Although the academic interest in ethical mutual fund performance has developed steadily, the evidence to date is mainly sample-specific. To tackle this critique, new research should extend to unexplored countries. Using this as a motivation, we examine the performance and risk sensitivities of Canadian ethical mutual funds vis-à-vis their conventional peers. In order to overcome the methodological deficiencies most prior papers suffered from, we use performance measurement approaches in the spirit of Carhart (1997, Journal of Finance 52(1): 57–82) and Ferson (...) and Schadt (1996, Journal of Finance 51(2): 425–461). In doing so, we investigate the aggregated performance and investment style of ethical and conventional mutual funds and allow for time variation in the funds’ systematic risk. Our␣Canadian evidence supports the conjecture that any␣performance differential between ethical mutual funds and their conventional peers is statistically insignificant. (shrink)

This volume provides a philosophical introduction to and analysis of the study of metaphor. By proceeding from the concrete analysis of complex metaphors, White is able to identify a range of features which are incompatible with standard accounts of the way words function in metaphor.

This book introduces student to the three major figures of modern philosophy known as the rationalists. It is not for complete beginners, but it is an accessible account of their thought. By concerning itself with metaphysics, and in particular substance, the book relates an important historical debate largely neglected by the contemporary debates in the once again popular area of traditional metaphysics. in philosophy. (Do Not USE).

Berkeley's idealism started a revolution in philosophy. As one of the great empiricist thinkers he not only influenced British philosophers from Hume to Russell and the logical positivists in the twentieth century, he also set the scene for the continental idealism of Hegel and even the philosophy of Marx. -/- There has never been such a radical critique of common sense and perception as that given in Berkeley's Principles of Human Knowledge (1710). His views were met with disfavour, and his (...) response to his critics was the Three Dialogues between Hylas and Philonous. -/- This edition of Berkeley's two key works has an introduction which examines and in part defends his arguments for idealism, as well as offering a detailed analytical contents list, extensive philosophical notes and an index. (shrink)

Introduction: Conversion and the practice of transformation -- The philosophical structure of Jonathan Edwards's religious affections -- Habit, habit change, and conversion in C.S. Peirce -- Reconstructing faith : religious overcoming in Dewey's pragmatism -- Transforming obligation in William James -- Dwelling in absence: the reflective origin of conversion -- Creative transformation : the work of conversion -- The evasion of conversion in recent American philosophy.

Introduction -- The mathematical roots of the concept of analogy -- Aristotle : the uses of analogy -- Aristotle : analogy and language -- Thomas Aquinas -- Immanuel Kant -- Karl Barth -- Final reflections.

Ageing is associated with a decline in autophagy and elevated reactive oxygen species (ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can cause further cellular damage, including DNA breaks and protein misfolding. This poses a challenge for longevous organisms, including humans. In this review, we hypothesise that in the course of human evolution selective autophagy receptors (SARs) acquired the ability to sense and respond to localised oxidative stress. We posit that in the vicinity of protein aggregates (...) and dysfunctional mitochondria oxidation of key cysteine residues in SARs induces their oligomerisation which initiates autophagy. The degradation of damaged cellular components thus could reduce ROS production and restore redox homeostasis. This evolutionarily acquired function of SARs may represent one of the biological adaptations that contributed to longer lifespan. Inversely, loss of this mechanism can lead to age‐related diseases associated with impaired autophagy and oxidative stress. (shrink)

Synaesthesia is considered a rare perceptual capacity, and one that is not capable of cultivation. However, meditators report the experience quite commonly, and in questionnaire surveys, respondents claimed to experience synaesthesia in 35% of meditation retreatants, in 63% of a group of regular meditators, and in 86% of advanced teachers. These rates were significantly higher than in nonmeditator controls, and displayed significant correlations with measures of amount of meditation experience. A review of ancient texts found reports suggestive of synaesthesia in (...) advanced meditators from India and China. These findings suggest that synaesthesia may be cultivated by meditation, and that laboratory studies of meditators could be rewarding. (shrink)

This book explores the concept of Knowing God and the Knowability of God from an interdisciplinary theological perspective. Approaching the issue from the perspectives of their respective theological disciplines, contributors reflect on what it means to know God, how people of faith have sought to know God in the past, and indeed whether, and to what extent, such knowledge is even possible.

Building on a long tradition of measuring cultural logics from a relational perspective, we analyze a recent survey of American university students to assess whether institutional logics operate in the lived experience of individuals. An institutional logic is an analytic troika of object, practice, and subject linked together through dually ordered systems of articulations. Using the formal method of correspondence analysis (MCA) we identify two latent dimensions that order physical, verbal, emotional, categorical, and moral practices of and investments in love. (...) We take these dimensions as evidence of an institutional logic. The dominant first dimension is organized through talk of love, non-genital physical intimacies, and affective investment. It has no sexual specificity. The subsidiary second dimension is organized through moral investment and it has a genital sexual specificity. There is little difference between women and men, either in the way these dimensions are organized or in the location of men and women within these dimensionalized spaces. We find that romantic love has a situated material effect in terms of increasing the probabilities of orgasm. (shrink)

The earliest Analects yet discovered, this work provides us with a new perspective on the central canonical text that has defined Chinese culture--and clearly illuminates the spirit and values of Confucius.

Ethicists differ considerably in their reasons for using empirical data. This paper presents a brief overview of four traditional approaches to the use of empirical data: “the prescriptive applied ethicists,” “the theorists,” “the critical applied ethicists,” and “the particularists.” The main aim of this paper is to introduce a fifth approach of more recent date (i.e. “integrated empirical ethics”) and to offer some methodological directives for research in integrated empirical ethics. All five approaches are presented in a table for heuristic (...) purposes. The table consists of eight columns: “view on distinction descriptive-prescriptive sciences,” “location of moral authority,” “central goal(s),” “types of normativity,” “use of empirical data,” “method,” “interaction empirical data and moral theory,” and “cooperation with descriptive sciences.” Ethicists can use the table in order to identify their own approach. Reflection on these issues prior to starting research in empirical ethics should lead to harmonization of the different scientific disciplines and effective planning of the final research design. Integrated empirical ethics (IEE) refers to studies in which ethicists and descriptive scientists cooperate together continuously and intensively. Both disciplines try to integrate moral theory and empirical data in order to reach a normative conclusion with respect to a specific social practice. IEE is not wholly prescriptive or wholly descriptive since IEE assumes an interdepence between facts and values and between the empirical and the normative. The paper ends with three suggestions for consideration on some of the future challenges of integrated empirical ethics. (shrink)

This paper sketches an account of public health ethics drawing upon established scholarship in feminist ethics. Health inequities are one of the central problems in public health ethics; a feminist approach leads us to examine not only the connections between gender, disadvantage, and health, but also the distribution of power in the processes of public health, from policy making through to programme delivery. The complexity of public health demands investigation using multiple perspectives and an attention to detail that is capable (...) of identifying the health issues that are important to women, and investigating ways to address these issues. Finally, a feminist account of public health ethics embraces rather than avoids the inescapable political dimensions of public health. (shrink)

Methylation of DNA plays an important role in the control of gene expression in higher eukaryotes. This is largely achieved by the packaging of methylated DNA into chromatin structures that are inaccessible to transcription factors and other proteins. Methylation involves the addition of a methyl group to the 5‐position of the cytosine base in DNA, a reaction catalysed by a DNA (cytosine‐5) methyltransferase. This reaction occurs in nuclear replication foci where the chromatin structure is loosened for replication, thereby allowing access (...) to methyltransferases. Partly as a result of their recognising the presence of a methylcytosine on the parental strand following replication, these large enzymes are able to maintain the distribution of methyl groups along the DNA of somatic cells and, thereby, maintain tissue‐specific patterns of gene expression. (shrink)

The growth activity of an organ (variable y) is defined simultaneously by the instantaneous absolute ratedy/dt and its variationd 2y/dt2. The use of these two descriptors allows a sigmoidal (i.e. continuous and non periodical, as observed for the logistic function) growth curve to be discretized into a series of 5 growth states or phases which are delimited by the following singular values: max, Vmax (=0), max, adult stage. The (V, ) plot, termedgrowth trajectory, visualizes, e.g. in the case of Richards-Nelder's (...) generalized logistics, the unequal duration of these phases and allows the dissymmetry property of the growth function to be characterized precisely.At a more integrated organization level, such anorganic series (e. g. the set of the leaves borne by a same branch), the above concepts allow two kinds of analyses to be carried out: (i) in thekinetic approach, the growth trajectory of the series can characterizes, under certain conditions, the emergence of a new property: theoccurrence of growth activity rhythms which are independent of meristem dormancy processes; (ii) thedemographic approach shows thegrowth structure of the phytomer population (a particular form of age structure) and the associated dimensional structure (plant partition into zones or regions in relation to the growth state of the various phytomers). (shrink)

This communication presents a discussion of some extensions of the formalism of Verhulst's simple logistics, which may constitute an autonomous growth model of a more general scope.For that purpose, the basis concept of growth diagram or trajectory is called upon, as it affords the graphic representation of the change in the growth variable y, using two relevant kinetic parameters: the instantaneous rate and the instantaneous acceleration. The two possible kinds of trajectories are in relation to the use of absolute (V (...) = dyldt; = dV/dt) or relative (or specific) values (R = (1/y)(dy/dt); R = dR/dt). (shrink)

This paper challenges the traditional assumption that descriptive and prescriptive sciences are essentially distinct by presenting a study on the implicit normativity of the production and presentation of biomedical scientific facts within evidence-based medicine. This interdisciplinary study serves as an illustration of the potential worth of the concept of implicit normativity for bioethics in general and for integrated empirical ethics research in particular. It demonstrates how both the production and presentation of scientific information in an evidence-based decision-support contain implicit presuppositions (...) and values, which pre-structure the moral environment of the clinical process of decision-making. As a consequence, the evidence-based decision support did not only support the clinical decision-making process; it also transformed it in a morally significant way. This phenomenon undermines the assumption within much of the literature on patient autonomy that information disclosure is a conditional requirement before patient autonomy even starts; patient autonomy is already influenced during the production and presentation of information. These results imply an increased responsibility of those who produce and present evidence-based facts(i.e. scientists in general and physicians in particular). The insights of this study not only involve a different focus on both theory and practice of patient autonomy and informed consent, but they also call for a broader scope of morality than does traditional empirical research in bioethics. The concept of implicit normativity within integrated empirical ethics research calls for a strong cooperation between bioethicists and descriptive scientists, i.e., a cooperation that goes beyond the discipline-specific epistemic values and that takes place during all phases of the research process. (shrink)

In this paper I argue that it is morally important for doctors to trust patients. Doctors' trust of patients lays the foundation for medical relationships which support the exercise of patient autonomy, and which lead to an enriched understanding of patients' interests. Despite the moral and practical desirability of trust, distrust may occur for reasons relating to the nature of medicine, and the social and cultural context within which medical care is provided. Whilst it may not be possible to trust (...) at will, the conscious adoption of a trusting stance is both possible and warranted as the burdens of misplaced trust fall more heavily upon patients than doctors. (shrink)

I treat you as a thermometer when I use your belief states as more or less reliable indicators of the facts. Should I treat myself in a parallel way? Should I think of the outputs of my faculties and yours as like the readings of two thermometers the way a third party would? I explore some of the difficulties in answering these questions. If I am to treat myself as well as others as thermometers in this way, it would appear (...) that I cannot reasonably trust my own convictions over yours unless I have antecedent reason to suppose that I am more likely than you to get things right. I appeal to some probabilistic considerations to suggest that our predicament as thermometers might not actually be as bad as it seems. (shrink)

Published in 1897, this was the first complete edition of Roger Bacon's influential thirteenth-century encyclopedia of science.

This paper defends moral testimony pessimism, the view that there is something morally or epistemically regrettable about relying on the moral testimony of others, against several arguments in Lillehammer. One central such argument is that reliance on testimony is inconsistent with the exercise of true practical wisdom. Lillehammer doubts whether such reliance is always objectionable, but it is important to note that moral testimony pessimism is best understood as a view about the pro tanto, rather than the overall, badness of (...) relying on testimony. One must also be clear about what counts as genuine moral testimony: there will be morally charged occasions when a virtuous person will properly rely on the views of others. It can also plausibly be argued that relying on moral testimony may constitute a lack of full autonomy. After discussing some remaining issues concerning the definition of moral testimony, a possible analogy between lying and relying on testimony, and the implications of untrustworthiness for the truth of moral testimony pessimism, the paper ends with a return to the case against relying on moral testimony, grounded on a conception of the role of knowledge and understanding in virtue. (shrink)

In this paper, we examine recent critiques of the debate about defining disease, which claim that its use of conceptual analysis embeds the problematic assumption that the concept is classically structured. These critiques suggest, instead, developing plural stipulative definitions. Although we substantially agree with these critiques, we resist their implication that no general definition of “disease” is possible. We offer an alternative, inductive argument that disease cannot be classically defined and that the best explanation for this is that the concept (...) is structured as a cluster. We further argue that we do not need to reject the possibility of defining the general concept “disease” to legitimate developing stipulative definitions of disease that are relative to particular purposes. A cluster definition of disease is compatible with contextually motivated definitions, which may be considered précisifications of the more general cluster concept. (shrink)

This paper strives to characterize the relation between accent placement and discourse in terms of independent constraints operating at the interface between syntax and interpretation. The Givenness Constraint requires un-F-marked constituents to be given. Key here is our definition of givenness, which synthesizes insights from the literature on the semantics of focus with older views on information structure. AvoidF requires speakers to economize on F-marking. A third constraint requires a subset of F-markers to dominate accents.The characteristic prominence patterns of "novelty (...) focus" and "contrastive focus" both arise from a combination of the Givenness Constraint and AvoidF. Patterns of prominence in questions as well as in answers to questions are explained in terms of the constraints, thanks in part to the way in which the Givenness relation is defined. Head/argument asymmetries noted in the literature on Focus Projection are placed in the phonology-syntax interface, independent of discourse conditions. Deaccenting follows when AvoidF is ranked higher than constraint(s) governing head/argument asymmetries. (shrink)

In the view of the Franco-Jewish philosopher Emmanuel Levinas money has a multitude of anthropological and ethical meanings, not excluding contradictions. For money functions on different levels, namely on that of the I and the effort of its being, that of the relation with the other and that of the ‘third’, that is to say on the socio-economical and judicial level.It will have become clear that Levinas’ philosophical approach to money not only offers a phenomenological description, but also expressly formulates (...) an ethical and thus normative dimension. It not only tries to understand what ‘is’ , but also opens up perspectives on what ‘should be’ . It is thus not a neutral, disengaged analysis, but literally a ‘pro vocative’ or ‘calling-forth’ approach that thereby calls the factual praxis of money critically into question regarding its ethical quality, or its humanity.This ethical approach lays bare not only the different sense but also the ambivalences and contradictions of money. In this respect, money is never a self-evident ‘good’ about which a naive sort of metaphysics or entrenched ‘doctrine of being’ could be developed, but a literally ‘ambivalent’ middle term that not only can enter the service of evil but, precisely through its so-called neutral objectivity, can bring to this same evil the seductive and misleading charm of the good. (shrink)

Roger Ariew presents a new account of Descartes as a philosopher who sought to engage his contemporaries and society. He argues that the Principles of Philosophy was written to rival Scholastic textbooks, and considers Descartes' enterprise in contrast to the tradition it was designed to replace and in relation to the works of the first Cartesians.