The motor modules during human walking are identified using non-negative matrix factorization from surface electromyography signals. The extraction of motor modules in healthy participants is affected by the change in pre-processing of EMG signals, such as low-pass filters ; however, the effect of different pre-processing methods, such as the number of necessary gait cycles in post-stroke patients with varying steps, remains unknown. We aimed to specify that the number of GCs influenced the motor modules extracted in the consideration of LPFs (...) in post-stroke patients. In total, 10 chronic post-stroke patients walked at a self-selected speed on an overground walkway, while EMG signals were recorded from the eight muscles of paretic lower limb. To verify the number of GCs, five GC conditions were set, namely, 25, 20, 15, 10, and 5 gate cycles with three LPFs. First, the number of modules, variability accounted for, and muscle weightings extracted by the NNMF algorithm were compared between the conditions. Next, a modified NNMF algorithm, in which the activation timing profiles among different GCs were unified, was performed to compare the muscle weightings more robustly between GCs. The number of motor modules was not significantly different, regardless of the GCs. The difference in VAF and muscle weightings in the different GCs decreased with the LPF of 4 Hz. Muscle weightings in 15 GCs or less were significantly different from those in 25 GCs using the modified NNMF. Therefore, we concluded that the variability extracted motor modules by different GCs was suppressed with lower LPFs; however, 20 GCs were needed for more representative extraction of motor modules during walking in post-stroke patients. (shrink)

Extracellular ATP released from necrotic cells in inflamed tissues activates the P2X7 receptor, stimulates the exposure of phosphatidylserine, and causes cell lysis. Recent findings indicated that XK, a paralogue of XKR8 lipid scramblase, forms a complex with VPS13A at the plasma membrane of T cells. Upon engagement by ATP, an unidentified signal(s) from the P2X7 receptor activates the XK‐VPS13A complex to scramble phospholipids, followed by necrotic cell death. P2X7 is expressed highly in CD25+CD4+ T cells but weakly in CD8+ T (...) cells, suggesting a role of this system in the activation of the immune system to prevent infection. On the other hand, a loss‐of‐function mutation in XK or VPS13A causes neuroacanthocytosis, indicating the crucial involvement of XK‐VPS13A‐mediated phospholipid scrambling at plasma membranes in the maintenance of homeostasis in the nervous and red blood cell systems. (shrink)

Aphasia is a language disorder that occurs after a stroke and impairs listening, speaking, reading, writing, and calculation skills. Patients with post-stroke aphasia in Japan are increasing due to population aging and the advancement of medical treatment. Opportunities for adequate speech therapy in chronic stroke are limited due to time constraints. Recent studies have reported that intensive speech therapy for a short period of time or continuous speech therapy using high-tech equipment, including speech applications (apps, can improve aphasia even in (...) the chronic stage. However, its underlying mechanism for improving language function and its effect on other cognitive functions remains unclear. In the present study, we investigated whether intensive speech therapy using a newly developed speech support app could improve aphasia and other cognitive functions in patients with chronic stroke. Furthermore, we examined whether it can alter the brain network related to language and other cortical areas. Thus, we conducted a prospective, single-comparison study to examine the effects of a new speech support app on language and cognitive functions and used resting state functional MRI (rs-fMRI) regions of interest (ROI) to ROI analysis to determine changes in the related brain network. Two patients with chronic stroke participated in this study. They used the independent speech therapy system to perform eight sets of 20 randomly presented words/time (taking approximately 20 min), for 8 consecutive weeks. Their language, higher cognitive functions including attention function, and rs-fMRI, were evaluated before and after the rehabilitation intervention using the speech support app. Both patients had improved pronunciation, daily conversational situations, and attention. The rs-fMRI analysis showed increased functional connectivity of brain regions associated with language and attention related areas. Our results show that intensive speech therapy using this speech support app can improve language and attention functions even in the chronic stage of stroke, and may be a useful tool for patients with aphasia. In the future, we will conduct longitudinal studies with larger numbers of patients, which we hope will continue the trends seen in the current study, and provide even stronger evidence for the usefulness of this new speech support app. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Guest Editor’s IntroductionNakajima Takahiro 「東京学派」とは聞きなれない名称であろう。日本研究において「京都学派」は大変よく知られている。たとえ「京都学派」が、「無の論理は論理ではない」と述べた上で、戸坂潤が発明した批判的な概念であったとしても 、現在ではそれは西田幾多郎や田辺元を中心とした一大哲学運動として世界的に認知されている。ところが、西田にしても田辺にしてももともとは東京帝国大学で学んだ学生であった。また、戦前においては、井上哲次郎か ら桑木厳翼へと続く東京帝国大学哲学科の流れは、当時の社会状況と相互に影響しあって、一定の意義を示していたのである。また、大森荘蔵、廣松渉、坂部恵といった戦後の東京大学の哲学者たちは、「京都学派」の問題 系を乗り越えることを重視していた。 この特別号では、発見的概念として「東京学派」を用いて、戦前・戦後におけるその意義と広がりを探究することにした。それは東京大学もしくは東京帝国大学に限定されたものではなく、それ以外の東京圏の大学との相互 交流も含まれるものである。「京都学派」に対しては、政治との距離をどう測るかがしばしば議論されてきたが、「東京学派」は政治により密着したものである。日本の近代の哲学の有している政治性そして倫理性を考える のであれば、やはり「東京学派」の議論は避けて通る ことのできないものである。 無論、「学派」というほどのまとまりを「東京学派」が有しているわけではないことも確かである。西田幾多郎が「京都学派」で果たした中心性は、「東京学派」にはない。そこで、トマス・カスリスが示唆するように、「 学派」の代わりに「サークル」や「スタイル」という言葉を使った方がより正確かもしれない。それでも、あえて「東京学派」と呼ぶのは、「京都学派」に比べて関心を持たれることの少ない、しかし当時は圧倒的な影響力 を有し、戦後決定的に忘却されていった東京の哲学者たちに光をあて、近代日本の哲学の総体を明らかにしたいからである。「東京学派」の研究は緒についたばかりである。今後、国際的な研究の高まりを期待しながら擱筆 する。The “Tokyo School” may be an unfamiliar term to readers. The Kyoto School is very well known in Japanese studies. Even if the Kyoto School is a critical concept invented by Tosaka Jun, who stated [End Page 2] that “the logic of nothingness is not logic,” it is now recognized worldwide as a major philosophical movement led by Nishida Kitarō and Tanabe (...) Hajime. However, both Nishida and Tanabe were originally students at Tokyo Imperial University. In addition, before the war, the output of the Department of Philosophy at Tokyo Imperial University, from Inoue Tetsujirō to Kuwaki Gen’yoku, had a certain significance because it interacted with the social conditions of the time. In addition, postwar philosophers at the University of Tokyo, such as Ōmori Shōzō, Hiromatsu Wataru, and Sakabe Megumi emphasized overcoming the problematics of the Kyoto School.In this special issue, we use the Tokyo School as a heuristic concept to explore its significance and spread in the prewar and postwar periods. It is not limited to the University of Tokyo or Tokyo Imperial University but includes interactions with other universities in the Tokyo area. While the Kyoto School has often been discussed in terms of how to measure its distance from politics, the Tokyo School is more closely connected to politics. If we consider the political and ethical dimensions of modern Japanese philosophy, we cannot avoid discussing the Tokyo School.Of course, it is true that the Tokyo School is not as coherent as a “school.” The central role that Nishida fulfilled in the Kyoto School is perhaps lacking in the Tokyo School. Therefore, as Thomas P. Kasulis suggests, it might be more accurate to use the term “circle” or “style” instead of “school.” Nevertheless, I dare to call it the Tokyo School because I would like to shed light on the Tokyo philosophers who were less popular than those of the Kyoto School but whose influence was overwhelming at the time and who were definitively forgotten after the war, so as to clarify the totality of philosophy in modern Japan.Research on the Tokyo School has only just begun. I am writing this introductory note in anticipation of further international research on the Tokyo School. [End Page 3]Copyright © 2023 State University of New York Press... (shrink)

Girard introduced phase semantics as a complete set-theoretic semantics of linear logic, and Okada modified phase-semantic completeness proofs to obtain normal-form theorems. On the basis of these works, Okada and Takemura reformulated Girard’s phase semantics so that it became phase semantics for proof-terms, i.e., lambda-terms. They formulated phase semantics for proof-terms of Laird’s dual affine/intuitionistic lambda-calculus and proved the normal-form theorem for Laird’s calculus via a completeness theorem. Their semantics was obtained by an application of computability predicates. In this paper, (...) we first formulate phase semantics for proof-terms of second-order intuitionistic propositional logic by modifying Tait-Girard’s saturated sets method. Next, we prove the completeness theorem with respect to this semantics, which implies a strong normalization theorem. (shrink)

In this paper, I will argue from a historical perspective that Gentzen’s 1935 consistency proof of 1st order Peano Arithmetic PA principally aimed to give a finitist interpretation of implication and this aspect of the 1935 proof emerged as the attempt to cope with the non-finiteness in BHK-interpretation of implication. My argument consists of two parts. First, I will explain that the fundamental idea of the 1935 proof is to show the soundness of PA on some finitist interpretation and Gentzen (...) had attempted to use BHK-interpretation as such an interpretation. It is claimed that he eventually thought that there is a ‘circularity’ which is due to the non-finiteness of BHK-interpretation of implication, so it cannot be used as a finitist interpretation. Secondly, I will argue that the principal aim of the 1935 proof is to give his own finitist interpretation of implication which avoids such a ‘circularity’. Finally, this paper’s conclusion and an open question are presented. (shrink)

Gentzen's three consistency proofs for elementary number theory have a common aim that originates from Hilbert's Program, namely, the aim to justify the application of classical reasoning to quantified propositions in elementary number theory. In addition to this common aim, Gentzen gave a “finitist” interpretation to every number-theoretic proposition with his 1935 and 1936 consistency proofs. In the present paper, we investigate the relationship of this interpretation with intuitionism in terms of the debate between the Hilbert School and the Brouwer (...) School over the significance of consistency proofs. First, we argue that the interpretation had the role of responding to a Brouwer-style objection against the significance of consistency proofs. Second, we propose a way of understanding Gentzen's response to this objection from an intuitionist perspective. (shrink)

The Zhuangzi is a deliciously protean text: it is concerned not only with personal realization, but also with social and political order. In many ways the Zhuangzi established a unique literary and philosophical genre of its own, and while clearly the work of many hands, it is one of the finest pieces of literature in the classical Chinese corpus. It employs every trope and literary device available to set off rhetorically charged flashes of insight into the most unrestrained way to (...) live one's life, free from oppressive, conventional judgments and values. The essays presented here constitute an attempt by a distinguished community of international scholars to provide a variety of exegeses of one of the Zhuangzi's most frequently rehearsed anecdotes, often referred to as "the Happy Fish debate." The editors have brought together essays from the broadest possible compass of scholarship, offering interpretations that range from formal logic to alternative epistemologies to transcendental mysticism. Many were commissioned by the editors and appear for the first time. Some of them have been available in other languages—Chinese, Japanese, German, Spanish—and were translated especially for this anthology. And several older essays were chosen for the quality and variety of their arguments, formulated over years of engagement by their authors. All, however, demonstrate that the Zhuangzi as a text and as a philosophy is never one thing; indeed, it has always been and continues to be, many different things to many different people. (shrink)

The Zhuangzi is a deliciously protean text: it is concerned not only with personal realization, but also with social and political order. In many ways the Zhuangzi established a unique literary and philosophical genre of its own, and while clearly the work of many hands, it is one of the finest pieces of literature in the classical Chinese corpus. It employs every trope and literary device available to set off rhetorically charged flashes of insight into the most unrestrained way to (...) live one's life, free from oppressive, conventional judgments and values. The essays presented here constitute an attempt by a distinguished community of international scholars to provide a variety of exegeses of one of the Zhuangzi's most frequently rehearsed anecdotes, often referred to as "the Happy Fish debate." The editors have brought together essays from the broadest possible compass of scholarship, offering interpretations that range from formal logic to alternative epistemologies to transcendental mysticism. Many were commissioned by the editors and appear for the first time. Some of them have been available in other languages—Chinese, Japanese, German, Spanish—and were translated especially for this anthology. And several older essays were chosen for the quality and variety of their arguments, formulated over years of engagement by their authors. All, however, demonstrate that the Zhuangzi as a text and as a philosophy is never one thing; indeed, it has always been and continues to be, many different things to many different people. (shrink)

El libro ilustra un caso de migración de ideas a través de un análisis contextual e histórico-filosófico que introduce al lector en la traducción de la tesis doctoral del filósofo japonés Nakajima Rikizo (1858-1918), La doctrina kantiana de la cosa en sí (1889), defendida en la Universidad de Yale. En el estudio introductorio se examina la aportación del pensador a la luz de la querella sobre la cosa en sí de Kant y esta se enmarca en la corriente neokantiana (...) del siglo XIX, extrayéndose, de ahí, consecuencias para situar el papel de la disertación en el interior de la recepción del idealismo alemán y el neokantismo en la historia de la modernidad filosófica en Japón a partir de la época Meiji (1868). En la tarea de la edición literaria que acompaña a la traducción, el lector encontrará referenciadas de manera sistemática las muchas fuentes que cita Nakajima en su tesis doctoral, aunque, como signo de su tiempo, en el original lo haga sin una convención coherente y, en ocasiones, sin detalles suficientes. Así pues, al aportar al lector acceso a las referencias a los libros que manejó el filósofo, se contribuye a que el texto tenga, además, un interés histórico que se suma al eminentemente filosófico, con el objetivo de impulsar y potenciar estudios sobre la red de interacciones filosóficas que atraviesan el escrito del autor japonés. Por último, el libro se suma a las publicaciones que, en torno a la obra de Immanuel Kant (1724-1804), ganan relevancia filosófica en un momento en el que se está a las puertas de la celebración del 300 aniversario de su nacimiento. (shrink)

Short-term motor practice leads to plasticity in the primary motor cortex. The purpose of this study is to investigate the factors that determine the increase in corticospinal tract excitability after motor practice, with special focus on two factors; “the level of muscle activity” and “the presence/absence of a goal of keeping the activity level constant.” Fifteen healthy subjects performed four types of rapid thumb adduction in separate sessions. In the “comfortable task” and “forceful task”, the subjects adducted their thumb using (...) comfortable and strong forces. In the “comfortable with a goal task” and “forceful with a goal task”, subjects controlled the muscle activity at the same level as in the C and F, respectively, by adjusting the peak electromyographic amplitude within the target ranges. Paired associative stimulation, which combines peripheral nerve stimulation and transcranial magnetic stimulation, with an inter-stimulus interval of 25 ms was also done. Before and after the motor tasks and PAS25, TMS was applied to the M1. None of the four tasks showed any temporary changes in behavior, meaning no learning occurred. Motor-evoked potential amplitude increased only after the FG and it exhibited a positive correlation with the MEP increase after PAS25, suggesting that FG and PAS25 share at least similar plasticity mechanisms in the M1. Resting motor threshold decreased only after FG, suggesting that FG would also be associated with the membrane depolarization of M1 neurons. These results suggest task-dependent plasticity from the synergistic effect of forceful muscle activity and of setting a goal of keeping the activity level constant. (shrink)

The purpose of this study was to investigate how the subjective impression of English speech would change when pause duration at punctuation marks was varied. Two listening experiments were performed in which written English speech segments were rated on a variety of evaluation items by both native-English speakers and non-native speakers. The ratings were then subjected to factor analysis. In the first experiment, the pauses in three segments were made into the same durations, from 0.075 to 4.8 s. Participants rated (...) the segments on 23 evaluation items on a rating scale from 1 to 10. A varimax rotation after PCA led to two factors that were related to speech style. These two factors could be interpreted as representing speech naturalness and speech rate. Speech segments with a pause duration of 0.6 s received the highest naturalness evaluation, while perceived speech rate decreased as the physical pause duration increased, without any changes in utterance segments. In the second experiment, a full-factorial design of pause durations within and between sentences, i.e., for commas and for periods, was implemented in two speech segments. The original speech segments and speech segments without any pauses were also included as control conditions. From ratings on 12 evaluation items, similar to Experiment 1, two factors representing speech naturalness and speech rate were obtained. The results showed again that the perceived speech rate decreased with an increase only in pause duration. As for speech naturalness, the highest evaluations occurred when pause durations were 0.6 s within sentences, and either 0.6 or 1.2 s between sentences. This recommends fixing all pause durations to 0.6 s as a practical way to train non-native speakers to make their spoken English appear more natural. (shrink)

本書は、人間的営みとしての学びの広さ・深さ・自由さを確認していく。人間の成長、人間形成という視点から、学びの実践を通して「学び」の人間学的原理、学ぶ主体にとっての意味を考察。個人の具体的な経験を通して 、多様な学びのあり方を提示。日本人の学び方、教え方の伝統や特徴とその問題について考察。.

It has not been sufficiently emphasized that there existed two kinds of modification theory of colours, Aristotle's modification theory and Descartes-Hook's modification theory. This seems to have caused some confusion in the interpretation of the optical controversy between Newton and Hooke in 1672. The aim of the present paper is to prove that these two kinds of modification theory really coexisted, and on that basis to present a new interpretation of the optical controversy of 1672. The characteristics and the historical (...) role of each of these theories will be described. Newton's colour theory was formed under the influence of Aristotle's modification theory, which had been disseminated through the work of an English Gassendist, Walter Charleton. Newton's optical theories were created not only under the influence of Descartes, as we have been often told, but also under the conspicuous influence of corpuscular philosophers. (shrink)

El objetivo de este trabajo es tratar sobre el concepto la cultura en la generación conocida como los patriarcas o fundadores del pensamiento filosófico latinoamericano. Luego de establecer la relación entre la cultura la filosofía, y de justificar el recurso a los fundadores para tratar sobre el concepto de cultura, intentaré describir las características más importantes de la filosofía de algunos filósofos de esta generación, como Alejandro Korn, Carlos Vaz Ferreira, Alejandro Deústua, Enrique Molina y Antonio Caso, y señalar las (...) principales ideas en torno al concepto de cultura, y su relación con la identidad latinoamericana. (shrink)

When faced with an environmental problem, corporations can either deal with it or merely give the appearance of managing it. The latter is often the case cause the corporation can maintain a positive public image while not actually doing anything to solve the problem. Advertising and public relations are the tools that are commonly utilized to create this illusion. The first part of this article illustrates the variety of ways in which green advertising and green public relations are exploited to (...) mislead the public regarding environmental issues. The many examples cover issues such as global warming, toxic chemicals, the precautionary principle, and environmental education. The second part of the article shows that Jacques Ellul’s theory of integration propaganda provides a good explanation for what has been observed about green advertising and green public relations. (shrink)

This article provides a comprehensive synthesis of state-of-the-art approaches used by industry to improve human, social, and environmental sustainability. Currently available methods such as product stewardship, industrial eco-park design, industrial ecology, Design for Environment (DfE), and others areexplained and their contribution summarized. Particular attention is paid to practices that make the material flows of a society more circular, as in natural ecosystems, and to the idea of companies selling services rather than products. It is concluded that the widespread implementation of (...) these frontier practices are a necessary but not sufficient condition for achieving human, social, and environmental sustainability. Nevertheless, the methods synthesized in this paper reveal a largely untapped potential for improving industrial practices. (shrink)

In this paper, I will describe the history of Japanese science studies (In the Japanese language, the term ?science studies? [Kagaku-ron] is used to indicate a broad area, which covers the history, philosophy, and social studies of science and technology.) from the beginning of the twentieth century to around the mid-1980s, and will argue how depoliticization took place in its history. Japanese science studies was formed under the conspicuous influence of German philosophy before World War II (hereafter WW II), especially (...) in its neo-Kantian tradition. During the military regime, science studies offered a hiding place for Marxists. However, after the end of the Asian-Pacific War, British influence became stronger in the history and sociology of science in two stages. First, logical positivism arrived, in this case, mainly from the USA under the name of ?analytic philosophy.? Second, the American influence was furthered by the introduction of Kuhn?s theory of paradigm which unexpectedly depoliticized Japanese science studies. This trend seems to have reflected the course of the Cold War. After the Fukushima Daiichi Nuclear Disaster, one of the most significant legacies of Cold War Science, we need to review the history of science studies in order to retrieve its ?critical? function. Even though this paper focuses on Japan, comparable reflections should be made worldwide. (shrink)

The external worlds do not objectively exist for living systems because these worlds are unknown from within systems. How can they escape solipsism to survive and reproduce as open systems? Living systems must construct their hypothetical models of external entities in the form of their internal structures to determine how to change states (i.e., sense and act) appropriately to achieve a favorable probability distribution of the events they experience. The model construction involves the generation of symbols referring to external entities. (...) This paper attempts to provide a new view that living systems are an inverse-causality operator. Inverse causality (IC) is an algorithmic process that generates symbols referring to external reality states based on a given data sequence. For applying this logical model involving if–then entailments to living systems involving material interactions, the cognizers-system model was employed to represent the IC process; here, living systems were modeled as a subject of cognition and action. A focal subject system is described as a cognizer composed of sub-cognizers, such as a sensor, a signal transducer, and an effector. Analysis using this model proposes that living systems invented the “measurers” for conducting IC operations through their evolution. (shrink)

Basic emotions such as happiness, sadness, and anger are universal, regardless of the human species, and are governed by specific brain regions. A recent report revealed that mentalizing, which is the ability to estimate other individuals’ emotional states via facial expressions, can be preserved with the help of awake surgery. However, it is still questionable whether we can maintain the ability to understand others’ emotions by preserving the positive mapping sites of intraoperative assessment. Here, we demonstrated the cortical regions related (...) to basic emotions via awake surgery for patients with frontal glioma and investigated the usefulness of functional mapping in preserving basic emotion. Of the 56 consecutive patients with right cerebral hemispheric glioma who underwent awake surgery at our hospital, intraoperative assessment of basic emotion could be successfully performed in 22 patients with frontal glioma and were included in our study. During surgery, positive responses were found in 18 points in 12 patients. Of these, 15 points from 11 patients were found at the cortical level, mainly the premotor and posterior part of the prefrontal cortices. Then, we focused on cortical 15 positive mappings with 40 stimulations and investigated the types of emotions that showed errors by every stimulation. There was no specific rule for the region-emotional type, which was beyond our expectations. In the postoperative acute phase, the test score of basic emotion declined in nine patients, and of these, it decreased under the cut-off value in three patients. Although the total score declined significantly just after surgery, it recovered within 3 months postoperatively. Our study revealed that through direct electrical stimulation, the premotor and posterior parts of the prefrontal cortices are related to various kinds of basic emotion, but not a single one. When the region with a positive mapping site is preserved during operation, basic emotion function might be maintained although it declines transiently after surgery. (shrink)