Driven by the use cases of PubChemRDF and SCAIView, we have developed a first community-based clinical trial ontology (CTO) by following the OBO Foundry principles. CTO uses the Basic Formal Ontology (BFO) as the top level ontology and reuses many terms from existing ontologies. CTO has also defined many clinical trial-specific terms. The general CTO design pattern is based on the PICO framework together with two applications. First, the PubChemRDF use case demonstrates how a drug Gleevec is linked to multiple (...) clinical trials investigating Gleevec’s related chemical compounds. Second, the SCAIView text mining engine shows how the use of CTO terms in its search algorithm can identify publications referring to COVID-19-related clinical trials. Future opportunities and challenges are discussed. (shrink)

This latest volume of BACAP Proceedings contains some innovative research by international scholars on Plato, Aristotle, and Sophocles. It covers such themes as Plato on the philosopher ruler, and Aristotle on essence and necessity in science. This publication has also been published in paperback, please click here for details.

This book shows otherwise. John Martin rehabilitates Neoplatonism, founded by Plotinus and brought into Christianity by St. Augustine.

The Routledge International Handbook of Neuroaesthetics is an authoritative reference work that provides the reader with a wide-ranging introduction to this exciting new scientific discipline. The book brings together leading international academics to offer a well-balanced overview of this burgeoning field while addressing two questions central to the field; how the brain computes aesthetic appreciation for sensory objects, and how is art created and experienced.

Online supplement, "Mulsow: Additions to Notes drawn from the 2002 edition of Moderne aus dem Untergrund" full versions of nearly 300 notes that were truncated in the print edition. Hosted on H. C. Erik Midelfort's website. Martin Mulsow's seismic reinterpretation of the origins of the Enlightenment in Germany won awards and renown in its original German edition, and now H. C. Erik Midelfort's translation makes this sensational book available to English-speaking readers. In Enlightenment Underground, Mulsow shows that even in (...) the late seventeenth century some thinkers in Germany ventured to express extremely dangerous ideas, but did so as part of a secret underground. Scouring manuscript collections across northern Europe, Mulsow studied the writings of countless hitherto unknown radical jurists, theologians, historians, and dissident students who pushed for the secularization of legal, political, social, and religious knowledge. Often their works circulated in manuscript, anonymously, or as clandestinely published books. Working as a philosophical microhistorian, Mulsow has discovered the identities of several covert radicals and linked them to circles of young German scholars, many of whom were connected with the vibrant radical cultures of the Netherlands, England, and Denmark. The author reveals how radical ideas and contributions to intellectual doubt came from Socinians and Jews, church historians and biblical scholars, political theorists, and unemployed university students. He shows that misreadings of humorous or ironic works sometimes gave rise to unintended skeptical thoughts or corrosively political interpretations of Christianity. This landmark book overturns stereotypical views of the early Enlightenment in Germany as cautious, conservative, and moderate, and replaces them with a new portrait that reveals a movement far more radical, unintended, and puzzling than previously suspected. (shrink)

L’addition, dans la cinquième édition en 1683 de La Logique ou L’Art de penser, d’un chapitre consacré à la définition générale du signe et de plusieurs chapitres relevant spécifiquement d’une analyse des signes linguistiques, a été parfois interprétée comme une apparition tardive du “problème du langage” dans le traité d’Arnauld et Nicole. Parce que la plupart de ces chapitres supplémentaires sont la transposition de passages auparavant destinés dans la Perpétuité de la foi (1669-1674) à réfuter le sens calviniste de Ceci (...) est mon corps, on a été enclin à attribuer l’importance de la question du signe et du “problème du langage” dans l’édition de 1683 à une origine théologique. J’essaie au contraire de montrer que, dès la première édition de L’Art de penser en 1662, la problématisation des écarts des expressions linguistiques avec une correspondance terme à terme entre les mots et les idées a été indissociable pour Port-Royal de l’analyse des opérations de l’esprit. Selon moi, dans la Perpétuité de la foi, la critique du sens calviniste de la formule eucharistique constitue elle-même une application de cette analyse logique du langage : les passages incorporés ensuite dans L’Art de penser sont dans le prolongement des réflexions de 1662 sur les difficultés d’adéquation entre le dire et le vouloir-dire. Je montre pour finir que la définition générale du signe à Port-Royal suppose une restructuration de la définition augustinienne du De doctrina christiana, et fonde en 1683 une identification de la relation de signification linguistique à un rapport de représentation des mots aux idées, qui vient redoubler le rapport de représentation des idées aux choses établi en 1662. (shrink)

Martin highlights the degree to which H. L. A. Hart’s legal positivism relies on Hobbesian assumptions. Like Hart, Hobbes combines utilitarian and retributivist elements. The best way to make sense of Hobbes’s theory of punishment is to follow Quentin Skinner and view both the “sovereign” and the “state” as distinct legal fictions. Unlike Hobbes, Hart asserts these fictions as facts. As a result, Hart’s philosophy of criminal law in Punishment and Responsibility is in tension with his legal philosophy in (...) The Concept of Law. Martin worries that Hart’s mixed theory is untenable: the utilitarian element threatens to overtake his core retributivist thesis. Ultimately, however, neither Hart nor Hobbes has the resources to explain why the autonomous individual matters in the context of criminal law. (shrink)

Of course, although this view on meaning was the prevailing one for almost a century, many of the people who initiated the enterprise of logical semantics, including people like Frege and Wittgenstein, had an open eye for all that it did not catch. However, the logical means which Frege, Wittgenstein, Russell, and the generation that succeeded them, had at their disposal were those of classical mathematical logic and set-theory, and these indeed are not very suited for an analysis of other (...) aspects of meaning than those which the slogan covers. A real change in view then had to await the emergence of other concepts, which in due course became available mainly under the influence of developments in computer science and cognate disciplines such as artificial intelligence. And this is one of the reasons why it took almost a century before any serious and successful challenge of the view that meaning equals truthconditions from within logical semantics could emerge. (shrink)

Recent developments in Continental philosophy have included the emergence of a school of “speculative realism,” which rejects the human-centered orientation that has long dominated Continental thought. Proponents of speculative realism differ on several issues, but many agree on the need for an object-oriented ontology. Some speculative realists identify realism with materialism, while others accord equal reality to objects that are non-material, even fictional. Several thinkers retain a focus on difference, a well-established theme in Continental thought. This paper looks at speculative (...) realism from the perspective of systems theory. Many of the tenets of speculative realism have long been features of systems metaphysics and are expressed clearly in a systems framework. However, some views of some speculative realists differ substantially from systems theoretic ideas. (shrink)

And, as The Promise of Salvation makes clear through abundant empirical evidence, religion will not disappear as long as these promises continue to help people ...

Studie předkládá interpretaci souboru článků, které Jan Patočka uveřejnil na počátku své filosofické kariéry a v nichž programově vyložil vlastní stanovisko k problematice historického poznání a smyslu dějin. Na základě výkladu Patočkových statí studie konstatuje, že soubor ve svém celku připravuje předložení ucelené filosofické koncepce a že jeho prostřednictvím Patočka přispěl k soudobé diskusi, „sporu o smysl českých dějin“. Studie nejprve nabízí představení tohoto sporu a jeho dobového kontextu a argumentuje, že tato souvislost má podstatný význam pro porozumění Patočkovým textům. (...) Na základě toho poté studie shrnuje Patočkovu interpretaci hlavních zainteresovaných argumentačních pozic a kritiku, kterou vůči nim snáší. V následujícím kroku studie předkládá interpretaci Patočkova vlastního pojetí dějin. Na závěr představuje východisko tohoto pojetí, Patočkovu koncepci člověka. The paper proposes an interpretation of a set of articles published by Jan Patočka at the beginning of his philosophical career, in which he programmatically sets forth his point of view of the problem of historical knowledge and the meaning of history. Based on the reading of the texts the paper arrives at the conclusion that this collection as a whole anticipates a comprehensive philosophical concept and that by means of these texts Patočka contributed to the discussion of the day, “the dispute over the meaning of Czech history”. The paper begins by presenting the dispute as well as its contemporary context and argues that this link bears essential significance to the understanding of Patočka’s texts. On this basis it then summarizes Patočka’s interpretation of the different parties of the argument and the critique to which he submits them. In the next step the paper presents Patočka’s interpretation of his own conception of history. It concludes by an exposition of the basis of this conception, Patočka’s concept of man. (shrink)

The phenomenon of altruism extends from the biological realm to the human sociocultural realm. This article sketches a coherent outline of multiple types of altruism of progressively increasing scope that span these two realms and are grounded in an ever-expanding sense of “self.” Discussion of this framework notes difficulties associated with altruism at different levels. It links scientific ideas about the evolution of cooperation and about hierarchical order to perennial philosophical and religious concerns. It offers a conceptual background for inquiry (...) into societal challenges that call for altruistic behavior, especially the challenge of environmental and social sustainability. (shrink)

The new western way of war from Vietnam in Iraq -- Theories of the new western way of war -- The global surveillance mode of warfare -- Rules of risk-transfer war -- Iraq: risk economy of a war -- A way of war in crisis.

Divided into four parts, this treatise begins with well-known criticisms of nonreligious ethics and then develops an atheistic metaethics. In Part 2, Martin criticizes the Christian foundation of ethics, specifically the ’divine command theory’ and the idea of imitating the life of Jesus as the basis of Christian morality. Part 3 demonstrates that life can be meaningful in the absence of religious belief. Part 4 criticizes the theistic point of view in general terms as well as the specific Christian (...) doctrines of the atonement, salvation, and the resurrection. (publisher, edited). (shrink)

El presente texto se interroga sobre los efectos performativos del himno de Chile en cuanto éste designa al país en la forma de una "copia feliz del Edén". A partir de ahí, se pregunta ¿cómo podría una copia afirmarse en la originalidad de una soberanía? Para solucionar la distancia entre copia y original y, por tanto, dar lugar al funcionamiento de la soberanía, el himno designa a esa copia como "feliz". El término "feliz" se constituye, así, en el operador que (...) vendría tanto a apuntalar a la constitución de una soberanía como a revelar el límite de su imposibilidad. "Feliz" permite disminuir la distancia entre copia y original, pero a la vez, la conserva irremediablemente. Por eso, decir que el país es la copia "feliz" es lo mismo que decir "infeliz" toda vez que ambos términos no hacen más que corroborar la diferencia ontológica entre copia y original. Se argumenta que el término "feliz" constituye un dispositivo teológico político, toda vez que replica la función angélica destinada a la administración de la creación divina. En estos términos se pregunta: ¿no será el proyecto de la República de Chile un proyecto esencialmente administrativo? A esta luz, el texto plantea la contraposición entre himno con el poema: el himno -se plantea- constituye el operador angélico que hace posible la articulación de una soberanía. El poema, en cambio, constituiría el resto irreductible que le resiste. This essay asks on the performative efects of the chilean hymn, because it names the country as a "happy copy of Eden". Since this problem, the essay asks: how could the copy may posits as the originality of the sovereignity? To solve the distance between the copy and the original and make posible the sovereignity´s operation, the hymn names the copy as "happy". The word "happy" supports the constitution of the sovereignity and reveals the limit of its own imposibility. "Happy" reduce the distance between the copy and the original but, at the same time, absolutely preserve it. That´s why, say that the country is the "happy" copy is the same than to say that is a "unhappy" one, because both words shows the ontological difference between the copy and the original. This essay argues that the word "happy" is a political theological device because repeats the angelical task of manage the divine creation. In theses terms we ask: ¿Is the chilean republican proyect an administrative one? In this light, the essay posits an aporia between the hymn and poem: the hymn constitutes the angelical operator that makes sovereignity posible, the poem constitutes a singular rest that resist it. (shrink)

Basado en los trabajos del filósofo italiano G. Agamben, el presente ensayo argumenta que la figura del prudente en Aristóteles constituiría el lugar de la soberanía y, en cuanto tal, tendría un carácter estrictamente biopolítico pues, permite “producir” la humanidad del ser vivo hombre, en cuanto zoon politikón (zoon lógon ekhon). Así, el presente texto da cuenta de una aporía inscrita en el seno de la política occidental y su concepto de justicia que, encarnado en la figura aristotélica del prudente (...) –en cuanto lugar de la decisión soberana- ha de producir la propia “humanidad” del ser vivo hombre, separando, al mismo tiempo, algo así como una nuda vida. (shrink)

Disjunctivism about perceptual appearances, as I conceive of it, is a theory which seeks to preserve a naïve realist conception of veridical perception in the light of the challenge from the argument from hallucination. The naïve realist claims that some sensory experiences are relations to mind-independent objects. That is to say, taking experiences to be episodes or events, the naïve realist supposes that some such episodes have as constituents mind-independent objects. In turn, the disjunctivist claims that in a case of (...) veridical perception like this very kind of experience that you now have, the experiential episode you enjoy is of a kind which could not be occurring were you having an hallucination. The common strategy of arguments from hallucination set out to show that certain things are true of hallucinations, and hence must be true of perceptions. For example, it is argued that hallucinations must have non-physical objects of awareness, or that such states are not relations to anything at all, but are at best seeming relations to objects. In insisting that veridical perceptual experience is of a distinct kind from hallucination, the disjunctivist denies that any of these conceptions of hallucination challenges our conception of veridical perceptions as relations to mind-independent objects. More specifically, I assume that the disjunctivist advocates naïve realism because they think that this position best articulates how sensory experience seems to us to be just through reflection. If the disjunctivist is correct in this contention, then anyone who accepts the conclusion of the argument from hallucination must also accept that the nature of sensory experience is other than it seems to us to be. In turn, one may complain that any such error theory is liable to lead to sceptical consequences. A Humean scepticism about the senses launches a challenge about our knowledge of the world through questioning the conception we have of what sense experience is, and how it can provide knowledge of the world. (shrink)

In this paper I propose a new solution to the problem of change: situationalism. According to this view, parts of reality fundamentally disagree about what is the case and reality as a whole is unsettled (i.e. metaphysically indeterminate). When something changes, parts of the world irreconcilably disagree about what properties it has. From this irreconcilable disagreement, indeterminacy arises. I develop this picture using situations, which are parts of possible worlds; this gives it the name situationalism. It allows a B-theory endurance (...) view on which there is genuine incompatibility when things change. There are costs to the view, which are explored, but it is a novel approach which offers a distinct explanation of what happens when things exist through change. (shrink)

The epistemological principles underlying randomized, controlled trials and evidence-based medicine generally have not received the attention they require. Broadly speaking, they are the application of work done over several centuries in philosophy and scientific method. The epistemological base is sound, but it also implies internal limitations, having to do with decreasing generality, which particularly affect application to psychological problems. The principles also have nothing to say about values. The question of the 'objective validity' of scientific method is briefly discussed.

Pastor and author Martin Thielen has compiled a list of ten things people need to believe, and ten things they don't, in order to be a Christian. This lively and engaging book will be a help to seekers as well as a comfort to believers who may find themselves questioning some of the assumptions they grew up with. With an accessible, storytelling style that's grounded in solid biblical scholarship, Thielen shows how Christians don't need to believe that sinners will (...) be "left behind" to burn in hell or that it's heresy to believe in evolution. And while we must always take the Bible seriously, we don't always have to take it literally. At the same time, Christians do need to believe in Jesus--his life, his teachings, his death and resurrection, and his vision for the world. A great benefit of those beliefs is that they provide promising answers to life's most profound questions, including: Where is God? What matters most? What brings fulfillment? What about suffering? Is there hope? Thielen articulates centrist, mainline Christianity in a way that's fresh and easy to understand, and offers authentic Christian insights that speak to our deepest needs. This new edition includes a leader's guide, previously only available online, and a new introduction from the author that reflects on the book's reception. The leader's guide features unique and easily implemented aids for carrying out a seven-week, congregation-wide initiative that will help local churches reach out to their communities. More information is available at thielen.wjkbooks.com. (shrink)

Tato studie se zabývá problémem metody v kritické teorii. Nejprve zkoumá ustavující texty, v nichž založili Horkheimer a Marcuse kritickou teorii jako dialektický a materialistický přístup k analýze kapitalistické společnosti adekvátní její objektivně-abstraktní povaze. Stať diskutuje též Hegela a Marxe, nejdůležitější předchůdce frankfurtské školy, a způsob, jímž kritická teorie čerpá z jejich děl. Dále příspěvek obrací svou pozornost k Adornovým metodologickým postulátům, jež vyústily v analytické kategorie „reálné abstrakce“ a „objektivní konceptuality“. Reichelt a Backhaus vyšli z Adorna, jehož byli žáky, (...) a interpretovali v tradici kritické teorie Marxovo dílo jako úsilí o zachycení určité kvality procesu inverze, v němž je práce, lidská moc ustavující společnost, nahrazena sociálním panstvím kapitalistických abstrakcí, které degradují její tvůrčí potenciál. Nové čtení Marxe dále analyzuje mizení smyslovosti v říši nadsmyslné reality kapitálu jako vůdčí hegeliánský motiv v celé Marxově práci. The essay deals with the problem of method in Critical theory. Firstly, it explores the constituent texts in which Horkheimer and Marcuse founded Critical theory as a dialectical and materialist approach for analysing capitalist society in terms of its objectively-abstract nature. It discusses its most important predecessors – Hegel and Marx – and the way critical theory is based on their works. Secondly, the essay turns its attention to Adorno's methodological postulates that resulted into analytical categories of ‘real abstraction’ and ‘objective conceptuality’. Building upon Adorno, their mentor, Reichelt and Backhaus interpreted, in the tradition of critical theory, Marx's oeuvre as an endeavour to catch determinate quality of the process of inversion in which labour, humanity's constituent power, is displaced and demoted by the social domination of capitalist abstractions. The neue Marx-Lektüre further analyses the disappearance of sensuousness in the realm of supersensible reality of capital as the defining Hegelian motive in Marx. (shrink)

This volume explores emotion in medieval and early modern thought, and opens a contemporary debate on the way emotions figure in our cognitive lives.

This book traces the development of theories of the self and personal identity from the ancient Greeks to the present day. From Plato and Aristotle to Freud and Foucault, Raymond Martin and John Barresi explore the works of a wide range of thinkers and reveal the larger intellectual trends, controversies, and ideas that have revolutionized the way we think about ourselves. The authors open with ancient Greece, where the ideas of Plato, Aristotle, and the materialistic atomists laid the groundwork (...) for future theories. They then discuss the ideas of the church fathers and medieval and Renaissance philosophers, including St. Paul, Philo, Augustine, Aquinas, and Montaigne. In their coverage of the emergence of a new mechanistic conception of nature in the seventeenth century, Martin and Barresi note a shift away from religious and purely philosophical notions of self and personal identity to more scientific and social conceptions, a trend that has continued to the present day. They explore modern philosophy and psychology, including the origins of different traditions within each discipline, and explain both the theoretical relevance of feminism and gender and ethnic studies and also the ways that Derrida and other recent thinkers have challenged the very idea that a unified self or personal identity even exists. Martin and Barresi cover a number of issues broached by philosophers and psychologists, such as the existence of a fixed and unchanging self and whether the concept of the soul has a use outside of religious contexts. They address the question of whether notions of the soul and the self are still viable in today's world. Together, they reveal the fascinating ways in which great thinkers have grappled with these and other questions and the astounding impact their ideas have had on the development of self-understanding in the west. (shrink)