Pierre Maquet1,2,6, Steven Laureys1,2, Philippe Peigneux1,2,3, Sonia Fuchs1, Christophe Petiau1, Christophe Phillips1,6, Joel Aerts1, Guy Del Fiore1, Christian Degueldre1, Thierry Meulemans3, André Luxen1, Georges Franck1,2, Martial Van Der Linden3, Carlyle Smith4 and Axel Cleeremans5.

■ Evidence from functional neuroimaging studies on resting state suggests that there are two distinct anticorrelated cortical systems that mediate conscious awareness: an “extrinsic” system that encompasses lateral fronto-parietal areas and has been linked with processes of external input (external awareness), and an “intrinsic” system which encompasses mainly medial brain areas and..

In the early nineteenth century, Henry Brougham endeavored to improve the moral character of England through the publication of educational texts. Soon after, Brougham helped form the Society for the Diffusion of Useful Knowledge to carry his plan of moral improvement to the people. Despite its goal of improving the nation’s moral character, the Society refused to publish any treatises on explicitly moral or religious topics. Brougham instead turned to a mathematician, Augustus De Morgan, to promote mathematics as a rational (...) subject that could provide the link between the secular and religious worlds. Using specific examples gleaned from the treatises of the Society, this article explores both how mathematics was intended to promote the development of reason and morality and how mathematical content was shaped to fit this particular view of the usefulness of mathematics. In the course of these treatises De Morgan proposed a fundamentally new pedagogical approach, one which focused on the student and the role mathematics could play in moral education.Keywords: Mathematics; Education; Henry Brougham; Augustus De Morgan; Nineteenth-century England. (shrink)

This book is the first to consider the outpouring of photo-based art created in China since the mid-1990s. Ambitious in scale and experimental in nature, these works reflect the turn toward media-based art that characterizes the next generation of younger Chinese artists. In addition to fostering a new understanding of contemporary Chinese art, Between Past and Future also provokes fresh and timely insights into the dynamics of Chinese culture in the 21st century.

Objectives: Recent fMRI studies have shown that it is possible to reliably identify the defaultmode network (DMN) in the absence of any task, by resting-state connectivity analyses in healthy volunteers. We here aimed to identify the DMN in the challenging patient population of disorders of consciousness encountered following coma. Experimental design: A spatial independent component analysis-based methodology permitted DMN assessment, decomposing connectivity in all its different sources either neuronal or artifactual. Three different selection criteria were introduced assessing anticorrelation-corrected connectivity with (...) or without an automatic masking procedure and calculating connectivity scores encompassing both spatial and temporal properties. These three methods were validated on 10 healthy controls and applied to an independent group of 8 healthy controls and 11 severely brain-damaged patients [locked-in syndrome (n ¼ 2), minimally conscious (n ¼ 1), and vegetative state (n ¼ 8)]. Principal observations: All vegetative patients showed fewer connections in the default-mode areas, when compared with controls, contrary to locked-in patients who showed nearnormal connectivity. In the minimally conscious-state patient, only the two selection criteria considering both spatial and temporal properties were able to identify an intact right lateralized BOLD connectivity pattern, and metabolic PET data suggested its neuronal origin. Conclusions: When assess-. (shrink)

This moving, insightful and ultimately hopeful and helpful blend of memoir and philosophical exploration begins in Christopher Phillips's native stomping grounds of the tiny volcanic island of Nisyros, Greece and unfurls through space and time as the author explores the connections between his immediate circumstances and the eternal wisdom of popular philosophers.

BACKGROUND: Through their action on the locus coeruleus, ␣ 2-adrenoceptor agonists induce rapidly reversible sedation while partially preserving cognitive brain functions. Our goal in this observational study was to map brain regions whose activity is modified by clonidine infusion so as to better understand its loci of action, especially in relation to sedation. METHODS: Six ASA I–II right-handed volunteers were recruited. Electroencephalogram (EEG) was monitored continuously. After a baseline H215O activation scan, clonidine infusion was started at a rate ranging from (...) 6 to 10 ␮g ⅐ kgϪ1 ⅐ h Ϫ1. A sequence of 11 similar scans was then performed at 8 min intervals. Plasma clonidine concentration was measured. Using statistical parametric mapping, we sought linear correlations between normalized regional cerebral blood flow (rCBF), an indicator of regional brain activity, and plasma clonidine concentration or spindle EEG activity. RESULTS: Clonidine induced clinical sedation and EEG patterns (spindles) comparable to early stage nonrapid eye movement sleep. A significant negative linear correlation between clonidine concentration and rCBF or spindle activity was observed in the thalamus, prefrontal, orbital and parietal association cortex, posterior cingulate cortex, and precuneus. CONCLUSIONS: The EEG patterns and decreases in rCBF of specific brain regions observed during clonidine-induced sedation are similar to those of early stage nonrapid eye movement sleep. Patterns of deactivated brain regions are also comparable to those observed during general anesthesia or vegetative state, reinforcing the hypothesis that alterations in the activity of a common network occur during these modified conscious states. (shrink)

PDZ (also called DHR or GLGF) domains are found in diverse membraneassociated proteins including members of the MAGUK family of guanylate kinase homologues, several protein phosphatases and kinases, neuronal nitric oxide synthase, and several dystrophin‐associated proteins, collectively known as syntrophins. Many PDZ domain‐containing proteins appear to be localised to highly specialised submembranous sites, suggesting their participation in cellular junction formation, receptor or channel clustering, and intracellular signalling events. PDZ domains of several MAGUKs interact with the C‐terminal polypeptides of a subset (...) of NMDA receptor subunits and/or with Shaker‐type K+ channels. Other PDZ domains have been shown to bind similar ligands of other transmembrane receptors. Recently, the crystal structures of PDZ domains, with and without ligand, have been determined. These demonstrate the mode of ligand‐binding and the structural bases for sequence conservation among diverse PDZ domains. (shrink)

David Lindsay Roberts. Republic of Numbers: Unexpected Stories of Mathematical Americans through History. ix + 244 pp., bibl., index. Baltimore: Johns Hopkins University Press, 2019. $29.95 (cloth); ISBN 9781421433080. E-book available. Julian Havil. Curves for the Mathematically Curious: An Anthology of the Unpredictable, Historical, Beautiful, and Romantic. xx + 259 pp., apps., refs., index. Princeton, N.J./Oxford: Princeton University Press, 2019. $29.95 (cloth); ISBN 9780691180052. E-book available. David S. Richeson. Tales of Impossibility: The Two-Thousand-Year Quest to Solve the Mathematical Problems of (...) Antiquity. xii + 436 pp., notes, refs., index. Princeton, N.J./Oxford: Princeton University Press, 2019. $29.95 (cloth); ISBN 9780691192963. E-book availabl. (shrink)