Research consent processes must provide potential participants with the necessary information to help them decide if they wish to join a study. On the Oxford ‘A’ Research Ethics Committee we’ve found that current research proposals mostly provide adequate detail (even if not in an easily comprehensible format), but often fail to support decision making, a view supported by published evidence. In a previous paper, we described how consent might be structured, and here we develop the concept of an Information and (...) Decision Aid (IDA) that can support decision making and be used to guide the dialogue between researcher and potential participant. Our proposal requires limited changes to current processes or paperwork and would provide an easily accessible document for others that the potential participant might approach for advice. It could later be integrated with the Informed Consent Form to ensure all matters of concern to the individual participant have been addressed before consent is formally signed off. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

A detailed review of hospital records, physician's notes, diaries, letters, and autopsy reports offers sufficient clinical grounds to establish that Eugene O'Neill developed adrenal insufficiency, secondary to tuberculosis, in later life--a fact hitherto unknown--the condition not becoming manifest until after he had abdominal surgery in 1936.

The present stage in the development of our society is marked by serious changes in social morality. The building of communism is entering a new stage. The man of the communist future is taking shape and being perfected before our eyes. Under these conditions, the Party - and this was emphasized at its Twenty-Fourth Congress - requires of a worker in the arts a thorough examination of contemporary life and of its hero to the full extent of his talent, and (...) demands that his ethical convictions and awareness of spirit be developed. Since this is the case, it is natural that literary criticism faces new, lofty tasks: tasks of analyzing literature in connection with those economic, societal, and moral processes which characterize social existence today. This was stated clearly both at the Party Congress and in the Resolution of the Central Committee of the CPSU "On Criticism in Literature and the Arts" [O literaturno-khudozhestvennoi kritiki]. (shrink)

The development and applicability of complex numbers is often cited in defence of the formalist philosophy of mathematics. This view is rejected through an examination of hamilton's development of the notion of complex numbers as ordered pairs of reals, And his later development of the quaternion theory, Which subsequently formed the basis of vector analysis. Formalism, By protecting informal assumptions from critical scrutiny, Constrained rather than encouraged the development of mathematics.

We review the relativistic classical and quantum mechanics of Stueckelberg, and introduce the compensation fields necessary for the gauge covariance of the Stueckelbert–Schrödinger equation. To achieve this, one must introduce a fifth, Lorentz scalar, compensation field, in addition to the four vector fields with compensate the action of the space-time derivatives. A generalized Lorentz force can be derived from the classical Hamilton equations associated with this evolution function. We show that the fifth (scalar) field can be eliminated through the (...) introduction of a conformal metric on the spacetime manifold. The geodesic equation associated with this metric coincides with the Lorentz force, and is therefore dynamically equivalent. Since the generalized Maxwell equations for the five dimensional fields provide an equation relating the fifth field with the spacetime density of events, one can derive the spacetime event density associated with the Friedmann–Robertson–Walker solution of the Einstein equations. The resulting density, in the conformal coordinate space, is isotropic and homogeneous, decreasing as the square of the Robertson–Walker scale factor. Using the Einstein equations, one see that both for the static and matter dominated models, the conformal time slice in which the events which generate the world lines are contained becomes progressively thinner as the inverse square of the scale factor, establishing a simple correspondence between the configurations predicted by the underlying Friedmann–Robertson–Walker dynamical model and the configurations in the conformal coordinates. (shrink)

Hamilton takes the tools of the competent New Testament scholar that he is and uses them to strip past the cultural overlays left on the New Testament by the first few centuries A.D. He does this to discover the primitive Jewish Christian Church's way of speaking about Jesus. This way of speaking, Hamilton feels, can inform our own cultural setting in a way that the less obscure, more Hellenistic New Testament traditions, with their elaborate metaphysical commitments, cannot. Basically, (...) this primitive Hebraic tradition sees Jesus as the eschatological prophet and emphasizes the fact that he was a Jew. Hamilton begins by tracing the primitive conception of "the future world," and then demonstrates its relation to the resurrection which, properly understood in that context, should serve to underscore the importance of the historical Jesus. An important part of Hamilton's project is to trace the separation of Hellenistic and Jewish cultures and to examine Christianity's unfortunate preference for the former. The book is forceful and convincing. Hamilton pays close attention to the texts, but his feeling for contemporary culture is as important a component of his persuasiveness as his dispassionate and penetrating scholarship.--S. O. H. (shrink)

J. N. Crossley [1] raised the question of whether the implication 2 + A = A ⇒ 1 + A = A is true for constructive order types (C.O.T.'s). Using an earlier definition of constructive order type, A. G. Hamilton [2] presented a counterexample. Hamilton left open the general question, however, since he pointed out that Crossley considers only orderings which can be embedded in a standard dense r.e. ordering by a partial recursive function, and that his counterexample (...) fails to meet this requirement. We resolve the question by finding a C.O.T. A which meets Crossley's requirement and such that 2 + A = A but 1 + A ≠ A. At the suggestion of A. B. Manaster and A. G. Hamilton we easily extend this construction to show that for any n ≧ 2, there is a C.O.T. A such that n + A = A but m + A ≠ A for 0 < m < n. Hence, Theorem 3 of [2] and all of its corollaries hold with the new definition of C.O.T. The construction is not difficult and requires no priority argument. The techniques are similar to those developed in [3], but no outside results are needed here. (shrink)

The ArgumentA scientific work presupposes a body of texts that are a condition for its intelligibility. This paper shows that the study of intertextual reference — of the ways a text indicates its relation to other texts — provides a fruitful perspective in the study of science that deserves more attention than it has hitherto received. The paper examines intertextual reference in early nineteenth-century mathematics, first surveying a variety of mathematical texts in the period and then examining in detail W.R. (...) Hamilton's work on quaternions.Three questions are addressed: (1) What forms of intertextual reference are employed? (2) What is the range of intertextual reference? (3) What are the functions of intertextual reference? The answers to the first two questions provide an unexplored perspective on the institutional changes in science during the period. The transitional status of the period in the development of later professional science is reflected in the relative openness in the forms of intertextual reference employed and the range of texts to which reference was made. In virtue of these features the period is particularly fruitful in the study of the functions of intertextual reference. With some major qualifications, the paper defends a Mertonian view that intertextual reference needs to be understood in terms of the claim to intellectual property rights. (shrink)

The symplectic structures (brackets, Hamilton's equations, and Lagrange's equations) for the Dirac electron and its classical model have exactly the same form. We give explicitly the Poisson brackets in the dynamical variables (x μ,p μ,v μ,S μv). The only difference is in the normalization of the Dirac velocities γμγμ=4 which has significant consequences.

Com este trabalho, buscamos verificar o quanto de poder o povo possui na forma de governo defendida no _Federalista_ em relação ao direcionamento do governo para os seus fins. Para isso, buscamos entender o papel dos conceitos de virtude e vontade na referida forma de governo e a relação de tais conceitos com o poder. Utilizamos como pano de fundo as ideias de Locke, Montesquieu e Rousseau sobre representação. Concluímos que o _Federalista_ se contrapõe a Rousseau e segue Montesquieu, trazendo (...) de volta a virtude como elemento principal de condução do governo aos seus fins, separando o povo dos governantes, que formariam agora uma classe profissional, e fazendo a substituição do cidadão para o homem ligado ao comércio e à vida privada. (shrink)

In an incendiary 2010 Nature article, M. A. Nowak, C. E. Tarnita, and E. O. Wilson present a savage critique of the best-known and most widely used framework for the study of social evolution, W. D. Hamilton’s theory of kin selection. More than a hundred biologists have since rallied to the theory’s defence, but Nowak et al. maintain that their arguments ‘stand unrefuted’. Here I consider the most contentious claim Nowak et al. defend: that Hamilton’s rule, the core (...) explanatory principle of kin selection theory, ‘almost never holds’. I first distinguish two versions of Hamilton’s rule in contemporary theory: a special version (HRS) that requires restrictive assumptions, and a general version (HRG) that does not. I then show that Nowak et al. are most charitably construed as arguing that HRS almost never holds, while HRG buys its generality at the expense of explanatory power. While their arguments against HRS are fairly uncontroversial, their arguments against HRG are more contentious, yet these have been largely overlooked in the ensuing furore. I consider the arguments for and against the explanatory value of HRG, with a view to assessing what exactly is at stake in the debate. I suggest that the debate hinges on issues concerning the causal interpretability of regression coefficients, and concerning the explanatory function Hamilton’s rule is intended to serve. (shrink)

While most business ethics texts focus exclusively on individual decision making--what should an individual do--this resource presents the whole business ethics story. Highly realistic, readable, and down-to-earth, it moves from the individual to the managerial to the organizational level, focusing on business ethics in an organizational context to promote an understanding of complex influences on behavior. The new Fifth Edition is the perfect text for students entering the workplace, those seeking to become professionals in training, communications, compliance, in addition to (...) chief ethics officers, corporate counsel, heads of human resources, and senior executives. (shrink)

Maria Rentetzi. Trafficking Materials and Gendered Research Practices: Radium Research in Early 20th Century Vienna.

'Two things', wrote Kant, 'fill the mind with ever new and increasing admiration and awe: the starry heavens above and the moral law within'. Many would argue that since Kant's day, the study of the starry heavens has advanced while ethics has stagnated, and in particular that Kant's ethics offers an empty formalism that tells us nothing about how we should live. In Acting on Principle Onora O'Neill shows that Kantian ethics has practical as well as philosophical importance. First published (...) in 1975, the book is regarded as a classic account and defence of the Kantian ethical position. It addresses Kant's account of reasoning about action, in particular his controversial claim that the Categorical Imperative guides action and is basic to ethics and justice. This second edition offers a substantial new introduction and updated bibliography, and will be valuable for a wide readership in Kant studies and those studying ethics. (shrink)

Esta dissertação encontra-se construída em torno de um núcleo central - a exposição, aná-lise e discussão do chamado 'Argumento da linguagem privada', de Wittengstein. A dinâmica própria da abordagem e discussão do tema leva necessariamente a percorrer o conjunto da obra de Wittengstein, o que motiva um notável aprofundamento do assunto e torna ainda mais aliciante este ensaio.

A series of meetings, in search of industrial equity, started in Worcester, Massachusetts, August, 1867, disclosed a belief that the solution of the labor problem will not be found in trades monopolies, special legislation to reduce the hours or increase the wages of service, co-operation on present methods of ownership, exchange, and finance, or other expedients, by restricting competition, to remove evils which natural forces would expel if allowed a chance; but rather in opportunity and reciprocity, in the unrestricted liberty (...) to create and equitable exchange of values which only asks government to step out of the way. In the progress of thought, service appeared to be the source of wealth, and the true basis of exchange; while interest, rent and profit or dividends seemed inadmissible, except for work done or risk incurred. The use of one's credit was found to be a natural right, antecedently independent of human law, and free money the destined mediator between labor and capital. After this faith was reaffirmed in the Boston Convention of January, 1869, we were agreeably surprised to learn that substantially the same conclusions had been reached, by a different line of argument, twenty years before, in a series of articles published in a Worcester County newspaper over the signature of "Omega." Reprinted in 1850 and 1857, these essays generously placed at our disposal by their author, we now have the pleasure of reissuing for general circulation. The truths stated in them are as fresh and practicable today as they were twenty years ago, and the public is better prepared to receive them. (shrink)

National Book Award Finalist. How did humanity originate and why does a species like ours exist on this planet? Do we have a special place, even a destiny in the universe? Where are we going, and perhaps, the most difficult question of all, "Why?" In The Meaning of Human Existence, his most philosophical work to date, Pulitzer Prize–winning biologist Edward O. Wilson grapples with these and other existential questions, examining what makes human beings supremely different from all other species. Searching (...) for meaning in what Nietzsche once called "the rainbow colors" around the outer edges of knowledge and imagination, Wilson takes his readers on a journey, in the process bridging science and philosophy to create a twenty-first-century treatise on human existence—from our earliest inception to a provocative look at what the future of mankind portends. Continuing his groundbreaking examination of our "Anthropocene Epoch," which he began with The Social Conquest of Earth, described by the New York Times as "a sweeping account of the human rise to domination of the biosphere," here Wilson posits that we, as a species, now know enough about the universe and ourselves that we can begin to approach questions about our place in the cosmos and the meaning of intelligent life in a systematic, indeed, in a testable way. Once criticized for a purely mechanistic view of human life and an overreliance on genetic predetermination, Wilson presents in The Meaning of Human Existence his most expansive and advanced theories on the sovereignty of human life, recognizing that, even though the human and the spider evolved similarly, the poet's sonnet is wholly different from the spider's web. Whether attempting to explicate "The Riddle of the Human Species," "Free Will," or "Religion"; warning of "The Collapse of Biodiversity"; or even creating a plausible "Portrait of E.T.," Wilson does indeed believe that humanity holds a special position in the known universe. The human epoch that began in biological evolution and passed into pre-, then recorded, history is now more than ever before in our hands. Yet alarmed that we are about to abandon natural selection by redesigning biology and human nature as we wish them, Wilson soberly concludes that advances in science and technology bring us our greatest moral dilemma since God stayed the hand of Abraham. (shrink)

The visual arts include painting, sculpture, photography, video, and film. But many people would argue that music is the universal or only art of sound. In the modernist era, Western art music has incorporated unpitched sounds or ‘noise’, and I pursue the question of whether this process allows space for a non-musical soundart. Are there non-musical arts of sound—is there an art phonography, for instance, to parallel art photography? At the same time, I attempt a characterization of music, contrasting acoustic, (...) aesthetic, and acousmatic accounts. My view is that there is some truth in all of these. I defend the claim that music is an art with a small ‘a’—a practice involving skill or craft whose ends are essentially aesthetic, that especially rewards aesthetic attention—whose material is sounds exhibiting tonal organization. But acoustic and acousmatic accounts help to distinguish between music and non-musical soundart, since music must have a preponderance of tones for its material. (shrink)

A complete translation of Aristotle's classic that is both faithful and readable, along with an introduction that provides the modern reader with a means of understanding this seminal work and its impact on our culture. In this volume, Joe Sachs (translator of Aristotle's _Physics, Metaphysics,_ and the _Nicomachean Ethics _)also supplements his excellent translation with well-chosen notes and glossary of important terms. Focus Philosophical Library translations are close to and are non-interpretative of the original text, with the notes and a (...) glossary intending to provide the reader with some sense of the terms and the concepts as they were understood by Aristotle’s immediate audience. (shrink)

This is the first modern, annotated and scholarly edition of Jean-Baptiste Du Bos’ _Critical Reflections on Poetry and Painting_, one of the seminal works of modern aesthetics in any language.