The replicon hypothesis, first proposed in 1963 by Jacob and Brenner(1), states that DNA replication is controlled at sites called origins. Replication origins have been well studied in prokaryotes. However, the study of eukaryotic chromosomal origins has lagged behind, because until recently there has been no method for reliably determining the identity and location of origins from eukaryotic chromosomes. Here, we review a technique we developed with the yeast Saccharomyces cerevisiae that allows both the mapping of replication origins and an (...) assessment of their activity. Two‐dimensional agarose gel electrophoresis and Southern hybridization with total genomic DNA are used to determine whether a particular restriction fragment acquires the branched structure diagnostic of replication initiation. The technique has been used to localize origins in yeast chromosomes and assess their initiation efficiency. In some cases, origin activation is dependent upon the surrounding context. The technique is also being applied to a variety of eukaryotic organisms. (shrink)

Book reviewed in this article: Rights and Advocacy for Retarded People. By Stanley S. Herr. Lexington.

Uskali Mäki has offered an innovative scientific realist account of Milton Friedman’s 1953 essay, ‘The Methodology of Positive Economics’, which directly challenges the dominant instrumentalist interpretation. This paper offers critical reflections on Mäki’s approach and interpretation. It is argued that Mäki’s method of rereading-rewriting the text is problematic; that an unforced instrumentalist account of unrealistic assumptions can be extracted from the text itself; and that seemingly realist passages can be plausibly read as expressing an instrumentalist stance.

The regulation of Native identity has been central to the colonization process in both Canada and the United States. Systems of classification and control enable settler governments to define who is "Indian," and control access to Native land. These regulatory systems have forcibly supplanted traditional Indigenous ways of identifying the self in relation to land and community, functioning discursively to naturalize colonial worldviews. Decolonization, then, must involve deconstructing and reshaping how we understand Indigenous identity.

: The regulation of Native identity has been central to the colonization process in both Canada and the United States. Systems of classification and control enable settler governments to define who is "Indian," and control access to Native land. These regulatory systems have forcibly supplanted traditional Indigenous ways of identifying the self in relation to land and community, functioning discursively to naturalize colonial worldviews. Decolonization, then, must involve deconstructing and reshaping how we understand Indigenous identity.

When a member of an organization has to make a decision or act in a way that may benefit some stakeholders at the expense of others, ethical dilemmas may arise. This paper examines ethical sensitivity regarding the duties to clients and owners (principals), employees (agents), and responsibilities to society (third parties). Within this framework, ethical perceptions of male and female managers are compared between the U.S. and Turkey – two countries that differ on power distance as well as the individualism/collectivism (...) dimensions. Our results show that ethical sensitivity varies depending upon whether the interests of principals, agents, or third parties are affected by a given ethical dilemma. We also find that, contingent upon the principal-agent–society relationships, the nationality and gender of the decision-maker influences ethical sensitivity. (shrink)

What is the connection between a representation, such as a painting, statue or engraving, and its subject? For example, what makes a painting a painting of McX? The problem is not how to paint McX, which belongs to art experts. So the answer is not, for example, ‘The painter starts at the top with an egg-shape for the head …” The question is rather: what makes the results of such efforts a painting of McX? What conditions must a painting satisfy (...) to warrant such a description? What is the force or meaning of the word ‘of’ in phrases like ‘painting of McX’? (shrink)

This exposition focuses on purposeful behavioursaseffortstoward self-actualization. I introducehabit as a set of value-based behaviours that is different than the typical habit of physical movements. Each of those praxis is controlled by cognition drivenby values –both personal and societal, and their following habitsare the result of complex learning. I will then elaborate on three important topics: (1) awareness and efficacy with respect tohabit, (2) collective habit, and (3) implications of existential habit on the individual’s as well as the society’s wellbeing.

Bonita Lee ABSTRACT: This exposition focuses on purposeful behaviours as efforts toward self-actualization. I introduce habit as a set of value-based behaviours that is different than the typical habit of physical movements. Each of those praxis is controlled by cognition driven by values – both personal and societal, and their following habits are the result...

Feminist critiques of deliberative democracy have focused on the abstraction, impartiality and rationality of mainstream accounts of deliberation. This paper explores the claim, common to many of these critiques, that these features are problematic because they are gendered, and that a more women-friendly account of democracy would embrace corporeality, contextuality and the affective. While acknowledging the merit of such a claim, the paper nonetheless suggests that the pursuit of social justice and democratic inclusion actually leads many feminists to embrace a (...) modified account of deliberative democracy, albeit in a modified account form. This can be explained by the dialogical conception of impartiality offered by theories of deliberative democracy. The paper suggests that the embrace of deliberative democracy by feminist theorists is a positive move, to be more widely acknowledged. Moreover, once acknowledged, feminists have much to offer deliberative democrats in terms of considering what the pursuit of dialogic impartiality might entail. If conceived as demanding both a 'lack of bias' and 'inclusivity', attention needs to be focused squarely on the issue of inclusion, and the institutional and material conditions for securing inclusion in deliberation. (shrink)

The popular idea that mental calculation involves covert operations as counterparts to the scribblings, sayings or manipulations involved in classroom calculation is rejected by familiar arguments in Section I. Philosophers do not readily agree on an alternative account. Section II considers reasons why they are puzzled, reasons which encourage a return to the discredited position. The currently fashionable Causal or Functionalist view is criticised in Section III. Section IV reconsiders the stubborn fact that when someone calculates in their head they (...) do something at the time which explains their arithmetical successes or failures. Some dispositional descriptions are rejected as inadequate. Though a restrained dispositionalism is finally supported, it does not have the implication that nothing was going on in the silence. (shrink)

1. The scientific study of sleep has recently been stimulated by comparisons between people and advanced computers, whose normal activities need to be suspended periodically for reprogramming. I quote from a popular account by Dr Christopher Evans, which appeared in the Sunday Times during 1969: Sleep is of course the state in which the brain-computer is ‘off-line’, during which time the vast mass of existing programmes are sorted, outdated ones revised in the light of recent experiences and useless ones or (...) the remnants of modified ones cleared and eliminated. These processes take place for a substantial part of the night, but because the brain is ‘off-line’ and consciousness suppressed, we are mostly not aware of them. However, if for some reason our sleep is disturbed or when we wake in the morning, as the conscious mind ‘comes to’ it catches the programme operations at work, and for a moment has no way of knowing whether the events are internal or external in origin. It sets to work therefore to try to make sense of the programme or fragments thereof that are being run through, and the result is what we call a dream— though we should presumably call it an interrupted dream. (shrink)

We interpret the probability rule of the CSL collapse theory to mean to mean that the scalar field which causes collapse is the gravitational curvature scalar with two sources, the expectation value of the mass density (smeared over the GRW scale a) and a white noise fluctuating source. We examine two models of the fluctuating source, monopole fluctuations and dipole fluctuations, and show that these correspond to two well-known CSL models. We relate the two GRW parameters of CSL to fundamental (...) constants, and we explain the energy increase of particles due to collapse as arising from the loss of vacuum gravitational energy. (shrink)

Two versions of the GRW “hitting” model for explicit wavefunction collapse, which are consistent with preserving the symmetry of the wavefunction, are considered. The predictions of the models for excitation of bound systems are calculated and compared with experiment and with the predictions of other similar models. It is shown that our preferred model strongly supports the idea that collapse, if it occurs, has gravitational origin.

Written descriptions can be no more than passwords to this great game. Guy Debord In every job that must be done, there is an element of fun.Mary Poppins1This article, formerly known to us as “Citi...

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

The book explores philosophical issues such as idealism and free will and speculates on the relationship of consciousness to quantum mechanics.

The proposal that the hippocampus is important for the encoding of episodic information, but not familiarity-based recognition, is incompatible with the available data. An alternative way to think about functional specialization within the medial temporal lobe memory system is suggested, based on neuroanatomy.

Quantum mechanics stands as one of the most remarkable achievements of the twentieth century: at once a new and startling insight into the nature of matter and a spectacularly successful predictive theory. However, while the predictive abilty of the quantum theory has been rigorously tested time and time again, so that it now satisfies any criterion of reliability as a tool of scientific inquiry, surprisingly fundamental difficulties remain with its interpretation. This book introduces the general reader to the philosophical issues (...) raised by the success of the quantum theory. What exactly is the wavefunction, the mathematical device that resides at the heart of the theory? In what sense does this device represent reality? The wavefunction is believed to describe the probability of a system's behaving in a particular way, yet the equations which describe the wave function are totally deterministic: what then is the relationship between determinism and ramdomness in the microworld? Does this tell us anything about the freedom of will in a world governed by the immutable world of physics? Do these laws rely for their existence on the presence of concious observers? Euan Squires explains to a non-specialised readership how these profound difficulties arise in the simplest of experimental arrangements. He outlines with great clarity the different points of view adopted by various schools of physicists who are striving to understand the meaning underlying the theories they use every day. The reader is encouraged to see how this most successful of physical theories is relevant to issues outside physics - even to the existence of God. other_titles. (shrink)

The public/private dichotomy has long been the object of considerable attention for feminists. We argue that, by focusing their attention on a divide which has declined in importance, feminists may fail to keep up with the current means by which sexual inequalities are perpetuated. Furthermore, by concentrating on this divide feminists risk reproducing such dichotomous thinking in their own work, discursively perpetuating that which they had initially hoped to displace. We begin by surveying feminist critiques of the public/private dichotomy, consider (...) recent moves to go beyond critique, yet suggest that the dichotomy continues to be a framing concern within feminist work. We then survey the way in which space has been understood within geography, and consider the implications of adopting a relational conception of space for analysis of public and private in political theory. We offer a broader framework for examining the ways in which sexual inequalities are reproduced in contemporary society. We therefore open up the possibility that over time inequalities may be mediated to a greater or lesser degree by spatial divisions. This places a further pressure on the assumption that the public/private divide, or some variation thereof, must be at the heart of feminist theorizing. (shrink)

Spanning nearly two decades, from 1980 to 1996, this Reader investigates the debates which have best characterized feminist theory. Including such articles as Pornography and Fantasy, The Body and Cinema, Nature as Female, and A Manifesto for Cyborgs, the extracts examine thoughts on sexualtiy as a domain of exploration, the visual representation of women, what being a feminist means, and why feminists are increasingly involved in political struggles to negotiate the context and meaning of technological development. With writings by bell (...) hooks, Alice Jardine, and Andrea Dworkin, this mulit-cultural Reader reflects the dynamic nature of feminist debates and the genuine diversity within current feminist theory. Capturing the sense of the rapid movement within feminist theory and criticism, Feminisms is ideal for anyone interested in feminism and the history behind it. (shrink)

We show how a recently introduced retarded version of the Bohm Model evades the Hardy proof that hidden-variable models must violate Lorentz Invariance. We also discuss a possible test of such models.

In today's world, moral uncertainty is found everywhere. MORALITY USA calls for recognition of the multiplicity of moral structures that now exist and argues that we need to rethink our concepts of morality.

The deconstruction of all 'principled positions' creates a value vacuum which, in turn, leads to a state of ethical and political paralysis. The contributors to Principled Positions ponder these dilemmas and try to build bridges between the modernist absolutes of truth, value and justice and the anti-totalising spirit of postmodernism.