A general framework by which dynamic interactions within a protein will promote the necessary series of structural changes, or “conformational cycle,” required for function is proposed. It is suggested that the free‐energy landscape of a protein is biased toward this conformational cycle. Fluctuations into higher energy, although thermally accessible, conformations drive the conformational cycle forward. The amino acid interaction network is defined as those intraprotein interactions that contribute most to the free‐energy landscape. Some network connections are consistent in every structural (...) state, while others periodically change their interaction strength according to the conformational cycle. It is reviewed here that structural transitions change these periodic network connections, which then predisposes the protein toward the next set of network changes, and hence the next structural change. These concepts are illustrated by recent work on tryptophan synthase. Disruption of these dynamic connections may lead to aberrant protein function and disease states. (shrink)

ch. 1. Ontologii︠a︡ razuma -- ch. 2. Gnoseologii︠a︡ razuma.

My review of Cornelius Castoriadis' book Crossroads in the Labyrinth ended with the apt reference, I now see, to the emperor being naked. In Joel Whitebook's second review, largely irrelevant to my criticisms of Castoriadis, he fears, though he doesn't know me personally, that only the lack of psychological counseling can explain my uncontrolled anger against Castoriadis. Let me dignify his long distance psychoanalysis by passing over it in silence. Silence is also the best remedy for Whitebook's transcendental deduction that (...) I have a “pluralistic, localistic, discontinuous ontology.” Even if I knew what that was I find it amazing that he located it in a 10 page review. Perhaps Whitebook just “feels” the presence of this ontology along with evidence of my mental problems. (shrink)

, Lawrie Reznek argues that disease is not a natural kind term. I raise objections to Reznek's two central arguments for establishing that disease is not a natural kind. In criticizing his a priori, conceptual argument against naturalism, I argue that his conclusion rests on a weaker argument that appeals to the empirical diversity in the symptoms and manifestations of disease. I also raise questions about the account of natural kinds which Reznek utilizes and his point that conventions for classification (...) are excluded by there being natural kinds. Keywords: Disease, natural kind, value judgement CiteULike Connotea Del.icio.us What's this? (shrink)

This writer who has warned us of the “ideological” function of both the oeuvre and the author as unquestioned forms of discursive organization has gone quite far in constituting for both these “fictitious unities” the name (with all the problems of such a designation) Michel Foucault. One text under review, La Volonté de Savoir, is the methodological introduction of a projected five-volume history of sexuality. It will apparently circle back over that material which seems to have a special fascination for (...) Foucault: the gradual emergence of medicine as an institution, the birth of political economy, demography and linguistics as “human sciences,” the invention of incarceration and confinement for the control of the “other” in society (the mad, the libertine, the criminal) and that special violence that lurks beneath the power to control discourse. (shrink)

Adolescence involves a profound number of changes in all domains of development. Among others, adolescence yields an enhanced awareness and responsibility toward the community, representing a critical age to develop prosocial behaviors. In this study, the mediation role of Trait Emotional Intelligence was detected for the relationship between the dark triad and prosocial behavior based on altruism and equity. A total of 129 healthy late adolescents filled in the Dark Triad Dirty Dozen, measuring Machiavellianism, psychopathy, and narcissism; the Altruistic Action (...) Scale, evaluating behaviors directed at helping others; the Equity Scale, assessing behaviors directed at equity in different forms; and the TEI Questionnaire-Short Form. Results showed that TEI mediated the negative effects of the three dark triad traits on both altruism and equity. This finding suggests that TEI, which relies on a set of dispositions, might reduce the malevolent effects of the dark triad on altruism and equitable behavior in late adolescence. This led to assume that intervention programs focused on improving emotional skills, also in late adolescence, can promote prosociality. (shrink)

John Searle’s argument that social-scientific laws are impossible depends on a special open-ended feature of social kinds. We demonstrate that under a noncontentious understanding of bridging principles the so-called "counts-as" relation, found in the expression "X counts as Y in (context) C," provides a bridging principle for social kinds. If we are correct, not only are social-scientific laws possible, but the "counts as" relation might provide a more perspicuous formulation for candidate bridge principles.

Contemporary Continental Philosophy steps back from current debates comparing Continental and analytic philosophy and carefully, yet critically outlines the tradition’s main philosophical views on epistemology and ontology. Forgoing obscure paraphrases, D’Amico provides a detailed, clear account and assessment of the tradition from its founding by Husserl and Heidegger to its challenge by Derrida and Foucault. Though intended as a survey of this tradition throughout the twentieth century, this study’s focus is on the philosophical problems which gave it birth and even (...) now continue to shape it.The book reexamines Husserl as an early critic of epistemological naturalism whose grasp of the philosophical importance of the theory of meaning was largely ignored. Heidegger’s contrasting effort to revive ontology is examined in terms of his distinction between ontic and ontological questions. In contrast with many earlier studies, the author outlines confusions engendered by the misappropriation of the distinct philosophical agendas of Husserl and Heidegger by such famous figures as Sartre and Merleau-Ponty. The book is also original in its emphasis on how social externalism in epistemology, inspired by Karl Mannheim, influenced this tradition’s structuralist and Marxist phases. The philosophical defenses of a theory of interpretation by Gadamer and Habermas are closely examined and assessed and the study concludes with a a probing yet balanced account of Foucault and Derrida as critics of philosophical autonomy. The book concludes by reassessing this century-long divide between the analytic and Continental traditions and its implication for the future of philosophy. (shrink)

In two articles, Smits, Buekens, and du Plessis have argued that John Searle’s account of institutional facts suffers serious flaws and should be replaced with a reductive account they call “incentivization.” We argue against their view in two ways. First, the specific flaws they find in Searle are based on misunderstandings. Second, “incentivization,” as they present it, fails as a reduction of strict collective actions and, thus, cannot account for institutional facts such as money or property.

Written as an introductory textbook for the study of world politics and the analysis of gender, this work is suitable for courses in International Relations, ...

Although motherhood is the female destiny par excellence in the biblical narrative, it is an experience only accessible through a male point of view. In order to reflect on the problems of representation of the maternal body in the Hebrew Bible, I propose an analysis of different maternal characters present in the books of Samuel and Kings. My reading aims, on the one hand, to identify the features that define the maternal in the biblical text and, on the other hand, (...) to offer an approach that allows to point to the implications that the crisis context the texts reflect have on the picture of the actions and the destinies of these female characters. (shrink)

Antecedente. Se considera «eutanasia» al acto de acabar con la vida del paciente a petición expresa de él, para terminar el sufrimiento propio de alguna enfermedad sin perspectiva de cura. Objetivo. Evaluar los conocimientos y la percepción sobre la eutanasia en estudiantes y profesionales de medicina, demostrando los conocimientos y clasificando la percepción sobre la eutanasia. Metodología. Estudio clínico-epidemiológico, observacional, cualitativo-cuantitativo, de corte transversal y con muestreo no probabilístico por conveniencia, en los estudiantes y profesionales de medicina de un hospital (...) en Venezuela. Resultados. La muestra estudiada tuvo una distribución según grado de instrucción: 64.85% de estudiantes, 19.33% de residentes y 15.82% de especialistas. Presentaron un grado de conocimiento medio, distribuido en 84.4% de especialistas, 77.3% de residentes y 80.5% de estudiantes (p 0.051). De acuerdo con los grados de conocimiento y el apoyo a la eutanasia, el 76.18% tiene un grado medio de conocimientos (p 0.0002). Conclusión. Se demostró que existe un grado medio de conocimiento, en particular en la población estudiantil. La eutanasia no fue percibida de manera negativa, demostrando una alta significancia en la atención a las implicaciones éticas que rodean este concepto. (shrink)

This article studies the underinvestigated but fascinating issue of the sociological determinants of accounting misbehavior while focusing on an allegedly illicit accounting practice (i.e., restatement) in family- vs. nonfamily-controlled corporations. Under the framework of institutional anomie theory, we examined whether sociological structures (i.e., legal forces and cultural values) influence accounting errors inducing restatements. By applying a multivariate regression analysis to a sample of restating firms listed in 23 countries during the 2006 to 2014 period, we found that legal forces and (...) cultural values significantly moderate the severity of accounting errors. The results of this study suggest that investors, managers, and policymakers should more fully consider the sociological structures of societies when debating the feasibility of corporate misbehaviors, as combining firm-level and country-level analyses could help to predict a firm’s accounting misbehaviors, such as more severe accounting errors. (shrink)

The proportionality standard demands a meaningful link between the severity of crimes and the punishments received for them. This article investigates the compatibility between this philosophical d...

Este artículo investiga las narraciones de 1 Sam 9 y 1 Sam 28 a la luz del trasfondo más amplio del contexto sacrificial en el primer libro de Samuel. En concreto, este estudio muestra cómo los episodios, unidos por la escena de un banquete y el reparto de la comida sagrada, constituyen las partes de un sistema simbólico definido que, en sus resultados, es capaz de describir, definir y dirigir las relaciones entre los participantes en el ritual y la deidad. (...) A través del ejemplo de los banquetes de Saúl, primero con Samuel y luego con una nigromante en la aldea de En Dor, el texto de 1Sam define una jerarquía precisa entre la práctica cultual y la monarquía naciente en Israel. (shrink)

A critical account of the case for historicism from Popper to Foucault, this volume, originally published in 1989, shows the viability of an historicist account of knowledge by replying to traditional objections and the need for defenses of realism and reference at the heart of most alternatives to historicism. The book provides insights to those in philosophy as well as literary criticism, intellectual history, history of science, and cultural criticism.

In two articles, Smits, Buekens, and du Plessis have argued that John Searle’s account of institutional facts suffers serious flaws and should be replaced with a reductive account they call “incentivization.” We argue against their view in two ways. First, the specific flaws they find in Searle are based on misunderstandings. Second, “incentivization,” as they present it, fails as a reduction of strict collective actions and, thus, cannot account for institutional facts such as money or property.

What roles do women play in world politics? Who are these women, and what impact do they have on international relations? D'Amico and Beckman have assembled a diverse array of contributors who provide a variety of answers. Some contributors consider women as national leaders and profile Chamorro, Gandhi, Thatcher, and Aquino as examples. Autobiographical essays and interviews describe the experiences of Margaret Anstee, Benazir Bhutto, Jeane Kirkpatrick, and Golda Meir. Other contributors analyze international women's movements, the roles of women (...) in the Green Movement and in the revolutionary movements in Cuba and Nicaragua, and the work of Jane Addams in the peace movement. Some analyze the attitudes and beliefs of America's leading opinion makers on the subject of women and men in leadership roles. Written for beginning students in comparative politics and international relations, their work is both fundamental as an introductory text and pioneering in scope and conception. (shrink)

ExcerptDavid Graeber and David Wengrow, The Dawn of Everything: A New History of Humanity. New York: Farrar, Straus and Giroux, 2021. Pp. 704. The Dawn of Everything is not just a massive book in terms of its total number of pages but also in the amount of archaeological evidence discussed concerning human “prehistory.” The authors range over current disputes within their disciplines as well as discussing in some detail political philosophies of the seventeenth and eighteenth centuries. In spite of its (...) size and range, the book has been widely reviewed and has had a publication success rarely seen with academic works. Attention to it may be in part due to the publishing career of its co-author David Graeber, who tragically died in 2020 just before the book appeared in print. The reason I mention this point is that Graeber’s work had both an academic and non-academic audience, in such books as Bullshit Jobs: A Theory, Debt: The First 5,000 Years, and The Democracy Project: A History, a Crisis, a Movement. He also had a public profile during the Occupy Wall Street movement beginning in 2011, which highlighted his advocacy of anarchism. Graeber’s political philosophy plays a significant role in this book. (shrink)