Clonal disease is often regarded as almost synonymous with cancer. However, it is becoming increasingly clear that our bodies harbor numerous mutant clones that are not tumors, and mostly give rise to no disease at all. Here we discuss three somatic mutations arising within the hematopoietic system: BCR‐ABL, characteristic of chronic myeloid leukemia; mutations of the PIG‐A gene, characteristic of paroxysmal nocturnal hemoglobinuria; the V617F mutation in the JAK2 gene, characteristic of myeloproliferative diseases. The population frequencies of these three blood (...) disorders fit well with a hierarchical model of hematopoiesis. The fate of any mutant clone will depend on the target cell and on the fitness advantage, if any, that the mutation confers on the cell. In general, we can expect that only a mutation in a hematopoietic stem cell will give long‐term disease; the same mutation taking place in a cell located more downstream may produce just a ripple in the hematopoietic ocean. (shrink)

This paper aims to contribute to the present debate about business ethics and Corporate Social Responsibility (CSR) that the Journal of Business Ethics is hosting. Numerous contributions argued theoretical frameworks and taxonomies of CSR practices. The authors want to ground in this knowledge and provide further evidence about how companies adopt CSR practices to address stakeholders’ claims and consolidate their trust. Evidence was provided by a longitudinal case study about an Italian food company that is one of the largest producers (...) of baby food. This company reshaped its corporate strategy along three decades through the adoption of CSR practices in order to win stakeholders’ trust about food safety and supply chain behaviour. The empirical exercise was informed by a literature review of the relevant contributions in terms of CSR business practices and levels of efforts to adopt them. In light of this review, the authors adopted for the research framework the taxonomy of business practices proposed by Spiller (2000, “Ethical Business and Investment: A Model for Business and Society”, Journal of Business Ethics 27, 149-160) and the levels of commitment towards CSR proposed by Stahl and Grigsby (1997, Strategic Management; Total Quality & Global Competition (Blackwell, Oxford)). The main findings are discussed in order to argue theoretical implications and identify further areas of research and debate. (shrink)

The interpretation of Hegel has been a focal point of philosophical controversy ever since the beginning of the twentieth century, both among Marxists and in the major European philosophical schools. Yet despite wide differences of emphasis most interpretations of Hegel share important similarities. They link his idea of Reason to the revolutionary and rationalist tradition which led to the French Revolution, and they interpret his dialectic as implying a latently atheist and even materialist world outlook. Lucio Colletti directly challenges (...) this picture of Hegel. He argues that Hegel was an essentially Christian philosopher, and that his dialectic was explicitly anti-materialist in both intention and effect. In contrast to earlier views, Colletti maintains that there is no contradiction between Hegel’s method and his system, once it is accepted that his thought is an exercise in Absolute Idealism stemming from a long Christian humanist tradition. He claims, on the contrary, that intellectual inconsistency is rather to be found in the works of Engels, Lenin, Lukás, Kojève and others, who have attempted to adapt Hegel to their own philosophical priorities. Colletti places his argument in the context of a broad re-examination of the whole relationship between Marxism and the Enlightenment, giving novel emphasis to the relationship between Marxism and Kant. He concludes by re-asserting the importance in Marxism of empirical science against the claim of “infinite reason,” while at the same time showing how Marx did transform key ideas in Hegelian thought to construct a consistently materialist dialectic. (shrink)

O artigo busca discutir a filosofia do Brasil, seus desafios e possíveis soluções, a partir de uma abordagem interdisciplinar e histórica. O texto apresenta a análise da filosofia universitária brasileira, sua origem e atuação no século XXI, ressaltando que grande parte da produção acadêmica é pouco autêntica por ser uma exegese estrangeira. Além disso, é discutida a condição dos povos originários e dos negros escravizados, expondo como foram desumanizados pela colonização e suas condições de vida precárias e sua relação com (...) a maneira que nos enxergamos. A partir disso, o artigo propõe a reflexão sobre a necessidade de pensar a filosofia brasileira a partir de sua situacionalidade e historicidade, superando o complexo de vira-lata e criando uma produção acadêmica autêntica e original, que reflita nossa identidade e individualidade, sem deixar de dialogar com outras tradições filosóficas. (shrink)

Le MST a connu de grands succès dans les années 1980 – 450 000 familles dans assentamentos (propriétaires) ou acampamentos (occupants) – et a servi d’exemple à de nombreuses mobilisations et occupations de terres dans le monde. Pendant l’ère Bolsonaro, le mouvement a connu diverses adaptations. Il a adopté le récit de l’entrepreneur agricole, influencé en cela par les évangélistes – de la « théologie de la libération » communautaire à la théologie individualiste de la réussite. Il a, par obligation (...) et répression, délaissé l’action d’occupation des terres pour le développement de l’agriculture biologique et la production d’aliments « sains », largement à destination des villes. Ainsi, il resserre les liens entre le rural et l’urbain et se rapproche stratégiquement du Mouvement des Sans Toit. (shrink)

An educational philosophy that appeals to the immutable element in things, to their eternal properties, to the truths that hold in any age, and simply urges that empirical methods are not the only methods, really is defending a negative position.

The essay deals with the subject of the curriculum as it was elaborated by the philosopher Jaques Maritain during the period of his stay in the United States and condensed above all in the 1943 text Education at the Crossroads. Maritain, above all a political philosopher, intends to present a line of personal and social education to the generations emerging from the Second World War. It was necessary to rethink education not only in the theoretical field but also in the (...) operational one, in particular in the main formative structure of the community: School and University. The design that comes out is very structured: aimed at proposing a new order of studies both with regard to the School and the University. (shrink)

O artigo apresenta brevemente as principais teses referentes à relação mente e cérebro no contexto dos emergentismos forte e fraco. Especificam-se ainda as principais consequências da discussão de uma possível neuroteologia para a compreensão dos processos de hominização, liberdade, limites do conhecimento cerebral e conhecimento do cérebro, relação entre mente-cérebro-mundo e “necessidade” do mistério gerada pela dinâmica cerebral.

Comments on the view of life shared by existential protagonists in six works by Woolf, Greene, Golding, Faulkner, Ellison, and Malamud.

Come si può intuire dalle parole contenute nel titolo e nel sottotitolo del volume di Giovanni Durbiano, la pertinenza del lavoro con questioni di ordine filosofico è qui dichiarata. Il tema del libro muove da una ricognizione di carattere storiografico dell’architettura italiana, ma più in specifico tratta del ruolo e dello statuto sociale, politico ed epistemico che il sapere e il fare dell’architetto hanno rivestito nella storia recente. Si tratta di un lavoro che possiede un carattere qua...

La dimensione finzionale e testuale può essere considerata come un laboratorio di osservazione sulla rappresentazione del futuro. Impiegare modelli e prototipi costruiti su modelli di narrazione fantascientifica rappresenta, del resto, una prassi accreditata nel campo dei future studies.L’articolo passa brevemente in rassegna alcune definizioni relative alla fantascienza, per poi concentrarsi sull’ ambito della fantascienza audiovisiva dedicato al near future: una immaginaria dimensione futura simile a quella attuale e per questo densa di elementi di inquietudine. Come casi rappresentativi vengono prese in (...) esame due analisi testuali: il film Ex Machina e la serie tv Black Mirror. Le analisi vengono affiancate da alcune proposte teoriche classiche - dal costruzionismo di Nelson Goodman alla trattazione di Paul Ricoeur sulla temporalità – sullo sfondo di una metodologia semiotica. Viene affrontata in breve la questione dei limiti concettuali nella descrivibilità del tempo, mentre alla dimensione spaziale nell’audiovisivo viene infine dedicato un ampio approfondimento che ne illustra il ruolo essenziale nella costruzione di un universo narrativo, nonché l’utilità nel costruire effetti di senso specifici per una efficace rappresentazione del futuro. (shrink)

A partir de la situación crítica de la modernidad, el autor afirma que todo ser humano perspicaz y amante de la vida se pregunta con angustia por nuestro destino colectivo. Como una respuesta a esta interrogante, el presente artículo examina diversas perspectivas evolucionarias universales de amplia escala temporal, apoyándose particularmente en el enfoque de la Fe Bahá’í, desde la que presenta un análisis sobre el rol de la religión, para abordar finalmente aquellos procesos que podrían orientar a una sociedad civil (...) mundial hacia una espiritualidad encarnada en los procesos sociales, desde nuestra condición actual concebida como el momento de la gran bifurcación y de la era de las comunidades. (shrink)

L’article présente une réflexion sur la question du temps dans les processus de migration et mise au travail des travailleurs et travailleuses détachés dans l’agriculture intensive. Nous proposons d’analyser le rapport entre les temporalités imposées aux détachés pour répondre aux besoins productifs et leurs conduites temporelles. Il s’agit de comprendre comment les personnes détachées vivent ces temporalités, mais aussi comment elles se les réapproprient et/ou les contournent afin de les articuler aux espaces-temps de la reproduction sociale. Notre recherche s’appuie sur (...) une enquête qualitative menée auprès des ouvriers et ouvrières mis à disposition des exploitants par des agences d’intérim espagnoles dans trois départements du sud de la France. L’analyse, structurée autour des parcours migratoires, du système du détachement et des temps sociaux, nous permet de saisir les effets des politiques migratoires sur les parcours des saisonniers dans les temps longs ; de retracer des stratégies de dépassement des temporalités imposées, qui amènent à l’installation et à l’emploi direct ; d’identifier les tentatives de « faire communauté » à travers des initiatives commerciales et récréatives collectives développées dans les temps libres. (shrink)

The paper responds to the recent calls for further evidence on corporate social responsibility (CSR) in small and medium‐sized enterprises (SMEs). Drawing on the extant literature, the authors identify four characteristics contended by academicians as peculiarities of SMEs’ approach to CSR: the intrinsic relationship between CSR and corporate strategy motivated by the need to continuously dialogue with stakeholders; the centrality of the entrepreneur's ethos in CSR decisions; the coexistence and the cross‐effect of economically instrumental and ethically motivated CSR policies; and (...) the finalization of CSR initiatives to specific firm growth objectives. These four peculiarities are explored in the case of an Italian medium‐sized company operating in the furniture industry. The outcomes show how the four peculiarities are salient in analyzing the CSR approach by the company and suggest areas for further research aimed at developing a thorough theory of CSR in SMEs. In particular, we deepen the analysis of the nature of the uniqueness of medium‐sized companies’ approach to CSR, providing possible interpretations of the reasons making medium‐sized companies’ approach to CSR different from both small and large companies. (shrink)

The paper responds to the recent calls for further evidence on corporate social responsibility (CSR) in small and medium-sized enterprises (SMEs). Drawing on the extant literature, the authors identify four characteristics contended by academicians as peculiarities of SMEs’ approach to CSR: the intrinsic relationship between CSR and corporate strategy motivated by the need to continuously dialogue with stakeholders; the centrality of the entrepreneur's ethos in CSR decisions; the coexistence and the cross-effect of economically instrumental and ethically motivated CSR policies; and (...) the finalization of CSR initiatives to specific firm growth objectives. These four peculiarities are explored in the case of an Italian medium-sized company operating in the furniture industry. The outcomes show how the four peculiarities are salient in analyzing the CSR approach by the company and suggest areas for further research aimed at developing a thorough theory of CSR in SMEs. In particular, we deepen the analysis of the nature of the uniqueness of medium-sized companies’ approach to CSR, providing possible interpretations of the reasons making medium-sized companies’ approach to CSR different from both small and large companies. (shrink)

The paper responds to the recent calls for further evidence on corporate social responsibility (CSR) in small and medium‐sized enterprises (SMEs). Drawing on the extant literature, the authors identify four characteristics contended by academicians as peculiarities of SMEs’ approach to CSR: the intrinsic relationship between CSR and corporate strategy motivated by the need to continuously dialogue with stakeholders; the centrality of the entrepreneur's ethos in CSR decisions; the coexistence and the cross‐effect of economically instrumental and ethically motivated CSR policies; and (...) the finalization of CSR initiatives to specific firm growth objectives. These four peculiarities are explored in the case of an Italian medium‐sized company operating in the furniture industry. The outcomes show how the four peculiarities are salient in analyzing the CSR approach by the company and suggest areas for further research aimed at developing a thorough theory of CSR in SMEs. In particular, we deepen the analysis of the nature of the uniqueness of medium‐sized companies’ approach to CSR, providing possible interpretations of the reasons making medium‐sized companies’ approach to CSR different from both small and large companies. (shrink)

1. Sui Quaderni filosofici di Lenin.--2. Materialismo dialettico e irrazionalismo.

This book identifies and presents the four main network-based methodologies including network analysis, Boolean network simulation modeling, artificial neural network simulation modeling, and agent-based simulation modeling in addition to their conceptual-epistemological implications and concrete applications within the social and natural sciences.

Abstract: Biology continues to use the Tree of Life image to show the temporal continuity and discontinuity of the living beings. Moreover, the development of genetic, molecular biology and paleontology has originated phylogenetics. This discipline studies evolutionary relatedness among various groups of organisms through molecular sequencing data and morphological data matrices. The Tree offers interesting points for semiotic perspectives and for theological approaches too. The symbolic reading of the Tree of Life, on the one hand, and the analogies with the (...) Biblical genealogies and some Christian images, on the other hand, will be explored. -/- . (shrink)