In this article we present a new kind of computing device that uses biochemical reactions networks as building blocks to implement logic gates. The architecture of a computing machine relies on these generic and composable building blocks, computation units, that can be used in multiple instances to perform complex boolean functions. Standard logical operations are implemented by biochemical networks, encapsulated and insulated within synthetic vesicles called protocells. These protocells are capable of exchanging energy and information with each other through transmembrane (...) electron transfer. In the paradigm of computation we propose, protoputing, a machine can solve only one problem and therefore has to be built specifically. Thus, the programming phase in the standard computing paradigm is represented in our approach by the set of assembly instructions that directs the wiring of the protocells that constitute the machine itself. To demonstrate the computing power of protocellular machines, we apply it to solve a NP-complete problem, known to be very demanding in computing power, the 3-SAT problem. We show how to program the assembly of a machine that can verify the satisfiability of a given boolean formula. Then we show how to use the massive parallelism of these machines to verify in less than 20 min all the valuations of the input variables and output a fluorescent signal when the formula is satisfiable or no signal at all otherwise. (shrink)

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Quantum mechanics is a very successful theory that has impacted on many areas of physics, from pure theory to applications. However, it is difficult to interpret, and philosophical contradictions and counterintuitive results are apparent at a fundamental level. In this book, Laloë presents our current understanding of the theory. The book explores the basic questions and difficulties that arise with the theory of quantum mechanics. It examines the various interpretations that have been proposed, describing and comparing them and discussing their (...) success and difficulties. The book is ideal for researchers in physics and mathematics who want to know more about the problems faced in quantum mechanics but who do not have specialist knowledge in the subject. It will also interest philosophers of science specializing in quantum physics. (shrink)

The Uniform Determination of Death Act (UDDA) provides that “an individual who has sustained either (1) irreversible cessation of circulatory and respiratory functions or (2) irreversible cessation of all functions of the entire brain, including the brain stem, is dead.” We show that the UDDA contains two conflicting interpretations of the phrase “cessation of functions.” By one interpretation, what matters for the determination of death is the cessation of spontaneous functions only, regardless of their generation by artificial means. By the (...) other, what matters is the cessation of both spontaneous and artificially supported functions. Because each UDDA criterion uses a different interpretation, the law is conceptually inconsistent. A single consistent interpretation would lead to the conclusion that conscious individuals whose respiratory and circulatory functions are artificially supported are actually dead, or that individuals whose brain is entirely and irreversibly destroyed may be alive. We explore solutions to mitigate the inconsistency. (shrink)

This book analyses the impact computerization has had on contemporary science and explains the origins, technical nature and epistemological consequences of the current decisive interplay between technology and science: an intertwining of formalism, computation, data acquisition, data and visualization and how these factors have led to the spread of simulation models since the 1950s. -/- Using historical, comparative and interpretative case studies from a range of disciplines, with a particular emphasis on the case of plant studies, the author shows how (...) and why computers, data treatment devices and programming languages have occasioned a gradual but irresistible and massive shift from mathematical models to computer simulations. -/- . (shrink)

Requiring family authorization for apnea testing subtracts health professionals control over death determination, a procedure that has traditionally been considered a matter of clinical expertise alone. In this commentary, we first provide evidence showing that health professionals’ (HPs) disposition to act on death determination without family’s prior consent could be much lower than that referred to by Berkowitz and Garrett (2020). We hypothesize that HPs may have reservations about their own expertise as regards death, and may thus hesitate to impose (...) their views on patients’ families. We then address the theoretical question of clinical expertise in death determination by distinguishing judgments about facts (e.g., the presence or absence of spontaneous breathing) from interpretations given of these facts (i.e., their meaning for the vital status of an individual). We argue that, while clinicians may claim some expert authority on the former, they hold no particular authority on the latter. (shrink)

This book is based on Professor Franck's highly acclaimed Hague Academy General Course. In it he offers a compelling view of the future of international legal reasoning and legal theory. The author offers a critical analysis of the prescriptive norms and institutions of modern international law and argues that international law has the capacity to advance, in practice, the abstract social values shared by the community of states and persons. This book is both thought-provoking and original and as such (...) is essential reading for students of international law and legal theory. (shrink)

The Habermasian concept of ‘interest’ has had a profound effect on the characterization of scientific disciplines. Going beyond issues unrelated to the theory itself, intra‐theoretical interest characterizes the specific ways of approaching any science‐related discipline, defining research topics and methodologies. This approach was developed by Jürgen Habermas in relation to empirical–analytical sciences, historical–hermeneutics sciences, and critical sciences; however, he did not make any specific references to health sciences. This article aims to contribute to shaping a general epistemological framework for health (...) sciences, as well as its specific implications for the medical and nursing areas, via an analysis of the basic knowledge interests developed by Habermas. (shrink)

Où trouver la force de continuer à vivre quand des épreuves terribles privent de l'énergie ou du désir nécessaires pour perpétuer une existence devenue en apparence absurde? Les récits de résilience sont nombreux. Mais il aura fallu attendre Nietzsche pour que la philosophie s'empare avec acuité de cette question. ± [...] je fis de ma volonté de santé, de vivre, ma philosophie? : accablé d'une maladie terriblement douloureuse, l'auteur du Gai Savoir fait d'une expérience vécue un terrain d'expérimentation pour la (...) pensée. La force de vivre est exclusive chez lui de toute recherche d'un quelconque salut dans une foi ou dans une cause. Non pas fuir la maladie, mais se l'approprier en l'explorant par la pensée. En découlent une leçon et une question. Une leçon : la souffrance ne prive pas la vie de son sens, ni ne préjuge de sa valeur. Une question, celle du philosophe qui se fait ± médecin de la civilisation? : le nihilisme peut-il être surmonté? (shrink)

O isolamento social para a contenção da contaminação pela COVID-19 impactou o processo educacional, resultando em efeitos severos na precarização da aprendizagem escolar, principalmente em estudantes de famílias de baixa renda. E como alternativas para que a educação escolar não estagnasse, foi proposta a realização de aulas síncronas através da internet. Entretanto, essa modalidade de ensino não proporciona a universalização do ensino e muito menos o acesso por todos, uma vez que muitos estudantes não possuem acesso à internet. Nas aulas (...) síncronas, o ensino híbrido possibilita que o processo de ensino tenha continuidade no período pandêmico, por utilizar diversas estratégias pedagógicas e também mitigar a aglomeração dos estudantes nas escolas. O professor e os alunos são inseridos em um processo educacional diferente em relação ao ensino tradicional, favorecendo o protagonismo dos alunos, para que possam trabalhar em grupos e compartilhar conhecimentos, e utilizando tecnologias digitais como aliadas nesse processo. (shrink)

The scholarly and scientific professions are undergoing changes like any other profession, also due to the ongoing mutations of the labor market. Intermittent scholars and researchers in a situation of economic uncertainty are increasingly numerous. These individuals are not just « deprived of status » as civil servants, but are also independent «free agents », with a different point view stemming partly from the necessity of remaining mobile, of leaving the familiar path in order to progress intellectually. Their independence in (...) relation to the academic environment and the professional status of professors or researchers, can be the result of a voluntary decision, which puts them into the forefront of the transversality which does not yet fully exist between the disciplines, objects and professions of scholarship, science and research. Yet the violence of this economically precarious situation is not something one chooses; it forces us to ask new questions, which must be approached from a social and political standpoint. Tie following article tells the tale of an independent cognitive laborer: an ecosystemic mistake in the eyes of some, an obvious symptom of ongoing mutations for others. (shrink)

La expansión de las actividades informales de feriantes en el conurbano bonaerense constituye una de las manifestaciones del fenómeno de la heterogeneidad no regulada del aprovisionamiento de bienes de consumo, que a su vez, emergen como intermediarios económicos que atienden a necesidades y demandas de consumidores territorialmente segregados y no articulados a los mercados formales, en su mayoría.Es en ese sentido que el presente artículo quiere rescatar y señalar los componentes centrales que asoman en un proceso que parte con el (...) supuesto de que la confianza constituye un elemento central cuando otras formas que actuarían como garante de las interacciones aparecen débiles, ausentes o no primordiales como garantía de las interacciones sociales, como es el caso de la feria de Solano. (shrink)

In an inspirational act of faith and hope, nearly one hundred contributors--social activists, thinkers, artists and spiritual leaders--reflect with poignant candor on our shared human condition and attempt to define a core set of human values in our rapidly changing socity. Contributors include: * The Dalai Lama * Wilma Mankiller * Oscar Arias * Jimmy Carter * Cornel West * Jack Miles * Mother Teresa * Nancy Willard * Elie Wiesel * James Earl Jones * Joan Chittister * Mary Evelyn (...) Tucker * Vaclav Havel * Archbishop Desmund Tutu What Does It Mean To Be Human? is a vital meditation on the endless possibilities of our humanity. (shrink)

This volume gathers together for the first time are all the key texts in a crucial debate in modern philosophy, centered on Leibniz's famous 1695 essay, the "New System of the Nature of Substances and their Communication," in which he introduced his strikingly original theory of metaphysics. His "system" became increasingly famous and drew him into discussion and development of these ideas, both in public and in private, with a variety of thinkers, most notably the great French philosopher Pierre Bayle. (...) Woolhouse's and Francks's new English edition gives the only full representation of this debate, and will therefore be essential reading for anyone who wishes to gain a proper understanding of Leibniz's philosophy and its intelletual context. All the texts are newly translated and extensively annotated; many appear in English for the first time. (shrink)

The many well-publicized food scandals in recent years have resulted in a general state of vulnerable trust. As a result, building consumer trust has become an important goal in agri-food policy. In their efforts to protect trust in the agricultural and food sector, governments and industries have tended to consider the problem of trust as merely a matter of informing consumers on risks. In this article, we argue that the food sector better addresses the problem of trust from the perspective (...) of the trustworthiness of the food sector itself. This broad idea for changing the focus of trust is the assumption that if you want to be trusted, you should be trustworthy. To provide a clear understanding of what being trustworthy means within the food sector, we elaborate on both the concept of trust and of responsibility. In this way we show that policy focused on enhancing transparency and providing information to consumers is crucial, but not sufficient for dealing with the problem of consumer trust in the current agri-food context. (shrink)

Food production, water management, land use, and animal and public health are all topics of extensive public debate. These themes are linked to the core activities of the agricultural sector, and more specifically to the work of farmers. Nonetheless, the ethical discussions are mostly initiated by interest groups in society rather than by farmers. At least in Europe, consumer organizations and animal welfare and environmental organizations are more present in the public debate than farmers. This is not how it should (...) be. First, because consumers often cannot but rely on agriculture. Second, because recent research shows that farmers have moral beliefs and convictions that appear to be broader than economic considerations and that are—to a certain extent—specific to their profession. This raises the question how to make input from farmers operational in the public debates on the future of farming. We discuss one option: entrusting farmers with professional autonomy concerning moral matters related to farming. We sketch the historical background of the current situation in which farmers are relatively silent on moral matters and we present some clear indications that farmers have values and moral beliefs that are relevant for the public debate. Next the concepts of professionalism and professional autonomy are discussed and applied to the practice of farming. Finally, we discuss the relevance and limits of professional moral autonomy for the agricultural profession. We close with an overview of what this moral autonomy implies for and requires from farmers in practice. We conclude that if some preconditions are met by farmers, then this type of moral autonomy can be relevant for farmers and for society, and contributes to the quality of the public debate on the future of farming. (shrink)

European animal disease policy seems to find its justification in a “harm to other” principle. Limiting the freedom of animal keepers—e.g., by culling their animals—is justified by the aim to prevent harm, i.e., the spreading of the disease. The picture, however, is more complicated. Both during the control of outbreaks and in the prevention of notifiable, animal diseases the government is confronted with conflicting claims of stakeholders who anticipate running a risk to be harmed by each other, and who ask (...) for government intervention. In this paper, we first argue that in a policy that aims to prevent animal diseases, the focus shifts from limiting “harm” to weighing conflicting claims with respect to “risks of harm.” Therefore, we claim that the harm principle is no longer a sufficient justification for governmental intervention in animal disease prevention. A policy that has to deal with and distribute conflicting risks of harm needs additional value assumptions that guide this process of assessment and distribution. We show that currently, policies are based on assumptions that are mainly economic considerations. In order to show the limitations of these considerations, we use the interests and position of keepers of backyard animals as an example. Based on the problems they faced during and after the recent outbreaks, we defend the thesis that in order to develop a sustainable animal disease policy other than economic assumptions need to be taken into account. (shrink)

Cet article vise à éclairer le contexte universitaire et éditorial qui favorisa la publication du Treatise on electricity and magnetism de James Clerk Maxwell afin de mieux cerner la nature de cette entreprise scientifique. Le projet fut formé en 1867 à l'occasion d'une réforme introduisant l'étude de l'électricité et du magnétisme dans l'enseignement délivré à Cambridge et s'inscrivait dans un mouvement plus vaste qui développait l'enseignement de ces disciplines dans les universités britanniques. L'étude des relations entre le projet de Maxwell (...) et d'autres ouvrages contemporains indique que le Treatise était en situation de devenir un ouvrage de référence en Grande-Bretagne. Ainsi, le livre de Maxwell était-il l'instrument d'une très ambitieuse tentative de transformation de l'électromagnétisme, indissociable de son contexte et conforme à sa fonction pédagogique. (shrink)

The rise of mathematical developments in the theories of consciousness has led to new measures to detect consciousness in a system. The Integrated Information Theory is one of the best mathematical rooted attempts to quantify the level of consciousness in a system with Φ as the effective information generated in a system above its parts. Recently, the IIT has inspired the Perturbational Complexity Index to detect conscious states in patients with disorders of consciousness, and it has shown to have almost (...) perfect classification accuracy. In this study, we explore the statistical correspondence between the theoretical Φ and the experimental PCI through a neurocomputational model of coupled oscillators that can be artificially perturbed, which mainly focuses on the dynamics of collective synchronization between subsets of brain areas. Our results reveal that both measures are statistically related but, in principle, this relationship is far to be perfect. These results are discussed in the context of the model of coupled oscillators, which mainly focuses on the dynamics of collective synchronization between subsets of brain areas. (shrink)

Cet ouvrage rend hommage à différents « Maîtres à penser » qui, par leur oeuvre, ont notablement enrichi leur discipline. Les juristes, historiens, politistes, philosophes, économistes étudiés ici ont en commun de réfléchir sur le pacte démocratique. Comment articuler liberté et égalité, économie et politique, religion et laïcité, violence et norme coercitive... pour qu'advienne une harmonie synonyme de paix sociale? Chacun - Sturzo, Cuche, Pocock, Quesnay, Zagrebelsky, Makhno, Fanon, Rivero, Albert, Bataille, Desjardins - apporte sa propre réponse. La diversité des (...) auteurs est à l'image de la dimension résolument pluridisciplinaire de ce nouvel opus du Bulletin annuel de Villetaneuse. (shrink)

Intention was seen traditionally as a philosophical concept, before being debated more recently from psychological and social perspectives. Today the cognitive sciences approach intention empirically, at the level of its underlying mechanisms. This naturalization of intention makes it more concrete and graspable by empirical sciences. This volume offers an interdisciplinary integration of current research on intentional processes naturalized through action, drawing on the theoretical and empirical approaches of cognitive neuroscience, psychology, philosophy, and sociology. Each chapter integrates several disciplinary perspectives. Taken (...) together, the chapters show that the reunification of the different dimensions of intentional processes may constitute an adequate basis for a general model of intentional processes and their links to action. This can be applied at various levels, from neuronal activity to self-constitution, from the expression of intentional actions at the individual level to their expression in social contexts, and to the recognition of intention in actions executed by others.ContributorsColin Allen, Mireille Bonnard, Vittorio Gallese, Jozina B. de Graaf, Franck Grammont, Patrick Haggard, Marco Iacoboni, Dorothée Legrand, Pierre Livet, Albert Ogien, Jean Pailhous, Jean-Luc Petit, Jean-Michel Roy, Jessica A. Sommerville, Manos Tsakiris, Amanda L. Woodward. (shrink)

The impact of socially responsible corporate behavior on economic performance is a major preoccupation of managers today. This article explores the links between narrowly defined constructs: stakeholder orientation, environmental proactivity and profitability, from the perspectives of stakeholder theory and resource-based theory. We collected data on the food and beverage, and household and personal products industries. Using structural equation modeling, this paper makes two contributions. We found a negative link between companies simply having a higher stakeholder orientation and profitability. Importantly, however, (...) environmental proactivity not only had a positive impact on profitability, but also appeared to mediate the relationship between stakeholder orientation and profitability. In other words, if a company is more environmentally proactive, it will be more attentive to a broad array of stakeholders, and this will in turn contribute positively to profitability. (shrink)

Jürgen Habermas a fait le constat que « Schelling n’est pas un penseur politique ». Il n’a laissé en effet aucun traité systématique de philosophie politique, rien de comparable en tout cas à la Grundlage des Naturrechts et à la Rechtslehre de Fichte, ni aux Grundlinien der Philosophie des Rechts de Hegel. Nous faisons ici l’hypothèse que son désintérêt pour la politique est lié au sens négatif que Schelling a très tôt attribué à la sphère du droit, faisant de l’État (...) et du droit des institutions de la limitation et de la contrainte. Schelling a maintenu cette thèse jusqu’à sa dernière philosophie qui voit dans la soumission à une contrainte étatique toujours croissante le moyen pour l’humanité d’expier sa faute originelle. Une seule période de la pensée schellingienne fait exception à ce pessimisme politique : c’est, de 1801 à 1806, la période de l’Identité où la politique est valorisée au point qu’une identité est posée entre la philosophie et le politeuein. Mais ces années sont aussi celles du travail commun avec Hegel : si l’influence de Schelling sur Hegel fut métaphysique, celle de Hegel sur Schelling fut essentiellement politique.Jürgen Habermas did notice that « Schelling is no political thinker ». It is a fact that Schelling did not publish any important and systematic work on politics, which could be compared with Fichte’s Grundlage des Naturrechts or Hegel’s Grundlinien der Philosophie des Rechts. We do here the supposition that Schelling’s disinterest for politics has something to do with his very early negative interpretation of law and state as institutions of limitation and constrain. Schelling did maintain this up to his late philosophie which consider the constantly growing constrain of State in history as means for humanity to expiate the original sin. In only one period we can find by Schelling a valorization of politics : during the period of Identity , Schelling thought expressly an identity between philosophie and politeuein. Seeing that these years are those of the closest collaboration between Hegel and Schelling, so we can state Hegel’s political influence on Schelling, in return of Schelling’s well known metaphysical influence on Hegel. (shrink)

En este texto se trata de pensar el proyecto que Foucault inició con el análisis de la parrhesía. Se aborda ese problema en relación a otros dos elementos de su obra: la reflexión sobre la función de los intelectuales y sus escritos sobre la noción de crítica. Desde esa perspectiva trataré de mostrar que las investigaciones sobre la parrhesía reflejan el intento de pensar una nueva política de la verdad.

BackgroundCurrent policies regulating the use of animals for scientific purposes are based on balancing between potential gain of knowledge and suffering of animals used in experimentation. The balancing process is complicated, on the one hand by plurality of views on our duties towards animals, and on the other hand by more recent discussions on uncertainty in the probability of reaching the final aim of the research and problems of translational failure.MethodsThe study combines ethical analysis based on a literature review with (...) neuropsychiatry-related preclinical research as a case study.ResultsBased on the analysis and the case study we show that neuropsychiatry-related preclinical research is an especially interesting case from an ethical perspective. The 3R principles are used to minimize the negative consequences for the animals used in research. However, neuropsychiatric research is characterized by specific challenges in assessing the probability of success of reaching the final aim, due to our limited mechanistic knowledge of human neuropsychiatric illness. Consequently, the translational value of the currently used animal models may be difficult to prove, which undermines the validity of these models and complicated the ethical assessment.ConclusionsWe conclude that a combined approach that deals with both science and the ethical dimensions is necessary to address the problems of validity and translation in neuropsychiatry-related preclinical research. We suggest this approach to comprise first, improved experimental methods, e.g. by using systematic reviews, second, a more patients-based approach that leads to models that reflect interindividual variation better, and third, more interdisciplinary cooperation. (shrink)

The abilities to attribute an action to its proper agent and to understand its meaning when it is produced by someone else are basic aspects of human social communication. Several psychiatric syndromes, such as schizophrenia, seem to lead to a dysfunction of the awareness of one’s own action as well as of recognition of actions performed by other. Such syndromes offer a framework for studying the determinants of agency, the ability to correctly attribute actions to their veridical source. Thirty normal (...) subjects and 30 schizophrenic patients with and without hallucinations and/or delusional experiences were required to execute simple finger and wrist movements, without direct visual control of their hand. The image of either their own hand or an alien hand executing the same or a different movement was presented on a TV-screen in real time. The task for the subjects was to discriminate whether the hand presented on the screen was their own or not. Hallucinating and deluded schizophrenic patients were more impaired in discriminating their own hand from the alien one than the non-hallucinating ones, and tended to misattribute the alien hand to themselves. Results are discussed according to a model of action control. A tentative description of the mechanisms leading to action consciousness is proposed. (shrink)

En este artículo se presenta un abordaje general de la teoría de la justicia social de John Rawls. Revisamos algunas críticas desde diversos frentes teóricos. Consideramos que la justicia social permite enjuiciar las consecuencias regresivas para la humanidad del capitalismo en su fase neoliberal y comenzar a imaginar otros mundos posibles.

El estudio examina mediante una revisión sistemática la literatura científica. La metodología se basó en la aplicación de los principios de la declaración PRISMA. Los resultados indicaron que la mayor producción de estudios fue en 2021, con predominancia de idioma inglés, España como el mayor productor, Reino Unido con el mayor número de revistas y el uso de realidad aumentada como la estrategia más estudiada. La producción científica en educación, y más particularmente en metodologías aplicada a la educación, ha generado (...) una serie de estudios bibliométricos, los cuales han demostrado la evolución de las mismas en lapsos de tiempo diversos. (shrink)

Alireza Bagheri supports a policy on organ procurement where individuals could choose their own definition of death between two or more socially accepted alternatives. First, we claim that such a policy, without any criterion to distinguish accepted from acceptable definitions, easily leads to the slippery slope that Bagheri tries to avoid. Second, we suggest that a public discussion about the circumstances under which the dead donor rule could be violated is more productive of social trust than constantly moving the line (...) between life and death. (shrink)

It is known that in differentially closed fields of characteristic zero, the ranks of stability $RU$, $RM$ and the topological rank $RH$ need not to be equal. Pillay and Pong have just shown however that the ranks $RU$ and $RM$ coincide in a group definable in this theory. At the opposite, we will show in this paper that the ranks $RM$ and $RH$ of a definable group can also be different, and even lead to non-equivalent notions of generic type.

Les problèmes de classification des noms de parenté tels que papa, maman, tonton, fiston, etc., comme noms propres ou comme noms communs, prennent une nouvelle dimension si l’on intègre, d’une part, certains emplois sans déterminant du nom commun tel que bébé (ex : Si maman va bien, bébé va bien), et d’autre part certains emplois sans déterminant de noms déposés (ex : Restez zen, Twingo maintient la pression de freinage automatiquement). L’objectif principal de cet article est d’utiliser ces emplois pour (...) faire évoluer les théories des noms, propres et communs. A partir de la proposition d’Alan Gardiner, qui fait jouer un rôle central au signifiant du nom propre, complétée par le concept de « sphère de validité » inspiré de Benoit de Cornulier, ce travail jette les bases d’une description unifiée. (shrink)

Le dossier que nous ouvrons ci-après sur « l’héritage judéo-chrétien, mythe ou réalité? » entend interroger l’expression complexe de judéo-christianisme qui renvoie inévitablement à l’idée d’un héritage commun aux deux religions. Or, l’idée d’un tel héritage commun enveloppe aujourd’hui des significations que nous avons voulu expliciter pour penser jusqu’au bout...