Over the course of a lifetime, the risk of professional disruption is considerable. The most frequent causes of disruption are linked to illness or accidents, which leads many employees or self-employed people to change their professional status by obtaining recognition as disabled workers from Maisons Departmentale des Personnes Handicapées (MDPHs) (Departmental Centres for Disabled People). This situation concerns a significant proportion of the population. This research study, which was carried out using a qualitative methodology based on ten interviews and eighty (...) questionnaires, sheds new light on the support provided during skills assessments. It re-examines the support provided to jobseekers who have been recognized as disabled workers by examining the in-between positions of employment support professionals, the in-between nature of the challenges they face, and the in-between nature of the timeframes required to get people forced to change career path back into the workplace. (shrink)

Objectives: To review the performance of research ethics committees in Spain in assessing multicentre clinical trial drug protocols, and to evaluate if they would comply with the requirements of the new EU Directive to be implemented by May 2004.Design and setting: Prospective study of applications of MCT submitted to RECs.Main measurements: Protocol related features and evaluation process dynamics.Results: 187 applications to be performed in 114 centres, were reviewed by 62 RECs. RECs had a median number of 14 members, of which (...) three were lay members. All applications were approved except four which were however approved by the other RECs involved. The median times from submission to approval and from submission to reception at the sponsor’s offices were 48 and 62 days, respectively. In 55% of all applications approved, 41 RECs raised 307 queries, 40% of these were protocol related issues, and 38% related to the patients’ information sheets. RECs charging an evaluation fee in advance and applications with no queries raised were statistically significantly associated with shorter evaluation times. However, there is a gap of at least 1.5 weeks between the date of the meeting and the reception of the approval letter in the sponsor’s office.Conclusions: Evaluating MCT protocols by RECs is a time consuming process. Needing 1.5 weeks for communicating the decision taken by RECs to the sponsor suggests serious administrative shortcomings within most RECs. By significantly reducing the time for communication of their decisions, the majority of RECs would comply with the Directive requirement of a maximum 60 day period for the assessment of MCT. (shrink)

In response to the COVID-19 pandemic, large-scale research and pharmaceutical regulatory processes have proceeded at a dramatically increased pace with new and effective, evidence-based COVID-19 interventions rapidly making their way into the clinic. However, the swift generation of high-quality evidence and the efficient processing of regulatory authorisation have given rise to more specific and complex versions of well-known research ethics issues. In this paper, we identify three such issues by focusing on the authorisation of Molnupiravir, a novel antiviral medicine aimed (...) at reducing the ability of SARS-CoV-2 to multiply in the body, for clinical use by the National Health Service in England and the concomitant testing of Molnupiravir through the large-scale PANORAMIC randomised control trial. By analysing the ways in which the authorisation and clinical use of Molnupiravir complicate standard approaches to clinical equipoise, standard of care, and participant consent in the PANORAMIC randomised control trial we will explain some of ethical implications for clinical trials that aim to study the efficacy and safety of new COVID-19 and other therapeutics when conditional authorisation has already been granted and when such treatments have already been made available to patients by national health providers. (shrink)

For more than 25 years, research misconduct is defined as fabrication, falsification, or plagiarism —although other research misbehaviors have been also added in codes of cond...

In response to the COVID-19 pandemic, large-scale research and pharmaceutical regulatory processes have proceeded at a dramatically increased pace with new and effective, evidence-based COVID-19 interventions rapidly making their way into the clinic. However, the swift generation of high-quality evidence and the efficient processing of regulatory authorisation have given rise to more specific and complex versions of well-known research ethics issues. In this paper, we identify three such issues by focusing on the authorisation of molnupiravir, a novel antiviral medicine aimed (...) at reducing the ability of SARS-CoV-2 to multiply in the body, for clinical use by the National Health Service in England and the concomitant testing of molnupiravir through the large-scale Platform Adaptive trial of Novel antiviRals for eArly treatMent of COVID-19 In the Community randomised control trial. By analysing the ways in which the authorisation and clinical use of molnupiravir complicate standard approaches to clinical equipoise, standard of care and participant consent in the PANORAMIC randomised control trial, we will explain some of ethical implications for clinical trials that aim to study the efficacy and safety of new COVID-19 and other therapeutics when conditional authorisation has already been granted and when such treatments have already been made available to patients by national health providers. (shrink)

Cet ouvrage rend hommage à différents « Maîtres à penser » qui, par leur oeuvre, ont notablement enrichi leur discipline. Les juristes, historiens, politistes, philosophes, économistes étudiés ici ont en commun de réfléchir sur le pacte démocratique. Comment articuler liberté et égalité, économie et politique, religion et laïcité, violence et norme coercitive... pour qu'advienne une harmonie synonyme de paix sociale? Chacun - Sturzo, Cuche, Pocock, Quesnay, Zagrebelsky, Makhno, Fanon, Rivero, Albert, Bataille, Desjardins - apporte sa propre réponse. La diversité des (...) auteurs est à l'image de la dimension résolument pluridisciplinaire de ce nouvel opus du Bulletin annuel de Villetaneuse. (shrink)

Vir a ser cidadão: Educação, Política e Psicologia do Desenvolvimento Resumo: Considerando a tese honnethiana de que, hodiernamente, há um desenlace entre Educação e Política, e afirmando um forte nexo entre essas áreas no pensamento de Jean-Jacques Rousseau, neste trabalho, apresentamos alguns aspectos de como, para este, é possível que o ser humano, como membro da espécie, venha a ser cidadão. Em seguida, contando com a crítica de Nussbaum sobre como muitas propostas educacionais não explicitam uma psicologia do desenvolvimento, aventamos (...) uma vinculação entre Educação, Política e ideias psicológicas em Rousseau. Adiante, trazemos elementos da pesquisa psicogenética de Jean Piaget, propondo que esse tipo de pesquisa permite um fortalecimento do nexo entre as áreas da Educação, Política e, agora, Psicologia do Desenvolvimento, contribuindo para a discussão ainda atual acerca do vir a ser cidadão. Palavras-chave: Cidadão; Desenvolvimento; Formação; Rousseau; Piaget. Becoming a citizen: Education, Politics and Developmental Psychology Abstract: Considering the Honnethian thesis that there is today a disconnexion between Education and Politics, and asserting a strong link between these fields in the thought of Jean-Jacques Rousseau, in this work we present some aspects of how, for him, it is possible for a human, as a member of the species, to become a citizen. Then, relying on Nussbaum's critique of the fact that many educational proposals do not make developmental psychology explicit, we suggest a link between Education, Politics and psychological ideas in Rousseau. Ahead, we bring elements of Jean Piaget's psychogenetic research, proposing that this type of research allows a strengthening of the nexus between the fields of Education, Politics and, now, Developmental Psychology, contributing to the still current discussion about becoming a citizen. Keywords: Citizen; Development; Formation; Rousseau; Piaget. Devenir citoyen: Éducation, Politique et Psychologie du développement Résumé: Considérant la thèse honnéthienne selon laquelle, aujourd'hui, il y a une déconnexion entre éducation et politique, et affirmant un lien fort entre ces domaines dans la pensée de Jean-Jacques Rousseau, nous présentons dans cette étude certains aspects de la façon dont, pour lui, il est possible pour l’être humain, en tant que membre de l'espèce, devenir citoyen. Puis, en nous appuyant sur la critique de Nussbaum sur le nombre de propositions éducatives qui ne rendrent pas explicite une psychologie du développement, nous avons suggéré un lien entre l'éducation, la politique et les idées psychologiques chez Rousseau. En avant, nous apportons des éléments de la recherche psychogénétique de Jean Piaget, en proposant que ce type de recherche permette un renforcement du lien entre les domaines de l'éducation, de la politique et, maintenant, de la psychologie du développement, contribuant à la discussion encore actuelle sur le devenir citoyen. Mots-clés: Citoyen ; Développement ; Formation ; Rousseau ; Piaget. Data de registro: 25/02/2021 Data de aceite: 19/01/2022. (shrink)

Everyday life practices are one of the focuses of interest for so-called 'sustainable transitions'. Efforts in making daily life more ecological have ranged from awareness-raising and behaviour change strategies to socio-technical innovations, but have produced limited results so far. In a present characterised by a prolonged and multifaceted crisis it is imperative that, as social scientists, we interrogate the (un)sustainability of everyday practices from a more critical angle, linking them to reflections about capitalism's ecological destructiveness. One fruitful way of doing (...) so is to interrogate the dimension of subjectivity as a space where collective discourses, practices and desires are embodied in concrete experience and actions. Drawing on ethnographic material on everyday energy use, I suggest that contemporary ways of living certainly contribute to the overall reproduction of capitalism and yet, in the (dis)juncture of the crisis, more sustainable livelihoods can be experimented with and prefigured. Subjectivity is one crucial dimension in which this process unravels. (shrink)

OBJECTIVES: To review the characteristics and performance of research ethics committees in Spain in the evaluation of multicentre clinical trial drug protocols. DESIGN: A prospective study of 100 applications. SETTING: Forty-one committees reviewing clinical trial protocols, involving 50 hospitals in 25 cities. MAIN MEASURES: Protocol-related features, characteristics of research ethics committees and evaluation dynamics. RESULTS: The 100 applications involved 15 protocols (of which 12 were multinational) with 12 drugs. Committees met monthly (except one). They had a mean number of 12 (...) members, requested a mean of six complete dossiers and nine additional copies of the protocol with a mean deadline of 14 days before the meeting. All applications were approved except three (two of the three were open-label long-term safety trials rejected by the same committee), which were approved by the other committees involved. The mean time from submission to approval was 64 days. The mean time from submission to arrival of the approval document at our offices was 85 days. Twenty-five committees raised queries for 38 of the 97 finally approved applications. Impact of evaluation fee, number of members, queries raised and experience of committees on timings were not statistically significant. CONCLUSION: Obtaining ethical approval is time-consuming. There is much diversity in the research ethics committees' performance. A remarkable delay (> 20 days) exists between the decision and the arrival of the written approval, suggesting administrative or organisational problems. (shrink)

Scholarship on the early modern period assumes that the Creation story of Genesis and its chronology were the only narratives openly available in Renaissance Europe. This essay revisits the topic by exploring a wide range of literature on the age and nature of the Earth in early modern Italy. It suggests that, contrary to received notions, in the early 1500s an Aristotelian ancient world characterized by slow geological change was a common assumption in discourse on the Earth. These notions were (...) freely disseminated by popularizations and didactic literature in the vernacular, which made them available to a large readership. Counter-Reformation cultural policies eventually called for a tighter integration of theology and natural philosophy; however, the essay argues that even then the creation of the world was usually placed in a remote and undetermined past, not necessarily tied to the short timescales of contemporary chronology. (shrink)

We argue against the claim that the employment of diagrams in Euclidean geometry gives rise to gaps in the proofs. First, we argue that it is a mistake to evaluate its merits through the lenses of Hilbert’s formal reconstruction. Second, we elucidate the abilities employed in diagram-based inferences in the Elements and show that diagrams are mathematically reputable tools. Finally, we complement our analysis with a review of recent experimental results purporting to show that, not only is the Euclidean diagram-based (...) practice strictly regimented, it is rooted in cognitive abilities that are universally shared. (shrink)

The aim of this paper is to investigate among a group of non-profit organizations: a) the effect of ethical leadership on volunteers’ satisfaction, affective organizational commitment and intention to stay in the same organization; b) the role played by job satisfaction as a mediator in the relationship between ethical leadership and volunteers’ intentions to stay in the same organization, as well as between ethical leadership and affective commitment. An anonymous questionnaire was individually administered to 198 Italian volunteers of different non-profit (...) organizations. The questionnaire contained the Ethical Leadership Scale, the Volunteers Satisfaction Index, the Affective organization Scale, as well as questions regarding the participants’ age, sex, type of work, level of education, length of their volunteer works, intention to volunteer in the following months in the same organization. The construct as well the effects of EL on volunteers is approached in light of the Social Exchange Theory and the Social Learning Theory. Structural equation models were used to test hypothesized relationships. The results confirm the role of mediation of volunteer satisfaction in the relationships between the variables studied. In particular, ethical leadership was found to be positively associated both with volunteers’ intention of staying and with their affective commitment. In the first case this relationship is fully explained by the mediation of the volunteers’ satisfaction, while the latter is explained by both direct and indirect factors. To the authors’ knowledge, this the first attempt to understand the role played by ethical leadership on volunteers’ behavior and, more in general, in the management of non-profit organizations. Findings are relevant both for practitioners and managers of non-profit organization, since they suggest the relevance of the perception of ethical leadership by volunteers, as well as for scholars, since they further deepen the knowledge on EL and its effects on the followers. Limits of the study: the questionnaire was administered only among a group of non-statistical sample of volunteers. Furthermore, the study reached only volunteers from Italian non-profit organization. (shrink)

Ugo Nespolo (1941) ha attraversato gli ultimi cinquant’anni sperimentando in quasi tutti i campi dell’arte ed esprimendo con ironia e atteggiamento ludico la propria poetica di confine, tra avanguardia e pop. Alla sua ricerca artistica - che spazia dalle installazioni oggettuali ai dipinti, dalle performance alle sculture, dalla produzione cinematografica a quella grafica e illustrativa - è dedicato questo numero speciale “Rivista di estetica” che offre riflessioni di carattere critico/letter...

Before being considered as independent fields, business cycles and productivity growth had long been regarded as closely interrelated dynamics. Growth and cycles theories and models developed independently. On one side, the growth analysis developed analyzing the existence and stability of a long-run deterministic growth path. On the other side, business cycles theory focused on the understanding of detrended data movements considering growth as an exogenous trend, independent of the cycle. This dichotomy is still present in the modern literature. _Business Cycles (...) and Growth Theory_ examines the role of monetary and financial factors in growth cycles dynamics interaction. It offers new perspectives for modelling growth cycles dynamics underlining the possibility of building an 'incomplete business cycles theory', as well as highlighting the existence of a convergence between the last theoretical developments of both growth and business cycles literatures. A significant read, this book demonstrates that such a convergence can provide benchmarks for a new paradigm of models in which endogenous growth mechanism, because it offers a strong propagation for shocks, can be the core of a new business cycles dynamics. (shrink)

SummaryThis paper explores the interactions between scientific travel, politics, instrument making and the epistemology of scientific instruments in Napoleon's Europe. In the early 1800s, the German astronomer Franz Xaver von Zach toured Italy and Southern France with instruments made by G. Reichenbach in his newly-established Bavarian workshop. I argue that von Zach acted as a broker for German technology and science and that travel, personal contacts and direct demonstrations were crucial in establishing Reichenbach's reputation and in conquering new markets. The (...) rise of German instrument making highlights the complexity of the scientific relationship between the centre and the peripheries in Napoleon's empire, and reveals the existence of diverging views on the role of instruments and of their makers. In von Zach's view, Reichenbach's instruments could not penetrate the French market because Parisian astronomers focused on mathematical astronomy and, for both political and epistemological reasons, dismissed instruments and material innovations from the peripheries. The German astronomer and his Italian colleagues, on the contrary, regarded Reichenbach's technical achievements as outstanding contributions to astronomy, and considered the political and cultural hegemony of the capital as a hindrance to the advancement of science. (shrink)