Tubulin is the ubiquitous protein that makes up the walls of the cytoskeletal elements known as microtubules. These 20 nm diameter cylindrical fibers are the spindle fibers for mitosis, provide the skeletal framework for cellular elongation, constitute the major structural and motile elements of cilia and flagella and probably play a number of other roles in eukaryote cells. In the electron microscope, they are never seen to attach or protrude directly into or on cellular membranes. It was therefore with much (...) skepticism that cell biologists responded to recent claims purporting to show that tubulin is (or can be) a membrane protein. This skepticism comes from a bias based on the generally understood function of cytoskeletal proteins as representing the intracellular ‘bones’ of cells. The traditional thinking was that microtubules may attach to cellular membranes but only via a cross‐linking connecting protein. In recent years, however, an increasing number of workers have come to believe that tubulin can exist as a normal membrane protein possibly independent of its role in microtubule function. (shrink)

European intellectuals diagnosed the end of the nineteenth century as “the sickness of an age.” Schopenhauer's pessimistic books suddenly became popular; Nietzsche announced the “death of god”; and Max Nordeau's Degeneration was an international best seller. To be sure, this mood of despair was initially limited to a handful of poets and philosophers. But once the outbreak of World War I revealed what “the treacherous years were all the while making for and meaning,” the sense that the West had somehow (...) been betrayed by its own most fundamental accomplishments and beliefs was globalized. Thomas Mann's Magic Mountain captured the idea neatly by describing Europe as a tuberculosis sanatorium behind whose walls splendid accomplishment rapidly rotted toward calamity. Spengler's Decay of the West and the early volumes of Toynbee's Study of History argued that decline was inevitable. As Europeans lost faith in their ability to erect The Heavenly City Of The Eighteenth Century Philosophers [Becker, 1932], the era of “enlightenment optimism” gave way to Auden's “Age of Anxiety.” If, as T.S. Eliot put it in East Coker, “the quiet-voiced elders” bequeathed us “merely a receipt for deceit,” then, to cite again W.B. Yeats’ famous poem, it became increasingly obvious that “things fall apart, the center cannot hold.” “[F]ollowing some rough beast” that “slouches toward Bethlehem to be born,” modern civilization began a desperate search for new values that could orient society in an unexpected world. (shrink)

So far my examples have illustrated purely descriptive and evaluative uses of "work of art," but my main claim is that most uses are not pure. Take a controversial example. Christo recently hung a huge, bright orange curtain between the sides of a canyon in Rifle Gap, Colorado. The curtain stretched all the way across the canyon, filled the canyon from top to bottom, and had a hole cut out for the road at the base of the canyon to pass (...) through. There was a good deal of controversy in Colorado at the time about whether the curtain was a work of art. . . . First, the curtain was not in a traditional medium, and this alone was enough to disqualify it as a work of art for some people. Still, it was an artifact, it was intended for public observation and contemplation, and it had no essential utilitarian function. That it met these criteria there could be no doubt, and this was enough for some to consider it a work of art. Others, however, required more before deciding. Of those, some said that a great deal of skill was required to produce it; that it definitely had significant formal qualities—especially the dramatic contrast in line and color between it and the completely natural surroundings; that it was certainly a creative endeavor; and that it was most conducive to aesthetic experience—comparable to certain natural phenomena. For these people it was, without a doubt, a work of art for both descriptive and evaluative reasons. Others, however, were much less charitable. They thought that if the production required skill at all, it was engineering not artistic skill; that not only did it not have significant formal qualities, it was formally trivial and sterile; that perhaps it was novel, but to call it creative was beyond the pale; that far from being conducive to aesthetic experience, it was a blight upon the landscape. Therefore, it was not a work of art. Finally, there were those people who were not sure which characteristics to attribute to the Christo production and were therefore uncertain whether it was a work of art. Robert McGregor is an associate professor of philosophy at the University of Denver and is the author of several articles on aesthetics. See also: "Christo's Gates and Gilo's Wall" by W. J. T. Mitchell in Vol. 32, No. 4. (shrink)

It should be clear that Lyell's scientific contemporaries would hardly have agreed with Robert Munro's remark that Antiquity of Man created a full-fledged discipline. Only later historians have judged the work a synthesis; those closer to the discoveries and events saw it as a compilation — perhaps a “capital compilation,”95 but a compilation none the less. Its heterogeneity made it difficult to judge as a unity, and most reviewers, like Forbes, concentrated on the first part of Lyell's trilogy. The (...) chapters on glaciation were admired by Lyell's friends but had relatively little appeal to more general readers. His discussion of the species question hedged far too much to please those who accepted the cogency of Darwin's evidence and arguments. This last section of the book blatantly lacks originality or commitment and certainly has no claim to classical status in anthropology.We are left, then, with the first twelve chapters, for it was this portion that dictated the book's title and that amassed the available evidence favoring the antiquity of the human species. Did it do anything more than marshall the evidence that others had discovered? I think not. Lyell could write with style and verve. Principles of Geology is a remarkably readable book. But Antiquity is the work of a geologist, not of a systematic student of man. Despite its occasional touches of power, it never captures the freshness and immediacy of Lubbock's Pre-historic Times nor the theoretical brilliance of E. B. Tylor's Researches into the Early History of Mankind (1865).96 Antiquity utilizes little of the comparative method whereby Lyell's contemporaries used data from modern “savagery” to elaborate the possible social functions of the prehistoric remains being uncovered. It contains little social theory and has virtually no integrated framework. Even the first twelve chapters do not really hang together. As Hooker, commenting to Darwin on Lubbock's review, sadly wrote: “Lubbock in [the] N[atural] H[istory] Review, had in a note called attention to Lyell's ... ‘doing injustice’ to Prestwich & Falconer. I modified this expression ‘injustice’ in Lubbock's paper (which was friendly and apologetic). I am deeply sorry for it, but what can one do? I do think Lyell's first XII chapters a complete mess.”97 In another letter to Darwin, Hooker described this first portion of Antiquity as “confused and confusing.”98Part of the problem, of course, lay in the subject's novelty for Lyell and for most of his contemporaries. At a deeper level, however, I believe that the book accurately reflects Lyell's uncertainties about Darwin's work and its implications for man.99 Leonard Wilson's edition of Lyell's Scientific Journals provides a unique insight into Lyell's mind during the years just before he began to write Antiquity.100 Preoccupied with the human implications of evolutionary biology, Lyell was not clear how many of those implications were compatible with his deep convictions about the dignity of man's place in the cosmos. With a certain naiveté, Lyell complained in 1873 that many of his readers had failed to see the “natural connections” among the three portions of Antiquity.101 Connections could indeed be drawn between man's antiquity and his evolutionary origins; Lyell's private Scientific Journals movingly demonstrate that he was well aware of this fact. But he never fully made the connections in his published writings. Antiquity of Man is more appropriately seen as the last gasp of the heroic period in British geology than as the opening salvo in a new, post-Darwinian anthropological synthesis. Between the founding of the Geological Society of London in 1807 and the middle of the nineteenth century, geology was recognized as one of the most exciting and innovative scientific fields in Britain.102 Lyell himself had contributed much to that drama, and by the 1860's he was a public figure of venerable proportions. More then any other man he represented a geology that had extended the boundaries of process, time, and life. The fundamental achievements of Lyell and his colleagues had been assimilated into the wider Victorian consciousness, yet the earlier public debates about “genesis and geology” had left untouched in its essentials the concept of Man as a moral, responsible, created being.103Lyell never abandoned this view of his own species, and in 1863 it was a completely responsible creature which, under the weight of empirical evidence, Lyell admitted had lived on earth far longer than had previously been thought. Certainly this more generous allowance for human existence was constitutive to what Burrow calls the evolutionary social theory of midcentury Britain.104 Unlike Lyell, the younger representatives of this anthropology quietly accepted both man's antiquity and his aboriginal animality. Herbert Spencer's Principles of Psychology (1855), as well as the other volumes of his grand Synthetic Philosophy, presented as part of the cosmic process the development of human from prehuman beings.105 Tylor's discussion of what in his Researches (1865) he called the “gesture-language” presupposed the gradual and de novo origin of language in early human populations.106 Lubbock's young and polished mind was untroubled by the human implications of Darwin's work, and he cast his Prehistoric Times into such a perfect mold that it and its companionpiece (On the Origin of Civilization, 1870) went through seven editions each between 1865 and World War I, with their original theoretical structures intact. In a way that Lyell could not grasp, Lubbock was intrigued by questions concerning the origins of moral and religious beliefs and did not flinch at the thought of an amoral, atheistic creature as an ancestor.107 Indeed, as the German naturalist Carl Vogt pointed out in his Lectures on Man, translated into English the year after Antiquity, both Darwin's theories and the primitive flint knives of the Stone Age bore witness to a time beyond that imaginable from the condition of the lowest present-day “savage”:From such a low condition [little better than anthropomorphous apes], compared to which that of the so-called savages of the old and new world is a refined civilisation, has the human species gradually extricated itself, in a bitter struggle for existence, which it was well able to maintain, by being gifted with a larger amount of brain and intelligence than that possessed by the surrounding animal world.108The easy integration of biological and social themes was perhaps the distinguishing hallmark of Victorian anthropology of the 1850's and 1860's. After his fashion, Lyell got both themes into Antiquity, but he carefully separated them with a seven-chapter wall of glacial ice. Lyell's anthropology was not that of a thoroughgoing evolutionist like Lubbock, Tylor, or Spencer. For Lyell prehistoric man was not a product of biological evolution. Rude and superstitious he may have been, but he possessed ritual and a belief in a future state, and thus deserved “the epithet of ‘noble,’ which Dryden gave to what he seems to have pictured to himself as the primitive condition of our race: as Nature first made man/when wild in woods the noble savage ran.”109As a systematic argument, Lyell's book was at best a significant failure. As a popularization, it was a success — largely because of the personal stature of its author and the particular moment of its appearance. It helped establish the fact of man's antiquity with a wider Victorian audience, in itself no mean achievement. But Lyell was unable to exploit the fuller implications of his material in the service of a secular science of man. Ironically, he exploited only his colleagues' discoveries. Though the aging Lyell, with failing eyesight but unfailing mental powers, can still be seen as a man of considerable importance, his Antiquity belongs to the carefully circumscribed world of British geology rather than to the less disciplined world of Victorian anthropology. (shrink)

Robert Batterman examines a form of scientific reasoning called asymptotic reasoning, arguing that it has important consequences for our understanding of the scientific process as a whole. He maintains that asymptotic reasoning is essential for explaining what physicists call universal behavior. With clarity and rigor, he simplifies complex questions about universal behavior, demonstrating a profound understanding of the underlying structures that ground them. This book introduces a valuable new method that is certain to fill explanatory gaps across disciplines.

This article discusses minimal model explanations, which we argue are distinct from various causal, mechanical, difference-making, and so on, strategies prominent in the philosophical literature. We contend that what accounts for the explanatory power of these models is not that they have certain features in common with real systems. Rather, the models are explanatory because of a story about why a class of systems will all display the same large-scale behavior because the details that distinguish them are irrelevant. This story (...) explains patterns across extremely diverse systems and shows how minimal models can be used to understand real systems. (shrink)

But do animals know that other creatures have minds? And how would we know if they do? In "Mindreading Animals," Robert Lurz offers a fresh approach to the hotly debated question of mental-state attribution in nonhuman animals.

Reconstructing Damon is the first comprehensive study of Damon, the most important theorist of music and poetic meter in ancient Athens, detailing his extensive influence, and providing the first systematic collection, translation, and critical examination of all ancient testimonia for him.

This paper examines contemporary attempts to explicate the explanatory role of mathematics in the physical sciences. Most such approaches involve developing so-called mapping accounts of the relationships between the physical world and mathematical structures. The paper argues that the use of idealizations in physical theorizing poses serious difficulties for such mapping accounts. A new approach to the applicability of mathematics is proposed.

This paper examines the role of mathematical idealization in describing and explaining various features of the world. It examines two cases: first, briefly, the modeling of shock formation using the idealization of the continuum. Second, and in more detail, the breaking of droplets from the points of view of both analytic fluid mechanics and molecular dynamical simulations at the nano-level. It argues that the continuum idealizations are explanatorily ineliminable and that a full understanding of certain physical phenomena cannot be obtained (...) through completely detailed, non-idealized representations. (shrink)

Among discrete emotions, basic emotions are the most elemental; most distinct; most continuous across species, time, and place; and most intimately related to survival-critical functions. For an emotion to be afforded basic emotion status it must meet criteria of: (a) distinctness (primarily in behavioral and physiological characteristics), (b) hard-wiredness (circuitry built into the nervous system), and (c) functionality (provides a generalized solution to a particular survival-relevant challenge or opportunity). A set of six emotions that most clearly meet these criteria (enjoyment, (...) anger, disgust, fear, surprise, sadness) and three additional emotions (relief/contentment, interest, love) for which the evidence is not yet quite as strong is described. Empirical approaches that are most and least useful for establishing basic-emotion status are discussed. Basic emotions are thought to have a central organizing mechanism and to have the capacity to influence behavior, thoughts, and other fundamental processes. (shrink)

This volume is a collection of fourteen essays by leading philosophers on issues concerning the nature, existence, and our knowledge of animal minds. The nature of animal minds has been a topic of interest to philosophers since the origins of philosophy, and recent years have seen significant philosophical engagement with the subject. However, there is no volume that represents the current state of play in this important and growing field. The purpose of this volume is to highlight the state of (...) the debate. The issues which are covered include whether and to what degree animals think in a language or in iconic structures, possess concepts, are conscious, self-aware, metacognize, attribute states of mind to others, and have emotions, as well as issues pertaining to our knowledge of and the scientific standards for attributing mental states to animals. (shrink)

This paper concerns what Jerry Fodor calls a 'metaphysical mystery': How can there by macroregularities that are realized by wildly heterogeneous lower level mechanisms? But the answer to this question is not as mysterious as many, including Jaegwon Kim, Ned Block, and Jerry Fodor might think. The multiple realizability of the properties of the special sciences such as psychology is best understood as a kind of universality, where 'universality' is used in the technical sense one finds in the physics literature. (...) It is argued that the same explanatory strategy used by physicists to provide understanding of universal behavior in physics can be used to explain how special science properties can be heterogeneously multiply realized. (shrink)

This paper aims to draw attention to an explanatory problem posed by the existence of multiply realized or universal behavior exhibited by certain physical systems. The problem is to explain how it is possible that systems radically distinct at lower-scales can nevertheless exhibit identical or nearly identical behavior at upper-scales. Theoretically this is reflected by the fact that continuum theories such as fluid mechanics are spectacularly successful at predicting, describing, and explaining fluid behaviors despite the fact that they do not (...) recognize the discrete nature of fluids. A standard attempt to reduce one theory to another, is shown to fail to answer the appropriate question about autonomy. (shrink)

This paper looks at emergence in physical theories and argues that an appropriate way to understand socalled “emergent protectorates” is via the explanatory apparatus of the renormalization group. It is argued that mathematical singularities play a crucial role in our understanding of at least some well-defined emergent features of the world.

If we are flexible, hybrid and unfinished creatures that tend to incorporate or at least employ technological artefacts in our cognitive lives, then the sort of technological regime we live under should shape the kinds of minds we possess and the sorts of beings we are. E-Memory consists in digital systems and services we use to record, store and access digital memory traces to augment, re-use or replace organismic systems of memory. I consider the various advantages of extended and embedded (...) approaches to cognition in making sense of E-Memory and some of the problems that debate can engender. I also explore how the different approaches imply different answers to questions such as: does our use of internet technology imply the diminishment of ourselves and our cognitive abilities? Whether or not our technologies can become actual parts of our minds, they may still influence our cognitive profile. I suggest E-Memory systems have four factors: totality, practical cognitive incorporability, autonomy and entanglement which conjointly have a novel incorporation profile and hence afford some novel cognitive possibilities. I find that thanks to the properties of totality and incorporability we can expect an increasing reliance on E-Memory. Yet the potentially highly entangled and autonomous nature of these technologie pose questions about whether they should really be counted as proper parts of our minds. (shrink)

In many evolutionary/functionalist theories, emotions organize the activity of the autonomic nervous system and other physiological systems. Two kinds of patterned activity are discussed: coherence, and specificity. For each kind of patterning, significant methodological obstacles are considered that need to be overcome before empirical studies can adequately test theories and resolve controversies. Finally, links that coherence and specificity have with health and well-being are considered.

A traditional view of mathematical modeling holds, roughly, that the more details of the phenomenon being modeled that are represented in the model, the better the model is. This paper argues that often times this ‘details is better’ approach is misguided. One ought, in certain circumstances, to search for an exactly solvable minimal model—one which is, essentially, a caricature of the physics of the phenomenon in question.

While 4E cognitive science is fundamentally committed to recognising the importance of the environment in making sense of cognition, its interest in the role of artefacts seems to be one of its least developed dimensions. Yet the role of artefacts in human cognition and agency is central to the sorts of beings we are. Internet technology is influencing and being incorporated into a wide variety of our cognitive processes. Yet the dominant way of viewing these changes sees technology as an (...) outside force “impacting” on our minds. Within this context, Material Engagement Theory seems well poised to help make sense of our cognitive involvement with the Internet as MET is precisely concerned with grasping the role of material culture in human cognition. This paper explores some of the resources MET provides to think through the effects the internet is having on human agency. This paper uses MET as a starting point for examining the way Internet technology can be involved with human agency, both to the provide a much needed and more adequate theorization of these phenomena, but also to illustrate ways in which the consideration of artefacts can be given a more central and adequate place within the 4E cognitive sciences. (shrink)

Autonomy -- Hydrodynamics -- Brownian motion -- From Brownian motion to bending beams -- An engineering approach -- The right variables and natural kinds.

This research study sought to identify whether there is a relationship between ethical perceptions and culture. An examination of the cultural variables suggests that there is a relationship between two of Hofstede's cultural dimensions (i.e., Uncertainty Avoidance and Individualism) and ethical perceptions. This finding supports the hypothetical linkage between the cultural environment and the perceived ethical problem variables posited in Hunt and Vitell's General Theory of Marketing Ethics (1986).

This paper examines a fundamental problem in applied mathematics. How can one model the behavior of materials that display radically different, dominant behaviors at different length scales. Although we have good models for material behaviors at small and large scales, it is often hard to relate these scale-based models to one another. Macroscale models represent the integrated effects of very subtle factors that are practically invisible at the smallest, atomic, scales. For this reason it has been notoriously difficult to model (...) realistic materials with a simple bottom-up-from-the-atoms strategy. The widespread failure of that strategy forced physicists interested in overall macro-behavior of materials toward completely top-down modeling strategies familiar from traditional continuum mechanics. The problem of the ``tyranny of scales'' asks whether we can exploit our rather rich knowledge of intermediate micro- scale behaviors in a manner that would allow us to bridge between these two dominant methodologies. Macroscopic scale behaviors often fall into large common classes of behaviors such as the class of isotropic elastic solids, characterized by two phenomenological parameters---so-called elastic coefficients. Can we employ knowledge of lower scale behaviors to understand this universality---to determine the coefficients and to group the systems into classes exhibiting similar behavior? (shrink)

In its broadest sense, "universality" is a technical term for something quite ordinary. It refers to the existence of patterns of behavior by physical systems that recur and repeat despite the fact that in some sense the situations in which these patterns recur and repeat are different. Rainbows, for example, always exhibit the same pattern of spacings and intensities of their bows despite the fact that the rain showers are different on each occasion. They are different because the shapes of (...) the drops, and their sizes can vary quite widely due to differences in temperature, wind direction, etc. There are different questions one might ask about such patterns. For instance, one might ask why the particular rainbow... (shrink)

Unlike the Senate of Republican Rome, this essay argues that councils were not the dominant or governing power in Greek oligarchies. Together with powerful officials and other powerful individuals, citizen assemblies mainly governed oligarchies, but admission to oligarchic assemblies was restricted by wealth. Before Solon, did the Areopagos Council govern oligarchic Athens? The principal source for this claim, [Arist.] Ath. Pol. 2-8, at least assigns the early Areopagos a broad judicial competence. Where did Ath. Pol.’s notion come from, and what (...) is it worth? Although ‘some people’ or ‘most people’ believed that Solon established the Areopagos Council, Ath. Pol. rejected that notion, possibly because along with others, Ath. Pol. and Aristotle thought that Solon founded Athens’ democracy, while for fourth century conservatives the early Areopagos was non-democratic. In part the competence of Ath. Pol.’s pre-Solonian Areopagos derives from and expanded its Solonian competence in Ath. Pol. 8.4, so that for Ath. Pol. democratic Solon will have reduced the Areopagos’ powers. In part it derives from fourth century conservative propaganda. This evidence is inadequate to claim that the Areopagos Council governed oligarchic Athens. (shrink)

This paper presents a theory of scientific study which is regarded as a social learning process of scientific knowledge creation, revision, application, monitoring and dissemination with the aim of securing good quality, general, objective, testable and complete scientific knowledge of the domain. The theory stipulates the aim of scientific study that forms the basis of its principles. It also makes seven assumptions about scientific study and defines the major participating entities. It extends a recent process model of scientific study into (...) a detailed interaction model as this process model already addresses many issues of philosophy of science. The detailed interaction model of scientific study provides a common template of scientific activities for developing logical models in different scientific disciplines, or alternatively for developing ontologies of different scientific disciplines. Differences between research and scientific studies are discussed, and a possible way to develop a scientific theory of scientific study is described. (shrink)

Spiritual values in the workplace, increasingly discussed and applied in the business ethics literature, can be viewed from an individual, organizational, or interactive perspective. The following study examined previously unexplored workplace spirituality outcomes. Using data collected from five samples consisting of full-time workers taking graduate coursework, results indicated that perceptions of organizational-level spirituality (“organizational spirituality”) appear to matter most to attitudinal and attachment-related outcomes. Specifically, organizational spirituality was found to be positively related to job involvement, organizational identification, and work rewards (...) satisfaction, and negatively related to organizational frustration. Personal spirituality was positively related to intrinsic, extrinsic, and total work rewards satisfaction. The interaction of personal spirituality and organizational spirituality was found related to total work rewards satisfaction. Future workplace spirituality research directions are discussed. (shrink)

This is the first book to evaluate the significance and usefulness of the practices of anthropomorphism and anecdotalism for understanding animals.

This paper addresses issues surrounding the concept of geometric phase or "anholonomy". Certain physical phenomena apparently require for their explanation and understanding, reference to toplogocial/geometric features of some abstract space of parameters. These issues are related to the question of how gauge structures are to be interpreted and whether or not the debate over their "reality" is really going to be fruitful.