Dual task is known to affect postural stabilty in children. We explored the effect of visual tasks on postural control in dyslexic and in age-matched non-dyslexic children. Thirty dyslexic children (mean age: 9.80 ± 0.28 years) were compared with thirty non-dyslexic children (mean age: 9.92 ± 0.35 years). All children underwent ophthalmologic and optometric evaluation. Eye movements were recorded by a video-oculography system (EyeBrain ® T2) and postural sway was recorded simultaneously by a force platform (TechnoConept®). Both groups of children (...) performed fixations, pursuits, pro- and anti-saccades tasks. Dyslexic children showed significantly poor near fusional vergence ranges (convergence and divergence) with respect to the non-dyslexic children. During the postural task, quality of fixation and anti-saccade performance in dyslexic children were significantly worse compared to non-dyslexic children. In contrast, the number of catch-up saccades during pursuits and the latency of pro-and anti-saccades were similar in both groups of children examined. Concerning postural quality, dyslexic children were more unstable than age-matched non-dyslexic children. For both groups of children tested we also observed that executing saccades (pro- and anti-saccades) reduced postural values significantly in comparison with fixation and pursuit tasks. The impairment in convergence and divergence fusional capabilities could be due to an immaturity in cortical structures controlling the vergence system. The poor oculomotor performance reported in dyslexic children suggested a deficit in allocating visual attention and their postural instability observed is in line with the cerebellar impairment previously reported in dyslexic children. Finally, pro- or anti-saccades reduce postural values compared to fixation and pursuit tasks in both groups of children tested, suggesting a different influence of visual tasks on postural control according to their attentional demand. (shrink)

Pour répondre aux problématiques engendrées par la diffusion de plus en plus massive des corpus linguistiques et à l’hétérogénéité de leurs formats, nous proposons une méthode permettant de prendre en main des corpus langagiers oraux et de les convertir dans un format permettant leur exploitation outillée. Pour cette recherche, le corpus ESLO nous sert d’exemple par sa licence de diffusion, son format, son volume et ses atouts sociolinguistiques et diachroniques. Notre travail se fonde sur la compilation de ce corpus pour (...) le rendre compatible avec l’outil de textométrie TXM. Nous opérons un ensemble de transformations des données pour l’utiliser au mieux. Enfin, pour illustrer les apports de ces avancées méthodologiques, nous proposons une analyse fine et multidimensionnelle de l’usage des interrogatives dans le corpus ESLO. (shrink)

Many individuals with disabling conditions have difficulty with gait and balance control that may result in a fall. Exoskeletons are becoming an increasingly popular technology to aid in walking. Despite being a significant aid in increasing mobility, little attention has been paid to exoskeleton features to mitigate falls. To develop improved exoskeleton stability, quantitative information regarding how a user reacts to postural challenges while wearing the exoskeleton is needed. Assessing the unique responses of individuals to postural perturbations while wearing an (...) exoskeleton provides critical information necessary to effectively accommodate a variety of individual response patterns. This report provides kinematic and neuromuscular data obtained from seven healthy, college-aged individuals during posterior support surface translations with and without wearing a lower limb exoskeleton. A 2-min, static baseline standing trial was also obtained. Outcome measures included a variety of 0 dimensional measures such as center of pressure RMS, peak amplitude, velocities, pathlength, and electromyographic RMS, and peak amplitudes. These measures were obtained during epochs associated with the response to the perturbations: baseline, response, and recovery. T-tests were used to explore potential statistical differences between the exoskeleton and no exoskeleton conditions. Time series waveforms of the COP and EMG data were also analyzed. Statistical parametric mapping was used to evaluate the 1D COP and EMG waveforms obtained during the epochs with and without wearing the exoskeleton. The results indicated that during quiet stance, COP velocity was increased while wearing the exoskeleton, but the magnitude of sway was unchanged. The OD COP measures revealed that wearing the exoskeleton significantly reduced the sway magnitude and velocity in response to the perturbations. There were no systematic effects of wearing the exoskeleton on EMG. SPM analysis revealed that there was a range of individual responses; both behaviorally and among neuromuscular activation patterns. Using both the OD and 1D measures provided a more comprehensive representation of how wearing the exoskeleton impacts the responses to posterior perturbations. This study supports a growing body of evidence that exoskeletons must be personalized to meet the specific capabilities and needs of each individual end-user. (shrink)

This handbook presents a comprehensive introduction to the core areas of philosophy of education combined with an up-to-date selection of the central themes. It includes 95 newly commissioned articles that focus on and advance key arguments; each essay incorporates essential background material serving to clarify the history and logic of the relevant topic, examining the status quo of the discipline with respect to the topic, and discussing the possible futures of the field. The book provides a state-of-the-art overview of philosophy (...) of education, covering a range of topics: Voices from the present and the past deals with 36 major figures that philosophers of education rely on; Schools of thought addresses 14 stances including Eastern, Indigenous, and African philosophies of education as well as religiously inspired philosophies of education such as Jewish and Islamic; Revisiting enduring educational debates scrutinizes 25 issues heavily debated in the past and the present, for example care and justice, democracy, and the curriculum; New areas and developments addresses 17 emerging issues that have garnered considerable attention like neuroscience, videogames, and radicalization. The collection is relevant for lecturers teaching undergraduate and graduate courses in philosophy of education as well as for colleagues in teacher training. Moreover, it helps junior researchers in philosophy of education to situate the problems they are addressing within the wider field of philosophy of education and offers a valuable update for experienced scholars dealing with issues in the sub-discipline. Combined with different conceptions of the purpose of philosophy, it discusses various aspects, using diverse perspectives to do so. Contributing Editors: Section 1: Voices from the Present and the Past: Nuraan Davids Section 2: Schools of Thought: Christiane Thompson and Joris Vlieghe Section 3: Revisiting Enduring Debates: Ann Chinnery, Naomi Hodgson, and Viktor Johansson Section 4: New Areas and Developments: Kai Horsthemke, Dirk Willem Postma, and Claudia Ruitenberg. (shrink)

The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Largely by the use of allegory, Ayn Rand's novel The Fountainhead repurposes and reinterprets the religious morality of Christopher Marlowe's Doctor Faustus to espouse an Objectivist, rather than theist, view of salvation and damnation. The Faustian narrative no longer belongs to Faustus alone, but is read against itself in order to theorize that giving up one's ego and independence, rather than giving up one's membership to the societal collective, is the straightest road to perdition.

The untimely passing of Reverend Canon Dr Christopher Newell, AM, came as a shock to many in the bioethics world. As well as an obituary, this article notes a number of important themes in his work, and provides a select bibliography. Christopher's major contribution to this field is that he was one of a handful of scholars who made disability not only an acceptable area of bioethics—indeed a vital, central, fertile area of enquiry. Crucially Christopher emphasised that where we do (...) ethics is actually in everyday life—while we mourn his passing, his rich work and example will continue to inspire bioethical inquiry. (shrink)

Continental Philosophy Beyond "the" Continent / Brian Treanor -- Prometheus' Gift of Fire and Technics: Contemplating the Meaning of Fire, Affect, and Californian Pyrophytes in the Pyrocene / Marjolein Oele -- The West as Slaughterbench: Thinking without Revolutions in the American West / Christopher Lauer -- The End of the West: The Time of Apocalypse in the Westerns of Cormac McCarthy / Amanda Parris -- The Trees of the West: Our Elders, Our Teachers / Andrew Jussaume -- Thinking Wolves / (...) Thomas Thorpe -- Robert Smith, Entropic Art, and the West / Shannon M. Mussett -- "Westering" and "BreakingThrough": Zen Buddhism on Cannery Row / Gerard Kuperus -- Life in Interregnum: Deleuze, Guattari, and Atleo / Russell Duvernoy -- Monstrous Topologies: Edward Abbey, Reiner Schürmann, and the Fate of the American West / Josh Hayes -- Turtle Island Anarchy / Jason Wirth. (shrink)

The humanities- in their conceptual and intellectual specificity, disciplinary rigor, and ethical, social, and political potential- are very much in need of defense and rearticulation in our time, particularly from a perspective that moves beyond the political and philosophical reductions of identity politics. Leaving aside polemics, Flynn asserts that discourses in the humanities will find real ethical-political purchase when they engage with the material events in art, literature, and social life that call for humanistic reflection.

Both the physiological and the pathological morphogenetic processes that we can meet in embryogenesis, neogenesis and degenerative dysgenesis present common features: they are ruled by three different kinds of mechanisms, one related to cell migration, the second to cell differentiation and the third to cell proliferation. We deal here with an application to the cambial growth which essentially involves the third type of mechanism.Woody plants produce secondary tissue (secondary xylem and phloem) from a meristematic tissue called vascular cambium, responsible for (...) the radial growth of a tree. This paper focuses on the formation of secondary xylem, considered in two dimensions in a cross-section framework. A new discrete modelling approach is used, based on the cellular scale, in order to attain a more accurate understanding of how the elementary microscopic behaviour of each cell takes part in the macroscopic morphogenesis. The mathematical model essentially uses an occurrence method simulating the main features of radial growth with simple geometric rules, such as Thom's division rule (Thom,1972)to account for the cell proliferation. The study applies to concrete instances in which the changes made in the geometrical cellular patterns of the vascular cambium clearly affect the shape of the tree, as in Pinus radiata (D. Don.). (shrink)

Morphogenesis is a key process in developmental biology. An important issue is the understanding of the generation of shape and cellular organisation in tissues. Despite of their great diversity, morphogenetic processes share common features. This work is an attempt to describe this diversity using the same formalism based on a cellular description. Tissue is seen as a multi-cellular system whose behaviour is the result of all constitutive cells dynamics. Morphogenesis is then considered as a spatiotemporal organization of cells activities. We (...) show how this formalism relies on Reaction–Diffusion/Positional Information approach and how it permits to generalize its modelling possibilities. Three quite different applications for concrete morphogenetic processes are presented. The first one is a model for epithelial invagination, the second is a model of cellular differentiation by local cell–cell signalling. The last example is the secondary radial growth of conifer trees. From the mathematical point of view, different modelling tools are used according to the specificity of each process. (shrink)

Cet article a pour objet la conception de matériel pédagogique pour l’apprentissage endolingue de la relation entre le passé composé et l’imparfait dans le récit en FLE. Faut-il privilégier le choix d’une visée sur le procès ou bien montrer que la distribution des temps s’effectue à partir d’indices contextuels qu’il faut repérer? La première position a été représentée, par exemple, dans le manuel Libre Échange, mais délaissée par la suite. Notre propre analyse de 17 manuels publiés entre 2006 et 2016 (...) confirme la tendance. On constate en outre qu’il n’y a aucun exemple d’un même procès sous les deux aspects accompli et inaccompli, comme si cette option avait été bannie. Toutefois, l’approche aspectuelle n’est pas tout-à-fait absente : on considère le cas d’un manuel tendant à intégrer présence d’un sujet opérant des choix de visée et emplois normés des temps. Finalement, on propose un matériel qui exploite la syntaxe distincte des énoncés avec l’imparfait et le passé composé. Dans un cadre énactif, on envisage que l’énonciateur prend deux états différents, où il perçoit un présent imaginé, ou bien où il devient « possesseur » d’un accompli. On détaille la conception théorique, décrit des visuels extraits du matériel, et suggère une gestuelle pédagogique pour montrer comment cette approche peut soutenir l’apprentissage des temps du récit. (shrink)

L’installation et le développement de la discipline universitaire « Sciences et techniques des activités physiques et sportives » ne peuvent être pleinement compris que si l’on voit qu’ils résultent de l’action conjointe de facteurs cognitifs et sociaux. La perspective sociohistorique montre que ce qui est arrivé récemment a d’abord été préparé par un long processus non linéaire et complexe. Mais il a encore fallu sur le court terme un dynamisme cognitif interne et des effets sociaux multiples, enchevêtrés, voulus et non (...) voulus, afin que s’établissent l’instutionnalisation irréversible de cette nouvelle discipline universitaire, son « académisation », puis son expansion « démographique ».The setting-up and development of the « sport sciences » as an academic discipline can only be fully grasped by acknowledging that it results from the combined action of both cognitive and social factors. Viewed in a social and historical light, what has recently taken place proves to have come at the end of a long, complex and winding process. But, in the short run, internal cognitive dynamics as well as multiple and intertwined social effects – whether intended or not – were also necessary for the non-reversible institutionalization of this new academic discipline, its establishment as part of the academia and eventually its « demographic » expansion. (shrink)

In an age where issues like climate change and the unintended consequences of technological innovation are high on the ethical and political agenda, questions about the nature and extent of our responsibilities to future generations have never been more important, yet simultaneously so difficult to answer. This book takes a unique approach to the problem by drawing on diverse traditions of thinking about care (including developmental psychology, phenomenology and feminist ethics) to explore the nature and meaning of our relationship with (...) the future. Demonstrating that many influential perspectives on intergenerational ethics, including positions advanced by John Rawls, Brian Barry, and Ulrich Beck are undermined by problems relating to uncertainty, it shows that an approach based on care ethics can confront the uncertain future successfully and give a viable account of the nature and scope of future-oriented responsibilities. (shrink)

One effect of information technology is the increasing need to present information visually. The trend raises intriguing questions. What is the logical status of reasoning that employs visualization? What are the cognitive advantages and pitfalls of this reasoning? What kinds of tools can be developed to aid in the use of visual representation? This newest volume on the Studies in Logic and Computation series addresses the logical aspects of the visualization of information. The authors of these specially commissioned papers explore (...) the properties of diagrams, charts, and maps, and their use in problem solving and teaching basic reasoning skills. As computers make visual representations more commonplace, it is important for professionals, researchers and students in computer science, philosophy, and logic to develop an understanding of these tools; this book can clarify the relationship between visuals and information. (shrink)

Aristotle's _Nicomachean Ethics_ is one of the most important texts in western philosophy, and arguably the most influential text on contemporary moral theory. This _GuideBook_ introduces and assesses: * Aristotle's life and the background to the _Nicomachean Ethics_ * The ideas and text of the _Nicomachean Ethics_ * Aristotle's central role in philosophy and his continuing contribution to our ethical thought.

The Realm of Reason develops a new, general theory of what it is for a thinker to be entitled to form a given belief. The theory locates entitlement in the nexus of relations between truth, content, and understanding. Peacocke formulates three principles of rationalism that articulate this conception. The principles imply that all entitlement has a component that is justificationally independent of experience. The resulting position is thus a form of rationalism, generalized to all kinds of content.To show how these (...) principles are realized in specific domains, Peacocke applies the theory in detail to several classical problems of philosophy, including the nature of perceptual entitlement, induction, and the status of moral thought. These discussions involve an elaboration of the structure of entitlement in ways that have applications in many other areas of philosophy. He also relates the theory to classical and recent rationalist thought, and to current issues in the theory of meaning, reference and explanation. In the course of these discussions, he proposes a general theory of the a priori.The focus of the work lies in the intersection of epistemology, metaphysics, and the theory of meaning, and will be of interest both to students and researchers in these areas, and to anyone concerned with the idea of rationality. (shrink)

Résumé Loin d’être un programme de recherche tourné uniquement vers l’abstraction, la physiocratie comporte une dimension empirique tout à fait centrale dans sa constitution et dans son développement. L’étude de cette dimension permet de mettre au jour les liens généalogiques et méthodologiques qui ont uni le mouvement physiocratique et les traditions anglaise et française de l’arithmétique politique. En outre, une attention portée à l’inventaire des différentes activités agricoles et à la mesure de leurs productions respectives témoigne d’une autre influence importante (...) dans la construction de l’économie politique de Quesnay, à savoir l’agronomie, alors en plein renouveau sous l’impulsion de Duhamel du Monceau. (shrink)

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

The agronomist who wants to study the nutrient and water uptake of roots needs a quantitative three-dimensional dynamic model of the structure of root systems.The model presented takes into account current knowledge about the morphogenesis of root systems. It describes the root system as a set of root axes, characterised by their orders. The morphogenetic properties of root axes differ according to their order. The axes of order 1 are directly inserted on the stem, the axes of order 2 are (...) inserted on axes of order 1, and so on. They tend to be more plagiotropec and to have less vascular bundles as the order increases. (shrink)

We propose that interaction rules derived from polyamine exchange in connected cells may explain the spatio‐temporal organization of gap junctions observed during tissue regeneration and tumorigenesis. We also hypothesize that polyamine exchange can be considered as signal that allows cells to sense the proliferation status of their neighbors. Polyamines (putrescine, spermidine, and spermine) are indeed small aliphatic polycations that serve as fuels to sustain elevated proliferation rates of the order observed in cancer cells. Based on recent reports, we consider here (...) that polyamines can be exchanged through gap junction channels between mammalian cells. Such intercellular exchange of polyamines has critical consequences on the local control of growth. In line with this hypothesis, the complex protein network that keeps polyamine levels finely tuned in mammalian cells can translate polyamine efflux or influx into integrated signals controlling transcription, translation, and cell communications. (shrink)

It is now integral to much of cultural, political and social analysis. This is the first comprehensive survey in one volume of the interdisciplinary field of cosmopolitan studies.

Suppose we believe that God created the world. Then surely we want it to be the case that he intended, in some sense at least, to create THIS world. Moreover, most theists want to hold that God didn't just guess or hope that the world would take one course or another; rather, he KNEW precisely what was going to take place in the world he planned to create. In particular, of each person P, God knew that P was to exist. (...) Call this the "standard" conception. Most theists find the standard conception appealing. Unfortunately, the view seems to conflict with the equally appealing idea — call it "temporal actualism" — that there are no "future" individuals beyond those that already exist in the present moment. For, on this view, for any historical person P, prior to creation, there was no such person as P and hence nothing about P for God to know. Hence, in particular, God couldn't have known that P was to exist. This is of course not a new problem. But past solutions to it are highly problematic. In this paper, after canvassing previous approaches, I will propose a solution that seems to preserve both temporal actualism and a suitably robust form of the standard conception while avoiding the pitfalls of the past. (shrink)

The Court of Justice of the European Union (CJEU) has some basic structural features similar to that of most judicial bodies. According to the treaties, the members of the Court are chosen from individuals whose independence is beyond doubt and who possess the ability required for appointment to higher judicial offices. The involvement of the Court and its president in the most important reforms of the European Union's judicial architecture in recent years is a striking feature which may be called (...) judicial self‐government. International courts have shifted away from being principally committed to dispute settlement towards pursuing other goals, such as advancing international norms and facilitating cooperative international arrangements. The reinforcement of the cooperation of the Court with national courts on the one hand, and with international courts and tribunals on the other, is one of the great current challenges facing the Court. (shrink)

This paper reflects on the notion of partial ambiguity. Using a framework decomposing ambiguity into distinct layers of analysis, among which are risk and model uncertainty, and allowing for different attitudes toward these layers, I show that partial ambiguity may prove less desirable than full ambiguity, even under ambiguity aversion. This observation poses difficulties for interpreting the notion of partial ambiguity in relation to the partial information available to determine the potential compositions of an ambiguous urn. Two Ellsberg-style thought experiments (...) are described to challenge the meaning of partial ambiguity further, and an alternative interpretation, based on a more ambiguous relation, is discussed. (shrink)

We have developed an approach to implementing a system for managing situated knowledge for complex instruments. Our aim is to develop a system that guides a user through the steps for operating complex scientific instruments. A user manual is often inadequate support for a community of users, so direct communication with an expert is often required. One reason for this is that not all of the author’s expert knowledge was included in the manual, thus limiting the contents to explicit knowledge. (...) This is a main concern of modern knowledge management practitioners who are attempting to design systems that consider both explicit and tacit knowledge. The key is to distribute explicit knowledge through interaction with the real world so that users can develop tacit knowledge as well as acquire explicit knowledge. We describe technical difficulties related to referencing the real world, which is required for interaction, and describe a novel approach to building a low-cost three-dimensional pointer for obtaining the required knowledge, which constitutes our preliminary result. (shrink)

Résumé Cet article présente l’analyse d’une expérience de construction de savoirs mathématiques en rapports avec les machines, dans les années 1950 et 1960, à une époque où le calcul analogique cohabitait avec le calcul digital (c’est-à-dire le futur « ordinateur », terme introduit dans la langue française pour désigner principalement les « digital computers »). Les mathématiques en jeu relèvent des théories des systèmes dynamiques, c’est-à-dire des outils mathématiques construits pour comprendre la dynamique de différents types de systèmes, qu’ils soient (...) mathématiques, physiques, biologiques, mécaniques, etc. L’objet du présent article est à la fois un groupe de chercheurs, leurs pratiques de « mathématiques pour l’ingénieur », leurs efforts pour construire des calculateurs analogiques (mécanique ou électronique) pour étudier la dynamique, le programme baptisé « Dynamique théorique » qu’ils se sont fixés, et l’épistémologie des mathématiques sous-tendant leur pratique. (shrink)

In February 54b.c. Cicero concludes a missive to his brother with a passing and – for us – tantalizing remark:Lucreti poemata ut scribis ita sunt, multis luminibus ingeni, multae tamen artis. sed cum veneris. virum te putabo si Sallusti Empedoclea legeris; hominem non putabo. Quintus had, it seems, readDe rerum natura, or at least parts thereof, just before he left Rome for an undisclosed location nearby, and he shared his enthusiasm with his brotherper codicillos. Meanwhile, he was corresponding with Julius (...) Caesar, whose staff in Gaul he was about to join. When, a few months later, he was stationed with Caesar, he was involved in another literary affair, this time concerning his brother who wrote to him, inquiring about his autobiographicalDe temporibus suis:quo modo nam, mi frater, de nostris versibus Caesar? nam primum librum se legisse scripsit ad me ante, et prima sic ut neget se ne Graeca quidem meliora legisse; reliqua ad quendam locum ῥᾳθυμότερα (hoc enim utitur verbo). dic mihi verum: num aut res eum aut χαρακτὴρ non delectat?(Q.fr.2.15.5). (shrink)