpretation or changes in the agent's subjective belief regarding the effectiveness of the selected action as well as the objective reality of the effectiveness of all other (...) possible actions (i.e. consequence realization). Complications arise when the economic agent is presented with a set of actions that render ambiguous preference, or when the effectiveness of an action cannot be perceived upon its selection, thereby necessitating a different theory of choice and consequence realization. (shrink)

本书选录自先秦至辛亥革命前一百多位作者的215则家训,分为立志、修身、勉学、处世等主题,以注释、评说形式进行介绍。.

La Meditación de la técnica contiene las reflexiones de José Ortega y Gasset sobre un fenómeno de invasora presencia en el mundo contemporáneo. Trata, en suma, de inscribir el hecho de la técnica en el marco de una antropología filosófica, fundada en el sistema orteguiano, para así contribuir a la comprensión del momento histórico contemporáneo. El volumen incluye, además del curso ¿Qué es la técnica?, desarrollado en 1933 en la Universidad de Santander, otros textos afines: la conferencia El mito del (...) hombre allende a la técnica pronuncida en Darmstadt y varios ensayos sobre el conocimiento científico, que prueban la permanente atención que Ortega prestó a las novedades de la ciencia contemporánea. En esta nueva edición el texto se ha revisado y corregido conforme a los manuscritos originales o las primeras ediciones. La principal novedad es una Introducción al curso ¿Qué es la técnica?, sólo editada póstumamente. (shrink)

Is a human more conscious than an octopus? In the science of consciousness, it’s oftentimes assumed that some creatures (or mental states) are more conscious than others. But in recent years, a number of philosophers have argued that the notion of degrees of consciousness is conceptually confused. This paper (1) argues that the most prominent objections to degrees of consciousness are unsustainable, (2) examines the semantics of ‘more conscious than’ expressions, (3) develops an analysis of what it is for a (...) degreed property to count as degrees of consciousness, and (4) applies the analysis to various theories of consciousness. I argue that whether consciousness comes in degrees ultimately depends on which theory of consciousness turns out to be correct. But I also argue that most theories of consciousness entail that consciousness comes in degrees. (shrink)

本书对构成现代西方哲学思潮的人本主义进行研究,以神话故事蕴涵的深刻意义为缘起论述西方人本主义思想的历史发展,并对中国传统文化人本主义思想进行探析等。.

The study of Joseon 朝鮮 Neo-Confucianism has recently given some attention to an inclination toward the Learning of the Mind-Heart, and Yi Gan 李柬 is at the center of this research. He was an outstanding disciple of Gwon Sang-ha 權尙夏 and a successor to the philosophical spirit of the Yulgok 栗谷 School; he is renowned for initiating the Horak 湖洛 Debate through his controversies with Han Won-jin 韓元震. In “A Thesis on the Not-Yet-Aroused State,” Yi asserted that the mind-heart is (...) purely good, basing his argument on the doctrine that “li 理 and qi 氣 are actualized as the same entity, and the mind-heart and nature are united as one.” Han Won-jin criticized this assertion as belonging to the Lu-Wang 陸王 School of Neo-Confucianism, and in fact, Yi Gan’s arguments were, in some aspects, consistent with Wang Yangming’s 王陽明 philosophy of the mind-heart. Indisputably, however, Yi Gan was an ardent follower of Zhu Xi’s 朱熹 philosophy. In this case, Yi Gan’s inclination toward the Learning of the Mind-Heart may perhaps be viewed in the tradition of the Learning of the Way, which emphasized self-cultivation and practice, a distinct feature of Joseon Neo-Confucianism. (shrink)

Qu’advient-il quand, à la pointe extrême du continent eurasien, la méditation de l’un des plus grands penseurs français franchit les océans pour être accueillie, critiquée sans concession aussi bien que reprise ? Faut-il s’attendre au récit d’un malentendu quand Henri Bergson se trouve relu par son contemporain Nishida Kitarô, né deux années après que son pays se soit ouvert à l’Occident ? Ce dernier va-t-il, depuis le Japon, risquer avec la pensée française ce que firent jadis les européens Leibniz et (...) Malebranche avec la chinoise, ou Schopenhauer avec l’indienne ? Y a-t-il là pure appropriation, et selon quelles spécificités notionnelles et méthodologiques ? Cette rencontre ne laisse-t-elle pas présager, au contraire, un échange véritable quoique encore fragile qui, s’il emprunte presque tout son vocabulaire et ses concepts à l’Europe, en tire un esprit subtil et nouveau ? Les trois études rassemblées dans cet ouvrage se proposent d’envisager ce débat, né il y a près d’un siècle de nous, et la contribution qu’il pourrait apporter à une réflexion sur l’idée de philosophie comparée. (shrink)