Focal brain metabolic effects detected by proton magnetic resonance spectroscopy (MRS) in obsessive-compulsive disorder (OCD) represent prospective indices of clinical status and guides to treatment design. Sampling bilateral pregenual anterior cingulate cortex (pACC), anterior middle cingulate cortex (aMCC), and thalamus in 40 adult patients and 16 healthy controls, we examined relationships of the neurometabolites glutamate+glutamine (Glx), creatine+phosphocreatine (Cr), and choline-compounds (Cho) with OCD diagnosis and multiple symptom types. The latter included OC core symptoms (Yale-Brown Obsessive-Compulsive Scale - YBOCS), depressive symptoms (...) (Montgomery-Åsberg Depression Rating Scale - MADRS), and general functioning (Global Assessment Scale - GAS). pACC Glx was 9.7% higher in patients than controls. Within patients, Cr and Cho correlated negatively with YBOCS and MADRS, while Cr correlated positively with the GAS. In aMCC, Cr and Cho correlated negatively with MADRS, while Cr in thalamus correlated positively with GAS. These findings present moderate support for glutamatergic and cingulocentric perspectives on OCD. Based on our prior metabolic model of OCD, we offer one possible interpretation of these group and correlational effects as consequences of a corticothalamic state of elevated glutamatergic receptor activity alongside below-normal glutamatergic transporter activity. (shrink)

Combined oral contraceptives have been demonstrated to have significant benefits for the treatment and prevention of disease. These medications also are associated with untoward health effects, and they may be directly contraceptive. Prescribers and users must compare and weigh the intended beneficial health effects against foreseeable but unintended possible adverse effects in their decisions to prescribe and use. Additionally, those who intend to abide by Catholic teachings must consider prohibitions against contraception. Ethical judgments concerning both health benefits and contraception are (...) approached in this essay through an overview of the therapeutic, prophylactic, untoward, and contraceptive effects of COC and discussion of magisterial and traditional Catholic teachings from natural law. Discerning through the principle of double effect, proportionate reason, and evidence gathered from the sciences, medical and moral conclusions are drawn that we believe to be fully compliant with good medicine and Catholic teaching. (shrink)

Through extensive training, experts acquire specialized knowledge and abilities. In this paper, I argue that experts also acquire specialized visual experiences. Specifically, I articulate and defend the account that experts enjoy visual experiences that represent gestalt properties through perceptual learning. I survey an array of empirical studies on face perception and perceptual expertise that support this account. I also look at studies on perceptual adaptation that some might argue present a problem for my account. I show how the data are (...) subject to an interpretation that is friendly to it. Last, I address two theoretical objections to the claim that visual experiences represent gestalt properties. (shrink)

During the debates about the legalization of Voluntary Assisted Dying in Victoria, Australia, the presence of anti-VAD health professionals in the medical community and reported high rates of conscientious objection to VAD suggested access may be limited. Most empirical research on CO has been conducted in the sexual and reproductive health context. However, given the fundamental differences in the nature of such procedures and the legislation governing it, these findings may not be directly transferable to VAD. Accordingly, we sought to (...) understand how CO operates in the context of VAD. Prior to the implementation of the VAD legislation in June 2019, we conducted semi-structured interviews with seventeen health professionals with a self-declared CO to VAD, to explore what motivated their CO. Participants identified multiple motivations, which can be broadly categorized as: concerns for oneself; concerns for patients; concerns about the current Victorian legislation; and concerns for the medical profession. Participants’ moral commitments included personal, professional, and political commitments. In some cases, one’s CO was specific to Victoria’s current legislation rather than VAD more broadly. Our findings suggest CO motivations extend beyond those traditionally cited and suggest a need to better understand and manage CO in the healthcare context. (shrink)

Since the development of assisted reproductive technologies, infertile individuals have crossed borders to obtain treatments unavailable or unaffordable in their own country. Recent media coverage has focused on the outsourcing of surrogacy to developing countries, where the cost for surrogacy is significantly less than the equivalent cost in a more developed country. This paper discusses the ethical arguments against international surrogacy. The major opposition viewpoints can be broadly divided into arguments about welfare, commodification and exploitation. It is argued that the (...) only valid objection to international surrogacy is that surrogate mothers may be exploited by being given too little compensation. However, the possibility of exploitation is a weak argument for prohibition, as employment alternatives for potential surrogate mothers may be more exploitative or more harmful than surrogacy. It is concluded that international surrogacy must be regulated, and the proposed regulatory mechanism is termed Fair Trade Surrogacy. The guidelines of Fair Trade Surrogacy focus on minimizing potential harms to all parties and ensuring fair compensation for surrogate mothers. (shrink)

Analytic particularism claims that judgments of moral wrongness are about particular acts rather than general principles. Metaphysical particularism claims that what makes true moral judgments true is not general principles but nonmoral properties of particular acts. Epistemological particularism claims that studying particular acts apart from general principles can justify beliefs in moral judgments. Methodological particularism claims that we will do better morally in everyday life if we look carefully at each particular decision as it arises and give up the search (...) for a complete moral theory. This paper raises problems for each of these versions of particularism. (shrink)

Perin argues that theSceptic is engaged in the search for truth and that since this is so, the Sceptic aims to satisfy certain basic rational requirements.

Reports of the Intergovernmental Panel on Climate Change (IPCC) employ an evolving framework of calibrated language for assessing and communicating degrees of certainty in findings. A persistent challenge for this framework has been ambiguity in the relationship between multiple degree-of-certainty metrics. We aim to clarify the relationship between the likelihood and confidence metrics used in the Fifth Assessment Report (2013), with benefits for mathematical consistency among multiple findings and for usability in downstream modeling and decision analysis. We discuss how our (...) proposal meshes with current and proposed practice in IPCC uncertainty assessment. (shrink)

Urban infrastructures serve as the backbone of modern economies, mediating global exchanges and responding to urban demands. Yet, our comprehension of these complex structures, particularly within diverse socio-political terrain, remains fragmented. In bridging this knowledge gap, this study delves into “boundary objects”—entities enabling diverse stakeholders to collaborate without a comprehensive consensus. Central to our investigation is the hypothesis that oceanic infrastructural developments are instrumental in molding the interface of urban, industrial, and energy sectors within marine contexts. Our lens is directed (...) at the Gulf of Mexico, which is distinguished by its industrial depth and expansive marine grid. We highlight the Gulf Intracoastal Waterway’s (GIWW) paramount role in regional movement and the ecological facets of practices such as dredging, which is vital for transport and coastal conservation. A striking revelation of our study is the transformation of offshore structures in the Gulf into vibrant marine habitats. Emphasizing the intertwined nature of marine infrastructures, we denote oceans as pivotal platforms for impending urban expansion, especially as land resources wane. Our research aspires to validate the role played by oceans as a nexus in the urban–industrial–energy fusion. (shrink)

Volume 19, Issue 6, June 2019, Page 30-31.

Illness creates a range of negative emotions in patients including anxiety, fear, powerlessness, and vulnerability. There is much debate on the ‘therapeutic’ or ‘helping’ nurse–patient relationship. However, despite the current agenda regarding patient-centred care, the literature concerning the development of good interpersonal responses and the view that a satisfactory nursing ethics should focus on persons and character traits rather than actions, nursing ethics is dominated by the traditional obligation, act-centred theories such as consequentialism and deontology. I critically examine these theories (...) and the role of duty-based notions in both general ethics and nursing practice. Because of well-established flaws, I conclude that obligation-based moral theories are incomplete and inadequate for nursing practice. I examine the work of Hursthouse on virtue ethics’ action guidance and the v-rules. I argue that the moral virtues and a strong (action-guiding) version of virtue ethics provide a plausible and viable alternative for nursing practice. I develop an account of a virtue-based helping relationship and a virtue-based approach to nursing. The latter is characterized by three features: (1) exercising the moral virtues such as compassion; (2) using judgement; and (3) using moral wisdom, understood to include at least moral perception, moral sensitivity, and moral imagination. Merits and problems of the virtue-based approach are examined. I relate the work of MacIntyre to nursing and I conceive nursing as a practice: nurses who exercise the virtues and seek the internal goods help to sustain the practice of nursing and thus prevent the marginalization of the virtues. The strong practice-based version of virtue ethics proposed is context-dependent, particularist, and relational. Several areas for future philosophical inquiry and empirical nursing research are suggested to develop this account yet further. (shrink)

Barz (2018) contends that there is no specification of the phenomenon of first-person authority that avoids falsity or triviality. This paper offers one. When a subject self-ascribes a current conscious mental state in speech, there is a presumption that what she says is true. To defeat this presumption, one must be able to explain how she has been led astray.

Kriegel has recently developed an adverbial account of intentionality, in part to solve the problem of how we can think of non-existents. The view has real virtues: it endorses a non-relational conception of intentionality and is ontologically conservative. Alas, the view ultimately cannot replace the act-object model of intentionality that it seeks to, because it depends on the act-object model for its intelligibility at key points. It thus fails as a revisionistic theory. I argue that the virtues of adverbialism can (...) be had from within the act-object framework, provided we understand intentional objects correctly. I use Crane as a guide here, and build on his work on intentional objects. In the end, we can provide a suitable solution to the problem of thinking of non-existents within the act-object framework without adopting implausible ontological or metaphysical views. So, adverbialism is neither a possible stand-alone revisionary option nor a needed modif... (shrink)

Educators are increasingly concerned with the use of artificial intelligence (AI) in student writing. Much of the concern focuses on the issue of students using ChatGPT to complete their work. I introduce the CUPID model for instructors to use when thinking about how to pedagogically handle ChatGPT. The CUPID model lays out five general approaches: Catch, Utilize, Prevent, Ignore, and Disincentivize. I suggest that instructors should especially consider using certain assignments that fall under the approach “Disincentivize”. Philosophy instructors in particular (...) should assign more low-stakes writing, such as journals and reflection pieces. The adoption of low-stakes writing assignments aims to discourage students from relying on AI while promoting clarity of thought and deeper engagement with philosophical ideas. (shrink)

In his last book, David Armstrong sets out his metaphysical system in a set of concise and lively chapters each dealing with one aspect of the world. He begins with the assumption that all that exists is the physical world of space-time. On this foundation he constructs a coherent metaphysical scheme that gives plausible answers to many of the great problems of metaphysics. He gives accounts of properties, relations, and particulars; laws of nature; modality; abstract objects such as numbers; (...) and time and mind. (shrink)

In the heart of southeast Texas, an industrial powerhouse often referred to as the 'Golden Triangle', the oil refineries and petrochemical plants stand as stalwart testaments to the region's economic evolution. Interestingly, before the discovery of oil at Spindletop, the lumber and cattle industries powered this region's economy. A profound shift occurred when the Lucas Gusher, a fountain of oil spurting thousands of feet into the air, struck the lands of Spindletop Hill on January 10, 1901. This remarkable discovery of (...) the Spindletop oilfield on a slat dome formation south of Beaumont, Texas, marked the birth of the modern petroleum industry and fundamentally transformed the region's geopolitical, economic, and cultural landscapes. People from all over the country relocated to Gladys City and Beaumont in search of work and new opportunities, creating a boomtown as the town's population swelled from 10,000 to 50,000. The newfound urbanization brought by the oil industry transformed the town and the surrounding areas, creating a ripple effect across the region that would be felt for generations to come. The surge in oil-driven economic activity transmuted the region into a vibrant nexus of commerce, with the oil industry emerging as a critical architect of growth and advancement. This newfound affluence incited by the petroleum sector ushered in an era of economic diversification, laying the groundwork for industrialization’s further evolution. The Spindletop Oil Fields not only underscored the United States’ ascent as the foremost petroleum-producing nation but also signaled the nation’s initiation into the Petroleum Age. It was Spindletop that solidified its position as America’s first significant oil field, becoming an enduring symbol of its industrial might. By 1985, over 153,000,000 barrels of oil had been produced and extracted from the Spindletop oil fields, underscoring the magnitude of this extraordinary resource. (shrink)

Suppose I make an utterance, intending it to be a command. You don’t take it to be one. Must one of us be wrong? In other words, must each utterance have, at most, one illocutionary force? Current debates over the constitutive norm of assertion and over illocutionary silencing, tend to assume that the answer is yes—that each utterance must be either an assertion, or a command, or a question, but not more than one of these. While I think that this (...) assumption is intuitive, I will argue in this paper that it is not sustainable. I’ll argue that this assumption makes it hard to explain what determines illocutionary force in a consistent and non-ad hoc way. I will demonstrate this is not fatal for the notion of illocutionary force writ large by offering some alternatives. (shrink)

Pessimists about moral testimony hold that there is something suboptimal about forming moral beliefs by deferring to another. This paper motivates an analogous claim about self-knowledge of the reason-responsive attitudes. When it comes to your own mind, it seems important to know things “from the inside”, in the first-personal way, rather than putting your trust in another. After motivating Pessimism, the paper offers an explanation of its truth. First-person knowledge is distinctive because it involves knowing a state of mind and (...) finding it intelligible from one’s point of view. It concludes by considering the value of this form of self-understanding. (shrink)

I argue that the debates over which norm constitutes assertion can be abandoned by challenging the three main motivations for a constitutive norm. The first motivation is the alleged analogy between language and games. The second motivation is the intuition that some assertions are worthy of criticism. The third is the discursive responsibilities incurred by asserting. I demonstrate that none of these offer good reasons to believe in a constitutive norm of assertion, as such a norm is understood in the (...) literature. Others who have made similar arguments conclude that assertion does not exist at all—that there is no such thing as assertion. I disagree: we do not have to relinquish the category of assertion just because it is not normatively constituted. There are alternative ways to understand and individuate assertion that do not rely on a constitutive norm. (shrink)

If there is a moral reason for A to do X, and if A cannot do X without doing Y, and if doing Y will enable A to do X, then there is a moral reason for A to do Y. This principle is plausible but mysterious, so it needs to be explained. It can be explained by necessary enabler consequentialism, but not by other consequentialisms or any deontological moral theory. Or so I argue. Frances Howard-Snyder objects that this argument (...) fails to establish consequentialism as understood by, because it fails to establish agent-neutrality. I respond by distinguishing consequentialism, which need not be agent-neutral, from utilitarianism, which claims agent-neutrality. Howard-Snyder also presents a schema for a non-consequentialist theory that is supposed to explain moral substitutability. I respond that her explanation cannot be completed without introducing incoherence into deontological moral theories. (shrink)

Thought: A Journal of Philosophy, EarlyView.

At the center of much contemporary work on self-knowledge of our attitudes is a debate between Agentialists and Empiricists. Empiricists hold that first-person knowledge of one’s own attitudes possesses a broadly empirical basis, such as observation or inference. Agentialists insist that an account of self-knowledge must make sense of the intimate connection between knowing one’s attitudes and actively forming them in response to reasons. But it is plausible to suppose that a psychologically realistic account of self-knowledge will emphasize both active (...) and passive elements. Focusing on the idea that we form self-ascriptions of belief on the basis of active deliberation, this paper outlines such a middle ground position. (shrink)

This is the first volume dedicated solely to the topic of epistemological disjunctivism. The original essays in this volume, written by leading and up-and-coming scholars on the topic, are divided into three thematic sections. The first set of chapters addresses the historical background of epistemological disjunctivism. It features essays on ancient epistemology, Immanuel Kant, J.L. Austin, Edmund Husserl, and Ludwig Wittgenstein. The second section tackles a number contemporary issues related to epistemological disjunctivism, including its relationship with perceptual disjunctivism, radical skepticism, (...) and reasons for belief. Finally, the third group of essays extends the framework of epistemological disjunctivism to other forms of knowledge, such as testimonial knowledge, knowledge of other minds, and self-knowledge. Epistemological Disjunctivism is a timely collection that engages with an increasingly important topic in philosophy. It will appeal to researches and graduate students working in epistemology, philosophy of mind, and philosophy of perception. (shrink)

The Centers for Medicare & Medicaid Services has initiated bundled payments for hip and knee total joint replacement in an effort to decrease healthcare costs and increase quality of care. The ethical implications of this program have not been studied. This article considers the ethics of patient selection to improve outcomes; specifically, screening patients by body mass index to determine eligibility for total joint replacement. I argue that this type of screening is not ethically defensible, and that the bundled payment (...) program as structured is likely to lead to unfair restrictions on who receives total joint replacements. (shrink)

The Intergovernmental Panel on Climate Change has developed a novel framework for assessing and communicating uncertainty in the findings published in their periodic assessment reports. But how should these uncertainty assessments inform decisions? We take a formal decision-making perspective to investigate how scientific input formulated in the IPCC’s novel framework might inform decisions in a principled way through a normative decision model.

In Christ the Heart of Creation, Rowan Williams argues that Christology as expounded by the classical tradition in Western theology holds a bounty for thinking in Christian ontology about the God-world relation. In particular, he uses the work of Søren Kierkegaard throughout to show that the relation between finite and infinite, immanent and transcendent, is not competitive, and thus there need be no metaphysical problem when holding that the incarnate God-man is both fully human and divine. This essay argues, however, (...) that Kierkegaard’s own pseudonymous work cited by Williams holds the incarnation to be far more paradoxical and intellectually offensive than Williams allows. However, such priority of offense does not put an end to Christ’s central ontological position but rather shifts it to new directions in our thinking about theological ontology. Rather than Williams’ own conception of a cosmos in which the divine and non-divine are compatible and harmonious, Kierkegaard presents a doctrine of existence in which God and the human are in constant, dynamic engagement and in which temporal being bears ultimate primacy for Christian existence. (shrink)

In this paper, I argue against Michael Gorman’s objection to Tim Crane’s view of intentional objects. Gorman (“Talking about Intentional Objects,” 2006), following Searle (Intentionality, 1983), argues that intentional content can be cashed out solely in terms of conditions of satisfaction. For Gorman, we have reason to prefer his more minimal satisfaction-condition approach to Crane’s be- cause we cannot understand Crane’s notion of an intentional object when applied to non-existent objects. I argue that Gorman’s criticism rests on a misunderstanding of (...) Crane’s position. I also discuss the importance of keeping track of the distinction between the intentional objects of intentional states and the referents of such states. I do agree with Gorman that conditions of satisfaction are needed to cash out propositional intentional content, but we cannot get these conditions of satisfaction right if we do not capture how the subject takes the world to be. And we cannot properly capture how the subject takes the world to be without commitment to intentional objects. I argue that Crane’s notion of an intentional object is one that avoids questionable ontological commitments. So, in the end we have a view of intentional objects with a respectable metaphysics and ontology that can properly capture the intentional content of subjects’ intentional states. (shrink)

Following a synthesis of naturalistic and experimental studies of language creation, we propose a theoretical model that describes the process through which human communication systems might arise and evolve. Three key processes are proposed that give rise to effective, efficient and shared human communication systems: motivated signs that directly resemble their meaning facilitate cognitive alignment, improving communication success; behavioral alignment onto an inventory of shared sign-to-meaning mappings bolsters cognitive alignment between interacting partners; sign refinement, through interactive feedback, enhances the efficiency (...) of the evolving communication system. By integrating the findings across a range of diverse studies, we propose a theoretical model of the process through which the earliest human communication systems might have arisen and evolved. Importantly, because our model is not bound to a single modality it can describe the creation of shared sign systems across a range of contexts, informing theories of language creation and evolution. (shrink)

According to Pessimism about moral testimony, it is objectionable to form moral beliefs by deferring to another. This paper motivates Pessimism about another source of moral knowledge: propositional memory. Drawing on a discussion of Gilbert Ryle’s on forgetting the difference between right and wrong, it argues that Internalism about moral motivation offers a satisfying explanation of Pessimism about memory. A central claim of the paper is that Pessimism about memory (and by extension, testimony) is an issue in moral psychology rather (...) than moral epistemology. That is because it is best explained by appeal to claims about the constitution of moral knowledge as a state of mind, rather than requirements on belief formation. The paper also provides reason to think that the focus on testimony, pervasive in the literature, is something of a red herring. (shrink)

Linda Zagzebski makes a compelling and many-faceted case for the primacy of virtue in both epistemology and ethics, and for the thesis that "epistemic evaluation just is a form of moral evaluation". Along the way, she explores a variety of theoretical problems in both ethics and epistemology, advancing promising new analyses and solutions. For a work of contemporary epistemology, Virtues of the Mind is uncommonly readable, relevant, and historically informed—and Zagzebski manages all this without sacrificing depth or rigor. Specialists and (...) nonspecialists alike will find it a rewarding study. (shrink)

Yli-Vakkuri offers a deductive argument for Content Externalism that primarily appeals to two main principles he says should be adopted by all parties to the debate. Sawyer criticizes this argument on the grounds that there are internalist theories that are not consistent with the two principles he offers, although she takes no issue with the derivation itself. While Sawyer’s critique is insightful and largely correct, there is a more fundamental problem with the original argument. The formal proof given in the (...) original paper begs the question. The informal argument is enthymematic, and all the possible valid reconstructions require assumptions that can be legitimately rejected by content internalists. This is significant to point out as someone might think that the internalist views that Sawyer says are not consistent with the two principles that drive Yli-Vakkuri’s argument can be successfully challenged and thereby the original argument defended. (shrink)

This paper begins with the thought that there is something out of place about offloading inquiry into one's own mind to AI. The paper's primary goal is to articulate the unease felt when considering cases of doing so. It draws a parallel between the use of algorithms in the criminal law: in both cases one feels entitled to be treated as an exception to a verdict made on the basis of a certain kind of evidence. Then it identifies an account (...) of first‐person authority that can make good on this: agentialism. Thus, the paper constitutes an argument in favor of an agentialist treatment of self‐knowledge and first‐person authority. (shrink)