Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. Three patients suffering from extremely resistant forms of depression, who did not respond to pharmacotherapy, psychotherapy, (...) and electroconvulsive therapy, were implanted with bilateral DBS electrodes in the nucleus accumbens. Stimulation parameters were modified in a double-blind manner, and clinical ratings were assessed at each modification. Additionally, brain metabolism was assessed 1 week before and 1 week after stimulation onset. Clinical ratings improved in all three patients when the stimulator was on, and worsened in all three patients when the stimulator was turned off. Effects were observable immediately, and no side effects occurred in any of the patients. Using FDG-PET, significant changes in brain metabolism as a function of the stimulation in fronto-striatal networks were observed. No unwanted effects of DBS other than those directly related to the surgical procedure (eg pain at sites of implantation) were observed. Dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. (shrink)

This collection includes twenty original philosophical essays in honour of Wolfgang Spohn. The contributions mirror the scope of Wolfgang Spohn’s work. They address topics from epistemology (e.g., the theory of ranking functions, belief revision, and the nature of knowledge and belief), philosophy of science (e.g., causation, induction, and laws of nature), the philosophy of language (e.g., the theory of meaning and the semantics of counterfactuals), and the philosophy of mind (e.g., intentionality and free will), as well as problems of ontology, (...) logic, the theory of practical rationality, and meta-philosophy. ― Contributors: Ansgar Beckermann, Wolfgang Benkewitz, Bernd Buldt, Ralf Busse, Christoph Fehige, Wolfgang Freitag, Gordian Haas, Volker Halbach, Franz Huber, Andreas Kemmerling, Manfred Kupffer, Hannes Leitgeb, Godehard Link, Arthur Merin, Thomas Müller, Julian Nida-Rümelin, Martine Nida-Rümelin, Hans Rott, Holger Sturm, Thomas Ede Zimmermann, Alexandra Zinke. (shrink)

Ob Mikroskop, Refraktometer, Vakuumpumpe oder Ultraschallbad - viele der Gerätschaften, die im chemischen und analytischen Labor Verwendung finden, lassen sich mit der Kenntnis ihrer physikalischen Grundlagen leichter und sicherer einsetzen. Dieses einführende Lehrbuch ist speziell für den Physikunterricht im Rahmen einer Ausbildung zum Chemisch-technischen Assistenten konzipiert und widmet sich vorrangig solchen Themen, die für die Laborpraxis von Bedeutung sind. Dazu gehören insbesondere die Optik, die Wärme- und Elektrizitätslehre sowie die Radioaktivität. Alle wichtigen Formeln und physikalischen Beziehungen werden durch Rechenbeispiele mit (...) Lösungen veranschaulicht. Mit seinem durchgehenden Praxisbezug leistet dieses Buch auch nach abgeschlossener Ausbildung noch gute Dienste. "Das Buch kann Chemisch-technischen Assistenten und Schülern an naturwissenschaftlich-technischen Berufsfachschulen nur empfohlen werden." (GIT Labor-Fachzeitschrift). (shrink)

Die 'Kritik der Urteilskraft' zerfällt nur scheinbar in zwei oder mehr relativ unverbundene Teile. Zu Unrecht wird häufig die Verknüpfung der 'Ästhetik' mit der Teleologie bemängelt oder bedauert. Der Zusammenhalt des ganzen Kritischen Systems und die Notwendigkeit seiner Bestimmungen erschließt sich einem Denken, welches die zentrale Stellung der praktischen Philosophie bei der gedanklichen Fassung der Idee der Freiheit durch Kant klar sieht. Ausgehend von der Herleitung der prinzipiellen Funktion der Kritik der Urteilskraft als derjenigen der Kultur und Zucht (disciplina) des (...) Vernunftglaubens verschafft die Untersuchung Einsicht in die prinzipielle Geschlossenheit und Einheit der dritten kantischen Kritik und Zugang zur Kantischen Glaubenslehre, wie sie dem Gedanken der Aufklärung zugehört. (shrink)

1. Bd. Die Entwicklung der deutschen Wissenssoziologie -- 2. Bd. Rezeption und Kritik der Wissenssoziologie.

The Logic Manual is a clear and concise introduction to logic for beginning philosophy students.

Die Suche nach Erkenntnis vollzieht sich stets unter bestimmten sozialen Bedingungen. Was folgt daraus für die Ideen der Rationalität und der Wahrheit? Ist Erkenntnis nur mehr als gültig zu betrachten im jeweils vorliegenden sprachlichen und kulturellen Kontext? Ist es noch vertretbar, als das Ziel der Forschung die Darstellung einer objektiven Realität anzusehen? Mit diesen und verwandten Fragen setzen sich die Autoren dieses Bandes auseinander. Im einzelnen werden behandelt: Pragmatische Aspekte der Erkenntnissuche, externale Einflüsse auf die Wissenschaft, die Beziehung zwischen Bewährung (...) und Wahrheit, die Revidierbarkeit der Logik, die Sprachabhängigkeit der Erkenntnis, Realismus und Intentionalität, der Kontextualismus und seine Probleme. (shrink)

Bewusstsein, Außenwelt und Sprache bilden eine untrennbare Einheit in der Frage nach dem Sinn und der Bedeutung sprachlicher Ausdrücke. Zeichen und ihre Verwendung lassen sich daher weder durch rein internalistische Bewusstseinsanalysen noch durch rein externalistische Gegenstandsbezüge angemessen rekonstruieren. Daher befinden sich Bedeutungen weder „innerhalb" noch „außerhalb" des Kopfes. Unterschiedliche Gebrauchsweisen und somit Bedeutungen spiegeln sich vielmehr in der Fähigkeit wieder, sprachliche Zeichen zu verstehen und auf unsere subjektiven Erlebnisse sowie die uns umgebende Welt anzuwenden. Volker Munz zeigt, inwieweit sowohl (...) rein phänomenale als auch rein physikalistische Interpretationsansätze zu kurz greifen, die Bedeutung sprachlicher Ausdrücke zu bestimmen. Beide Positionen stehen nicht in Widerstreit zueinander, sondern ergänzen einander vielmehr in der Bestimmung des Sinnes und der Bedeutung sprachlicher Zeichen. Sowohl externalistische Semantiken (Putnams Zwillingserde, Kripkes Marsianer, Davidsons Sumpfmann etc.) als auch internalistische Positionen (Locke, Thomas Nagel, Jackson etc.) werden anhand spezifischer Gedankenexperiment kritisch auf ihre Rolle und Schlüssigkeit hin überprüft und mit alternativen Gedankenszenarios konfrontiert. Neben den genannten Autoren werden auch Russell, Frege und insbesondere Wittgenstein ausführlich diskutiert. (shrink)

Der vorliegende Band liefert eine umfassende Analyse zum Verhältnis von Sprache und Realität in der Philosophie Ludwig Wittgensteins. Die Untersuchungen konzentrieren sich dabei auf die im _Tractatus Logico-philosophicus_ entwickelte Idee einer strukturellen Identität zwischen Satz, Gedanke und Sachverhalt, auf die Forderung nach einer phänomenologischen Sprache als Ausdruck unserer unmittelbaren Erfahrungen sowie auf die zentralen Begriffe der grammatischen Regel und ihrer sinnvollen Anwendung. Das Buch versteht sich vor allem als ein Beitrag zur Frage der Beziehung zwischen einem Satz und seinem Sinn, (...) wobei es versucht, besonders die Probleme und Motive zu rekonstruieren, welche im Zusammenhang zu Wittgensteins gewandeltem Sprachverständnis stehen. In diesem Band werden erstmalig auch Auszüge bisher unveröffentlichter Mitschriften von Wittgenstein-Vorlesungen publiziert. Die Aufzeichnungen stammen von Yorick Smythies, einem engen Freund und Schüler Wittgensteins und sind größtenteils aus den Jahren 1937 bis 1939. Darüber hinaus enthält der Text ebenfalls unveröffentlichtes Material aus dem philosophischen Nachlass von Rush Rhees. (shrink)

Im Rahmen einer viel beachteten interdisziplinären Ringvorlesung nehmen sich Philosophen, Ökonomen, Politologen, Theologen und Germanisten der Humboldt-Universität zu Berlin der Provokation von Marx' 11. Feuerbach-These an.

English summary: From an international and interdisciplinary viewpoint, Thomas Aquinas was the most important scholastic philosopher and theologian. His life, work and legacy are set out in this four section handbook which provides orientation in what is currently known about the man, his affinities and character, his work and its impact. The volume offers a summary of research up until now, as well as a basis for further investigation. Comprehensive indexes and literature sources mean it can be used as a (...) work of reference whose articles can be separately or integrally understood. Writing from their different perspectives, philosophy and history scholars along with Protestant and Catholic theologians all help paint this portrait from their different perspectives. German description: Das Thomas Handbuch bietet eine Darstellung von Leben, Werk und Wirkung von Thomas von Aquin, dem wohl bedeutendsten Vertreter der scholastischen Philosophie und Theologie in interdisziplinarer und internationaler Perspektive. In vier Sektionen enthalt es Ausfuhrungen zur Orientierung in der gegenwartigen Forschungslage, zur Person des Thomas und ihren Verbindungen und Pragungen, zu seinem Werk und zu seiner Wirkung. Es bietet eine Zusammenfassung der bisherigen Forschungen zu Thomas von Aquin und eine Grundlage fur weitere Arbeiten. Erschlossen durch umfassende Register und Literaturangaben, kann es als Nachschlagewerk genutzt werden, dessen einzelne Artikel je fur sich verstehbar sind, aber auch als umfassende Gesamtdarstellung. Die interdisziplinaren Beitrage eroffnen eine Gesamtschau, in welcher verschiedene Perspektiven ihren Ort finden und ihren je eigenen Beitrag zum Gesamten bieten. Mit Beitragen von: Henryk Anzulewicz, Carmela Baffioni, Michael Basse, David Berger, Inos Biffi, Volker Henning Drecoll, Mechthild Dreyer, Stephan Ernst, Sabine Folger-Fonfara, Elias Fullenbach, Ruedi Imbach, Ingo Klitzsch, Ulrich Kopf, Pieter de Leemans, Volker Leppin, Jurgen Miethke, Thomas Prugl, Francois-Xavier Putallaz, Reinhold Rieger, Philipp W. Rosemann, Marianne Schlosser, Gury Schneider-Ludorff, Rolf Schonberger, Christoph Schwobel, Notger Slenczka, Wolfgang Sturner, Hubert Philip Weber. (shrink)

International organizations such as the UN, EU and IMF play an increasingly important role in international politics. Fully revised and updated, this broad-ranging text provides a systematic theoretical and empirical introduction to the structure, policies and performance of international organizations.

The realm of non-rational influence, which includes nudging, is home to many other morally interesting phenomena. In this paper, I introduce the term bumping, to discuss the category of unintentional non-rational influence. Bumping happens constantly, wherever people make choices in environments where they are affected by other people. For instance, doctors will often bump their patients as patients make choices about what treatments to pursue. In some cases, these bumps will systematically tend to make patients’ decisions worse. Put another way: (...) doctors will sometimes harm their patients by bumping them in systematic ways. I use the case of medical overuse, the provision of medical services where the likely harm outweighs the likely benefit to the patient, as a touchstone for arguing that doctors who systematically bump their patients towards harm can be blameworthy for their unwitting influence. (shrink)

Wittgenstein’s Whewell’s Court Lectures contains previously unpublished notes from lectures given by Ludwig Wittgenstein between 1938 and 1941. The volume offers new insight into the development of Wittgenstein’s thought and includes some of the finest examples of Wittgenstein’s lectures in regard to both content and reliability.

At the centre of the traditional discussion of truth is the question of how truth is defined. Recent research, especially with the development of deflationist accounts of truth, has tended to take truth as an undefined primitive notion governed by axioms, while the liar paradox and cognate paradoxes pose problems for certain seemingly natural axioms for truth. In this book, Volker Halbach examines the most important axiomatizations of truth, explores their properties and shows how the logical results impinge on (...) the philosophical topics related to truth. In particular, he shows that the discussion on topics such as deflationism about truth depends on the solution of the paradoxes. His book is an invaluable survey of the logical background to the philosophical discussion of truth, and will be indispensable reading for any graduate or professional philosopher in theories of truth. (shrink)

The attempts to mitigate the unprecedented health, economic, and social disruptions caused by the COVID-19 pandemic are largely dependent on establishing compliance to behavioral guidelines and rules that reduce the risk of infection. Here, by conducting an online survey that tested participants’ knowledge about the disease and measured demographic, attitudinal, and cognitive variables, we identify predictors of self-reported social distancing and hygiene behavior. To investigate the cognitive processes underlying health-prevention behavior in the pandemic, we co-opted the dual-process model of thinking (...) to measure participants’ propensities for automatic and intuitive thinking vs. controlled and reflective thinking. Self-reports of 17 precautionary behaviors, including regular hand washing, social distancing, and wearing a face mask, served as a dependent measure. The results of hierarchical regressions showed that age, risk-taking propensity, and concern about the pandemic predicted adoption of precautionary behavior. Variance in cognitive processes also predicted precautionary behavior: participants with higher scores for controlled thinking (measured with the Cognitive Reflection Test) reported less adherence to specific guidelines, as did respondents with a poor understanding of the infection and transmission mechanism of the COVID-19 virus. The predictive power of this model was comparable to an approach (Theory of Planned Behavior) based on attitudes to health behavior. Given these results, we propose the inclusion of measures of cognitive reflection and mental model variables in predictive models of compliance, and future studies of precautionary behavior to establish how cognitive variables are linked with people’s information processing and social norms. (shrink)

Louis de Sacy send his Traité de l’Amitié (1703) to Fénelon in order to get a judgement. To his surprise, the result is a debate on his explanation of the ciceronian idea “a friend is another self”, transformed by Erasmus and Montaigne into a rhetorical commonplace. By neglecting this rhetorical side, the editors of Fenelon’s letter have misunderstood the literary and doctrinaire issue of the debate between the lawyer and the archbishop. Emulating Cicero, Louis de Sacy refers to conversations in (...) the salon of Marquise de Lambert whose opuscule on friendship is obviously influenced by Montaigne. Fénelon counters de Sacy by relating friendship to “amour-propre”, this topic ensuring the concern of pagans for his vision of “pur amour”. (shrink)

What was classification as it first took modern form in the eighteenth century, how did it work, and how did it relate to earlier describing and ordering? We offer new answers to these questions by considering an example less well known than that of botany or zoology, namely medicine, and by reconstructing practice on paper. The first and best-known disease classification is the “nosology” of the Montpellier physician François Boissier de Sauvages de Lacroix. Its several editions, we show, were less (...) products than process: published tools for building a classification system. The disorder of a hitherto unstudied notebook that Boissier de Sauvages kept throughout this process provided a way of breaking with the topical order of earlier physicians’ humanistic commonplace books of disease observation while sustaining the paper practices those earlier physicians—and Sauvages himself as a student—had used to order disease. This suggests a different picture of historical change than that of a scholarly world of ordered words giving way to a scientific one of ordered things. Classification, in the case of Sauvages’ nosology, arose through an incomplete break with, and intensified practice of, a past way of ordering the described world. The humanist paper practice that had made observationes, differently applied, now made species. Classification into genera and species by similarity and difference, which Sauvages’ nosology shared with botany, was an algorithm of paper and ink practice—in its operation more machine-like than humanist textual practice yet in its effects more creative and re-creative of categories and questions of relationship. Thus a new empiricism of generalizations arose out of the older, Renaissance empiricism of particulars. (shrink)

Definitional and axiomatic theories of truth -- Objects of truth -- Tarski -- Truth and set theory -- Technical preliminaries -- Comparing axiomatic theories of truth -- Disquotation -- Classical compositional truth -- Hierarchies -- Typed and type-free theories of truth -- Reasons against typing -- Axioms and rules -- Axioms for type-free truth -- Classical symmetric truth -- Kripke-Feferman -- Axiomatizing Kripke's theory in partial logic -- Grounded truth -- Alternative evaluation schemata -- Disquotation -- Classical logic -- Deflationism (...) -- Reflection -- Ontological reduction -- Applying theories of truth. (shrink)

We investigate axiomatizations of Kripke's theory of truth based on the Strong Kleene evaluation scheme for treating sentences lacking a truth value. Feferman's axiomatization KF formulated in classical logic is an indirect approach, because it is not sound with respect to Kripke's semantics in the straightforward sense: only the sentences that can be proved to be true in KF are valid in Kripke's partial models. Reinhardt proposed to focus just on the sentences that can be proved to be true in (...) KF and conjectured that the detour through classical logic in KF is dispensable. We refute Reinhardt's Conjecture, and provide a direct axiomatization PKF of Kripke's theory in partial logic. We argue that any natural axiomatization of Kripke's theory in Strong Kleene logic has the same proof-theoretic strength as PKF, namely the strength of the system RA< ωω ramified analysis or a system of Tarskian ramified truth up to ωω. Thus any such axiomatization is much weaker than Feferman's axiomatization KF in classical logic, which is equivalent to the system RA<ε₀ of ramified analysis up to ε₀. (shrink)

In [STU 00, KUT 03] we introduced a family of ‘modal' languages intended for talking about distances. These languages are interpreted in ‘distance spaces' which satisfy some of the standard axioms of metric spaces. Among other things, we singled out decidable logics of distance spaces and proved expressive completeness results relating classical and modal languages. The aim of this paper is to axiomatize the modal fragments of the semantically defined distance logics of [KUT 03] and give a new proof of (...) their decidability. (shrink)

We provide an overview of three ways in which the expression “Historical epistemology” (HE) is often understood: (1) HE as a study of the history of higher-order epistemic concepts such as objectivity, observation, experimentation, or probability; (2) HE as a study of the historical trajectories of the objects of research, such as the electron, DNA, or phlogiston; (3) HE as the long-term study of scientific developments. After laying out various ways in which these agendas touch on current debates within both (...) epistemology and philosophy of science (e.g., skepticism, realism, rationality of scientific change), we conclude by highlighting three topics as especially worthy of further philosophical investigation. The first concerns the methods, aims and systematic ambitions of the history of epistemology. The second concerns the ways in versions of HE can be connected to versions of naturalized and social epistemologies. The third concerns the philosophy of history, and in particular the level of analysis at which a historical analysis should aim. (shrink)