Abstract

In this work, indicators of the level of expression of the anti-apoptotic protein Bcl-2 in different stages of bladder leukoplakia were determined. The results showed that in the control group, this protein was expressed at a low level only in the basal layer of the lining epithelium of the urinary bladder. During the initial stage I of the development of leukoplakia, during the emergence of the metaplastic process in the changing epithelium, the expression of Bcl-2 protein was observed to increase to a high level in the cells of the basal layer of the epithelium with acanthosis. In the II stage of leukoplakia, all cells of the epithelial layers are metaplastic and located vertically, Bcl-2 protein is expressed at a relatively higher level in the cells of the basal and intermediate layers, and in the III stage of the disease, the expression of this protein is even stronger.