New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

We tend to suppose that the ancient Greeks had primitive ideas of the self, of responsibility, freedom, and shame, and that now humanity has advanced from these to a more refined moral consciousness. Bernard Williams's original and radical book questions this picture of Western history. While we are in many ways different from the Greeks, Williams claims that the differences are not to be traced to a shift in these basic conceptions of ethical life. We are more like the (...) ancients than we are prepared to acknowledge, and only when this is understood can we properly grasp our most important differences from them, such as our rejection of slavery. The author is a philosopher, but much of his book is directed to writers such as Homer and the tragedians, whom he discusses as poets and not just as materials for philosophy. At the center of his study is the question of how we can understand Greek tragedy at all, when its world is so far from ours. Williams explains how it is that when the ancients speak, they do not merely tell us about themselves, but about ourselves. _Shame and Necessity_ gives a new account of our relations to the Greeks, and helps us to see what ethical ideas we need in order to live in the modern world. (shrink)

Bernard Williams's remarkable essay on morality confronts the problems of writing moral philosophy, and offers a stimulating alternative to more systematic accounts which seem nevertheless to have left all the important issues somewhere off the page. Williams explains, analyses and distinguishes a number of key positions, from the purely amoral to notions of subjective or relative morality, testing their coherence before going on to explore the nature of 'goodness' in relation to responsibilities and choice, roles, standards, and human nature. (...) The final chapters make a fascinating enquiry into what morality is about, looking beyond happiness to other human aims and ideals. This re-issue of a classic in moral philosophy includes a new foreword by the author. (shrink)

La philosophie de Michel Onfray fait une place très importante au corps. Mais de quel corps s’agit-il? Avec certitude il ne s’agit pas d’un corps souffrant et torturé : christique ou du corps péjoré de la religion chrétienne, encore moins d’un corps éthéré et privé de ses sens, corps céleste et abstrait. Bien au contraire, il s’agit davantage du corps des cyniques, des cyrénaïques ou des épicuriens, d’un corps nietzschéen ou « la mettrien » qui fait une large place à (...) au moins quatre des cinq sens, à l’érotisme à la sensualité. C’est un corps qui rejette la hiérarchie habituelle des sens allant de l’odorat (sens mineur) à la vue (sens majeur) et la renverse faisant la part belle au goût et à l’odorat et mettant à distance ou du moins à la place que selon l’auteur elles méritent : l’ouïe et la vue. Un sens pourtant est peu présent chez Onfray : le toucher où plutôt le toucher lorsqu’il s’agit pour le philosophe d’être lui-même touché. Là se développe la tactique du porc épic ou du hérisson. Pour autant, il reste, en s’appuyant sur la méthodologie de Le Ventre des philosophes, à comprendre la genèse de ce corps hédoniste solaire, de ce corps qui rejette la mort et les limbes et le crucifié. (shrink)

Bernard Williams is remembered as one of the most brilliant and original philosophers of the past fifty years. Widely respected as a moral philosopher, Williams began to write about politics in a sustained way in the early 1980s. There followed a stream of articles, lectures, and other major contributions to issues of public concern--all complemented by his many works on ethics, which have important implications for political theory. This new collection of essays, most of them previously unpublished, addresses many (...) of the core subjects of political philosophy: justice, liberty, and equality; the nature and meaning of liberalism; toleration; power and the fear of power; democracy; and the nature of political philosophy itself. A central theme throughout is that political philosophers need to engage more directly with the realities of political life, not simply with the theories of other philosophers. Williams makes this argument in part through a searching examination of where political thinking should originate, to whom it might be addressed, and what it should deliver. Williams had intended to weave these essays into a connected narrative on political philosophy with reflections on his own experience of postwar politics. Sadly he did not live to complete it, but this book brings together many of its components. Geoffrey Hawthorn has arranged the material to resemble as closely as possible Williams's original design and vision. He has provided both an introduction to Williams's political philosophy and a bibliography of his formal and informal writings on politics. Those who know the work of Bernard Williams will find here the familiar hallmarks of his writing--originality, clarity, erudition, and wit. Those who are unfamiliar with, or unconvinced by, a philosophical approach to politics, will find this an engaging introduction. Both will encounter a thoroughly original voice in modern political theory and a searching approach to the shape and direction of liberal political thought in the past thirty-five years. (shrink)

Dieses Buchlein schlagt sich fur die Philosophie, aber es ist moglich, daB die Philosophen das nicht schatzen. Sein Ton ist nicht vornehm. Es ist provoziert durch das verbreitete Gerede yom,Ende der Philosophie' einerseits sowie andererseits durch die argerliche Tat­ sache, daB dies Gerede angesichts des gegenwartigen Zustandes der Philosophie eine Berechtigung zu haben scheint. Es hiingt zusamrnen mit rneinem Buch,Selbst­ behauptung und Anerkennung'; der Polernik, die sich dort aus Grunden systernatischer Strenge verbot, ist hier freier Lauf gelassen, die Programrnatik, die (...) hier nur angedeutet ist, ist dort ausgearbeitet. Ich widme dieses Buchlein all den Freunden in der Philosophie, die mir begegnet sind seit ich vor genau zwanzig J ahren unter der Anleitung von Lehrern wie Heinz Heirnsoeth und J oachirn Ritter die ersten Schritte machte. Ich hoffe, daB auch nach dem Erscheinen von jenen Freunden einige ubrig bleiben. Bochum und Munster, Bernard Willms irn Herbst 1977 5 Inhalt Vorbemerkung............................... 5 Einleitung.................................. 9 I. Steine und Schlangen........................ 14 1. Die bezahlte Universitatsphilosophie............ 14 2. Steine................................ 20 Reflexion............................ 21 Logik.............................. 24 Kritik.............................. 26 Praxis.............................. 29 - Modische Ubiquitat und Erbaulichkeit......... 31 3. Schlangen.............................. 34 Der philosophische Defatismus.............. 35 Die militante Ideologie des Gegensystems....... 39 II. Die Auffanglinie........................... 42 1. Historisches Philosophieren.................. 42 2. F ehlformen............................ 46 3. Politische Philosophie...................... 47 III. Die Aufgabe der Philosophie................... 51 1. Die philosophische Arbeit................... 51 2. Abgrenzungen........................... 64 - Falsche Erwartungen.................... 64 7,Ewige Wahrheiten'.................... 65 Ooktrinare Bestatigung.................. 68 - Handlungsrezepturen................... 69 - Lebenshilfe.......................... 70 3. (shrink)

This new volume of philosophical papers by Bernard Williams is divided into three sections: the first Action, Freedom, Responsibility, the second Philosophy, Evolution and the Human Sciences; in which appears the essay which gives the collection its title; and the third Ethics, which contains essays closely related to his 1983 book Ethics and the Limits of Philosophy. Like the two earlier volumes of Williams's papers published by Cambridge University Press, Problems of the Self and Moral Luck, this volume will (...) be welcomed by all readers with a serious interest in philosophy. It is published alongside a volume of essays on Williams's work, World, Mind, and Ethics: Essays on the Ethical Philosophy of Bernard Williams, edited by J. E. J. Altham and Ross Harrison, which provides a reappraisal of his work by other distinguished thinkers in the field. (shrink)

Bernard Williams; XIV*—The Truth in Relativism, Proceedings of the Aristotelian Society, Volume 75, Issue 1, 1 June 1975, Pages 215–228, https://doi.org/10.1093.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Nationalism is one of modern history’s great surprises. How is it that the nation, a relatively old form of community, has risen to such prominence in an era so strongly identified with the individual? Bernard Yack argues that it is the inadequacy of our understanding of community—and especially the moral psychology that animates it—that has made this question so difficult to answer. Yack develops a broader and more flexible theory of community and shows how to use it in the (...) study of nations and nationalism. What makes nationalism such a powerful and morally problematic force in our lives is the interplay of old feelings of communal loyalty and relatively new beliefs about popular sovereignty. By uncovering this fraught relationship, Yack moves our understanding of nationalism beyond the oft-rehearsed debate between primordialists and modernists, those who exaggerate our loss of individuality and those who underestimate the depth of communal attachments. A brilliant and compelling book, _Nationalism and the Moral Psychology of Community_ sets out a revisionist conception of nationalism that cannot be ignored. (shrink)

In Ethics and the Autonomy of Philosophy, Bernard Walker sets out with two objectives. First, Walker argues that ethics is autonomous as a discipline. Oftentimes ethics books, from a Christian perspective, lean toward grounding ethics in theology or in biblical proof texting. Walker departs from this tradition. Ethics grounded in theology entails a limited scope for those doing ethics in that the Christian God must be assumed for both Christian and non-Christian when at the table of ethical dialogue. For (...) the non-Christian, this loads the dice and shuts down ethical consensus and dialogue, if not ethical truth. With that said, this book does not depart from Christian ethical views on such issues as the sanctity of life, antiracism, the death penalty, the objectivity of ethics, and the importance of integrating faith into ethics; however, Walker does so from a common denominator of philosophy rather than theology. Second, Walker ventures into the streets and engages the man/woman on the streets approach to ethics and ethical decision-making. He points out the shortcomings of the ubiquitous views of the man/woman on the streets, viz., cultural relativism, skepticism, and the attitude that ethics is merely a matter of personal choice. (shrink)

Bernard Yack seeks to identify and account for the development of a form of discontent held in common by a large number of European philosophers and social critics, including Rousseau, Schiller, the young Hegel, Marx, and Nietzsche. Yack contends that these individuals, despite their profound disagreements, shared new perspectives on human freedom and history, and that these perspectives gave their discontent its peculiar breadth and intensity.

Despite its importance in various fields, analogical reasoning has not yet received a unified formal representation. Our contribution proposes a general scheme of inference that is compatible with different types of logic (deductive, probabilistic, non-monotonic). Firstly, analogical assessment precisely defines the similarity of two objects according to their properties, in a relative rather than absolute way. Secondly, analogical inference transfers a new property from one object to a similar one, thanks to an over-hypothesis linking two sets of properties. The belief (...) strength in the conclusion is then directly related to the belief strength in this meta-hypothesis. (shrink)

Intentionalism is the claim that the phenomenological properties of a perceptual experience supervene on its intentional properties. The paper presents a counter-example to this claim, one that concerns visual grouping phenomenology. I argue that this example is superior to superficially similar examples involving grouping phenomenology offered by Peacocke (Sense and Content, Oxford: Oxford University Press), because the standard intentionalist responses to Peacocke’s examples cannot be extended to mine. If Intentionalism fails, it is impossible to reduce the phenomenology of an experience (...) to its content. (shrink)

This book offers the fullest and most sophisticated account of Gert's influential moral theory, a model first articulated in the classic work The Moral Rules: A New Rational Foundation for Morality, published in 1970. In this final revision, Gert makes clear that the moral rules are only one part of an informal system that does not provide unique answers to every moral question but does always provide a range of morally acceptable options. A new chapter on reasons includes an account (...) of what makes one reason better than another and a second new chapter is devoted to the question of justifying violations of the rules. Moral impartiality, the moral ideals, and virtue and vice, are all treated in greater detail. Throughout, Gert attempts to answer all of the challenges that his work has provoked. (shrink)

Two main schemes explain how a system adapts to its environment. Evolutionary models are grounded on three usual processes (variation, transmission, selection) acting at the population level. Learning models are concerned with the endogenous search for a better performance at the individual level. The first ones were initially favored by biology and the second well illustrated by game theory. The article examines first how game theory went to evolution and how biology later considered learning. It shows some examples of a (...) hybrid use of models of each type. It finally proposes a common framework for both types of models. (shrink)

This book is the result of over 30 years of collaboration among its authors. It uses the systematic account of our common morality developed by one of its authors to provide a useful foundation for dealing with the moral problems and disputes that occur in the practice of medicine. The analyses of impartiality, rationality, and of morality as a public system not only explain why some bioethical questions, such as the moral acceptability of abortion, cannot be resolved, but also provide (...) a method for determining the correct answer for those occasions when a bioethical question has a unique correct answer. This new edition includes an entire chapter that has been added to address the controversial issue of abortion within the authors' distinct framework. This book presents the latest revisions of the authors' orignial analyses of the concepts of death and disease, analyses that have had a significant impact on the field of bioethics. It also includes an added chapter on mental disorders, where the authors' definition influenced what psychiatry classifies as a mental disorder, and so has had an impact that reveals beyond the field of bioethics. In this edition, the authors also offer a new, more developed perspective on the concept of valid or informed consent by considering what information physicians should be required to know before proposing screening, diagnostic testing, prescribing medications, or performing surgery. The book also integrates some of the important insights of the field of clinical epidemiology into its discussion of valid consent. Its account of paternalism and its justification, perhaps the most ubiquitous moral problem in medical ethics, has had considerable influence. Its discussion of euthanasia and physician assisted suicide challenges the standard views that have been put forward by both proponents and opponents of physician assisted suicide and voluntary active euthanasia. (shrink)

Moral problems do not always come in the form of great social controversies. More often, the moral decisions we make are made quietly, constantly, and within the context of everyday activities and quotidian dilemmas. Indeed, these smaller decisions are based on a moral foundation that few of us ever stop to think about but which guides our every action. Here distinguished philosopher Bernard Gert presents a clear and concise introduction to what he calls "common morality" -- the moral system (...) that most thoughtful people implicitly use when making everyday, common sense moral decisions and judgments. Common Morality is useful in that -- while not resolving every disagreement on controversial issues -- it is able to distinguish between acceptable and unacceptable answers to moral problems. In the first part of the book Gert lays out the fundamental features of common morality: moral rules, moral ideals, and a two-step procedure for determining when a violation of a moral rule is justified. Written in a non-technical style, the ten general moral rules include rules on which everyone can agree, such as "do not kill," "do not deceive," and "keep your promises." The moral ideals include similarly uncontroversial precepts such as "Relieve pain" and "Aid the needy." In the second part of the book Gert examines the underlying concepts that justify common morality, such as the notions of rationality and impartiality. The distillation of over 40 years of scholarship, this book is the most accessible version of Gert's influential theory of morality as well as an eye-opening look at the moral foundations of our everyday actions. Throughout the discussion is clear enough for a reader with little or no philosophy background. (shrink)

In addition to this much-needed clarification of the uses and abuses of the term "modernity," Yack here provides a fresh look at familiar modern ideas and practices such as nationalism, constitutionalism, and liberal democratic politics. Our world, the author suggests, offers us far stranger and more unexpected combinations that are dreamt of in modernist and postmodernist philosophies. His critique of the tendency to treat modernity as an integrated and coherent whole will expand the reader's vision to take in the broader (...) landscape of surprising and inconsistent features in the social and political world that surrounds us. The Fetishism of Modernities will be of interest to social, political and cultural theorists, intellectual historians and philosophers, as well as anyone with a stake in current debates about modernity and postmodernity. (shrink)

Time is analyzed as being those processes by which a system notes the processes which comprise its own existence. The directionality of time is given by the concepts, past, present, and future. To understand the meaning of these concepts, a set of experiments was carried out with four male subjects in which areas of time were expanded or ablated by means of post-hypnotic suggestions. These operations were carried out singly or in combination. The data suggest that the present is primarily (...) associated with stimulus input, the past with the criteria for defining that input as well as the development of response inhibitions and the future with the directionality of that input. Marked personality changes which range from the occurence of catatonic-like states to obsessive types of reaction and manic-like reactions are associated with different combinations of time alterations. Some of the changes are in accord with the serialist position on time of J. W. Dunne. The concept of death is very important both with regard to one’s view of time and how one lives. While it is important to live in the present, the present has no meaning without at least a past or a future. Implications of these findings for psychopathology in general and schizophrenia in particular are considered. (shrink)

An updated and expanded successor to Culver and Gert's Philosophy in Medicine, this book integrates moral philosophy with clinical medicine to present a comprehensive summary of the theory, concepts, and lines of reasoning underlying the ...

This paper is a discussion of Michael Thau's interesting critique in Chapter 2 of Consciousness and Cognition, Oxford: Oxford University Press, 2002, of the common view that beliefs are internal states.