As next‐generation genomic sequencing, including whole‐genome sequencing information, becomes more common in research, clinical, and public health contexts, there is a need for comprehensive communication strategies and education approaches to prepare patients and clinicians to manage this information and make informed decisions about its use, and nowhere is that imperative more pronounced than when genomic sequencing is applied to newborns. Unfortunately, in‐person counseling is unlikely to be applicable or cost‐effective when parents obtain genomic risk information directly via the Internet. As (...) a rule, communication strategies should match how people are accessing health information. Today, many people can obtain health information in a variety of settings, including through direct‐to‐consumer services, via websites, and through other digital channels or settings. In response to these changes, new communication strategies need to be considered. Adopting a comprehensive communication model means understanding the multiple levels of influence experienced by parents and the clinicians who serve them. In addition, applying communication‐science principles can help in addressing some key challenges to effectively communicating genomic information to parents. (shrink)

In their target article, Conley et al. (2023) appropriately highlight the ongoing conceptual and practical opacity of public engagement (PE) in the translation of human gene editing (HGE) (Conley e...

Aversive autobiographical memories sometimes prompt maladaptive emotional responses and contribute to affective dysfunction in anxiety and depression. One way to regulate the impact of such memories is to create a downward counterfactual thought–a mental simulation of how the event could have been worse–to put what occurred in a more positive light. Despite its intuitive appeal, counterfactual thinking has not been systematically studied for its regulatory efficacy. In the current study, we compared the regulatory impact of downward counterfactual thinking, temporal distancing, (...) and memory rehearsal in 54 adult participants representing a spectrum of trait anxiety. Participants recalled regretful experiences and rated them on valence, arousal, regret, and episodic detail. Two to six days later, they created a downward counterfactual of the remembered event, thought of how they might feel about it 10 years from now, or simply rehearsed it. A day later, participants re-rated the phenomenological characteristics of the events. Across all participants, downward counterfactual thinking, temporal distancing, and memory rehearsal were equally effective at reducing negative affect associated with a memory. However, in individuals with higher trait anxiety, downward counterfactual thinking was more effective than rehearsal for reducing regret, and it was as effective as distancing in reducing arousal. We discuss these results in light of the functional theory of counterfactual thinking and suggest that they motivate further investigation into downward counterfactual thinking as a means to intentionally regulate emotional memories in affective disorders. (shrink)

England and Wales are moving toward a model of ‘opt out’ for use of personal confidential data in health research. Existing research does not make clear how acceptable this move is to the public. While people are typically supportive of health research, when asked to describe the ideal level of control there is a marked lack of consensus over the preferred model of consent. This study sought to investigate a relatively unexplored difference between the consent model that people prefer and (...) that which they are willing to accept. It also sought to explore any reasons for such acceptance. (shrink)

This study aims to investigate the spillover impact of work-family/family–work conflict and stress on five major industrial sectors, during the first wave of Covid-19. The purpose of this cross-sectional study is twofold; firstly, to test a hypothesized model where work-family/family-work conflicts are related to stress and where stress could exert a mediating role in such relationships. Secondly, we seek to explore the presence of these conflicts and stress in each of the five major industrial sectors and evaluate if there are (...) significant differences between them, identifying the sociodemographic characteristics associated. Two questionnaires were applied to 748 employees from the selected industries. According to our results, stress predicts both types of conflict and also exerts a mediator role. It was primarily found that the five sectors are significantly different regarding the work-family/family-work conflicts and stress. Findings and implications are discussed. (shrink)

In a review of the cell biology and heredity studies of 1900–1910, Bernardino Fantini argues that the choice of an experimental subject or organism was crucial in opening up new discoveries and new theories for specific fields of research.69 Thinking on a broader level, Bütschli expressed a similar view when he stated that an understanding of the true nature and structure of the “elementary organism” was crucial to the whole of biology. In this article we have traced the impact of (...) Bütschli's unicellular model of protozoa up to the general acceptance of the eukaryotic cell as nature's primary organism. We have also seen that Bütschli's vision in the Studien gave birth to Protistenforschung and Zellforschung, sister sciences whose task it was to further and integrate knowledge of the living cell. Of necessity, we have confined ourselves to German scientific developments. However, our attempt to recapture and define the unity and meaning of a biology of the “cell-microcosm” has given us pause to reconsider the development and nature of Wilhelmian biological science. (shrink)

Are the state’s obligations to victims of its own wrongdoing greater than to persons who have suffered from bad luck? Many people endorse an affirmative answer to this question. Call this the Difference View. This view can seem arbitrary from the perspective of the victims in question; why should a victim of bad luck, who is just as badly off through no fault of her own, be entitled to less assistance from the state than a victim of state-caused wrongful harm? (...) This paper defends a qualified version of the Difference View, the Threshold Version of the Difference View. According to this view, all disadvantaged persons, no matter what the cause of their disadvantage, must be compensated until they reach a minimum threshold of wellbeing; however, among disadvantaged persons above this threshold, full compensation is owed for those who are victims of state wrongdoing, whereas full compensation is not necessarily owed to those who are disadvantaged due to bad luck. (shrink)

Conscience and Conscientious Objection of Health Care Professionals Refocusing the Issue Content Type Journal Article Pages 351-364 DOI 10.1007/s10730-009-9113-x Authors Natasha T. Morton, The University of Western Ontario Ontario Canada N6A 5B9 Kenneth W. Kirkwood, Arthur and Sonia Labatt Health Sciences Building London Ontario Canada N6A 5B9 Journal HEC Forum Online ISSN 1572-8498 Print ISSN 0956-2737 Journal Volume Volume 21 Journal Issue Volume 21, Number 4.

The definition of consumerism is multifaceted, extending from the consumption of goods and services to its more negative connotations: the obsessive consumption of goods, exploitation of the people who create them and greed. In a society heavily influenced by consumerism, we find ourselves manipulated by social media and targeted advertising to buy goods or to cultivate a certain lifestyle, raising important ethical questions about responsibility and our autonomy to make decisions. How has the nature of how we create and consume (...) goods evolved and how is this linked to moral responsibility and autonomy? Can it also be argued that there is aesthetic appreciation to be gained from some of the items that we create and consume? (shrink)

We investigate the effects of various forcings on several forms of the Halpern– Läuchli theorem. For inaccessible κ, we show they are preserved by forcings of size less than κ. Combining this with work of Zhang in [17] yields that the polarized partition relations associated with finite products of the κ-rationals are preserved by all forcings of size less than κ over models satisfying the Halpern– Läuchli theorem at κ. We also show that the Halpern–Läuchli theorem is preserved by <κ-closed (...) forcings assuming κ is measurable, following some observed reflection properties. (shrink)

In some cultures, people tend to believe that it is very important to be sexually exclusive in romantic relationships and idealise monogamous romantic relationships; but there is a tension in this ideal. Sex is generally considered to have value, and usually when we love someone we want to increase the amount of value in their lives, not restrict it without good reason. There is thus a call, not yet adequately responded to by philosophers, for greater clarity in the reasons §why (...) it might be reasonable for a couple to adopt a policy of sexual exclusivity. This article argues that we cannot justify the demand for sexual exclusivity by a need to protect the relationship from the risk of one partner ‘trading-up’, or by appealing to jealousy. However, sexual exclusivity can be intelligible if it supports the romantic relationship and helps to distinguish it from other relationships. Nonetheless, sexual exclusivity ought not to be the hegemonic social norm that it currently is in some societies because this diminishes the potential value it might have and gives the idea of faithfulness the wrong focus. (shrink)

This paper investigates when it is possible for a partial ordering P to force Pκ(λ) \ V to be stationary in VP. It follows from a result of Gitik that whenever P adds a new real, then Pκ(λ) \ V is stationary in VP for each regular uncountable cardinal κ in VP and all cardinals λ > κ in VP [4]. However, a covering theorem of Magidor implies that when no new ω-sequences are added, large cardinals become necessary [7]. The (...) following is equiconsistent with a proper class of ω₁-Erdős cardinals: If P is N₁-Cohen forcing, then Pκ(λ) \ V is stationary in VP, for all regular κ ≥ N₂ and all λ > κ. The following is equiconsistent with an ω₁-Erdős cardinal: If P is N₁-Cohen forcing, then PN₂ (N₃) \ V is stationary in VP. The following is equiconsistent with κ measurable cardinals: If P is κ-Cohen forcing, then Pκ + (Nκ \ V is stationary in VP. (shrink)

For many families, the idea of going out for walks and family adventures can be a dream that is erased by the determination of autistic spectrum in a child. Gaps in the health and quality of life of young people with autism spectrum disorder (ASD) are well documented. One particularly noticeable gap that affects both physical health and quality of life is in the area of outdoor recreation, particularly including outdoor recreation activities such as biking, hiking, running, canoeing/kayaking, horseback riding, (...) and skiing. Of the many outdoor activities to promote physical fitness, hiking is perhaps the most versatile and accessible for people with ASD. Hiking is a natural extension of walking. It is one of the first skills we acquire, one of the most important activities in everyday life and one of the few forms of recreation that does not require specific equipment and conditions. On the other hand, except for perhaps the most densely populated urban areas, there are almost always trails nearby. Lately even urban hikes that move around the city are becoming more and more popular. Whether you’re climbing the mountains at an expert level or hiking a trail, hiking gets your kids moving, which is of utmost importance in our modern society, when childhood seems to be filled more and more with time spent in front of the screens, and for children with autism this can become a serious problem. The main goal of this paper, on the one hand, is to increase awareness of the importance of hiking for psychophysical health, both for people from the general population and for people with ASD, but also to give recommendations for the approach and the way of organizing hiking activities for people with ASD, on the other hand. (shrink)

Creativity is an imperative need of the twenty-first century, and it seems to be a skill that will monopolize interest for many years. It is, in substance, a newly established scientific field and despite attempts to encroach on the science of psychology, its origin and functions have not been probed yet. Still, it continues to be researched, with ever-increasing vigor, almost in every area of science and action, with the main scope of potential exploitation being education. The philosophical foundation of (...) creativity has not reached the depths that one would expect, and most scientists-thinkers (and... (shrink)

Sexual infidelity is widespread, but it is also widely condemned, yet relatively little philosophical work has been done on what makes it wrong and how wrong it is. In this paper, I argue that sexual infidelity is wrong if it involves breaking a commitment to be sexually exclusive, which has special significance in the relationship. However, it is not necessarily worse than other kinds of infidelity, and the context in which it takes place ought to be considered. I finish the (...) paper by looking at how the hegemonic norm of monogamy makes infidelity both more likely and more difficult to deal with. (shrink)

Natasha McKeever argues that prima facie, a friends-with-benefits relationship can be, at the same time, a good friendship. This is because sex is compatible with friendship in that it can complement and potentially even strengthen the three core characteristics of friendship: mutual liking, mutual caring, and mutual sharing. She acknowledges that, by generating uncertainty and having the potential to generate feelings of romantic love, sex does pose risks to friendship. However, she argues that while these risks are significant considerations, (...) they can be mitigated and managed and so do not provide strong reasons against friends-with-benefits relationships. (shrink)

Global co-stationarity of the ground model from an N₂-c.c, forcing which adds a new subset of N₁ is internally consistent relative to an ω₁-Erdös hyperstrong cardinal and a sufficiently large measurable above.

This paper describes how to ethically conduct research with Black populations at the intersection of COVID-19 and the Black Lives Matter movement. We highlight the issues of historical mistrust in the USA and how this may impact Black populations’ participation in COVID-19 vaccination trials. We provide recommendations for researchers to ethically engage Black populations in research considering the current context. Our recommendations include understanding the impact of ongoing trauma, acknowledging historical context, ensuring diverse research teams and engaging in open and (...) honest conversations with Black populations to better address their needs. The core of our recommendation is recognising the impact of trauma in our research and health care practices. (shrink)

Previous work has shown that memory performance in older adults is affected by activation of a stereotype of age-related memory decline. In the present experiment, we examined whether stereotype threat would affect metamemory in older adults; that is, whether under stereotype threat they make poorer judgments about what they could remember. We tested older adults (MAge= 66.18 years) on a task in which participants viewed words paired with point values and “bet” on whether they could later recall each word. If (...) they bet on and recalled a word, they gained those points, but if they bet on and failed to recall a word, they lost those points. Thus, this task required participants to monitor how much they could remember and prioritize high value items. Participants performed this task over six lists of items either under stereotype threat about age-related memory decline or not under stereotype threat. Participants from both groups performed similarly on initial lists, but on later lists, participants under stereotype threat showed impaired performance as indicated by a lower average point score and a lower average gamma coefficient. The results suggest that a modest effect of stereotype threat on recall combined with a modest effect on metacognitive judgments to result in a performance deficit. This pattern of results may reflect an effect of stereotype threat on executive control reducing the ability to strategically use memory. (shrink)

Harry Frankfurt has a comprehensive and, at times, compelling, account of love, which are outlined in several of his works. However, he does not think that romantic love fits the ideal of love as it ‘includes a number of vividly distracting elements, which do not belong to the essential nature of love as a mode of disinterested concern’. In this paper, I argue that we can, nonetheless, learn some important things about romantic love from his account. Furthermore, I will suggest, (...) conversely, that there is distinct value in romantic love, which derives from the nature of the relationship on which it is based. Frankfurt tries to take agape and reformulate it so that it can also account for love of particular people. Whilst he succeeds, to some extent, in describing parental love, he fails to accurately describe romantic love and friendship, and, moreover, overlooks what is distinctly valuable about them. Although it was not his intention to describe romantic love, by failing to include features such as reciprocity in his account of love, Frankfurt leaves no room for a kind of love that is important and valuable to many people. (shrink)

The universal homogeneous triangle-free graph, constructed by Henson [A family of countable homogeneous graphs, Pacific J. Math.38(1) (1971) 69–83] and denoted H3, is the triangle-free analogue of the Rado graph. While the Ramsey theory of the Rado graph has been completely established, beginning with Erdős–Hajnal–Posá [Strong embeddings of graphs into coloured graphs, in Infinite and Finite Sets. Vol.I, eds. A. Hajnal, R. Rado and V. Sós, Colloquia Mathematica Societatis János Bolyai, Vol. 10 (North-Holland, 1973), pp. 585–595] and culminating in work (...) of Sauer [Coloring subgraphs of the Rado graph, Combinatorica26(2) (2006) 231–253] and Laflamme–Sauer–Vuksanovic [Canonical partitions of universal structures, Combinatorica26(2) (2006) 183–205], the Ramsey theory of H3 had only progressed to bounds for vertex colorings [P. Komjáth and V. Rödl, Coloring of universal graphs, Graphs Combin.2(1) (1986) 55–60] and edge colorings [N. Sauer, Edge partitions of the countable triangle free homogenous graph, Discrete Math.185(1–3) (1998) 137–181]. This was due to a lack of broadscale techniques. We solve this problem in general: For each finite triangle-free graph G, there is a finite number T(G) such that for any coloring of all copies of G in H3 into finitely many colors, there is a subgraph of H3 which is again universal homogeneous triangle-free in which the coloring takes no more than T(G) colors. This is the first such result for a homogeneous structure omitting copies of some nontrivial finite structure. The proof entails developments of new broadscale techniques, including a flexible method for constructing trees which code H3 and the development of their Ramsey theory. (shrink)

Early life -- The decline of Athens -- The making of a philosopher -- A self-proclaimed gadfly -- Socrates on trial -- Socrates' execution and legacy.

The development of the Universal Declaration of Ethical Principles for Psychologists has sparked debate about its applicability to cultural groups around the globe. Focusing on the principle of respect espoused in the Declaration, this article uses examples largely drawn from the indigenous Ma-ori culture of Aotearoa/New Zealand, to highlight how the ethical imperatives espoused by the Declaration may conflict with the perspectives of M?ori. A discussion of actions denoting respect is given from a M?ori perspective. Distinctions between the ethical expectations (...) the discipline of psychology and Ma-ori have of psychological practitioners are also addressed. (shrink)

This book explores the ethical problems of algorithmic bias and its potential impact on populations that experience health disparities by examining the historical underpinnings of explicit and implicit bias, the influence of the social determinants of health, and the inclusion of racial and ethnic minorities in data. Over the last twenty-five years, the diagnosis and treatment of disease have advanced at breakneck speeds. Currently, we have technologies that have revolutionized the practice of medicine, such as telemedicine, precision medicine, big data, (...) and AI. These technologies, especially AI, promise to improve the quality of patient care, lower health care costs, improve patient treatment outcomes, and decrease patient mortality. AI may also be a tool that reduces health disparities; however, algorithmic bias may impede its success. This book explores the risks of using AI in the context of health disparities. It is of interest to health services researchers, ethicists, policy analysts, social scientists, health disparities researchers, and AI policy makers. (shrink)

This paper argues that there are important irrational elements to love. In the philosophical literature, we typically find that love is either thought of as rational or arational and that any irrational elements are thought to be defective, or extraneous to love itself. We argue, on the contrary, that irrationality is in part connected to what we find valuable about love. -/- We focus on 3 basic elements of love: -/- 1) Whom you love 2) How much you love them (...) 3) How much of a role love plays in your life -/- And in each case, we argue that love can be irrational and valuable. (shrink)

Analogues of Ramsey’s Theorem for infinite structures such as the rationals or the Rado graph have been known for some time. In this context, one looks for optimal bounds, called degrees, for the number of colors in an isomorphic substructure rather than one color, as that is often impossible. Such theorems for Henson graphs however remained elusive, due to lack of techniques for handling forbidden cliques. Building on the author’s recent result for the triangle-free Henson graph, we prove that for (...) each [Formula: see text], the k-clique-free Henson graph has finite big Ramsey degrees, the appropriate analogue of Ramsey’s Theorem. We develop a method for coding copies of Henson graphs into a new class of trees, called strong coding trees, and prove Ramsey theorems for these trees which are applied to deduce finite big Ramsey degrees. The approach here provides a general methodology opening further study of big Ramsey degrees for ultrahomogeneous structures. The results have bearing on topological dynamics via work of Kechris, Pestov, and Todorcevic and of Zucker. (shrink)

The afterword discusses how this special issue’s articles work from different angles to unsettle the precepts of “attentional sovereignty” — the socially, politically, and economically valorized virtue that anchors most discussions over attention in its contemporary technological predicament. Whether the attentional sovereign appears in its liberal humanist or its neoliberal behavioral economic guise, sovereignty is valorized and considered under threat. By revealing the contemporary and historical backstories to our investment in this notion, these articles shift the terms of the debate (...) around the attention crisis and clear space for thinking anew about the possibilities and limits of attention today. (shrink)

We show how sequent calculi for some generalized quantifiers can be obtained by generalizing the Herbrand approach to ordinary first order proof theory. Typical of the Herbrand approach, as compared to plain sequent calculus, is increased control over relations of dependence between variables. In the case of generalized quantifiers, explicit attention to relations of dependence becomes indispensible for setting up proof systems. It is shown that this can be done by turning variables into structured objects, governed by various types of (...) structural rules. These structured variables are interpreted semantically by means of a dependence relation. This relation is an analogue of the accessibility relation in modal logic. We then isolate a class of axioms for generalized quantifiers which correspond to first-order conditions on the dependence relation. (shrink)

Colleges and universities exist within a political arena where external demands for accountability materialize within a market-driven environment. As a result, government agencies pressure colleges and universities to rely on assessment and transparent reporting to become more market-driven assuming that the competition within the market, led by public choice and institutional selection, will drive improvements in learning and will also self-govern the institutions. This article explores how Foucault informs our conception of neoliberal governmentality through political rationality and technologies of self-governance (...) in order to inform our understanding of accountability in higher education and to challenge institutions to develop a counter dialogue which meets institutional obligations to the public and market. (shrink)

The generic ultrafilter${\cal G}_2 $forced by${\cal P}\left/\left$was recently proved to be neither maximum nor minimum in the Tukey order of ultrafilters, but it was left open where exactly in the Tukey order it lies. We prove${\cal G}_2 $that is in fact Tukey minimal over its projected Ramsey ultrafilter. Furthermore, we prove that for each${\cal G}_2 $, the collection of all nonprincipal ultrafilters Tukey reducible to the generic ultrafilter${\cal G}_k $forced by${\cal P}\left/{\rm{Fin}}^{ \otimes k} $forms a chain of lengthk. Essential to (...) the proof is the extraction of a dense subsetεkfrom +which we prove to be a topological Ramsey space. The spacesεk,k≥ 2, form a hierarchy of high dimensional Ellentuck spaces. New Ramsey-classification theorems for equivalence relations on fronts on εkare proved, extending the Pudlák–Rödl Theorem for fronts on the Ellentuck space, which are applied to find the Tukey and Rudin–Keisler structures below${\cal G}_k $. (shrink)

We extend the hierarchy of finite-dimensional Ellentuck spaces to infinite dimensions. Using uniform barriers [Formula: see text] on [Formula: see text] as the prototype structures, we construct a class of continuum many topological Ramsey spaces [Formula: see text] which are Ellentuck-like in nature, and form a linearly ordered hierarchy under projections. We prove new Ramsey-classification theorems for equivalence relations on fronts, and hence also on barriers, on the spaces [Formula: see text], extending the Pudlák–Rödl theorem for barriers on the Ellentuck (...) space. The inspiration for these spaces comes from continuing the iterative construction of the forcings [Formula: see text] to the countable transfinite. The [Formula: see text]-closed partial order [Formula: see text] is forcing equivalent to [Formula: see text], which forces a non-p-point ultrafilter [Formula: see text]. This work forms the basis for further work classifying the Rudin–Keisler and Tukey structures for the hierarchy of the generic ultrafilters [Formula: see text]. (shrink)

(2013). Open Access Digital Data Sharing: Principles, Policies and Practices☆. Social Epistemology: Vol. 27, No. 1, pp. 47-67. doi: 10.1080/02691728.2012.760663.

This text responds to the review forum on The Life and Death of States featuring Clara Maier, Kathryn Ciancia, Charles Maier, and Nathaniel Berman. It considers the place of Central Europe and the Habsburg Empire in our geographies of the modern world. Rather than hopelessly hamstrung by backwardness, the empire and its subjects were, in Clara Maier’s words, “simply struggling more insistently than complacent Westerners with the perplexities of the modern condition.” The text also considers questions of the post-colonial and (...) the post-imperial, literary genre, and the relationship between conceptual clarity and political legitimacy. (shrink)

A general method for constructing a new class of topological Ramsey spaces is presented. Members of such spaces are infinite sequences of products of Fraïssé classes of finite relational structures satisfying the Ramsey property. The Product Ramsey Theorem of Sokič is extended to equivalence relations for finite products of structures from Fraïssé classes of finite relational structures satisfying the Ramsey property and the Order-Prescribed Free Amalgamation Property. This is essential to proving Ramsey-classification theorems for equivalence relations on fronts, generalizing the (...) Pudlák–Rödl Theorem to this class of topological Ramsey spaces. To each topological Ramsey space in this framework corresponds an associated ultrafilter satisfying some weak partition property. By using the correct Fraïssé classes, we construct topological Ramsey spaces which are dense in the partial orders of Baumgartner and Taylor generating p-points which are k-arrow but not \-arrow, and in a partial order of Blass producing a diamond shape in the Rudin-Keisler structure of p-points. Any space in our framework in which blocks are products of n many structures produces ultrafilters with initial Tukey structure exactly the Boolean algebra \\). If the number of Fraïssé classes on each block grows without bound, then the Tukey types of the p-points below the space’s associated ultrafilter have the structure exactly \. In contrast, the set of isomorphism types of any product of finitely many Fraïssé classes of finite relational structures satisfying the Ramsey property and the OPFAP, partially ordered by embedding, is realized as the initial Rudin-Keisler structure of some p-point generated by a space constructed from our template. (shrink)

This book theorises technology and its host of social, material, and epistemic transformation techniques, tools, and methods as indeterminate through sixteen methodologically diverse contributions from media philosophy, art and architectural theory, mathematics, computer science, and anthropology scholars.