The global market for biologics and biosimilar pharmaceutical products is experiencing rapid expansion, primarily driven by the continuous discovery of new molecules. However, information regarding Latin America’s biological market remains limited.

Background Biomedical and ethnographic studies among indigenous people are common practice in health and geographical research. Prior health research misconduct has been documented, particularly when obtaining genetic material. The objective of this study was to crossmatch previously published data with the perceptions of the Waorani peoples about the trading of their genetic material and other biological samples. Methods We conducted a mixed methods study design using a tailored 15-item questionnaire in 72 participants and in-depth interviews in 55 participants belonging to (...) 20 Waorani communities about their experiences and perceptions of participating in biomedical research projects. Additionally, we conducted a systematic review of the literature in order to crossmatch the published results of studies stating the approval of an ethics committee and individual consent within their work. Results A total of 40 men and 32 women, with a mean age of 57 ± 15 years agreed to be interviewed for inclusion. Five main categories around the violation of good clinical practices were identified, concerning the obtention of blood samples from a recently contacted Waorani native community within the Amazonian region of Ecuador. These themes are related to the lack of adequate communication between community members and researchers as well as the voluntariness to participate in health research. Additionally, over 40 years, a total of 38 manuscripts related to the use of biological samples in Waorani indigenous people were published. The majority of the studies did not state within their article obtaining research ethics board approval, and 71% did not report obtaining the informed consent of the participants prior to the execution of the project. Conclusion Clinical Research on the Waorani community in the Ecuadorian Amazon basin has been performed on several occasions. Unfortunately, the majority of these projects did not follow the appropriate ethical and professional standards in either reporting the results or fulfilling them. The results of our investigation suggest that biological material, including genetic material, has been used by researchers globally, with some omitting the minimum information required to guarantee transparency and good clinical practices. We highlight the importance of stating ethics within research to avoid breaches in research transparency. (shrink)

The meanings of utterances and thoughts are commonly regarded in philosophical semantics as abstract objects, called «propositions», which account for how different utterances and thoughts can be synonymous and which constitute the primary truth-bearers. I argue that meanings are instead natural properties that play causal roles in the world, that the kind of «One over Many» thinking underlying the characterization of shared meanings as abstract objects is misguided and that utterances and thoughts having truth-values in virtue of their meanings does (...) not entail that meanings themselves are truth-bearers. (shrink)

A large part of technological advances, especially in the field of industry, have been focused on the optimization of productive processes. However, the detection of anomalies has turned out to be a great challenge in fields like industry, medicine or stock markets. The present work addresses anomaly detection on a control level plant. We propose the application of different intelligent techniques, which allow to obtain one-class classifiers using real data taken from the correct plant operation. The performance of each classifier (...) is assessed and validated with real created faults, achieving successful overall results. (shrink)

Nowadays, the quality standards of higher education institutions pay special attention to the performance and evaluation of the students. Then, having a complete academic record of each student, such as number of attempts, average grade and so on, plays a key role. In this context, the existence of missing data, which can happen for different reasons, leads to affect adversely interesting future analysis. Therefore, the use of imputation techniques is presented as a helpful tool to estimate the value of missing (...) data. This work deals with the academic records of engineering students, in which imputation techniques are applied. More specifically, it is assessed and compared to the performance of the multivariate imputation by chained equations methodology, the adaptive assignation algorithm based on multivariate adaptive regression splines and a hybridization based on self-organisation maps with Mahalanobis distances and AAA algorithm. The results show that proposed methods obtain successfully results regardless the number of missing values, in general terms. (shrink)

The use of batteries became essential in our daily life in electronic devices, electric vehicles and energy storage systems in general terms. As they play a key role in many devices, their design and implementation must follow a thorough test process to check their features at different operating points. In this circumstance, the appearance of any kind of deviation from the expected operation must be detected. This research deals with real data registered during the testing phase of a lithium iron (...) phosphate—LiFePO4—battery. The process is divided into four different working points, alternating charging, discharging and resting periods. This work proposes a hybrid classifier, based on one-class techniques, whose aim is to detect anomalous situations during the battery test. The faults are created by modifying the measured cell temperature a slight ratio from their real value. A detailed analysis of each technique performance is presented. The average performance of the chosen classifier presents successful results. (shrink)

Based on an ethnographic case study, we describe the family experiences and the access to formal education of 30 Paraguayan women to show how these factors influence their labor insertion at the Paraná Tri-Border Area. We will start by reviewing the theoretical debates about gender inequality in labor insertion in border territories. Then, we will explain the study’s methodology and the profile of the interviewees. The analysis consists in describing the relationship between the rural origins of these women and gender (...) inequalities; we will establish how these inequalities are related to low access to formal education and the precariousness of their insertion into the job market. In addition, we will show how these circumstances imply a contradiction in their work experience on the border, between the abuses suffered and the autonomy gained; and we will analyze the expectations of transgenerational transformation that our protagonists project in their children. (shrink)

Este artigo discute como os clipes Mandume, Boa Esperança e Eminência Parda do rapper de Emicida, realizam um retorno à ferida colonial e apontam opacidades históricas, opressões e exclusões daí derivadas, como forma de conduzir a uma releitura afetiva e resistente do/no tempo e instigar ações estéticas de re-existência. Para isso, realizamos uma análise audioverbovisual dos clipes procurando observar a construção desse discurso a partir de três categorias analíticas: retorno memorialístico, corporalidade desumanizada e vida livre da violência e da morte.

En este trabajo se pretende mostrar el sentido político que adquirió la defensa de la teoría por parte de Adorno en los últimos años de su vida. él empleó esta defensa como una respuesta a los imperativos de los estudiantes de izquierda de plegar la teoría crítica a la intervención práctica inmediata. Para justificar esta tesis se atiende no sólo a lo que decía, sino también, en un nivel discursivo diferente, a lo que estaba haciendo cuando empleaba concentraciones de términos (...) y enunciados densos y eruditos para manifestarse. Esto lleva a incluir las reflexiones y valoraciones de Adorno referentes a la actitud teorética y a la praxis, principalmente aquellas esbozadas en Dialéctica negativa, en un contexto más amplio. This work pretends to show the political sense that the defense of the theory by Adorno acquired in the last years of his life. He used this defense as an answer to the students's imperatives of applying the critical theory to the immediate practical intervention. In order to justify this thesis will be considered not only what Adorno said, but also, in a different discursive level, what he was doing on having used concentrations of terms and dense and erudite declarations. This entails, then, to relate Adorno's reflections and assessments concerning to the theoretical and practical approach -specially those outlined in Negative Dialectic- to a broader contextual framework. (shrink)

En partant de la notion de « jargon » mobilisée par Adorno dans son livre contre Heidegger, cet article entend contribuer à une histoire sociale du concept d’authenticité, dans une perspective critique qui s’intéresse à ses usages au sein de différents milieux musicaux et musicologiques. Le rock et la pop, les musiques ethniques et/ou traditionnelles, les musiques anciennes, sont autant de contextes où dans la deuxième moitié du vingtième siècle ont pris forme de manière indépendante ce qu’on peut appeler des (...) querelles de l’authenticité. Nous faisons l’hypothèse que cela s’explique moins pour des raisons techniques communes à ces différents types de musiciens que parce que la diffusion de l’existentialisme et la vogue de la contreculture dans les années 1960 ont installé dans le sens commun l’idée qu’une vie authentique est l’un des noms contemporains de la vie bonne. (shrink)

This article addresses the question raised by the Anthropocene of rethinking the concept of autonomy which, in the conditions of the new geological epoch, is subject to a crisis of legitimation. It explores the ‘strong hypothesis’ according to which nature is a necessary condition of our qualitative experience of the world and a constitutive relation of autonomy defined as the self-realisation of individual identity. With this aim in mind, the article attempts to rethink the concept of recognition in order to (...) conceive a recognising attitude of nature in the form of love of nature as a form of adequate recognition. Rethinking recognition can serve as foundation of an ‘objective’ theory of autonomy, that is, a theory that explains how nature can be defined as a condition and constitutive relation of autonomy. The article, therefore, proposes to reformulate the concept of autonomy as the self-realisation of an ecological or environmental identity in the form of the self-realisation of an ecological ethos, that is, an attitude of respect and care for nature. This enquiry, ultimately, is a contribution to the task of rethinking the basis of our conceptions of autonomy and freedom in the Anthropocene, so that the idea of autonomy can legitimately constitute the central value of the social transformation that is needed to face the ecological crisis. (shrink)

Este artículo tematiza la relevancia del Hamlet, de Shakespeare, para el pensamiento de T. W. Adorno, aun cuando este no haya escrito in extenso sobre aquel. El drama aparece sobre todo en su discurso oral como modelo para describir la relación de discontinuidad entre teoría y práctica. Aquí se desea mostrar cómo el teórico crítico del pensamiento moral abstracto piensa el paso del conocimiento a la praxis a partir del vínculo entre Hamlet y el llamado “factor añadido” (Das Hinzutretende). Desde (...) esta lectura, el Hamlet de Adorno representa un lugar clave de transiciones malogradas. (shrink)

Este artículo analiza relatos biográficos críticos acerca de las experiencias con profesionales y terapias del ámbito de la salud mental por problemas relacionados con depresiones. En un contexto de expansión y diversificación de los discursos y prácticas del campo psi, indaga en las perspectivas y cuestionamientos de usuarios/as de servicios psicoterapéuticos. La pregunta principal que lo orienta es: ¿En las narrativas biográficas cuáles son las críticas que realizan a las prácticas terapéuticas y a quienes la ejercen? Un segundo interrogante: ¿Es (...) posible localizar alguna relación de afinidad entre tipos particulares de críticas y de estilo de terapia psi? Estas cuestiones son abordadas a partir de una investigación empírica, realizada en la ciudad de Santa Fe, Argentina. Se analizan 42 entrevistas biográficas para indagar en el repertorio de objeciones que efectúan a las terapéuticas psi personas involucradas en procesos psicoterapéuticos. El artículo localiza un conjunto de relatos que cuestionan la falta de empatía; la falta de provisión de herramientas; la falta de credibilidad; la jerarquía en la relación; y, finalmente, la ilusión de recuperación. Cada uno de estos tipos de críticas suelen adquirir mayor presencia en determinadas prácticas terapéuticas. En estos estilos de objeciones se hallan críticas más singularizadas —orientadas a personas particulares que ejercen de terapeutas— y más generalizadas —dirigidas a los fundamentos de las terapias. El trabajo contribuye a los estudios sociales sobre el campo psi al producir conocimiento empírico acerca de los saberes críticos por experiencia de personas involucradas en diferentes terapias psi. (shrink)

This article analyses three works or sets of works by Zubiri that I have edited. They are: “The concept of matter” and “The living being”, the “theologic trilogy” and Science and Reality. We analyze their “genesis”, and how this generates some “novelties” in Zubiri’s thinking. The article shows that in order to go deeper into what a philosopher “thinks”, it is necessary to know how his thought is progressing.

In this paper we propose to analyze the representations that Compañero sought to build in the 1963-1964 biennium about two key actors in the peronist movement: Juan D. Perón himself and his union wing. Specifically, we intend to investigate the incidence that notions of hegemonic masculinities had in said representations. To do this, we will focus our attention on the discursive modalities displayed by the journal, using the theoretical-methodological tools provided by Discourse Analysis.

This article presents a detailed exposition of Celsus’ criticism for Christianity, for the first time in Spanish. Celsus was the first known philosopher in Antiquity, who lashed against the dawning Christianity from the point of view of the Greek tradition, the Alethes Logos. The paper shows, first, the metaphysical and philosophical perspective of Celsus’ criticism. Secondly, it brings us inside the ethical and political stirs of Christianity, from Celsus’ own point of view and how this has affected his civil world. (...) This criticism marks the starting point of a philosophical vindication of European paganism, with Giordiano Bruno and Friedrich Nietzsche as its greatest advocates. (shrink)

El presente escrito pretende explicar la relevancia y actualidad ética del pensamiento personalista comunitario de Emmanuel Mounier contextualizándolo en medio de los desafíos del post-humanismo. De este modo, la exposición se centrará en un primer momento en el mundo actual y la “muerte del ser humano”, para luego detallar en qué consiste el post-humanismo y el personalismo comunitario. Finalmente, se confrontarán las ideas provenientes del post-humanismo con la propuesta de Mounier.

Concern with elective-death decisions usually focuses on individuals' competence and understanding of their situations and prospects. If problematic influences on individuals are considered, they almost invariably have to do with matters such as depression and the effects of medication. Too little attention is paid to how individuals, as subjects, are products of both external cultural and social influences on them, and of internal efforts and needs that determine their subjectivity.

We explore the relationship between evidence and knowledge when knowledge is described by a standard partition over a finite state space, and evidence is represented by a state-dependent collection of finite sets of messages. When the collection is measurable with respect to the partition, there is evidence for an event only if the event is self-evident—i.e., known at every one of its states. Thus, an event is commonly known in and only if there is _mutual_ evidence that implies that the (...) event has occurred, and all knowledge can be proved only when the agent is informed about the state or knows nothing. The existence of partial provability outside these two extremes hinges on the non monotonic nature of provability. (shrink)

In this paper we intend to present some medieval foundations, especially Franciscan, of the revitalized civic republicanism of the 20th century. There is an unjustified leap from Rome to the Renaissance that has its origin in the forgetfulness and simplistic view that Hanna Arendt has of medieval thought and Aristotelianism, caused by the historiographic criteria of her time. For this we will show some characteristics of the thought of this new republicanism in order to present the central ideas of four (...) Franciscan authors: Francesc Eiximenis, Bonaventure, Duns Scotus and Alfonso de Castro. First we will try to show the continuity that exists between the Middle Ages and the Modern Age. With this historical approach we intend to analyze that the legitimate aspiration of this new republicanism is distorted and limited if it leaves aside medieval contributions that help to understand more fully the republican pretension the republican pretension that, without rejecting the autonomy of the individual or the sense of community, highlights the interactive nature of social life and instigates him to persevere in the pursuit of the common good. (shrink)

Este artículo, desde posiciones teóricas diversas y a partir de anclajes históricos relevantes, advierte de la necesidad de no bajar la guardia ante comportamientos que promueven la violencia y amenazan la libertad, porque las imposiciones totalitarias siempre han ido precedidas de relatos salvíficos y apelaciones altruistas.

Automatic control of physiological variables is one of the most active areas in biomedical engineering. This paper is centered in the prediction of the analgesic variables evolution in patients undergoing surgery. The proposal is based on the use of hybrid intelligent modelling methods. The study considers the Analgesia Nociception Index to assess the pain in the patient and remifentanil as intravenous analgesic. The model proposed is able to make a one-step-ahead prediction of the remifentanil dose corresponding to the current state (...) of the patient. The input information is the previous remifentanil dose, the ANI variable and the electromyogram signal. Modelling techniques used are Artificial Neural Networks and Support Vector machines for Regression combined with clustering methods. Both training and validation were done with a real dataset from different patients. Results obtained show the potential of this methodology to calculate the drug dose corresponding to a given analgesic state of the patient. (shrink)

RESUMEN Este artículo dialoga con tres importantes reflexiones estéticas procedentes de la filosofía alemana contemporánea. En primer lugar, se ocupa del trabajo de Albrecht Wellmer, representante de la “segunda generación de la Teoría Crítica”; en segundo lugar, se refiere al abordaje del actual profesor de estética en Berlín, Georg W. Bertram; y, en última instancia, indaga los aportes de Juliane Rebentisch, coeditora de la nueva versión de la Zeitschrift für Sozialforschung. Si bien los planteos de estos autores presentan matices diversos, (...) todos ellos son, de uno u otro modo, herederos de un incisivo proceso de reconsideración crítica de la teoría estética de Theodor W. Adorno que viene desarrollándose desde los años setenta. La intención del artículo es reconstruir la modalidad de crítica planteada por estos tres autores y explorar a partir de ello algunas líneas de desarrollo para un estética postadorniana. ABSTRACT This work dialogues with three important reflections on aesthetics, originating in contemporary German philosophy. First, the work of Albrecht Wellmer, representative of the "second generation of the Critical Theory," is analyzed. Second, the approach of the current professor of Aesthetics in Berlin, Georg W. Bertram, and ultimately the contributions of Juliane Rebentisch, co-editor of the new version of the "Zeitschrift für Sozialforschung". While the proposals of these authors have different nuances, they are all, in one way or another, heirs of a long process of critical review of the aesthetic theory of Theodor W. Adorno in development since the seventies. (shrink)

En las últimas décadas, la tendencia a pensar la estética a partir del carácter autónomo de su objeto ha sido dominante en la discusión filosófica alemana. Sin embargo, la crítica a la estética de la autonomía ha cobrado recientemente un nuevo aliento. Uno de los intentos más ambiciosos por destronar la centralidad de este paradigma en la estética actual corresponde al filósofo Georg W. Bertram. El propósito de este artículo es reconstruir la teoría estética de Bertram y exponer cómo ella (...) se inserta en la disciplina estética. Paralelamente, se mostrarán algunas dificultades de la revitalización de una ontología del arte basada en la continuidad entre praxis artística y vida cotidiana. (shrink)

RESUMENEl artículo se propone registrar los puntos principales de la controvertida relación que Theodor Adorno mantuvo, entre 1950 y 1966, con los jóvenes músicos reunidos en torno a los Cursos Internacionales para la Nueva Música realizados en Darmstadt. Se expondrá el modo en que en la música serial, a pesar de su progresismo, que el filósofo medía por el trato con la modernidad radical representada por la escuela vienesa de Schönberg, resonaban elementos que neutralizaban las fuerzas productivas de la nueva (...) música. Al final se elucidará la justificación política que acompañaba a los síntomas estéticos de envejecimiento que Adorno atribuía al círculo de compositores de postguerra.PALABRAS CLAVEADORNO, ESTÉTICA NEGATIVA, RACIONALIZACIÓN, ARTE AUTÓNOMO,MÚSICA SERIALABSTRACTThe paper proposes to record the main points of the controversial relationship Theodor Adorno held, between 1950 and 1966, with the young musicians gathered around the International Courses for the New Music performed in Darmstadt. Here is presented the way in which in serial music, despite its progressivism, which the philosopher measured in the treatment with the radical modernity represented by the Viennese School of Schönberg, resounded elements that neutralized the productive forces of the new music. Finally, I intend to elucidate the political justification that accompanied the aesthetics symptoms of aging that Adorno attributed to the circle of post-war composers.KEYWORDSADORNO, NEGATIVE AESTHETICS, RATIONALIZATION, AUTONOMOUS ART, SERIAL MUSIC. (shrink)