Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

Is a human more conscious than an octopus? In the science of consciousness, it’s oftentimes assumed that some creatures (or mental states) are more conscious than others. But in recent years, a number of philosophers have argued that the notion of degrees of consciousness is conceptually confused. This paper (1) argues that the most prominent objections to degrees of consciousness are unsustainable, (2) examines the semantics of ‘more conscious than’ expressions, (3) develops an analysis of what it is for a (...) degreed property to count as degrees of consciousness, and (4) applies the analysis to various theories of consciousness. I argue that whether consciousness comes in degrees ultimately depends on which theory of consciousness turns out to be correct. But I also argue that most theories of consciousness entail that consciousness comes in degrees. (shrink)

This paper examines the idea of "objective phenomenology," or a way of understanding the phenomenal character of conscious experiences that doesn’t require one to have had the kinds of experiences under consideration. My central thesis is that structural facts about experience—facts that characterize purely how conscious experiences are structured—are objective phenomenal facts. I begin by precisifying the idea of objective phenomenology and diagnosing what makes any given phenomenal fact subjective. Then I defend the view that structural facts about experience are (...) objective. I also argue that structural facts about experience, despite being objective, nevertheless still give rise to an explanatory gap. (shrink)

How should politicians act? When should they try to lead public opinion and when should they follow it? Should politicians see themselves as experts, whose opinions have greater authority than other people's, or as participants in a common dialogue with ordinary citizens? When do virtues like toleration and willingness to compromise deteriorate into moral weakness? In this innovative work, Andrew Sabl answers these questions by exploring what a democratic polity needs from its leaders. He concludes that there are systematic, (...) principled reasons for the holders of divergent political offices or roles to act differently. Sabl argues that the morally committed civil rights activist, the elected representative pursuing legislative results, and the grassroots organizer determined to empower ordinary citizens all have crucial democratic functions. But they are different functions, calling for different practices and different qualities of political character. To make this case, he draws on political theory, moral philosophy, leadership studies, and biographical examples ranging from Everett Dirksen to Ella Baker, Frances Willard to Stokely Carmichael, Martin Luther King Jr. to Joe McCarthy. Ruling Passions asks democratic theorists to pay more attention to the "governing pluralism" that characterizes a diverse, complex democracy. It challenges moral philosophy to adapt its prescriptions to the real requirements of democratic life, to pay more attention to the virtues of political compromise and the varieties of human character. And it calls on all democratic citizens to appreciate "democratic constancy": the limited yet serious standard of ethical character to which imperfect democratic citizens may rightly hold their leaders--and themselves. (shrink)

A Physicalist Manifesto is a full treatment of the comprehensive physicalist view that, in some important sense, everything is physical. Andrew Melnyk argues that the view is best formulated by appeal to a carefully worked-out notion of realization, rather than supervenience; that, so formulated, physicalism must be importantly reductionist; that it need not repudiate causal and explanatory claims framed in non-physical language; and that it has the a posteriori epistemic status of a broad-scope scientific hypothesis. Two concluding chapters argue (...) in detail that contemporary science provides no significant empirical evidence against physicalism and some considerable evidence for it. Written in a brisk, candid and exceptionally clear style, this 2003 book should appeal to professionals and students in philosophy of mind, metaphysics and philosophy of science. (shrink)

A satisfactory theory of linguistic communication must explain how it is that, through the interpersonal exchange of auditory, visual, and tactile stimuli, the communicative preconditions for the acquisition of testimonial knowledge regularly come to be satisfied. Without an account of knowledge-yielding communication this success condition for linguistic theorizing is left opaque, and we are left with an incomplete understanding of testimony, and communication more generally, as a source of knowledge. This paper argues that knowledge-yielding communication should be modelled on knowledge (...) itself. It is argued that knowledge-yielding communication occurs iff interlocutors coordinate on truth values in a non-lucky and non-deviant way. This account is able to do significant explanatory work: it sheds light on the nature of referential communication, and it allows us to capture, in an informative way, the sense in which interlocutors must entertain similar propositions in order to communicate successfully. (shrink)

Empirical evidence suggests that a majority of people believe that time robustly passes, and that many also report that it seems to them, in experience, as though time robustly passes. Non-dynamists deny that time robustly passes, and many contemporary non-dynamists—deflationists—even deny that it seems to us as though time robustly passes. Non-dynamists, then, face the dual challenge of explaining why people have such beliefs and make such reports about their experiences. Several philosophers have suggested the stable-self explanation, according to which (...) what partly explains one or both of the explananda is that people believe themselves to have a stable persisting self which is imagined either as moving through time, or as being stationary, with time moving around it. This paper empirically investigates this explanation. We found, however, no evidential support for the stable-self explanation, leaving the non-dynamist but also, we will argue, the dynamist, with an extant explanatory challenge. (shrink)

What is the true calling of the intellectual? In this provocative new book, Andrew Shanks presents a distinctive fresh answer. The Other Calling is a systematic riposte both to the elitism of philosophy in the heritage of Plato, and to the typical individualism of Plato's philosophic opponents. Here, instead, intellectual integrity is identified with a form of priesthood. Asserts that intellectuals are critical to bringing together the common aspirations of a community Offers a strikingly original approach to the moral (...) and political aspects of theology’s relationship with philosophy, exploring the perspectives of both disciplines Draws on the work and thought of Christians, Muslims, Hindus, Buddhists, Agnostics, and Atheists Argues for a new, religiously multicultural “priesthood of all thinkers”, considering how once, all intellectuals were as a matter of course also priests Published in the new and prestigious Illuminations series. (shrink)

In this paper I argue that the enkratic principle in its classic formulation may not be a requirement of rationality. The investigation of whether it is leads to some important methodological insights into the study of rationality. I also consider the possibility that we should consider rational requirements as a subset of a broader category of agential requirements.

Paracelsus was a transmutational alchemist: For most of his career, he believed that one metal could be turned into another. In an alchemical text, the De renovatione et restauratione, he explored the theoretical foundations of transmutation and hinted at recipes for bringing it about. He proposed that from plants, gems, metals, and minerals might be prepared a class of marvelous medicaments, which he called prima entia (first entities). Each primum ens had particular uses, but the entia were all supposed to (...) be able to revitalize the human body and cleanse it of disease. Certain entia could also transmute metals. The De renovatione et restauratione affirmed the metaphysical centrality, in goldmaking and medicine alike, not just of purification or alteration but of renewal and transformation. It expressed the author’s eschatological excitement at God’s works of wonder, whether within or above nature. (shrink)

Empirical work has lately confirmed what many philosophers have taken to be true: people are ‘biased toward the future’. All else being equal, we usually prefer to have positive experiences in the future, and negative experiences in the past. According to one hypothesis, the temporal metaphysics hypothesis, future-bias is explained either by our beliefs about temporal metaphysics—the temporal belief hypothesis—or alternatively by our temporal phenomenology—the temporal phenomenology hypothesis. We empirically investigate a particular version of the temporal belief hypothesis according to (...) which future-bias is explained by the belief that time robustly passes. Our results do not match the apparent predictions of this hypothesis, and so provide evidence against it. But we also find that people give more future-biased responses when asked to simulate a belief in robust passage. We take this to suggest that the phenomenology that attends simulation of that belief may be partially responsible for future-bias, and we examine the implications of these results for debates about the rationality of future-bias. (shrink)

Introduction: Reason, ethics, and animals -- Part I: Making the rational case -- Why animal suffering matters morally -- How we minimize animal suffering and how we can change -- Part II: Three practical critiques -- First case: Hunting with dogs -- Second case: Fur farming -- Third case: Commercial sealing -- Conclusion: Re-establishing animals and children as a common cause and six objections considered.

How is it that a speaker _S_ can at once make it obvious to an audience _A_ that she intends to communicate some proposition _p_, and yet at the same time retain plausible deniability with respect to this intention? The answer is that _S_ can bring it about that _A_ has a high justified credence that ‘_S_ intended _p_’ without putting _A_ in a position to know that ‘_S_ intended _p_’. In order to achieve this _S_ has to exploit a (...) sense in which communication can be lottery-like. After defending this view of deniability I argue that it compares favorably to a rival account recently developed by Dinges and Zakkou (Mind, https://doi.org/10.1093/mind/fzac056, 2023 ). (shrink)

This is a discussion of the state of discussion on pragmatic reasons for belief.

ABSTRACT Pettigrove’s paper argues strongly and effectively against a proportionality principle grounded on a univocal scale of value, and argues in favour of a kind of virtue ethics that is focused exclusively on the characteristic and non-univocal attitudes of the subject. In my critique, however, I point out that not all proponents of value ethics adhere to the proportionality principle and that the radical shift from object to subject has risks that were highlighted in a book by C. S. Lewis, (...) The Abolition of Man. I also point out that Pettigrove in fact treats ‘I love you’ and ‘I forgive you’ substantively in terms of a first-person act in which any relationship-enabling response by the second person is accidental. On this account, there seems to be an underlying ethical challenge, namely that the Pettigrovian valuers are in reality isolated, cut off from relationships based on genuine union with second persons. (shrink)

This book is about the link between animal abuse and human violence.

An examination, by a diverse field of experts, of Pickering's mangle theory and its applicability (or lack thereof) beyond the limited cases he presented in the ...

Previously, we introduced a capability approach to assess the responsible use of brain-computer interface. In this commentary, we say more about the ethical basis of our capability view and respond to three objections. The first objection holds that by stressing that capability lists are provisional and subject to change, we threaten the persistence of human dignity, which is tied to capabilities. The second objection states that we conflate capabilities and abilities. The third objection claims that the goal of using neuroenhancements (...) should be preserving capabilities, not altering them. (shrink)

This commentary examines Glenberg's characterization of “suppression” in light of negative priming and related phenomena. After offering a radically different slant on suppression, an attempt is made to weave this alternative version into Glenberg's provocative discussion of embodied memories.

This chapter explores the ethical dimensions of diplomatic efforts to form a global agreement on climate change. It offers a brief historical background on the core multilateral climate negotiation body, the United Nations Framework Convention on Climate Change, and highlights some contentious moral elements of these negotiations. In particular, it explores the complex ways in which the principle of “common but differentiated responsibilities” has driven debates on how burdens for mitigation, adaptation, and finance should be distributed between developed and developing (...) countries. It then considers the transformation in these climate negotiations since 2009, including the move toward a bottom-up architecture as part from the Copenhagen Accord to the Paris Agreement. Finally, it assesses the current state of climate diplomacy in relation to broader diplomatic priorities, arguing that climate diplomacy must be elevated alongside other top-tier foreign policy issues today in order to eventually achieve some level of climate stability. (shrink)

This essay considers Kant’s theory of modality in light of a debate in contemporary modal metaphysics and modal logic concerning the Barcan formulas. The comparison provides a new and fruitful perspective on Kant’s complex and sometimes confusing claims about possibility and necessity. Two central Kantian principles provide the starting point for the comparison: that the possible must be grounded in the actual and that existence is not a real predicate. Both are shown to be intimately connected to the Barcan formulas, (...) and Kant’s views on what he distinguishes as three different kinds of modality are then considered in light of this connection. (shrink)

Nicolas Malebranche is one of the most important philosophers of the 17th Century after Descartes. A pioneer of Rationalism, he was one of the first to champion and to further Cartesian ideas. Andrew Pyle places Malebranche's work in the context of Descartes and other philosophers, and also in its relation to ideas about faith and reason. He examines the entirety of Malebranche's writings, including the famous The Search After Truth , which was admired and criticized by both Leibniz and (...) Locke. Pyle presents an integrated account of Malebranche's central theses, occasionalism and 'vision in God', before exploring and assessing Malebranche's contribution to debates on physics and biology, and his views on the soul, self-knowledge, grace, and the freedom of the will. This penetrating and wide-ranging study will be of interest to not only philosophers, but also to historians of science and philosophy, theologians, and students of the Enlightenment or 17th Century thought. (shrink)

An important advance in normativity research over the last decade is an increased understanding of the distinction, and difference, between normativity and rationality. Normativity concerns or picks out a broad set of concepts that have in common that they are, put loosely, guiding. For example, consider two commonly used normative concepts: that of a normative reason and that of ought. To have a normative reason to perform some action is for there to be something that counts in favour of performing (...) that action. Likewise with ought, when there is sufficient evidence for something, one ought to believe it (at least under normal circumstances). Not all guidance need be directed towards a specific state or a specific action. Subject to the requirements of normativity, too, are relations. It is commonly believed, for example, that we ought not to hold contradictory beliefs.1 At least some of the requirements that concern relations amongst an agent’s mental states are, or seem, distinctive. Agents who fail to satisfy these requirements are considered, at least to some degree, irrational. On many current views, being irrational is distinct in some way from not being how one ought to be; rationality is a concept distinct from normativity. Much of the literature on this topic over the last decade stems from attempts to capture the characteristic features of the requirements of rationality. Two influential views in particular did much to set the agenda. The first of these two was put forward John Broome.2 His view, the particulars of which I shall discuss in more detail below, is that the requirements of rationality could be expressed using a normative relation, which he calls a ‘normative requirement’. Normative requirements are conditionals governed by an all-thingsconsidered ought. In the case of rationality, the conditional is made up entirely of mental states.. (shrink)

The mystery of Aquinas's virtue ethics -- The gifts as second-personal dispositions -- Virtues and the second-person perspective -- The fruition of the virtues and gifts -- Conclusions and implications.

In this chapter, I present and explore various arguments for skepticism that are related to memory. My focus will be on the aspects of the arguments that are unique to memory, which are not shared, for example, by the more often explored skeptical arguments related to perception. -/- Here are some interesting upshots. First, a particular problem for justifiably concluding that one's memory is reliable is that any reasoning in favor of this conclusion will either result in epistemically circularity or (...) not be sufficient to justify the conclusion. Second, since many beliefs stored in memory do not appear to be based on evidence, it might also appear to follow that they are not justified. Third, although many stored memory beliefs are not based on stored memory experiences in the same way that perceptual beliefs are based on perceptual experiences, skeptical scenarios loom just as problematically for memory beliefs as they do for perceptual beliefs. (shrink)

Organized across national boundaries and with millions of supporters worldwide, transnational environmental activist groups such as Greenpeace, the World Wildlife Fund, and Friends of the Earth play a central role in the way the world addresses environmental issues. This book provides the most systematic and theoretically informed study to date of the strategies these organizations use to advance global environmental protection. Based on case studies of three transnational groups, it argues that in addition to lobbying governments, activists operate within and (...) across societies to effect widespread change. They work through transnational social, economic, and cultural networks to alter corporate practices, educate vast numbers of people, pressure multilateral development banks, and shift standards of good conduct. Wapner argues that because this activity takes place outside the formal arena of inter-state politics, environmental activists practice "world civic politics"; they politicize global civil society. The theoretical import of this book is to bring the practice of world civic politics into sharp relief and generalize its significance beyond environmental affairs to explain the efforts of all NGOs in world politics. (shrink)

One of the key achievements of critical realism has been to expose the modernist myth of universal reason, which holds that authentic knowledge claims must be objectively ‘pure’, uncontaminated by the subjectivity of local place, specific time and particular culture. Wright aims to address the lack of any substantial and sustained engagement between critical realism and theological critical realism with particular regard to: (a) the distinctive ontological claims of Christianity; (b) their epistemic warrant and intellectual legitimacy; and (c) scrutiny of (...) the primary source of the ontological claims of Christianity, namely the historical figure of Jesus of Nazareth. As such, it functions as a prolegomena to a much needed wider debate, guided by the under-labouring services of critical realism, between Christianity and various other religious and secular worldviews. This important new text will help stimulate a debate that has yet to get out of first gear. This book will appeal to academics, graduate and post-graduate students especially, but also Christian clergy, ministers and informed laity, and members of the general public concerned with the nature of religion and its place in contemporary society. (shrink)

This paper argues that underlying social biases are able to affect the processes underlying linguistic interpretation. The result is a series of harms systematically inflicted on marginalised speakers. It is also argued that the role of biases and stereotypes in interpretation complicates Miranda Fricker's proposed solution to epistemic injustice.

This paper presents the case of the post-crisis discursive defence of shadow banking in the Netherlands to argue, first, that there is a need to dust off older elite theories and adapt them to post-democratic conditions where there are no widely shared ‘political formulas’ to secure mass support for elite projects. Second, that temporality should be taken more seriously; it is when stories fail that elite storytelling can be observed in practice. As new ‘political formulas’ are minted and become established, (...) elites can again hope to withdraw from the political scene and leave policy-making to the self-evidence of output legitimacy and/or the perpetuum mobile of There-Is-No-Alternative. This suggests that elite theory should replace an epochal reading of post-democracy with a more conjunctural one. (shrink)

This book offers an exciting re-interpretation of Auguste Comte, the founder of French sociology. Following the development of his philosophy of positivism, Comte later focused on the importance of the emotions in his philosophy resulting in the creation of a new religious system, the Religion of Humanity. Andrew Wernick provides the first in-depth critique of Comte's concept of religion and its place in his thinking on politics, sociology and philosophy of science. He places Comte's ideas in the context of (...) post-1789 French political and intellectual history, and of modern philosophy, especially postmodernism. Wernick relates Comte to Marx and Nietzsche as seminal figures of modernity and examines key features of modern and postmodern French social theory, tracing the inherent flaws and disintegration of Comte's system. Wernick offers original and fascinating insights in this rich study which will attract a wide audience from sociologists and philosophers to cultural theorists and historians. (shrink)

Some postcolonial theorists argue that the idea of a single system of belief known as "Hinduism" is a creation of nineteenth-century British imperialists. Andrew J. Nicholson introduces another perspective: although a unified Hindu identity is not as ancient as some Hindus claim, it has its roots in innovations within South Asian philosophy from the fourteenth to seventeenth centuries. During this time, thinkers treated the philosophies of Vedanta, Samkhya, and Yoga, along with the worshippers of Visnu, Siva, and Sakti, as (...) belonging to a single system of belief and practice. Instead of seeing such groups as separate and contradictory, they re-envisioned them as separate rivers leading to the ocean of Brahman, the ultimate reality. Drawing on the writings of philosophers from late medieval and early modern traditions, including Vijnanabhiksu, Madhava, and Madhusudana Sarasvati, Nicholson shows how influential thinkers portrayed Vedanta philosophy as the ultimate unifier of diverse belief systems. This project paved the way for the work of later Hindu reformers, such as Vivekananda, Radhakrishnan, and Gandhi, whose teachings promoted the notion that all world religions belong to a single spiritual unity. In his study, Nicholson also critiques the way in which Eurocentric concepts—like monism and dualism, idealism and realism, theism and atheism, and orthodoxy and heterodoxy—have come to dominate modern discourses on Indian philosophy. (shrink)

Literature cultivates "deep selves" for whom books matter because they take over from religion fundamental questions about the meaning of existence. This volume embraces and questions this perspective, while also developing a "new humanist' critical vocabulary which specifies, and therefore opens to debate, the human significance of literature.

Drawing on the philosophy of C. S. Peirce, Robinson develops a ‘semiotic model’ of the Trinity and proposes a new theology of nature according to which the evolving cosmos may be understood as bearing ‘vestiges of the Trinity in ...

The author offers a conceptual investigation of the tension between openness and protection in well-developed welfare states. Because of a combination of demographic tendencies and labor market shortages, a growing number of European welfare states is currently exploring market-led immigration policies. However, the level of protection these welfare states offer seems hard to reconcile with the low threshold markets that are needed to incorporate newcomers. The author argues that the “solution”lies not so much in a clear political choice for either (...) but rather in the coordinated institutionalization of differentiated citizenship rights. The author illustrates this case with examples taken from the Dutch context, claiming further that the particular combination of corporatist welfare arrangements and the tradition of lenient enforcement in the Netherlands provides a “natural”habitat for the kind of regime pluralism that differentiated citizenship requires. (shrink)

David Lewis—famously—never tasted vegemite. Did he have any knowledge of what it's like to taste vegemite? Most say 'no'; I say 'yes'. I argue that knowledge of what it’s like varies along a spectrum from more exact to more approximate, and that phenomenal concepts vary along a spectrum in how precisely they characterize what it’s like to undergo their target experiences. This degreed picture contrasts with the standard all-or-nothing picture, where phenomenal concepts and phenomenal knowledge lack any such degreed structure. (...) I motivate the degreed picture by appeal to (1) limits in epistemic abilities such as recognition, imagination, and inference, and (2) the semantics of ‘knows what it’s like’ expressions. I argue that approximate phenomenal knowledge cannot be explained merely via determinable or vague phenomenal concepts. I develop a framework for systematizing approximate knowledge of phenomenal character. And I explain how my view challenges some standard assumptions about the acquisition conditions, requirements for mastery, and referential mechanisms of phenomenal concepts. (shrink)

The Society of Jesus has had a long relationship with China, beginning with the failed attempt by Francis Xavier to enter the country through to the achievements of Matteo Ricci, his companions, and successors. The missionaries introduced European science, including medicine, with which they engaged both the imperial court and the commoners. The eventual expulsion of the Jesuits and formal reconnection with China via the current papacy gives a poignancy to the consideration of medicine and environmental concerns. Pope Francis is (...) the first Jesuit to be elected to the papacy. He is also the first pope to formalize an agreement with Beijing over the... (shrink)